Abstract
Myocardial infarction results from the rupture of an atherosclerotic plaque, which occurs in response to both mechanical stress and inflammatory processes. In order experimentally observe flow into atherosclerotic coronary artery morphologies, a novel technique for molding realistic compliant phantom featuring injection-molded inclusions and multiple layers has been developed. This transparent phantom allows for particle image velocimetry (PIV) flow analysis and can supply experimental data to validate computational fluid dynamics algorithms and hypothesis.
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Mr. Jean Brunette is currently completing his PhD Biomedical Engineering at the Montreal Heart Institute under the University of Montreal Faculty of Medicine program. He did his master degree in Biomedical Engineering at the École Polytechnique of Montreal on intravascular ultrasound imaging. He is presently working on experimental blood dynamics into atherosclerotic coronary arteries and development of cardiovascular devices. Mr. Brunette is currently preparing his postdoctoral industrial fellowship in stent deployment and cryoablation interventions.
Dr. Rosaire Mongrain is an Assistant Professor in Mechanical Engineering at McGill University. He is also a researcher at the Montreal Heart Institute and shares a Biomechanics Laboratory with clinical researchers and basic scientists. He completed his PhD at the École Polytechnique of Montreal in biomedical engineering on blood dynamics and a postdoctoral fellowship at Brigham’s Women Hospital in interventional radiology. Dr. Mongrain research interests include blood flow dynamics, cardiovascular rheology, circulatory disorders and the design and improvement of cardiovascular devices.
Dr. Jean-Claude Tardif is an associate professor of Montreal faculty of medicine at the Montreal Heart Institute, where he also serves as a cardiologist and Director of Research. Dr. Tardif is holder of a chair on atherosclerosis created by the Pfizer pharmaceutical society, Health Research Canada and the University of Montreal. Conducting 40 people within his team, he is specialized into antioxidants and intravascular ultrasound imaging. He wrote numerous articles in prestigious journals like the New England Journal of Medicine and has been stated as one of the most promising researchers of the new generation by the American Time magazine.
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Brunette, J., Mongrain, R. & Tardif, J.C. A realistic coronary artery phantom for particle image velocimetry. J Vis 7, 241–248 (2004). https://doi.org/10.1007/BF03181639
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DOI: https://doi.org/10.1007/BF03181639