Abstract
Multimodal registration of CT and MR scans is a required step in leading edge adaptive MR-based image guided radiation therapy protocols. Yet, anatomical changes limit the precision of the registration process and therefore that of the whole intervention. In prostate radiation therapy, the difference in bladder and rectum filling can significantly displace both the targeted area and the organs at risk. Here, we describe a method that integrates an image-based similarity criterion with the anatomical information from manual contours to guide the registration process toward an accurate solution. Whole pelvis CT and MR scans of 33 patients have been nonrigidly registered, and the proposed method leads to an average improvement of 0.17 DSC when compared to a baseline nonrigid registrations. The increased accuracy will thus enhance an MR-based prostate radiation therapy protocol.
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This research was supported by the Cancer Council NSW (RG 11-05), the Prostate Cancer Foundation of Australia (YI2011), Movember and Cure Cancer Australia.
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Rivest-Hénault, D., Greer, P., Fripp, J., Dowling, J. (2014). Structure-Guided Nonrigid Registration of CT–MR Pelvis Scans with Large Deformations in MR-Based Image Guided Radiation Therapy. In: Erdt, M., et al. Clinical Image-Based Procedures. Translational Research in Medical Imaging. CLIP 2013. Lecture Notes in Computer Science(), vol 8361. Springer, Cham. https://doi.org/10.1007/978-3-319-05666-1_9
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DOI: https://doi.org/10.1007/978-3-319-05666-1_9
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