This paper reviews the use of prescriptive approaches to develop personalised treatment plans in healthcare. A systematic literature review was conducted to identify existing methodologies developed for suggesting treatments in medicine using Systematic Mapping Process, PRISMA methodology, and recommended Critical Appraisal Tools. A final set of 30 documents was analised. The findings indicate that despite efforts to establish prescriptive methodologies, there remains a significant gap in formalising the recommendations within frameworks and by healthcare professionals. Moreover, limited evidence exists on the effective implementation of these proposals in real-world scenarios.