Abstract
This article proposes a breath analysis system that makes use of chemical sensors to detect acetone in human breath, and hence detect the diabetes and measure the blood glucose levels of diabetics. We captured the breath samples from healthy persons and patients known to be afflicted with diabetes and conducted experiments on disease identification and simultaneous blood glucose measurement. SVM classifier was used to identify diabetes from healthy samples and three models were built to fit the curves that can represent the blood glucose levels. The results show that the system is not only able to distinguish between breath samples from patients with diabetes and healthy subjects, but also to represent the fluctuation of blood sugar of diabetics and therefore to be an evaluation tool for monitoring the blood glucose of diabetes.
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DAmico, A., Di Natale, C., Paolesse, R., Macagnano, A., Martinelli, E., et al.: Olfactory systems for medical applications. Sensors & Actuators: B. Chemical 130(1), 458–465 (2007)
Schubert, J., Miekisch, W., Geiger, K., Noldge-Schomburg, G.: Breath analysis in critically ill patients: potential and limitations. Expert Rev. Mol. Diagn. 4(5), 619–629 (2004)
Miekisch, W., Schubert, J., Noeldge-Schomburg, G.: Diagnostic potential of breath analysis-focus on volatile organic compounds. Clinica Chimica Acta 347(1-2), 25–39 (2004)
Sehnert, S., Jiang, L., Burdick, J., Risby, T.: Breath biomarkers for detection of human liver diseases: preliminary study. Biomarkers 7(2), 174–187 (2002)
Amann, A., Schmid, A., Scholl-Burgi, S., Telser, S., Hinterhuber, H.: Breath analysis for medical diagnosis and therapeutic monitoring. Spectroscopy Europe 17(3), 18–20 (2005)
Deykin, A., Massaro, A., Drazen, J., Israel, E.: Exhaled nitric oxide as a diagnostic test for asthma: online versus offline techniques and effect of flow rate. American journal of respiratory and critical care medicine 165(12), 1597–1601 (2002)
Silkoff, P., Robbins, R., Gaston, B., Lundberg, J., Townley, R.: Endogenous nitric oxide in allergic airway disease. The Journal of Allergy and Clinical Immunology 105(3), 438–448 (2000)
Heffler, E., Guida, G., Marsico, P., Bergia, R., Bommarito, L., Ferrero, N., Nebiolo, F., De Stefani, A., Usai, A., Bucca, C., et al.: Exhaled nitric oxide as a diagnostic test for asthma in rhinitic patients with asthmatic symptoms. Respiratory medicine 100(11), 1981–1987 (2006)
McGrath, L., Patrick, R., Mallon, P., Dowey, L., Silke, B., Norwood, W., Elborn, S.: Breath isoprene during acute respiratory exacerbation in cystic fibrosis. European Respiratory Journal 16(6), 1065–1069 (2000)
Phillips, M., Sabas, M., Greenberg, J.: Increased pentane and carbon disulfide in the breath of patients with schizophrenia. Journal of clinical pathology 46(9), 861–864 (1993)
Phillips, M., Altorki, N., Austin, J., Cameron, R., Cataneo, R., Greenberg, J., Kloss, R., Maxfield, R., Munawar, M., Pass, H., et al.: Prediction of lung cancer using volatile biomarkers in breath. Cancer Biomarkers 3(2), 95–109 (2007)
Phillips, M., Cataneo, R., Cummin, A., Gagliardi, A., Gleeson, K., Greenberg, J., Maxfield, R., Rom, W.: Detection of Lung Cancer With Volatile Markers in the Breath, Chest 123(6), 2115–2123 (2003)
Davies, S., Spanel, P., Smith, D.: Quantitative analysis of ammonia on the breath of patients in end-stage renal failure. Kidney international 52(1), 223–228 (1997)
Spanel, P., Davies, S., Smith, D.: Quantification of ammonia in human breath by the selected ion flow tube analytical method using H3O+ and O2+ precursor ions. Rapid communications in mass spectrometry 12(12), 763–766 (1998)
http://diabetes.about.com/od/whatisdiabetes/u/symptomsdiagnosis.htm
Tassopoulos, C., Barnett, D., Russell Fraser, T.: Breath-acetone and blood-sugar measurements in diabetes. The Lancet. 293(7609), 1282–1286 (1969)
Wang, C., Mbi, A., Shepherd, M.: A study on breath acetone in diabetic patients using a cavity ringdown breath analyzer: Exploring correlations of breath acetone with blood glucose and glycohemoglobin a1c. IEEE Sensors Journal 10(1), 54–63 (2010)
Burges, C.J.C.: A tutorial on support vector machines for pattern recognition. Data mining and knowledge discovery 2(2), 121–167 (1998)
Melker, R., Bjoraker, D., Lampotang, S.: System and method for monitoring health using exhaled breath. uS Patent App. 11/512, 856, August 29 (2006)
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Guo, D., Zhang, D., Li, N., Zhang, L., Yang, J. (2010). Diabetes Identification and Classification by Means of a Breath Analysis System. In: Zhang, D., Sonka, M. (eds) Medical Biometrics. ICMB 2010. Lecture Notes in Computer Science, vol 6165. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-13923-9_6
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DOI: https://doi.org/10.1007/978-3-642-13923-9_6
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-13922-2
Online ISBN: 978-3-642-13923-9
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