Abstract
The influenza virus changes its antigenicity frequently due to rapid mutations, leading to immune escape and failure of vaccination. Rapid determination of the influenza antigenicity could help identify the antigenic variants in time. Here, we built a stacked auto-encoder (SAE) model for predicting the antigenic variant of human influenza A(H3N2) viruses based on the hemagglutinin (HA) protein sequences. The model achieved an accuracy of 0.95 in five-fold cross-validations, better than the logistic regression model did. Further analysis of the model shows that most of the active nodes in the hidden layer reflected the combined contribution of multiple residues to antigenic variation. Besides, some features (residues on HA protein) in the input layer were observed to take part in multiple active nodes, such as residue 189, 145 and 156, which were also reported to mostly determine the antigenic variation of influenza A(H3N2) viruses. Overall, this work is not only useful for rapidly identifying antigenic variants in influenza prevention, but also an interesting attempt in inferring the mechanisms of biological process through analysis of SAE model, which may give some insights into interpretation of the deep learning models.
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Acknowledgement
This study was supported by the National Natural Science Foundation (31500126 and 31371338), the National Key Plan for Scientific Research and Development of China (2016YFD0500300 and 2016YFC1200200), and the Chinese Academy of Medical Sciences (2016-I2 M-1-005).
There are no conflicts of interest.
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Tan, Z., Xu, B., Li, K., Jiang, T., Peng, Y. (2017). Predicting the Antigenic Variant of Human Influenza A(H3N2) Virus with a Stacked Auto-Encoder Model. In: Zou, B., Han, Q., Sun, G., Jing, W., Peng, X., Lu, Z. (eds) Data Science. ICPCSEE 2017. Communications in Computer and Information Science, vol 728. Springer, Singapore. https://doi.org/10.1007/978-981-10-6388-6_25
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DOI: https://doi.org/10.1007/978-981-10-6388-6_25
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