Abstract
We describe a diffeomorphic registration algorithm that allows groups of images to be accurately aligned to a common space, which we intend to incorporate into the SPM software. The idea is to perform inference in a probabilistic graphical model that accounts for variability in both shape and appearance. The resulting framework is general and entirely unsupervised. The model is evaluated at inter-subject registration of 3D human brain scans. Here, the main modeling assumption is that individual anatomies can be generated by deforming a latent ‘average’ brain. The method is agnostic to imaging modality and can be applied with no prior processing. We evaluate the algorithm using freely available, manually labelled datasets. In this validation we achieve state-of-the-art results, within reasonable runtimes, against previous state-of-the-art widely used, inter-subject registration algorithms. On the unprocessed dataset, the increase in overlap score is over 17%. These results demonstrate the benefits of using informative computational anatomy frameworks for nonlinear registration.
M. Brudfors and Y. Balbastre—These authors contributed equally to this work.
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\((\text {TPR}_{\mathrm {MB}} - \text {TPR}_{\mathrm {Shoot}})/(\text {TPR}_{\mathrm {MB}} - \text {TPR}_{\mathrm {Affine}}) \times 100\%\).
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Acknowledgements
MB was funded by the EPSRC-funded UCL Centre for Doctoral Training in Medical Imaging (EP/L016478/1) and the Department of Health’s NIHR-funded Biomedical Research Centre at University College London Hospitals. YB was funded by the MRC and Spinal Research Charity through the ERA-NET Neuron joint call (MR/R000050/1). MB and JA were funded by the EU Human Brain Project’s Grant Agreement No. 785907 (SGA2). GF and the Wellcome Centre for Human Neuroimaging is supported by core funding from the Wellcome (203147/Z/16/Z).
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Brudfors, M., Balbastre, Y., Flandin, G., Nachev, P., Ashburner, J. (2020). Flexible Bayesian Modelling for Nonlinear Image Registration. In: Martel, A.L., et al. Medical Image Computing and Computer Assisted Intervention – MICCAI 2020. MICCAI 2020. Lecture Notes in Computer Science(), vol 12263. Springer, Cham. https://doi.org/10.1007/978-3-030-59716-0_25
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