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Autofluorescence imaging in recurrent oral squamous cell carcinoma

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Abstract

The survival of patients with oral cancer is decreased by locoregional recurrence after an initial multimodal treatment. In order to identify lesions in the oral cavity for a possible recurrence, clinical evaluation as well as MRI or CT scanning is advised. The evaluation of mucosa lesions is hampered by changes related to radio- and chemotherapy as well as reconstruction with tissue flaps. Several techniques for easier identification of tissue abnormalities in the oral cavity have been advocated as adjuncts in order to facilitate identification. Especially methods using altered tissue fluorescence have gained much interest during the last decade. The aim of our prospective study was to evaluate fluorescence properties of undiagnosed mucosa lesions with the VELscope device in patients with multimodal treated oral cancer prior to histological confirmation. In total, 41 patients with a history of oral squamous cell carcinomas (OSCC) (19 females and 22 males) with undiagnosed mucosa lesions where included in the study. After clinical evaluation, examination and documentation using the VELscope® device were performed. Then, an incisional biopsy was performed. An autofluorescence loss indicating a malignant or dysplastic mucosa condition could be detected in six patients (14.6 %); however, only one OSCC and one SIN revealed a complete autofluorescence loss. In four patients, OSCC was present in lesions with retained autofluorescence. Sensitivity and specificity for the VELscope® examination to identify malignant oral lesions by autofluorescence were 33.3 and 88.6 %, respectively. The positive and negative predictive values were 33.3 and 88.6 %, respectively. No statistical correlation between gender and lesion appearance versus autofluorescence loss could be detected. In contrast to mucosa lesions in patients with no prior treatment, the autofluorescence evaluation with the VELscope reveals no additional information in our analysis. Accordingly, invasive biopsies as gold standard are still needed to get sufficient evidence regarding potential malignancy in patients after multimodal treatment for oral cancer.

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Authors and Affiliations

  1. Department for Oral and Craniomaxillo and Facial Plastic Surgery, Johannes Wesling Klinikum Minden, Hans-Nolte-Str. 1, 32429, Minden, Germany

    Martin Scheer

  2. Department for Oral and Craniomaxillo and Facial Plastic Surgery, University of Cologne, Cologne, Germany

    Juliana Fuss, Mehmet Ali Derman, Matthias Kreppel, Daniel Rothamel & Joachim E. Zoeller

  3. Dental Private Practice, Bayer, Kistler, Elbertzhagen and Colleagues, Landsberg am Lech, Germany

    Jörg Neugebauer

  4. Department of Pathology, University of Cologne, Cologne, Germany

    Uta Drebber

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  1. Martin Scheer
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  2. Juliana Fuss
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  3. Mehmet Ali Derman
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  4. Matthias Kreppel
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  5. Jörg Neugebauer
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  6. Daniel Rothamel
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  8. Joachim E. Zoeller
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Correspondence to Martin Scheer.

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Martin Scheer and Juliana Fuss joined first authorship.

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Scheer, M., Fuss, J., Derman, M.A. et al. Autofluorescence imaging in recurrent oral squamous cell carcinoma. Oral Maxillofac Surg 20, 27–33 (2016). https://doi.org/10.1007/s10006-015-0520-7

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  • DOI: https://doi.org/10.1007/s10006-015-0520-7

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