A Deep Learning-Based Approach for the Detection and Localization of Prostate Cancer in T2 Magnetic Resonance Images | Journal of Imaging Informatics in Medicine
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A Deep Learning-Based Approach for the Detection and Localization of Prostate Cancer in T2 Magnetic Resonance Images

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Abstract

We address the problem of prostate lesion detection, localization, and segmentation in T2W magnetic resonance (MR) images. We train a deep convolutional encoder-decoder architecture to simultaneously segment the prostate, its anatomical structure, and the malignant lesions. To incorporate the 3D contextual spatial information provided by the MRI series, we propose a novel 3D sliding window approach, which preserves the 2D domain complexity while exploiting 3D information. Experiments on data from 19 patients provided for the public by the Initiative for Collaborative Computer Vision Benchmarking (I2CVB) show that our approach outperforms traditional pattern recognition and machine learning approaches by a significant margin. Particularly, for the task of cancer detection and localization, the system achieves an average AUC of 0.995, an accuracy of 0.894, and a recall of 0.928. The proposed mono-modal deep learning-based system performs comparably to other multi-modal MR-based systems. It could improve the performance of a radiologist in prostate cancer diagnosis and treatment planning.

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Acknowledgements

The authors would also like to thank Dr. Waleed Hassen and Dr. Eric Vens from Cleveland Clinic, Abu Dhabi, and Dr. Salah El-Rai from Sheikh Khalifa General Hospital for their support and collaboration.

Funding

This work is support by a research grant from Al-Jalila foundation ref. AJF-201616.

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Authors and Affiliations

  1. Khalifa University of Science and Technology, PO Box 127788, Abu Dhabi, United Arab Emirates

    Ruba Alkadi, Fatma Taher & Naoufel Werghi

  2. University of Louisville, Louisville, KY, 40292, USA

    Ayman El-baz

Authors
  1. Ruba Alkadi
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  2. Fatma Taher
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  3. Ayman El-baz
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  4. Naoufel Werghi
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Correspondence to Ruba Alkadi.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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http://i2cvb.github.io/

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Alkadi, R., Taher, F., El-baz, A. et al. A Deep Learning-Based Approach for the Detection and Localization of Prostate Cancer in T2 Magnetic Resonance Images. J Digit Imaging 32, 793–807 (2019). https://doi.org/10.1007/s10278-018-0160-1

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