Deciphering the Genetic Blueprint of Cerebellar Development by the Gene Expression Profiling Informatics | SpringerLink
Skip to main content

Deciphering the Genetic Blueprint of Cerebellar Development by the Gene Expression Profiling Informatics

  • Conference paper
Neural Information Processing (ICONIP 2004)

Abstract

The brain is the ultimate genetic system to which a large number of genes are devoted. To extract and visualize biological information from such large data sets accumulated in the post-sequencing era, the use of bioinformatics would be a very powerful means. To understand the genetic basis of mouse cerebellar postnatal development, we have analyzed the whole transcription or gene expression (transcriptome) during the developmental stages on a genome-wide basis, and have systematized the spatio-temporal gene expression profile information in a comprehensive database (Cerebellar Development Transcriptome [CDT] database) from a bioinformatics point of view. This CDT database would open up a new field for deciphering the genetic blueprint for cerebellar development.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Subscribe and save

Springer+ Basic
¥17,985 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
JPY 3498
Price includes VAT (Japan)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
JPY 5719
Price includes VAT (Japan)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
JPY 7149
Price includes VAT (Japan)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  1. International Human Genome Sequencing Consortium: Initial sequencing and analysis of the human genome. Nature 409, 860–921 (2001)

    Google Scholar 

  2. Mouse Genome Sequencing Consortium: Initial sequencing and comparative analysis of the mouse genome. Nature 420, 520–562 (2002)

    Google Scholar 

  3. Shiraishi, Y., Mizutani, A., Bito, H., Fujisawa, K., Narumiya, S., Mikoshiba, K., Furuichi, T.: Cupidin, an isoform of Homer/Vesl, interacts with the actin cytoskeleton and activated Rho family samall GTPases and is expressed in developing mouse cerebellar granule cells. J. Neuosci. 19, 8389–8400 (1999)

    Google Scholar 

  4. Kaplan, B.B.: Current Approaches to the Study of Gene Expression in the Adult and Developing Brain. In: Rassin, D., Harber, B., Brujan, B. (eds.) Basic and Clinical Aspects of Nutrition and brain Development, pp. 131–155. Alan R. Liss, Inc., New York (1987)

    Google Scholar 

  5. Kaplan, B.B.: RNA-DNA Hybridization: Analysis of Gene Expression. In: Lajtha, A. (ed.) The Handbook of Neurochemistry, vol. 2, pp. 1–26. Plenum Press, New York (1982)

    Google Scholar 

  6. Sutcliffe, J.G.: mRNA in the Mammalian Central Nervous System. Ann. Rev. Neurosci. 11, 157–198 (1988)

    Article  Google Scholar 

  7. Kagami, Y., Furuichi, T.: Investigation of differentially expressed genes during the development of mouse cerebellum. Gene Expression Patterns 1, 39–59 (2001)

    Article  Google Scholar 

  8. Sadakata, T., Mizoguchi, A., Sato, Y., Katoh-Semba, R., Fukuda, M., Mikoshiba, K., Furuichi, T.: Secretory granule-associated protein CAPS2 regulates neurotrophin release and cell survival. J. Neurosci. 24, 43–52 (2004)

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2004 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Sato, A. et al. (2004). Deciphering the Genetic Blueprint of Cerebellar Development by the Gene Expression Profiling Informatics. In: Pal, N.R., Kasabov, N., Mudi, R.K., Pal, S., Parui, S.K. (eds) Neural Information Processing. ICONIP 2004. Lecture Notes in Computer Science, vol 3316. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-30499-9_135

Download citation

  • DOI: https://doi.org/10.1007/978-3-540-30499-9_135

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-23931-4

  • Online ISBN: 978-3-540-30499-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics