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A numerical model of blood oxygenation during veno-venous ECMO: analysis of the interplay between blood oxygenation and its delivery parameters

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Abstract

Veno-venous extracorporeal membrane oxygenation (VV-ECMO) is an important tool in the management of most severe forms of acute respiratory failure. The determinants and management of oxygen delivery in patients treated with VV-ECMO is a complex topic. The physiological principles of oxygenation on VV-ECMO are reviewed in many textbooks. However a numerical model is an additional instrument to be used in understanding and exploring this intricate subject matter. We present a numerical model of blood oxygenation during VV-ECMO. Using this model we examined the role and impact of each determinant on blood oxygenation. The numerical analysis of variation and interplay between each oxygenation determinants during VV-ECMO is presented in graphical form. These results corroborate all the findings of previous studies. The proposed numerical model facilitates understanding of oxygenation physiology during VV-ECMO; it can be used for a medical simulation system and for teaching the principles of oxygenation during VV-ECMO.

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Acknowledgments

None of the authors has a support or financial relationship with a research organization.

Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

  1. Service de réanimation, Centre Hospitalier de Cholet, 1 rue Marengo, BP 507, 49325, Cholet, France

    Elmi Messai

  2. Departement de Physique, Université de Souk-Ahras, 41000, Souk-Ahras, Algeria

    Abdesselam Bouguerra

  3. Cardiac Surgery, Department of Sperimental and Clinical Medicine, University of Florence, Florence, Italy

    Guy Harmelin, Gabriella Di Lascio & Massimo Bonacchi

  4. Anaesthesia and Intensive Care Unit of Emergency Department, Careggi Teaching Hospital, Florence, Italy

    Manuela Bonizzoli

Authors
  1. Elmi Messai
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  2. Abdesselam Bouguerra
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  3. Guy Harmelin
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  4. Gabriella Di Lascio
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  5. Manuela Bonizzoli
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  6. Massimo Bonacchi
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Corresponding author

Correspondence to Elmi Messai.

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Messai, E., Bouguerra, A., Harmelin, G. et al. A numerical model of blood oxygenation during veno-venous ECMO: analysis of the interplay between blood oxygenation and its delivery parameters. J Clin Monit Comput 30, 327–332 (2016). https://doi.org/10.1007/s10877-015-9721-8

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  • DOI: https://doi.org/10.1007/s10877-015-9721-8

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