Abstract
Calculations of potential numbers of interactions between gene products to generate physiological functions show that we can expect a highly non-linear relation between genome size and functional complexity. Moreover, very small differences in gene numbers or sequence can translate into very large differences in functionality.
This is a preview of subscription content, log in via an institution to check access.
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
International Human Genome Mapping Consortium, A physical map of the human genome. Nature 409, 934–941 (2001)
Venter, C., et al.: The sequence of the human genome. Science 291, 1304–1351 (2001)
Collins, F.S., et al.: A vision for the future of genomics research. Nature 422, 835–847 (2003)
Chervitz, S.A., et al.: Comparison of the Complete Protein Sets of Worm and Yeast: Orthology and Divergence. Science 282, 2022–2028 (1998)
Sulston, J., Ferry, G.: The Common Thread. Bantam Press, London (2002)
Hutchison, C.A., et al.: Global Transposon Mutagenesis and a Minimal Mycoplasma Genome. Science 286, 2165–2169 (1999)
Palsson, B.O.: The challenges of in silico biology. Nature Biotechnology 18, 1147–1150 (2000)
Edwards, J.S., Palsson, B.O.: In Silico predictions of Escherichia coli metabolic capabilities are consistent with experimental data. Nature Biotechnology 19(2), 125–130 (2001)
Stelling, J., et al.: Metabolic network structure determines key aspects of functionality and regulation. Nature 420, 190–193 (2002)
Garny, A., et al.: Comparative study of sino-atrial node cell models. Chaos, Solitons and Fractals 13, 1623–1630 (2002)
Winslow, R.L., Rice, J.J., Jafri, S.: Modeling the cellular basis of altered excitationcontraction coupling in heart failure. Progress in Biophysics and Molecular Biology 69, 497–514 (1998)
Magnan, C.: Personal communication (2003)
Celotto, A.M., Graveley, B.R.: Alternative splicing of the Drosophila Dscam pre-mRNA is both temporally and spatially regulated. Genetics 159, 599–608 (2001)
Antzelevitch, C., et al.: Influence of transmural gradients on the electrophysiology and pharmacology of ventricular myocardium. Cellular basis for the Brugada and long-QT syndromes. Philosophical Transactions of the Royal Society, series A 359, 1201–1216 (2001)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2005 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Feytmans, E., Noble, D., Peitsch, M.C. (2005). Genome Size and Numbers of Biological Functions. In: Priami, C. (eds) Transactions on Computational Systems Biology I. Lecture Notes in Computer Science(), vol 3380. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-32126-2_4
Download citation
DOI: https://doi.org/10.1007/978-3-540-32126-2_4
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-25422-5
Online ISBN: 978-3-540-32126-2
eBook Packages: Computer ScienceComputer Science (R0)