Abstract
Phosphorylation cycles are a common motif in biological intracellular signaling networks. A phosphorylaton cycle can be modeled as an artificial biochemical neuron, which can be considered as a variant of the artificial neurons used in neural networks. In this way the artificial neural network metaphor can be used to model and study intracellular signaling networks. The question what types of computations can occur in biological intracellular signaling networks leads to the study of the computational power of networks of artificial biochemical neurons. Here we consider the computational properties of artificial biochemical neurons, based on mass-action kinetics. We also study the computational power of feedforward networks of such neurons. As a result, we give an algebraic characterization of the functions computable by these networks.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Cohen, P.: The Regulation of Protein Function by Multisite Phosphorylation, a 25 Year Update. Trends Biochem. Sci. 25(12), 596–601 (2000)
Bray, D.: Bacterial Chemotaxis and the Question of Gain. Proc. Nat. Acad. Sci. 99(1), 123–127 (2002)
Rao, C., Arkin, A.: Control Motifs for Intracellular Regulatory Networks. Annu. Rev. Biomed. Eng. 3, 391–419 (2001)
Gomperts, B.D., Kramer, I.M., Tatham, P.E.R.: Signal Transduction. Academic Press, London (2002)
Kitano, H.: Systems Biology, A Brief Overview. Science 295(5560), 1662–1664 (2002)
Ball, P.: Chemistry Meets Computing. Nature 406, 118–120 (2000)
Arkin, A., Ross, J.: Computational Functions in Biochemical Reaction Networks. Biophys. J. 67(2), 560–578 (1994)
Bray, D.: Protein Molecules as Computational Elements in Living Cells. Nature 376(6538), 307–312 (1995)
Bhalla, U.: Understanding complex signaling networks through models and metaphors. Progr. Biophys. Mol. Biol. 81, 45–65 (2003)
Hjelmfelt, A., Weinberger, E., Ross, J.: Chemical Implementation of Neural Networks and Turing Machines. Proc. Nat. Acad. Sci. 88(24), 10983–10987 (1991)
Bartlett, A., Hollot, C., Lin, H.: Root Locations of an Entire Polytope of Polynomials: It Suffces to Check the Edges. Math. Control Signals Systems 1, 61–71 (1988)
Dixon, M., Webb, E.C.: Enzymes. Longman (1979)
Goldbeter, A., Koshland, D.: An amplified sensitivity arising from covalent modification in biological systems. Proc. Nat. Acad. Sci. 78(11), 6840–6844 (1981)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2009 Springer Tokyo
About this paper
Cite this paper
ten Eikelder, H.M.M., Crijns, S.P.M., Steijaert, M.N., Liekens, A.M.L., Hilbers, P.A.J. (2009). Computing with Feedforward Networks of Artificial Biochemical Neurons. In: Suzuki, Y., Hagiya, M., Umeo, H., Adamatzky, A. (eds) Natural Computing. Proceedings in Information and Communications Technology, vol 1. Springer, Tokyo. https://doi.org/10.1007/978-4-431-88981-6_4
Download citation
DOI: https://doi.org/10.1007/978-4-431-88981-6_4
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-88980-9
Online ISBN: 978-4-431-88981-6
eBook Packages: Computer ScienceComputer Science (R0)