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O)Tj 0.003 Tc 0.06 Tw 2.631 0 Td [(t)4(he)1(r)3( c)1(om)-4(put)4(e)1(r)3( vi)4(s)2(i)4(on w)-4(or)3(ki)4(ng gr)3(oups)2( )]TJ 0 Tc 0 Tw -10.493 -1.098 Td ([)Tj 0.003 Tc -0.003 Tw (29)Tj 0 Tc 0 Tw (] )Tj 0.002 Tc -0.002 Tw 2.069 0 Td [(ar)2(e )]TJ 0.003 Tc 0.143 Tw 1.622 0 Td [(e)1(xpl)4(or)3(i)4(ng s)2(e)1(m)-4(a)1(nt)4(i)4(c)1( t)4(e)1(c)1(hnol)4(ogy w)-4(i)4(t)4(h da)1(t)4(a)1(s)2(e)1(t)4(s)2( t)4(ha)1(t)4( a)1(r)3(e)1( )]TJ 0.19 Tw -3.691 -1.122 Td [(not)4( ne)1(c)1(e)1(s)2(s)2(a)1(r)3(y f)2(oc)1(us)2(e)1(d on unc)1(e)1(r)3(t)4(a)1(i)4(nt)4(y)]TJ 0 Tc 0 Tw 15.604 0 Td (,)Tj 0.249 0 Td ( )Tj 0.003 Tc 0.19 Tw 0.442 0 Td [(but)4( ha)1(ve)1( a)1( r)3(i)4(c)1(h s)2(e)1(t)4( of)2( )]TJ -0.003 Tw -16.295 -1.098 Td [(ont)4(ol)4(ogi)4(e)1(s)2( )]TJ -0.004 Tw [(a)1(nd d)]TJ [(a)1(t)4(a)1(s)2(e)1(t)4(s)2( f)2(or)3( c)1(ol)4(l)4(a)1(bor)3(a)1(t)4(i)4(on a)1(nd c)1(om)-4(pa)1(r)3(i)4(s)2(ons)]TJ -0.001 Tc 0 Tw 23.304 0 Td (. )Tj 0 Tc ( )Tj 0.002 Tc 0.362 Tw -21.841 -1.732 Td [(T)-3(h)-1(e p)-1(ap)-1(er)1( )]TJ 0 Tc 0 Tw 5.024 0 Td [(i)1(n)-3(v)-3(e)-2(s)-1(t)1(i)1(g)-3(a)-2(t)1(e)-2(s)]TJ ( )Tj 5.351 0 Td [(t)1(h)-3(e)]TJ 1.226 0 Td ( )Tj 0.003 Tc 0.361 Tw 0.614 0 Td [(us)2(e)1( of)]TJ 0 Tc 0 Tw 2.79 0 Td ( )Tj 0.006 Tc 0.358 Tw 0.614 0 Td [(U)-1(RRE)1(F)2( f)5(o)3(r)6( W)-4(A)-1(M)-4(I)]TJ 0 Tc 0 Tw 8.563 0 Td ( )Tj -25.645 -1.098 Td [(t)1(ra)-2(c)-2(k)-3(i)1(n)-3(g)]TJ 3.289 0 Td (.)Tj 0.249 0 Td ( )Tj -0.001 Tc 0.615 Tw 0.864 0 Td [(S)-5(e)-3(c)-3(tio)-4(n)-4( I)-1(I)-1( )]TJ 0.003 Tc -0.003 Tw 5.408 0 Td [(e)1(xpl)4(or)3(e)1(s)2( )]TJ 0.611 Tw 4.266 0 Td [(t)4(he)1( i)4(s)2(s)2(ue)1(s)2( of)2( unc)1(e)1(r)3(t)4(a)1(i)4(nt)4(y )]TJ 0.002 Tc -0.002 Tw -14.077 -1.122 Td [(ch)-1(ar)2(act)3(er)2(i)3(zat)3(i)3(o)-1(n)]TJ 0 Tc 0 Tw 6.407 0 Td ( )Tj 0.003 Tc 0.347 Tw 0.6 0 Td [(a)1(nd S)-1(e)1(c)1(t)4(i)4(on I)3(I)]TJ 0 Tc 0 Tw 6.332 0 Td (I,)Tj 0.582 0 Td ( )Tj 0.003 Tc 0.347 Tw 0.6 0 Td [(t)4(he)1( unc)1(e)1(r)3(t)4(a)1(i)4(nt)4(y e)1(va)1(l)4(ua)1(t)4(i)4(on )]TJ 0 Tc 0 Tw -14.521 -1.098 Td [(f)-1(ra)-2(m)-8(e)-2(w)-7(o)-3(rk)]TJ -0.001 Tc 0.239 Tw 4.413 0 Td [(. S)-5(e)-3(c)-3(tio)-4(n)-4( I)]TJ 0 Tc 0 Tw 4.57 0 Td (V)Tj 0.729 0 Td ( )Tj 0.002 Tc 0.236 Tw 0.488 0 Td [(p)-1(r)2(es)1(en)-1(t)3(s)1( a W)-8(A)-5(M)-8(I)2( )]TJ 0 Tc 0 Tw [(t)1(ra)-2(c)-2(k)-3(i)1(n)]TJ 0.003 Tc -0.003 Tw 10.899 0 Td (g )Tj 0.002 Tc 0.236 Tw 0.991 0 Td [(u)-1(s)1(e cas)1(e )]TJ 0.003 Tc 0.258 Tw -22.09 -1.122 Td [(us)2(i)4(ng t)4(he)1( U)-4(R)-3(R)-3(E)-2(F)]TJ 0 Tc 0 Tw 7.675 0 Td ( )Tj 0.002 Tc 0.259 Tw 0.511 0 Td [(f)1(o)-1(r)2( t)3(i)3(m)-6(el)3(i)3(n)-1(ess,)3( accu)-1(r)2(acy)-1(,)3( an)-1(d)-1( co)-1(n)-1(f)1(i)3(d)-1(en)-1(ce)]TJ -0.001 Tc 0.001 Tw 17.211 0 Td (. )Tj -25.396 -1.098 Td [(S)-5(e)-3(c)-3(tio)-4(n)-4( )]TJ 0 Tc 0 Tw 3.262 0 Td (V)Tj 0.729 0 Td ( )Tj 0.003 Tc -0.004 Tw 0.249 0 Td [(pr)3(ovi)4(de)1(s)2( a)1(nd di)4(s)2(c)1(us)2(s)2(i)4(on a)1(nd S)-1(e)1(c)1(t)4(i)4(on V)-4(I)3( c)1(onc)1(l)4(us)2(i)4(ons)2(.)4( )]TJ 0 Tc 0 Tw 21.356 0 Td ( )Tj 0.005 Tc -0.005 Tw -23.315 -2.585 Td (II.)Tj /TT2 1 Tf 0 Tc 0 Tw 0.931 0 Td ( )Tj /TT0 1 Tf 1.364 0 Td (T)Tj 0.006 Tc -0.006 Tw 7.92 0 0 7.92 95.6492 216.36 Tm [(H)-1(E)1( )]TJ 0 Tc 0 Tw 9.84 0 0 9.84 108.3132 216.36 Tm (U)Tj 0.007 Tc -0.007 Tw 7.92 0 0 7.92 115.5349 216.36 Tm [(NC)1(E)2(R)1(T)2(AI)4(NT)2(Y )]TJ 0 Tc 0 Tw 9.84 0 0 9.84 168.6404 216.36 Tm (R)Tj 0.006 Tc -0.006 Tw 7.92 0 0 7.92 175.3103 216.36 Tm [(EPR)-1(ESEN)-2(TA)-2(TI)3(O)-2(N)-2( )]TJ 0 Tc 0 Tw 9.84 0 0 9.84 241.7517 216.36 Tm (P)Tj 0.006 Tc -0.006 Tw 7.92 0 0 7.92 247.3132 216.36 Tm [(R)-1(O)-2(B)-1(LEM)]TJ 0 Tc 0 Tw 9.84 0 0 9.84 280.6492 216.36 Tm ( )Tj 0.002 Tc -0.002 Tw -22.533 -1.537 Td [(T)-3(h)-1(e )]TJ 0.003 Tc 0.341 Tw 2.159 0 Td [(I)3(nf)2(or)3(m)-4(a)1(t)4(i)4(on F)-1(us)2(i)4(on)]TJ 0 Tc 0 Tw 8.13 0 Td ( )Tj 0.003 Tc 0.342 Tw 0.595 0 Td [(c)1(om)-4(m)-4(uni)4(t)4(y e)1(nvi)4(s)2(i)4(ons)2( e)1(f)2(f)2(or)3(t)4(l)4(e)1(s)2(s)2( )]TJ 0.83 Tw -12.348 -1.098 Td [(i)4(nt)4(e)1(r)3(a)1(c)1(t)4(i)4(on be)1(t)4(w)-4(e)1(e)1(n hum)-4(a)1(ns)2( a)1(nd )]TJ 0.002 Tc 0.831 Tw 16.554 0 Td [(co)-1(m)-5(p)-1(u)-1(t)3(er)2(s)1(,)3( s)1(eam)-5(l)3(es)1(s)1( )]TJ 0.003 Tc 0.073 Tw -16.554 -1.122 Td [(i)4(nt)4(e)1(r)3(ope)1(r)3(a)1(bi)4(l)4(i)4(t)4(y a)1(nd i)4(nf)2(or)3(m)-4(a)1(t)4(i)4(on e)1(xc)1(ha)1(nge)1( )]TJ 0.074 Tw 17.48 0 Td [(a)1(m)-4(ong a)1(ppl)4(i)4(c)1(a)1(t)4(i)4(ons)]TJ -0.001 Tc 0.001 Tw 7.917 0 Td (, )Tj 0.002 Tc 0.528 Tw -25.396 -1.098 Td [(an)-1(d)-1( r)2(ap)-1(i)3(d)-1( an)-1(d)-1( accu)-1(r)2(at)3(e i)3(d)-1(en)-1(t)3(i)3(f)1(i)3(cat)3(i)3(o)-1(n)-1( an)]TJ 0.003 Tc 0.527 Tw 18.507 0 Td [(d i)4(nvoc)1(a)1(t)4(i)4(on of)2( )]TJ -0.003 Tw -18.507 -1.122 Td [(a)1(ppr)3(opr)3(i)4(a)1(t)4(e)1( )]TJ 0.314 Tw 5.139 0 Td [(s)2(e)1(r)3(vi)4(c)1(e)1(s)2(.)4( A)-3(s)2( w)-3(or)3(k w)-3(i)4(t)4(h s)2(e)1(m)-4(a)1(nt)4(i)4(c)1(s)2( a)1(nd s)2(e)1(r)3(vi)4(c)1(e)1(s)2( )]TJ 0.133 Tw -5.139 -1.098 Td [(gr)3(ow)-4(s)2( m)-4(or)3(e)1( a)1(m)-4(bi)4(t)4(i)4(ous)2(,)4( t)4(he)1(r)3(e)1( i)4(s)2( i)4(nc)1(r)3(e)1(a)1(s)2(i)4(ng a)1(ppr)3(e)1(c)1(i)4(a)1(t)4(i)4(on of)2( t)4(h)]TJ 0.002 Tc -0.002 Tw 25.199 0 Td (e )Tj 0.003 Tc 0.16 Tw -25.199 -1.122 Td [(ne)1(e)1(d f)2(or)3( pr)3(i)4(nc)1(i)4(pl)4(e)1(d a)1(ppr)3(oa)1(c)1(he)1(s)2( t)4(o r)3(e)1(pr)3(e)1(s)2(e)1(nt)4(i)4(ng a)1(nd r)3(e)1(a)1(s)2(oni)4(ng )]TJ 0.132 Tw 0 -1.098 TD [(unde)1(r)3( unc)1(e)1(r)3(t)4(a)1(i)4(nt)4(y.)4( )]TJ 0.002 Tc -0.002 Tw 7.823 0 Td [(H)-5(er)2(e,)3( )]TJ 0 Tc 0.135 Tw 2.588 0 Td [(t)1(h)-3(e)-2( t)1(e)-2(rm)-7( ")-2(u)-3(n)-3(c)-2(e)-2(rt)1(a)-2(i)1(n)-3(t)1(y)-3(")-2( i)1(s)-1( i)1(n)-3(t)1(e)-2(n)-3(d)-3(e)-2(d)-3( t)1(o)-3( )]TJ 0.002 Tc 0.45 Tw -10.411 -1.122 Td [(en)-1(co)-1(m)-5(p)-1(as)1(s)1( )-1(a )-1(v)-1(ar)2(i)3(et)3(y)-1( o)-1(f)1( )-1(as)1(p)-1(ect)3(s)1( o)-1(f)1( i)3(m)-5(p)-1(er)2(f)1(ect)3( k)-1(n)-1(o)-1(w)-5(l)3(ed)-1(g)-1(e,)3( )]TJ 0.003 Tc 1.072 Tw 0 -1.098 TD [(i)4(nc)1(l)4(udi)4(ng i)4(nc)1(om)-4(pl)4(e)1(t)4(e)1(ne)1(s)2(s)2(,)4( i)4(nc)1(onc)1(l)4(us)2(i)4(ve)1(ne)1(s)2(s)2(,)4( va)1(gue)1(ne)1(s)2(s)2(,)4( )]TJ 0.297 Tw 0 -1.122 TD [(a)1(m)-4(bi)4(gui)4(t)4(y,)4( a)1(nd ot)4(he)1(r)]TJ [(s)2(.)4( T)-1(he)1( t)4(e)1(r)3(m)-4( ")2(unc)1(e)1(r)3(t)4(a)1(i)4(nt)4(y r)3(e)1(a)1(s)2(oni)4(ng")2( i)4(s)2( )]TJ 0.401 Tw 0 -1.098 TD [(m)-4(e)1(a)1(nt)4( t)4(o de)1(not)4(e)1( t)4(he)1( f)3(ul)4(l)4( r)3(a)1(nge)1( of)3( m)-4(e)1(t)4(hods)2( de)1(s)2(i)4(gne)1(d f)3(or)3( )]TJ 0.346 Tw 27.488 65.878 Td [(r)3(e)1(pr)3(e)1(s)2(e)1(nt)4(i)4(ng a)1(nd r)3(e)1(a)1(s)2(oni)4(ng w)-4(i)4(t)4(h know)-4(l)4(e)1(dge)1( w)-4(he)1(n B)-3(ool)4(e)1(a)1(n )]TJ 0 Tc 0 Tw 0 -1.122 TD [(t)1(ru)-3(t)1(h)]TJ 1.894 0 Td (-)Tj 0.003 Tc 0.642 Tw [(va)1(l)4(ue)1(s)2( a)1(r)3(e)1( unknow)-4(n,)4( unknow)-4(a)1(bl)4(e)1(,)4( or)3( i)4(na)1(ppl)4(i)4(c)1(a)1(bl)4(e)1(.)4( )]TJ 0.634 Tw -1.894 -1.098 Td [(C)-3(om)-5(m)-5(onl)4(y )-1(a)1(ppl)4(i)4(e)1(d a)1(ppr)3(oa)1(c)1(he)1(s)1( t)4(o unc)1(e)1(r)3(t)4(a)1(i)4(nt)4(y r)3(e)1(a)1(s)1(oni)4(ng)]TJ 0 Tc 0 Tw 25.645 0 Td ( )Tj 0.003 Tc 0.312 Tw -25.645 -1.122 Td [(i)4(nc)1(l)4(ude)1( pr)3(oba)1(bi)4(l)4(i)4(t)4(y t)4(he)1(or)3(y)]TJ 0 Tc 0 Tw 11.055 0 Td ( )Tj 0.565 0 Td ([)Tj 0.003 Tc -0.003 Tw (30)Tj 0 Tc 0 Tw (])Tj -0.001 Tc 0.001 Tw (, )Tj 0.001 Tc 0.314 Tw 2.487 0 Td [(e)-1(x)-2(p)-2(e)-1(r)1(t)2( sy)-2(st)2(e)-1(m)-6(s [)]TJ 0.003 Tc -0.003 Tw 7.154 0 Td (31)Tj -0.001 Tc 0.001 Tw [(])-1(, )]TJ 0.002 Tc -0.002 Tw 2.153 0 Td [(f)1(u)-1(zzy)-1( )]TJ 0 Tc 0 Tw -23.413 -1.098 Td [(l)1(o)-3(g)-3(i)1(c)-2(,)1( )]TJ 0.003 Tc -0.001 Tw 2.508 0 Td [(s)2(ubj)4(e)1(c)1(t)4(i)4(ve)1( l)4(ogi)4(c)]TJ 0 Tc 0 Tw 6.329 0 Td ( )Tj 0.252 0 Td ([)Tj 0.003 Tc -0.003 Tw (32)Tj -0.001 Tc 0.001 Tw (, )Tj 0.003 Tc -0.003 Tw 1.841 0 Td (33)Tj 0 Tc 0 Tw (])Tj -0.001 Tc 0.001 Tw (, )Tj 0.002 Tc -0.002 Tw 1.841 0 Td [(D)-5(em)-6(p)-1(st)3(er)]TJ 0 Tc 0 Tw 3.91 0 Td (-)Tj 0.003 Tc -0.001 Tw [(S)-1(ha)1(f)2(e)1(r)3( t)4(he)1(or)3(y,)4( )]TJ 0.004 Tc -0.004 Tw [(D)-3(Sm)-4(T)]TJ 0 Tc 0 Tw 8.965 0 Td ( )Tj -25.645 -1.122 Td ([)Tj 0.003 Tc -0.003 Tw (34)Tj 0 Tc 0 Tw (])Tj -0.001 Tc 0.001 Tw (, )Tj 0.003 Tc -0.004 Tw 2.171 0 Td [(a)1(nd num)-4(e)1(r)3(ous)2( ot)4(he)1(r)3( )]TJ -0.003 Tw 8.229 0 Td [(t)4(e)1(c)1(hni)4(que)1(s)]TJ 0 Tc 0 Tw 4.295 0 Td (.)Tj 0.249 0 Td ( )Tj 0.51 Tw -13.48 -1.707 Td [(T)-5(o)-3( illu)-3(s)-2(tr)-1(a)-2(te)]TJ 0 Tw ( )Tj 0.002 Tc 0.508 Tw 6.144 0 Td [(t)3(h)-1(e ch)-1(al)3(l)3(en)-1(g)-1(es)1( o)-1(f)1( ev)-1(al)3(u)-1(at)3(i)]TJ 0.003 Tc 0.507 Tw 11.757 0 Td [(ng unc)1(e)1(r)3(t)4(a)1(i)4(nt)4(y )]TJ 0.492 Tw -19.364 -1.122 Td [(r)3(e)1(pr)3(e)1(s)2(e)1(nt)4(a)1(t)4(i)4(on a)1(nd r)3(e)1(a)1(s)2(oni)4(ng i)4(n i)4(nf)2(or)3(m)-4(a)1(t)4(i)4(on s)]TJ -0.001 Tc 0.497 Tw 20.683 0 Td [(y)-4(s)-2(te)-3(m)-8(s)-2(, w)-8(e)-3( )]TJ 0.003 Tc 0.212 Tw -20.683 -1.098 Td [(c)1(ons)2(i)4(de)1(r)3( be)1(l)4(ow)-4( )]TJ 0.002 Tc 0.213 Tw 6.79 0 Td [(a f)1(ew)-5( r)2(eas)1(o)-1(n)-1(i)3(n)-1(g)-1( ch)-1(al)3(l)3(en)-1(g)-1(es)]TJ 0 Tc 0 Tw 11.493 0 Td ( )Tj -0.001 Tc 0.216 Tw 0.465 0 Td [(f)-2(a)-3(c)-3(e)-3(d)-4( w)-8(ith)-4(in)-4( th)-4(e)-3( )]TJ 0.003 Tc 0.015 Tw -18.748 -1.122 Td [(W)-7(or)3(l)4(d W)-7(i)4(de)1( W)-7(e)1(b dom)-4(a)1(i)4(n)]TJ 0 Tc 0 Tw 10.477 0 Td ( )Tj 0.003 Tc 0.015 Tw 0.268 0 Td [(t)4(ha)1(t)4( c)1(oul)4(d be)1( a)1(ddr)3(e)1(s)2(s)2(e)1(d by r)3(e)1(a)1(s)2(oni)4(ng )]TJ 0.267 Tw -10.746 -1.098 Td [(unde)1(r)3( unc)1(e)1(r)3(t)4(a)1(i)4(nt)4(y)]TJ 0 Tc 0 Tw 7.323 0 Td ( )Tj 0.52 0 Td ([)Tj (1)Tj 0.836 0 Td (])Tj (.)Tj 0.582 0 Td ( )Tj 0.52 0 Td (U)Tj -0.001 Tc 0.001 Tw 0.729 0 Td [(n)-4(c)-3(e)-3(r)-1(ta)-3(in)-4(ty)]TJ 0 Tc 0 Tw 4.012 0 Td ( )Tj 0.27 Tw 0.52 0 Td [(i)1(s)-1( a)-2(n)-3( i)1(n)-3(t)1(ri)1(n)-3(s)-1(i)1(c)-2( f)-1(e)-2(a)-2(t)1(u)-3(re)-2( )1(o)-3(f)-1( )]TJ 0.003 Tc -0.003 Tw -15.042 -1.122 Td [(m)-4(a)1(ny )]TJ 0.073 Tw 2.564 0 Td [(of)2( t)4(he)1( r)3(e)1(qui)4(r)3(e)1(d t)4(a)1(s)2(ks)2(,)4( a)1(nd a)1( f)2(ul)4(l)4( r)3(e)1(a)1(l)4(i)4(z)1(a)1(t)4(i)4(on of)2( t)4(he)1( W)-7(or)3(l)4(d )]TJ 0.002 Tc 0.222 Tw -2.564 -1.098 Td [(W)-8(i)3(d)-1(e W)-8(eb)-1( as)1( a s)1(o)-1(u)-1(r)2(ce o)-1(f)1( p)-1(r)2(o)-1(ces)1(s)1(ab)-1(l)3(e d)-1(at)3(a an)-1(d)-1( )]TJ 0 Tc 0 Tw 20.903 0 Td [(i)1(n)-3(f)-1(o)-3(rm)-7(a)-2(t)1(i)1(o)-3(n)-3( )]TJ 0.003 Tc -0.003 Tw -20.903 -1.122 Td [(m)-4(a)1(na)1(ge)1(m)-4(e)1(nt)4( )]TJ 5.824 0 Td [(s)2(e)1(r)3(vi)4(c)1(e)1(s)]TJ 0 Tc 0 Tw 3.232 0 Td ( )Tj 0.683 0 Td [([3)-3(])]TJ ( )Tj 0.002 Tc 0.431 Tw 1.853 0 Td [(d)-1(em)-5(an)-1(d)-1(s)1( f)1(o)-1(r)2(m)-5(al)3(i)3(s)1(m)-5(s)1( cap)-1(ab)-1(l)3(e o)-1(f)1( )]TJ 0.003 Tc -0.004 Tw -11.593 -1.098 Td [(r)3(e)1(pr)3(e)1(s)2(e)1(nt)4(i)4(ng a)1(nd r)3(e)1(a)1(s)2(oni)4(ng unde)1(r)]TJ 0 Tc 0 Tw 13.354 0 Td ( )Tj -0.001 Tc 0.001 Tw 0.249 0 Td [(u)-4(n)-4(c)-3(e)-3(r)-1(ta)-3(in)-4(ty)]TJ 0 Tc 0 Tw 4.515 0 Td ( )Tj 0.003 Tc -0.004 Tw 0.249 0 Td [(s)2(uc)1(h a)1(s)2(:)]TJ 0 Tc 0 Tw 3.205 0 Td ( )Tj 0.249 0 Td ( )Tj /C2_0 1 Tf -21.364 -1.805 Td <0001>Tj /TT2 1 Tf 0.462 0 Td ( )Tj /TT1 1 Tf 0.003 Tc -0.004 Tw 0.452 0 Td [(A)-2(ut)3(om)-4(at)3(e)1(d age)1(nt)3(s)]TJ /TT0 1 Tf 0 Tc 0 Tw ( )Tj -0.001 Tc 7.478 0 Td [(\()-1(e)-3(.g)-4(., to)]TJ 0 Tc 3.059 0 Td ( )Tj 0.002 Tc -0.002 Tw 0.249 0 Td [(ex)-1(ch)]TJ 0.003 Tc -0.004 Tw 1.898 0 Td [(a)1(nge)1( W)-7(e)1(b i)4(nf)2(or)3(m)-4(a)1(t)4(i)4(on)]TJ 0 Tc 0 Tw 9.042 0 Td (\))Tj (;)Tj 0.611 0 Td ( )Tj /C2_0 1 Tf -23.25 -1.78 Td <0001>Tj /TT2 1 Tf 0.462 0 Td ( )Tj /TT1 1 Tf -0.001 Tc 0.001 Tw 0.452 0 Td [(U)-8(n)-4(c)-3(e)-3(r)-3(ta)-4(in)-4(ty)]TJ 0 Tc 0 Tw 4.798 0 Td (-)Tj 0.003 Tc -0.004 Tw [(l)4(ade)1(n dat)4(a)]TJ /TT0 1 Tf -0.001 Tc 0.001 Tw 4.601 0 Td (. )Tj 0.498 0 Td [(\()-1(e)-3(.g)-4(.)]TJ 0 Tc 0 Tw 1.78 0 Td (,)Tj 0.249 0 Td ( )Tj -0.001 Tw 0.249 0 Td [(t)1(e)-2(rra)-2(i)1(n)-3( i)1(n)-3(f)-1(o)-3(rm)-7(a)-2(t)1(i)1(o)-3(n)-3(\))]TJ 0 Tw 7.941 0 Td (;)Tj 0.277 0 Td ( )Tj /C2_0 1 Tf -21.308 -1.805 Td <0001>Tj /TT2 1 Tf 0.462 0 Td ( )Tj /TT1 1 Tf 0.003 Tc -0.003 Tw 0.452 0 Td [(N)-3(on)]TJ 0 Tc 0 Tw (-)Tj 0.003 Tc -0.004 Tw [(s)2(e)1(ns)2(or)2(y)1( c)1(ol)4(l)4(e)1(c)1(t)4(e)1(d i)4(nf)4(or)2(m)-3(at)4(i)4(on)]TJ /TT0 1 Tf 0 Tc 0 Tw 13.945 0 Td ( )Tj 0.003 Tc -0.004 Tw 0.249 0 Td [(\()3(e)1(.)4(g.)4(,)4( hum)-4(a)1(n s)2(our)3(c)1(e)1(s)2(\))]TJ 0 Tc 0 Tw 8.613 0 Td (;)Tj 0.277 0 Td ( )Tj /C2_0 1 Tf -23.999 -1.78 Td <0001>Tj /TT2 1 Tf 0.462 0 Td ( )Tj /TT1 1 Tf 0.003 Tc -0.004 Tw 0.452 0 Td [(D)-4(y)1(nam)-4(i)4(c)1( c)1(om)-4(pos)1(abi)4(l)4(i)4(t)4(y)]TJ /TT0 1 Tf 0 Tc 0 Tw 9.517 0 Td ( )Tj -0.001 Tc 0.001 Tw 0.249 0 Td [(\()-1(e)-3(.g)-4(.,)]TJ 0 Tc 0 Tw 2.029 0 Td ( )Tj 0.002 Tc -0.003 Tw 0.249 0 Td [(W)-8(eb)-1( S)-2(er)2(v)-1(i)3(ces)]TJ 0 Tc 0 Tw 5.554 0 Td (\))Tj -0.001 Tw [(;)1( o)-3(r)]TJ 0 Tw ( )Tj /C2_0 1 Tf -18.513 -1.805 Td <0001>Tj /TT2 1 Tf 0.462 0 Td ( )Tj /TT1 1 Tf 0.003 Tc -0.004 Tw 0.452 0 Td [(I)3(nf)4(or)2(m)-4(at)4(i)4(on e)1(x)1(t)4(r)2(ac)1(t)]TJ -0.003 Tw 7.834 0 Td [(i)4(on )]TJ /TT0 1 Tf 0 Tc 0 Tw 1.532 0 Td (\(e)Tj -0.001 Tc 0.001 Tw 0.779 0 Td (.g)Tj 0.752 0 Td (.,)Tj 0 Tc 0 Tw ( )Tj 0.003 Tc -0.003 Tw 0.747 0 Td [(i)4(nde)1(xi)4(ng )]TJ 0 Tc -0.001 Tw 3.765 0 Td [(f)-1(ro)-3(m)-8( l)1(a)-2(rg)-3(e)-2( )]TJ 0.002 Tc -0.002 Tw 4.459 0 Td [(d)-1(at)3(ab)-1(as)1(es)]TJ 0 Tc 0 Tw (\))Tj /TT1 1 Tf ( )Tj /TT0 1 Tf 4.43 0 Td ( )Tj 0.002 Tc 0.434 Tw -24.208 -1.707 Td [(T)-3(h)-1(ese p)-1(r)1(o)-1(b)-1(l)2(em)-6(s)]TJ 0 Tc 0 Tw 6.829 0 Td ( )Tj 0.002 Tc 0.434 Tw 0.686 0 Td [(ar)2(e al)3(l)3( r)2(el)3(at)3(ed)-1( )]TJ 0 Tc 0 Tw 7.013 0 Td [(t)1(o)-3( )]TJ 0.003 Tc 0.433 Tw 1.466 0 Td [(i)4(nf)2(or)3(m)-4(a)1(t)4(i)4(on f)2(us)2(i)4(on,)4( )]TJ 0.111 Tw -17.457 -1.122 Td [(i)4(nvol)4(ve)1( bot)4(h )]TJ 0 Tc 0 Tw 5.528 0 Td [(t)1(e)-2(x)-3(t)]TJ 1.504 0 Td (-)Tj 0.002 Tc -0.002 Tw [(b)-1(as)1(ed)-1( )]TJ ET BT /TT0 1 Tf 0 Tc 0 Tw 9.84 0 0 9.84 413.5725 454.44 Tm ([)Tj 0.003 Tc -0.003 Tw (35)Tj 0.111 Tw [(])3( a)1(nd phys)2(i)4(c)1(s)]TJ 0 Tc 0 Tw 6.867 0 Td (-)Tj 0.002 Tc 0.112 Tw [(b)-1(as)1(ed)-1( [)]TJ 0.003 Tc -0.003 Tw 3.32 0 Td (36)Tj 0 Tc 0 Tw (])Tj ( )Tj -0.001 Tc 0.001 Tw 1.704 0 Td [(d)-4(a)-3(ta)]TJ 0.003 Tc 0.111 Tw 1.672 0 Td [(,)4( a)1(nd )]TJ 0.002 Tc 0.027 Tw -23.58 -1.098 Td [(can)-1( b)-1(e eas)1(i)3(l)3(y)-1( ex)-1(t)3(r)2(ap)-1(o)-1(l)3(at)3(ed)-1( t)3(o)-1( r)2(ep)-1(r)2(es)1(en)-1(t)3( t)3(h)-1(e m)-5(o)-1(r)2(e g)-1(en)-1(er)2(al)3( cl)3(as)1(s)1(es)1( )]TJ 0.003 Tc 0.083 Tw T* [(of)2( pr)3(obl)4(e)1(m)-4(s)2( f)2(ound i)4(n t)4(he)1( )]TJ 10.611 0 Td [(s)2(e)1(ns)2(or)3(,)4( da)1(t)4(a)1(,)4( a)1(nd i)4(nf)3(or)3(m)-4(a)1(t)4(i)4(on )]TJ -0.003 Tw 12.275 0 Td [(f)2(us)1(i)4(on)]TJ 0 Tc 0 Tw 2.511 0 Td (.)Tj 0.249 0 Td ( )Tj 0.09 Tw -25.645 -1.098 Td [(A)-7( re)]TJ 0.002 Tc 0.088 Tw 1.848 0 Td [(cen)-1(t)3( ex)-1(am)-5(p)-1(l)3(e o)-1(f)1( h)-1(ar)2(d)]TJ 0 Tc 0 Tw 8.72 0 Td (-)Tj 0.003 Tc 0.086 Tw [(s)2(of)3(t)4( f)3(us)2(i)4(on us)2(e)1(s)2( a)1( c)1(ont)4(r)3(ol)4(l)4(e)1(d na)1(t)4(ur)3(a)1(l)4( )]TJ -0.003 Tw -10.568 -1.122 Td [(l)4(a)1(ngua)1(ge)1( )]TJ 0 Tc 0 Tw 3.876 0 Td [(\(C)-6(N)-7(L)-4(\) )]TJ 0.003 Tc -0.004 Tw 2.933 0 Td [(f)2(or)3( da)1(t)4(a)]TJ 0 Tc 0 Tw 3.091 0 Td (-)Tj [(t)1(o)]TJ 1.114 0 Td (-)Tj 0.003 Tc -0.004 Tw [(de)1(c)1(i)4(s)2(i)4(ons)2( [)]TJ -0.003 Tw 4.652 0 Td (37)Tj 0 Tc 0 Tw (].)Tj 1.588 0 Td ( )Tj 0.249 0 Td ( )Tj 0.005 Tc -0.005 Tw -15.205 -2.561 Td (III.)Tj /TT2 1 Tf 0 Tc 0 Tw 1.269 0 Td ( )Tj /TT0 1 Tf 1.195 0 Td (T)Tj 0.006 Tc -0.006 Tw 7.92 0 0 7.92 367.9704 385.56 Tm [(H)-1(E)1( )]TJ 0 Tc 0 Tw 9.84 0 0 9.84 380.6345 385.56 Tm (U)Tj 0.007 Tc -0.007 Tw 7.92 0 0 7.92 387.8562 385.56 Tm [(NC)1(E)2(R)1(T)2(AI)4(NT)2(Y)]TJ 0 Tc 0 Tw 6.453 0 Td ( )Tj 9.84 0 0 9.84 440.9617 385.56 Tm (E)Tj 0.007 Tc -0.007 Tw 7.92 0 0 7.92 447.0701 385.56 Tm [(VAL)2(UAT)2(I)4(O)-1(N )]TJ 0 Tc 0 Tw 9.84 0 0 9.84 496.1716 385.56 Tm (F)Tj 0.007 Tc -0.007 Tw 7.92 0 0 7.92 501.7331 385.56 Tm [(RA)-1(M)-2(E)1(W)-3(O)-1(RK)]TJ 0 Tc 0 Tw 9.84 0 0 9.84 549.2878 385.56 Tm ( )Tj 0.002 Tc -0.002 Tw -22.346 -1.537 Td [(T)-3(h)-1(e )]TJ 0.003 Tc 0.323 Tw 2.14 0 Td [(unc)1(e)1(r)3(t)4(a)1(i)4(nt)4(y r)3(e)1(pr)3(e)1(s)2(e)1(nt)4(a)1(t)4(i)4(on a)1(nd r)3(e)1(a)1(s)2(oni)4(ng e)1(va)1(l)4(ua)1(t)4(i)4(on )]TJ 0 Tc 0.145 Tw -3.604 -1.122 Td [(f)-1(ra)-2(m)-8(e)-2(w)-7(o)-3(rk)-3( \(U)-7(R)-6(R)-6(E)-5(F)-4(\))]TJ 0 Tw 8.724 0 Td ( )Tj 0.003 Tc -0.003 Tw 0.395 0 Td [(i)4(nc)1(l)4(ude)1(s)2( )]TJ 0.142 Tw 3.741 0 Td [(bot)4(h ha)1(r)3(d \()3(e)1(.)4(g.)4( i)4(m)-4(a)1(gi)4(n)]TJ -0.001 Tc 0.146 Tw 9.328 0 Td [(g)-4(, r)-1(a)-3(d)-4(a)-3(r)-1(, )]TJ 0.003 Tc 0.083 Tw -22.188 -1.098 Td [(vi)4(de)1(o,)4( e)1(t)4(c)1(.)4(\))3( a)1(nd s)2(of)2(t)4( \()]TJ -0.001 Tc 0.087 Tw 8.866 0 Td [(e)-3(.g)-4(., h)-4(u)-4(m)-8(a)-3(n)]TJ 0 Tc 0 Tw 4.772 0 Td ( )Tj 0.085 Tw 0.336 0 Td [(re)-2(p)-3(o)-3(rt)1(s)-1(,)1( s)-1(o)-3(f)-1(t)1(w)-7(a)-2(re)-2( a)-2(l)1(e)-2(rt)1(s)-1(,)1( e)-2(t)1(c)-2(.)1(\))]TJ 0 Tw 11.672 0 Td ( )Tj 0.003 Tc -0.003 Tw -25.645 -1.122 Td [(s)2(our)3(c)1(e)1(s)2(,)4( )]TJ -0.004 Tw 3.51 0 Td [(w)-4(hi)4(c)1(h r)3(e)1(qui)4(r)3(e)1( i)4(nt)4(e)1(gr)3(a)1(t)4(i)4(on f)2(or)3( unc)1(e)1(r)3(t)4(a)1(i)4(nt)4(y M)-7(O)-4(E)-2(s)]TJ -0.001 Tc 0.001 Tw 19.21 0 Td (. )Tj 0 Tc 0 Tw 0.498 0 Td ( )Tj /TT3 1 Tf 0.002 Tc -0.002 Tw -21.755 -1.707 Td [(E)-4(f)2(f)2(ect)3(i)3(ven)-2(ess)]TJ /TT0 1 Tf 0 Tc 0 Tw 5.465 0 Td ( )Tj 0.054 Tw 0.304 0 Td [(re)-2(l)1(a)-2(t)1(e)-2(s)-1( t)1(o)-3( a)-2( s)-1(y)-3(s)-1(t)1(e)-2(m)-7(\222s)-1( c)-2(a)-2(p)-3(a)-2(b)-3(i)1(l)1(i)1(t)1(y)-3( t)1(o)-3( p)-3(ro)-3(d)-3(u)-3(c)-2(e)-2( a)-2(n)-3( )]TJ 0.002 Tc 0.002 Tw -7.233 -1.122 Td [(ef)1(f)1(ect)3(.)3( )]TJ 0 Tc 0 Tw 3.039 0 Td (B)Tj 0.003 Tc 0.001 Tw 0.673 0 Td [(e)1(ne)1(f)2(i)4(t)4(s)2( of)2( f)2(us)2(i)4(on i)4(nc)1(l)4(ude)1( pr)3(ovi)4(di)4(ng l)4(oc)1(a)1(t)4(i)4(ons)2( of)2( e)]TJ -0.001 Tc 19.565 0 Td [(v)-4(e)-3(n)-4(ts)-2(, )]TJ 0.003 Tc 0.103 Tw -23.277 -1.098 Td [(e)1(xt)4(e)1(ndi)4(ng c)1(ove)1(r)3(a)1(ge)1(,)4( a)1(nd r)3(e)1(duc)1(i)4(ng a)1(m)-4(bi)4(gui)4(t)4(y a)1(nd f)2(a)1(l)4(s)2(e)1( a)1(l)4(a)1(r)3(m)-4(s)]TJ 0 Tc 0 Tw 25.396 0 Td (.)Tj 0.249 0 Td ( )Tj 0.003 Tc 0.042 Tw -25.645 -1.122 Td [(T)-2(he)1( goa)1(l)3( )]TJ 0.001 Tc -0.001 Tw 3.884 0 Td [(o)-2(f )]TJ 0 Tc 0.045 Tw 1.132 0 Td [(t)1(h)-3(e)-2( IF)-4(S)-4( i)1(s)-1( t)1(o)-3( s)-1(u)-3(p)-3(p)-3(o)-3(rt)1( u)-3(s)-1(e)-2(rs)-1( i)1(n)-3( t)1(h)-3(e)-2(i)1(r t)1(a)-2(s)-1(k)-3(s)-1( )]TJ 0 Tw 16.485 0 Td [(t)1(o)-3( )]TJ 0.003 Tc -0.003 Tw 1.075 0 Td [(pr)3(ovi)4(d)]TJ 0 Tc 0 Tw 2.623 0 Td (e)Tj 0.446 0 Td ( )Tj 0.003 Tc 0.374 Tw -25.645 -1.098 Td [(r)3(e)1(f)2(i)4(ne)1(d i)4(nf)2(or)3(m)-4(a)1(t)4(i)4(on,)4( r)3(e)1(duc)]TJ 0 Tc 0 Tw 11.32 0 Td (e)Tj 0.446 0 Td ( )Tj 0.627 0 Td [(t)1(i)1(m)-7(e)]TJ 1.786 0 Td ( )Tj 0.003 Tc 0.374 Tw 0.627 0 Td [(a)1(nd w)-4(or)3(k)]TJ 0 Tc 0 Tw 4.148 0 Td [(l)1(o)-3(a)-2(d)]TJ -0.001 Tc 0.378 Tw 1.729 0 Td [(, o)-4(r)-1( )]TJ 0.002 Tc -0.002 Tw 2.34 0 Td [(en)-1(ab)-1(l)3(e)]TJ 0 Tc 0 Tw ( )Tj 0.002 Tc 0.096 Tw -23.024 -1.122 Td [(co)-1(m)-5(p)-1(l)3(et)3(e,)3( accu)-1(r)2(a)]TJ 0 Tc 0 Tw 6.901 0 Td [(t)1(e)]TJ -0.001 Tc 0.001 Tw 0.723 0 Td (, )Tj 0.003 Tc 0.095 Tw 0.596 0 Td [(a)1(nd qua)1(l)4(i)4(t)4(y t)4(a)1(s)2(k c)1(om)-4(pl)4(e)1(t)4(i)4(on.)]TJ 0 Tc 0 Tw 11.669 0 Td ( )Tj 0.002 Tc -0.002 Tw 0.348 0 Td [(E)-3(f)1(f)1(ect)2(i)2(v)-1(en)-1(ess )]TJ 0 Tc 0 Tw -20.237 -1.098 Td (i)Tj 0.003 Tc -0.003 Tw 0.277 0 Td [(nc)1(l)4(ude)1(s)]TJ 0 Tc 0 Tw 3.069 0 Td ( )Tj /TT1 1 Tf -0.001 Tc 0.001 Tw 0.395 0 Td [(e)-3(ffic)-3(ie)-3(n)-4(c)-3(y)]TJ /TT0 1 Tf 0.003 Tc 0.142 Tw 3.842 0 Td [(:)4( doi)4(ng t)4(hi)4(ngs)2( i)4(n t)4(he)1( m)-4(os)2(t)4( e)1(c)1(onom)-4(i)4(c)1(a)1(l)4( w)-4(a)1(y )]TJ 0.061 Tw -7.583 -1.122 Td [(\()3(good i)4(nput)4( t)4(o out)4(put)4( r)3(a)1(t)4(i)4(o\))3(,)4( )]TJ /TT1 1 Tf -0.001 Tc 0.001 Tw 11.745 0 Td [(e)-3(ffic)-3(a)-4(c)-3(y)]TJ /TT0 1 Tf 0.003 Tc 0.061 Tw 3.119 0 Td [(:)4( ge)1(t)4(t)4(i)4(ng t)4(hi)4(ngs)2( done)1(,)4( )]TJ 0 Tc 0 Tw 8.978 0 Td [(\(i)1(.)1(e)-2(.)]TJ -0.001 Tc 0.001 Tw 1.555 0 Td (, )Tj 0.003 Tc 0.016 Tw -25.396 -1.122 Td [(m)-4(e)1(e)1(t)4(i)4(ng obj)4(e)1(c)1(t)4(i)4(ve)1(s)]TJ 0 Tc 0 Tw 7.577 0 Td (\))Tj -0.001 Tc 0.001 Tw (, )Tj 0.003 Tc -0.003 Tw 0.852 0 Td [(a)1(nd )]TJ /TT1 1 Tf 0.002 Tc -0.002 Tw 1.722 0 Td [(co)-1(r)1(r)1(ect)3(n)-1(es)1(s)]TJ /TT0 1 Tf 0.003 Tc 0.016 Tw 4.629 0 Td [(:)4( doi)4(ng ")1(r)3(i)4(ght)4(")1( t)4(hi)4(ngs)2(,)4( )]TJ 0 Tc 0 Tw 9.062 0 Td (\()Tj -0.001 Tc 0.001 Tw [(i.e)-3(.)]TJ 1.555 0 Td (, )Tj 0.003 Tc 0.079 Tw -25.396 -1.098 Td [(s)2(e)1(t)4(t)4(i)4(ng r)3(i)4(ght)4( t)4(hr)3(e)1(s)2(hol)4(ds)]TJ 0 Tc 0 Tw 9.36 0 Td ( )Tj 0.003 Tc 0.079 Tw 0.333 0 Td [(t)4(o a)1(c)1(hi)4(e)1(ve)1( a)1(n ove)]TJ 0 Tc 0.082 Tw 7.247 0 Td [(ra)-2(l)1(l)1( g)-3(o)-3(a)-2(l)1( )]TJ 0 Tw (-)Tj ( )Tj 4.395 0 Td [(t)1(h)-3(e)-2( )]TJ /TT1 1 Tf -0.001 Tc 0.001 Tw 1.559 0 Td [(e)-3(ff)]TJ 0.002 Tc -0.002 Tw (ect)Tj /TT0 1 Tf -0.001 Tc 0.001 Tw 2.17 0 Td [(\))-1(. )]TJ 0.002 Tc 0.439 Tw -25.063 -1.122 Td [(T)-3(h)-1(e M)-8(O)-5(E)-3(s su)-1(p)-1(p)-1(o)-1(r)1(t)2( sy)-1(st)2(em)]TJ 0 Tc 0 Tw 12.075 0 Td (-)Tj 0.003 Tc 0.437 Tw [(l)4(e)1(ve)1(l)4( m)-4(a)1(na)1(ge)1(m)-4(e)1(nt)4( a)1(nd de)1(s)2(i)4(gn )]TJ -0.001 Tc 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Td ( )Tj 0.249 0 Td ( )Tj 0.002 Tc 0.335 Tw -20.05 -1.707 Td [(K)-5(ey)-1( asp)-1(ect)3(s o)-1(f)1( ef)1(f)1(ect)3(i)3(v)-1(en)-1(ess )]TJ 0.003 Tc 0.334 Tw 13 0 Td [(i)4(nc)1(l)4(ude)1( qua)1(l)4(i)4(t)4(y of)2( s)2(e)1(r)3(vi)4(c)1(e)]TJ 0 Tc 0 Tw 11.182 0 Td ( )Tj -25.645 -1.122 Td [(\(Q)-7(o)-3(S)]TJ 0.003 Tc 0.145 Tw 2.125 0 Td [(\))3( a)1(nd qua)1(l)4(i)4(t)4(y of)2( i)4(nf)2(or)3(m)-4(a)1(t)4(i)4(on,)4( a)1(l)4(s)2(o know)-4(n a)1(s)2( i)4(nf)2(or)3(m)-4(a)1(t)4(i)4(on )]TJ -0.001 Tc 0.113 Tw -2.125 -1.098 Td [(q)-4(u)-4(a)-3(lity)-4( \()-1(I)-1(Q)-8(\))-1(. Q)-8(o)-4(S)-5( r)-1(e)-3(la)-3(te)-3(s)-2( to)-4( th)-4(e)-3( a)-3(b)-4(ility)-4( o)-4(f)-2( a)-3( s)-2(y)-4(s)-2(te)-3(m)-8( to)-4( p)-4(r)-1(o)-4(v)-4(id)-4(e)-3( )]TJ 0.003 Tc 0.293 Tw T* [(t)4(i)4(m)-4(e)1(l)4(y a)1(nd de)1(pe)1(nda)1(bl)4(e)1( da)1(t)4(a)1( t)4(r)3(a)1(ns)2(m)-4(i)4(s)2(s)2(i)4(on)]TJ -0.001 Tc 0.297 Tw 17.528 0 Td [(. Q)-8(I)-1( r)-1(e)-3(la)-3(te)-3(s)-2( to)-4( th)-4(e)-3( )]TJ 0.003 Tc 0.064 Tw -17.528 -1.098 Td [(f)2(i)4(t)4(ne)1(s)1(s)1( f)2(or)3( pur)3(pos)1(e)]TJ 0 Tc 0 Tw 7.604 0 Td ( )Tj 0.003 Tc 0.064 Tw 0.317 0 Td [(of)2( t)4(he)1( c)1(ont)4(e)1(nt)4(.)4( Q)-4(oS)-1( a)1(nd Q)-4(I)3( )]TJ 0.063 Tw 11.791 0 Td [(m)-4(e)1(t)4(r)3(i)4(c)1(s)2( c)1(a)1(n be)1( )]TJ -0.001 Tc 0.116 Tw -19.712 -1.122 Td [(u)-4(tiliz)-3(e)-3(d)-4( f)-2(o)-4(r)-1( h)-4(a)-3(r)-1(d)]TJ 0 Tc 0 Tw 6.693 0 Td (-)Tj 0.003 Tc 0.112 Tw [(s)2(of)3(t)4( s)2(e)1(m)-4(a)1(nt)4(i)4(c)1( i)4(nf)3(or)3(m)-4(a)1(t)4(i)4(on f)3(us)2(i)4(on )]TJ 0 Tc 0 Tw 14.123 0 Td ([)Tj 0.003 Tc -0.003 Tw (38)Tj -0.001 Tc 0.001 Tw (, )Tj 0.003 Tc -0.003 Tw 1.954 0 Td (39)Tj -0.001 Tc 0.001 Tw (, )Tj 0.003 Tc -0.003 Tw 1.62 0 Td (40)Tj -0.001 Tc 0.001 Tw (, )Tj 0.003 Tc -0.003 Tw -24.39 -1.098 Td (41)Tj 0 Tc 0 Tw (])Tj 0.003 Tc 0.632 Tw [(.)4( R)-3(e)1(pr)3(e)1(s)2(e)1(nt)4(i)4(ng a)1(nd m)-4(e)1(a)1(s)2(ur)3(i)4(ng Q)-4(I)3( t)4(ypi)4(c)1(a)1(l)4(l)4(y r)3(e)1(qui)4(r)3(e)1(s)2( )]TJ ET endstream endobj 3 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Rotate 0/Type/Page>> endobj 4 0 obj <>stream 0 0 0 0 k /GS0 gs 49.32 513.72 252 -214.32 re f q 106.2 318.12 138.24 190.319 re W n q /Perceptual ri 138.2400127 0 0 190.3200002 106.1999969 318.1200022 cm /Im0 Do Q Q BT 0.75 0.68 0.655 0.902 k /TT0 1 Tf 9.84 0 0 9.84 244.4399 318.12 Tm ( )Tj -0.001 Tc 0.001 Tw 7.92 0 0 7.92 108.7131 311.16 Tm [(Fi)3(g)1(u)1(r)2(e)2( )]TJ 0 Tc 0 Tw 2.846 0 Td (2)Tj 0.499 0 Td ( )Tj 0.246 0 Td (\226)Tj 0.499 0 Td ( )Tj -0.002 Tc -0.002 Tw 0.246 0 Td [(T)-2(h)-1(e U)-3(R)-3(R)-3(E)-2(F)-2( o)-1(n)-1(t)1(o)-1(l)1(o)-1(g)-1(y)-1( m)-4(ai)1(n)-1( cl)1(asses.)]TJ 0 Tc 0 Tw ( )Tj ET 0 0 0 0 k 54.84 221.88 236.4 -151.2 re f q /Perceptual ri 218.8799836 0 0 126.0000012 63.7200089 90.3600147 cm /Im1 Do Q BT 0.75 0.68 0.655 0.902 k /TT0 1 Tf -0.001 Tc 0.001 Tw 7.92 0 0 7.92 86.9651 82.92 Tm (Fi)Tj 0.83 0 Td [(gur)2(e)1( )]TJ 0 Tc 0 Tw 2.016 0 Td (3)Tj 0.499 0 Td ( )Tj 0.246 0 Td (\226)Tj 0.499 0 Td ( )Tj -0.001 Tc -0.003 Tw 0.246 0 Td [(U)-2(R)-1(R)-1(E)-1(F O)-2(nt)3(ol)3(ogy:)3( U)-2(nc)1(e)1(r)2(t)3(a)1(i)3(nt)3(y T)-1(ype)1( C)-1(l)3(a)1(s)1(s)1(.)]TJ 0 Tc 0 Tw 17.401 0 Td ( )Tj 0.003 Tc -0.003 Tw 9.84 0 0 9.84 44.52 729.48 Tm [(a)1(ddr)3(e)1(s)2(s)2(i)4(ng )]TJ 0.029 Tw 4.578 0 Td [(t)4(he)1( s)2(e)1(m)-4(a)1(nt)4(i)4(c)1(s)2( of)2( t)4(he)1( dom)-4(a)1(i)4(n a)1(nd t)4(he)1( pr)3(obl)4(e)1(m)-4(.)4( T)-1(hus)2(,)4( )]TJ 0.258 Tw -4.578 -1.122 Td [(ont)4(ol)4(ogi)4(e)1(s)2( a)1(r)3(e)1( a)1(n i)4(ndi)4(s)2(pe)1(ns)2(i)4(bl)4(e)1( t)4(ool)4( f)2(or)3( m)-4(e)1(a)1(s)2(ur)3(i)4(ng Q)-4(I)3( )]TJ 0 Tc 0 Tw 23.724 0 Td ([)Tj 0.003 Tc -0.003 Tw (42)Tj 0 Tc 0 Tw (])Tj -0.001 Tc 0.001 Tw (. )Tj 0 Tc 0 Tw 2.171 0 Td ( )Tj 0.002 Tc 0.118 Tw -25.894 -1.098 Td [(B)-4(ecau)-1(se Q)-5(I)2( i)3(s i)3(n)-1(h)-1(er)2(en)-1(t)3(l)3(y)-1( f)1(o)-1(cu)-1(sed)-1( o)-1(n)-1( u)-1(n)-1(cer)2(t)3(ai)3(n)-1(t)3(y)-1(,)3( )]TJ -0.001 Tc 0.001 Tw 20.631 0 Td [(p)-4(r)-1(o)-4(b)-4(a)-3(b)-4(ilis)-2(tic)-3( )]TJ 0.003 Tc -0.004 Tw -20.631 -1.122 Td [(ont)4(ol)4(ogi)4(e)1(s)2( [)]TJ -0.003 Tw 4.766 0 Td (43)Tj 0 Tc 0 Tw (])Tj ( )Tj 1.588 0 Td [(a)-2(re)]TJ 1.225 0 Td ( )Tj 0.003 Tc -0.004 Tw 0.249 0 Td [(us)2(e)1(f)2(ul)4( f)2(or)3( r)3(e)1(pr)3(e)1(s)2(e)1(nt)4(i)4(ng Q)-4(I)3( m)-4(e)1(t)4(r)3(i)4(c)1(s)]TJ 0 Tc 0 Tw 13.599 0 Td (.)Tj 0.249 0 Td ( )Tj 0.249 0 Td ( )Tj 0.005 Tc -0.005 Tw -20.462 -1.707 Td (Th)Tj 0.003 Tc 0.002 Tw 1.119 0 Td [(e)1( U)-4(R)-3(R)-3(E)-2(F)-1( ont)4(ol)4(ogy,)4( w)-4(hos)2(e)1( m)-4(a)1(i)4(n c)1(onc)1(e)1(pt)4(s)2( a)1(r)3(e)1( de)1(pi)4(c)1(t)4(e)1(d i)4(n )]TJ -0.003 Tw -2.582 -1.122 Td [(F)-1(i)4(gur)3(e)1( )]TJ 0 Tc 0 Tw 3.142 0 Td (2)Tj -0.001 Tc 0.27 Tw 0.503 0 Td [(, is)-2( a)-3( f)-2(ir)-1(s)-2(t s)-2(te)-3(p)-4( to)-4(w)-8(a)-3(r)-1(d)-4(s)-2( )]TJ 0.003 Tc 0.266 Tw 10.888 0 Td [(a)1( c)1(om)-4(m)-4(on f)2(r)3(a)1(m)-4(e)1(w)-4(or)3(k f)2(or)3( )]TJ 0.008 Tw -14.533 -1.098 Td [(e)1(va)1(l)4(ua)1(t)4(i)4(ng unc)1(e)1(r)3(t)4(a)1(i)4(nt)4(y i)4(n f)2(us)2(i)4(on s)2(ys)2(t)4(e)1(m)-4(s)]TJ 0 Tc 0 Tw 16.213 0 Td (.)Tj 0.249 0 Td ( )Tj 0.002 Tc 0.009 Tw 0.261 0 Td [(T)-3(h)-1(ese co)-1(r)1(e cl)2(asses ar)1(e )]TJ 0.003 Tc -0.001 Tw -16.723 -1.122 Td [(s)2(ubc)1(l)4(a)1(s)2(s)2(e)1(s)2( of)3( t)4(he)1( t)4(op l)4(e)1(ve)1(l)4( c)1(l)4(a)1(s)2(s)2(,)4( w)-3(hi)4(c)1(h i)4(n O)-3(W)-7(L)-1( i)4(s)2( c)1(a)1(l)4(l)4(e)1(d )]TJ /TT1 1 Tf -0.003 Tw 23.05 0 Td [(T)-1(hi)4(ng)]TJ /TT0 1 Tf -0.001 Tc 0.001 Tw (. )Tj 0 Tc 0 Tw 2.844 0 Td ( )Tj 0.002 Tc -0.002 Tw -25.894 -1.098 Td [(T)-2(he)1( )]TJ 0.044 Tw 1.86 0 Td [(co)-1(r)2(e o)-1(f)1( t)3(h)]TJ 0.003 Tc 0.043 Tw 3.935 0 Td [(e)1( ont)4(ol)4(ogy i)4(s)2( t)4(he)1( )]TJ /TT1 1 Tf 0.002 Tc -0.003 Tw 7.092 0 Td [(C)-4(ri)3(t)3(eri)3(a)-1( cl)3(a)-1(ss)]TJ /TT0 1 Tf -0.001 Tc 0.047 Tw 5.488 0 Td [(, w)-8(h)-4(ic)-3(h)-4( )]TJ 0.003 Tc 0.043 Tw 3.297 0 Td [(dr)3(i)4(ve)1(s)2( t)4(he)]TJ 0 Tc 0 Tw 3.973 0 Td ( )Tj 0.003 Tc -0.003 Tw -25.645 -1.122 Td [(de)1(ve)1(l)4(opm)-4(e)1(nt)4( )]TJ 0.002 Tc 0.13 Tw 5.575 0 Td [(o)-1(f)1( t)3(h)-1(e el)3(em)-5(en)-1(t)3(s)1( o)-1(f)1( t)3(h)-1(e s)1(u)-1(b)-1(cl)3(as)1(s)1(es)]TJ 0 Tc 0 Tw 13.79 0 Td ( )Tj 0.382 0 Td [(\(S)-4(e)-2(c)-2(t)1(i)1(o)-3(n)-3( )]TJ 3.728 0 Td (II.)Tj 0.006 Tc -0.006 Tw 0.916 0 Td (B\))Tj -0.001 Tc 0.001 Tw 1.006 0 Td (. )Tj 0.002 Tc -0.002 Tw -25.396 -1.098 Td [(T)-3(h)-1(e )]TJ 0.056 Tw 1.873 0 Td [(U)-5(n)-1(cer)2(t)3(ai)3(n)-1(t)3(y)-1( C)-4(l)3(asses w)-5(er)2(e ei)3(t)3(h)-1(er)2( t)3(ak)-1(en)-1( o)-1(r)2( ad)-1(ap)-1(t)3(ed)-1( f)1(r)2(o)-1(m)-6( t)3(h)-1(e )]TJ 0.003 Tc 0.007 Tw -1.873 -1.122 Td [(U)-4(nc)1(e)1(r)3(t)4(a)1(i)4(nt)4(y O)-4(nt)4(ol)4(ogy de)1(ve)1(l)4(ope)1(d by t)4(he)1( W)-7(3C)-3(\222)3(s)1( U)-4(R)-3(W)-7(3)]TJ 0 Tc 0 Tw 22.176 0 Td (-)Tj 0.007 Tc -0.007 Tw (XG)Tj 0 Tc 0 Tw ( )Tj 2.051 0 Td ([)Tj (1)Tj 0.836 0 Td (].)Tj 0.582 0 Td ( )Tj 0.003 Tc 0.136 Tw -25.645 -1.098 Td [(T)-2(he)1( ont)3(ol)3(ogy m)-5(us)1(t)3( a)1(l)3(s)1(o b)]TJ 0.002 Tc 0.137 Tw 10.769 0 Td [(e u)-1(s)1(ed)-1( as)1( a h)-1(i)3(g)-1(h)]TJ 0 Tc 0 Tw 6.913 0 Td (-)Tj 0.002 Tc 0.137 Tw [(l)3(ev)-1(el)3( r)2(ef)1(er)2(en)-1(ce f)1(o)-1(r)2( )]TJ -0.001 Tc 0.005 Tw -17.681 -1.122 Td [(d)-4(e)-3(f)-2(in)-4(in)-4(g)-4( th)-4(e)-3( a)-3(c)-3(tu)-4(a)-3(l e)-3(v)-4(a)-3(lu)-4(a)-3(tio)-4(n)-4( c)-3(r)-1(ite)-3(r)-1(ia)-3( ite)-3(m)-8(s)-2( th)-4(a)-3(t w)-8(ill c)-3(o)-4(m)-8(p)-4(r)-1(is)-2(e)-3( a)-3( )]TJ 0.003 Tc 0.127 Tw 0 -1.098 TD [(c)1(om)-4(pr)3(e)1(he)1(ns)2(i)4(ve)1( unc)1(e)1(r)3(t)4(a)1(i)4(nt)4(y e)1(va)1(l)4(ua)1(t)4(i)4(on f)2(r)3(a)1(m)-4(e)1(w)-4(or)3(k.)]TJ 0 Tc 0 Tw 20.585 0 Td ( )Tj -0.001 Tc 0.131 Tw 0.38 0 Td [(O)-8(th)-4(e)-3(r)-1( m)-9(a)-3(in)-4( )]TJ 0 Tw -20.965 -1.122 Td [(c)-3(la)-3(s)-2(s)-2( d)-4(e)-3(f)-2(in)-4(itio)-4(n)-4(s)-2( in)-4(c)-3(lu)-4(d)-4(e)-3(:)]TJ 0 Tc 9.972 0 Td ( )Tj /C2_0 1 Tf -9.515 -1.78 Td <0001>Tj /TT2 1 Tf 0.462 0 Td ( )Tj /TT0 1 Tf 0.007 Tc -0.007 Tw 0.452 0 Td (A )Tj /TT1 1 Tf 0.003 Tc -0.003 Tw 1.078 0 Td [(s)2(our)2(c)1(e)1( )]TJ -0.001 Tc 0.001 Tw 2.971 0 Td [(c)-3(la)-4(s)-2(s)]TJ /TT0 1 Tf 0 Tc 0 Tw 2.007 0 Td ( )Tj 0.099 Tw 0.35 0 Td [(i)1(s)-1( t)1(h)-3(e)-2( o)-3(ri)1(g)-3(i)1(n)-3( o)-3(f)-1( t)1(h)-3(e)-2( i)1(n)-3(f)-1(o)-3(rm)-7(a)-2(t)1(i)1(o)-3(n)-3(.)]TJ 0 Tw 13.093 0 Td ( )Tj 0.002 Tc 0.098 Tw 0.35 0 Td [(A)-5( p)-1(h)-1(y)-1(si)3(cal)3( )]TJ 0.001 Tc -0.001 Tw -19.849 -1.122 Td [(se)-1(n)-2(so)]TJ 0.003 Tc 0.063 Tw 2.233 0 Td [(r)3( i)4(s)2( one)1( i)4(m)-4(por)3(t)4(a)1(nt)4( e)1(xa)1(m)-4(pl)4(e)1( of)2( a)1( s)2(our)3(c)1(e)1(;)4( )]TJ 0.002 Tc -0.002 Tw 16.481 0 Td [(w)-5(h)-1(er)2(e )]TJ -0.001 Tc 0.001 Tw 2.774 0 Td [(n)-4(a)-3(tu)-4(r)-1(a)-3(l )]TJ 0.003 Tc -0.004 Tw -21.487 -1.098 Td [(l)4(a)1(ngua)1(ge)1( i)4(nput)]TJ 0 Tc 0 Tw 5.94 0 Td (s)Tj 0.39 0 Td ( )Tj 0.003 Tc -0.004 Tw 0.249 0 Td [(f)2(r)3(om)-5( a)1( hum)-5(a)1(n i)4(s)1( a)1(not)4(he)1(r)3(.)]TJ 0 Tc 0 Tw ( )Tj /C2_0 1 Tf -7.494 -24.268 Td <0001>Tj /TT2 1 Tf 0.462 0 Td ( )Tj /TT0 1 Tf 0.007 Tc -0.007 Tw 0.452 0 Td (A )Tj /TT1 1 Tf 0 Tc 0 Tw 1.204 0 Td (S)Tj 0.002 Tc 0.166 Tw 0.503 0 Td [(en)-1(t)3(en)-1(ce cl)3(a)-1(s)1(s)]TJ /TT0 1 Tf 0 Tc 0 Tw ( )Tj 0.002 Tc -0.002 Tw 5.967 0 Td [(cap)-1(t)3(u)-1(r)2(es)1( )]TJ 3.82 0 Td [(an)-1( )]TJ 0.003 Tc 0.222 Tw 1.424 0 Td [(e)1(xpr)3(e)1(s)2(s)2(i)4(on i)4(n s)2(om)-4(e)1( l)4(ogi)4(c)1(a)1(l)4( )]TJ 0 Tc 0.367 Tw -12.918 -1.122 Td [(l)1(a)-2(n)-3(g)-3(u)-3(a)-2(g)-3(e)-2( t)1(h)-3(a)-2(t)1( e)-2(v)-3(a)-2(l)1(u)-3(a)-2(t)1(e)-2(s)-1( t)1(o)-3( a)-2( t)1(ru)-3(t)1(h)]TJ 0 Tw 15.071 0 Td (-)Tj 0.002 Tc 0.365 Tw [(v)-1(al)3(u)-1(e \()]TJ -0.001 Tc 0.001 Tw 3.459 0 Td [(e)-3(.g)-4(., )]TJ 2.313 0 Td [(f)-2(o)-4(r)-1(m)-9(u)-4(la)-3(, )]TJ 0 Tw -20.843 -1.098 Td [(a)-3(x)-4(io)-4(m)-8(, a)-3(s)-2(s)-2(e)-3(r)-1(tio)-4(n)-4(\))-1(. )]TJ 0 Tc 7.411 0 Td ( )Tj /C2_0 1 Tf -8.325 -1.805 Td <0001>Tj /TT2 1 Tf 0.462 0 Td ( )Tj /TT0 1 Tf 0.007 Tc -0.007 Tw 0.452 0 Td (A )Tj /TT1 1 Tf 0 Tc 0 Tw 1.092 0 Td (U)Tj -0.001 Tc 0.001 Tw 0.729 0 Td [(n)-4(c)-3(e)-3(r)-2(ta)-4(in)-4(ty)-3( )]TJ 0 Tc 0 Tw 4.376 0 Td (D)Tj -0.001 Tc 0.001 Tw 0.729 0 Td [(e)-3(r)-2(iv)-3(a)-4(tio)-4(n)]TJ /TT0 1 Tf 0 Tc 0 Tw 3.623 0 Td ( )Tj -0.001 Tc 0.001 Tw 0.364 0 Td [(c)-3(la)]TJ 0.001 Tc -0.001 Tw 1.169 0 Td (ss)Tj 0 Tc 0 Tw ( )Tj 1.144 0 Td [(re)-2(f)-1(e)-2(rs)]TJ ( )Tj 0.002 Tc 0.111 Tw 2.646 0 Td [(t)3(o)-1( t)3(h)-1(e w)-5(ay)-1( i)3(t)3( can)-1( b)-1(e )]TJ 0.001 Tc -0.001 Tw -15.873 -1.122 Td [(a)-1(sse)-1(sse)-1(d)]TJ 0 Tc 0 Tw 3.403 0 Td ( )Tj 0.003 Tc -0.004 Tw 0.249 0 Td [(w)-4(hi)4(c)1(h i)4(s)1( de)1(c)1(om)-5(pos)1(e)1(d i)4(nt)4(o:)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc -0.003 Tw 24.294 50.683 Td (1\))Tj 0 Tc 0 Tw 0.836 0 Td ( )Tj /TT1 1 Tf 0.002 Tc 0.535 Tw 0.844 0 Td [(O)-5(b)-1(j)3(ect)3(i)3(ve S)-1(u)-1(b)-1(cl)3(a)-1(ss)]TJ /TT0 1 Tf 0 Tc 0 Tw 8.15 0 Td [(:)1( )]TJ -0.001 Tc 0.001 Tw 1.121 0 Td [(\()-1(e)-3(.g)-4(.)]TJ 0 Tc 0 Tw 1.78 0 Td (,)Tj 0.249 0 Td ( )Tj 0.002 Tc -0.002 Tw 0.844 0 Td [(f)1(act)3(u)-1(al)3( )]TJ 0.003 Tc -0.003 Tw 3.573 0 Td [(a)1(nd )]TJ 0.002 Tc -0.002 Tw 2.296 0 Td [(r)2(ep)-1(eat)3(ab)-1(l)3(e )]TJ 0.003 Tc -0.004 Tw -17.863 -1.122 Td [(de)1(r)3(i)4(va)1(t)4(i)4(on pr)3(oc)1(e)1(s)2(s)]TJ 0 Tc 0 Tw (\).)Tj 7.913 0 Td ( )Tj 0.008 Tc -0.008 Tw -9.742 -1.195 Td (2\))Tj /TT1 1 Tf 0 Tc 0 Tw 0.847 0 Td ( )Tj 0.446 0 Td ( )Tj 0.008 Tc 0.188 Tw 0.446 0 Td [(Subj)4(e)1(c)1(t)4(i)4(v)1(e)1( Subc)1(l)4(as)2(s)]TJ 0.005 Tc -0.005 Tw (: )Tj /TT0 1 Tf 0 Tc 0 Tw 8.963 0 Td (\()Tj 0.007 Tc 0.246 Tw 0.338 0 Td [(e.)3(g)-1(.)3(,)3( a s)1(u)-1(b)-1(j)2(ect)3( m)-5(at)3(t)3(er)2( ex)-1(p)-1(er)2(t)3(')4(s)]TJ 0 Tc 0 Tw 12.777 0 Td ( )Tj 0.005 Tc -0.005 Tw -21.987 -1.22 Td [(\(S)-4(M)-9(E)-4(\222s)-1(\))]TJ 0 Tc 0 Tw 3.5 0 Td ( )Tj 0.004 Tc -0.004 Tw 0.254 0 Td [(e)-3(s)-2(tim)-8(a)-3(tio)-4(n)]TJ 0.005 Tc -0.005 Tw 4.234 0 Td (\).)Tj 0 Tc 0 Tw 0.592 0 Td ( )Tj 0.254 0 Td ( )Tj /C2_0 1 Tf -12.036 -1.805 Td <0001>Tj /TT2 1 Tf 0.462 0 Td ( )Tj /TT0 1 Tf 0.452 0 Td (A)Tj 0.729 0 Td ( )Tj /TT1 1 Tf 0.002 Tc 0.257 Tw 0.566 0 Td [(U)-5(n)-1(cert)3(a)-1(i)3(n)-1(t)3(y M)-7(o)-1(d)-1(el)3( cl)3(a)-1(ss)]TJ /TT0 1 Tf 0 Tc 0 Tw 10.394 0 Td ( )Tj 0.003 Tc 0.313 Tw 0.566 0 Td [(c)1(ont)4(a)1(i)4(ns)2( i)]TJ 4.189 0 Td [(nf)2(or)3(m)-4(a)1(t)4(i)4(on on t)4(he)1( )]TJ 0.241 Tw -16.444 -1.122 Td [(m)-4(a)1(t)4(he)1(m)-4(a)1(t)4(i)4(c)1(a)1(l)4( t)4(he)1(or)3(i)4(e)1(s)2( f)3(or)3( t)4(he)1( r)3(e)1(pr)3(e)1(s)2(e)1(nt)4(i)4(ng a)1(nd r)3(e)1(a)1(s)2(oni)4(ng )]TJ -0.004 Tw T* [(w)-4(i)4(t)4(h t)4(he)1( unc)1(e)1(r)3(t)4(a)1(i)4(nt)4(y t)4(ype)1(s)]TJ 0 Tc 0 Tw 10.395 0 Td (.)Tj 0.249 0 Td ( )Tj /TT3 1 Tf 0.012 Tc -0.012 Tw -12.016 -2.39 Td (A.)Tj /TT4 1 Tf 0 Tc 0 Tw 0.988 0 Td ( )Tj /TT3 1 Tf 0.007 Tc -0.003 Tw 0.841 0 Td [(U)-5(n)-2(cert)1(a)-1(i)3(n)-2(t)1(y)-1( T)-4(y)-1(p)-2(e C)-5(l)2(a)-1(ss)]TJ 0 Tc 0 Tw 10.219 0 Td ( )Tj /TT1 1 Tf 0.002 Tc 0.296 Tw -12.048 -1.415 Td [(U)-5(n)-1(cert)3(a)-1(i)3(n)-1(t)3(y T)-2(yp)-1(e)]TJ /TT0 1 Tf 0 Tc 0 Tw 7.301 0 Td ( )Tj 0.003 Tc 0.351 Tw 0.605 0 Td [(i)4(s)2( a)1( c)1(onc)1(e)1(pt)4( t)4(ha)1(t)4( f)2(oc)1(us)2(e)1(s)2( on unde)1(r)3(l)4(yi)4(ng )]TJ -0.001 Tc 0.236 Tw -7.905 -1.122 Td [(c)-3(h)-4(a)-3(r)-1(a)-3(c)-3(te)-3(r)-1(is)-2(tic)-3(s)-2( o)-4(f)-2( th)-4(e)-3( in)-4(f)-2(o)-4(r)-1(m)-8(a)-3(tio)-4(n)-4( th)-4(a)-3(t m)-8(a)-3(k)-4(e)-3( it u)-4(n)-4(c)-3(e)-3(r)-1(ta)-3(in)]TJ 0 Tc 0 Tw 23.91 0 Td (.)Tj 0.249 0 Td ( )Tj 0.485 0 Td [(It)1(s)-1( )]TJ 0.003 Tc -0.003 Tw -24.644 -1.098 Td [(s)2(ubc)1(l)4(a)1(s)2(s)2(e)1(s)]TJ 0 Tc 0 Tw 4.183 0 Td ( )Tj 0.002 Tc -0.002 Tw 1.216 0 Td [(ar)2(e )]TJ /TT1 1 Tf 0 Tc 0 Tw 2.441 0 Td [(A)-5(m)-7(b)-3(ig)-3(u)-3(ity)]TJ /TT0 1 Tf -0.001 Tc 0.001 Tw 4.131 0 Td (, )Tj /TT1 1 Tf 0.002 Tc -0.002 Tw 1.465 0 Td [(I)2(n)-1(co)-1(m)-5(p)-1(l)3(et)3(en)-1(es)1(s)]TJ /TT0 1 Tf -0.001 Tc 0.001 Tw 6.194 0 Td (, )Tj /TT1 1 Tf 0.003 Tc -0.003 Tw 1.465 0 Td [(V)-2(ague)1(ne)1(s)1(s)]TJ /TT0 1 Tf -0.001 Tc 0.001 Tw (, )Tj /TT1 1 Tf 0 Tc 0 Tw -21.096 -1.122 Td (R)Tj 0.003 Tc -0.003 Tw 0.616 0 Td [(andom)-4(ne)1(s)2(s)]TJ /TT0 1 Tf 0.02 Tw 4.471 0 Td [(,)4( a)1(nd )]TJ /TT1 1 Tf -0.003 Tw [(I)3(nc)1(ons)2(i)4(s)2(t)4(e)1(nc)1(y)]TJ /TT0 1 Tf -0.001 Tc 0.024 Tw 7.712 0 Td [(, a)-3(ll d)-4(e)-3(p)-4(ic)-3(te)-3(d)-4( in)-4( )]TJ 0 Tc 0 Tw 6.524 0 Td (F)Tj 0.56 0 Td [(i)1(g)-3(u)-3(re)-2( )]TJ 2.336 0 Td (3)Tj 0.002 Tc 0.021 Tw 0.503 0 Td [(.)3( T)-3(h)-1(es)1(e )]TJ 0.003 Tc 0.057 Tw -22.722 -1.098 Td [(s)2(ubc)1(l)4(a)1(s)2(s)2(e)1(s)2( w)-3(e)1(r)3(e)1( ba)1(s)2(e)1(d on t)4(he)1( l)4(a)1(r)3(ge)1( body of)3( w)-3(or)3(k on e)1(vi)4(de)1(nt)4(i)4(a)1(l)4( )]TJ -0.004 Tw 0 -1.122 TD [(r)3(e)1(a)1(s)2(oni)4(ng by D)-4(a)1(vi)4(d S)-1(c)1(hum)]TJ 0 Tc 0 Tw 10.914 0 Td ( )Tj 0.249 0 Td ([)Tj 0.003 Tc -0.003 Tw (31)Tj 0 Tc 0 Tw (])Tj (.)Tj 1.922 0 Td ( )Tj /TT3 1 Tf 0.011 Tc -0.011 Tw -13.085 -2.366 Td (B.)Tj /TT4 1 Tf 0 Tc 0 Tw 0.932 0 Td ( )Tj /TT3 1 Tf 0.007 Tc -0.007 Tw 0.897 0 Td [(C)-5(ri)3(t)1(eri)3(a)]TJ 0 Tc 0 Tw 3.498 0 Td ( )Tj 0.004 Tc -0.004 Tw 0.254 0 Td [(C)-8(la)-4(s)-3(s)]TJ 0 Tc 0 Tw 2.315 0 Td ( )Tj /TT0 1 Tf 0.005 Tc -0.005 Tw -7.897 -1.439 Td (Th)Tj 0.002 Tc -0.002 Tw 1.119 0 Td (e )Tj /TT1 1 Tf -0.001 Tc 0.062 Tw 0.814 0 Td [(C)-7(r)-3(ite)-3(r)-3(ia)-4( C)-7(la)-4(s)-3(s)]TJ /TT0 1 Tf 0 Tc 0 Tw 5.779 0 Td ( )Tj 0.118 Tw 0.368 0 Td [(i)1(s)-1( t)1(h)-3(e)-2( m)-7(a)-2(i)1(n)-3( c)-2(l)1(a)-2(s)-1(s)-1( o)-3(f)-1( t)1(h)]TJ 0.003 Tc 0.115 Tw 9.312 0 Td [(e)1( U)-4(R)-3(R)-3(E)-2(F)-1( ont)4(ol)4(ogy,)4( )]TJ -0.001 Tc 0.049 Tw -17.392 -1.098 Td [(a)-3(n)-4(d)-4( it is)-2( m)-8(e)-3(a)-3(n)-4(t to)-4( e)-3(n)-4(c)-3(o)-4(m)-8(p)-4(a)-3(s)-2(s)-2( a)-3(ll th)-4(e)-3( d)-4(if)-2(f)-2(e)-3(r)-1(e)-3(n)-4(t a)-3(s)-2(p)-4(e)-3(c)-3(ts)-2( th)-4(a)-3(t m)-8(u)-4(s)-2(t )]TJ 0.003 Tc 0.692 Tw 0 -1.122 TD [(be)1( c)1(ons)2(i)4(de)1(r)3(e)1(d w)-4(he)1(n e)1(va)1(l)4(ua)1(t)4(i)4(ng )]TJ 0 Tc 0 Tw 15.443 0 Td [(i)1(n)-3(f)-1(o)-3(rm)-7(a)-2(t)1(i)1(o)-3(n)]TJ 4.742 0 Td ( )Tj 0.003 Tc -0.003 Tw 0.945 0 Td [(unc)1(e)1(r)3(t)4(a)1(i)4(nt)4(y )]TJ 0.146 Tw -21.13 -1.098 Td [(ha)1(ndl)4(i)4(ng i)4(n m)-4(ul)4(t)4(i)]TJ 0 Tc 0 Tw 7.214 0 Td (-)Tj 0.003 Tc 0.146 Tw [(s)2(e)1(ns)2(or)3( f)3(us)2(i)4(on s)2(ys)2(t)4(e)1(m)-4(s)2(.)4( F)-1(i)4(gur)3(e)1( )]TJ 0 Tc 0 Tw 13.061 0 Td (4)Tj 0.503 0 Td ( )Tj -0.001 Tc 0.15 Tw 0.399 0 Td [(d)-4(e)-3(p)-4(ic)-3(ts)-2( th)-4(e)-3( )]TJ 0.001 Tw -21.177 -1.122 Td [(C)-7(r)-1(ite)-3(r)-1(ia)-3( )]TJ 0 Tc 0 Tw 3.312 0 Td (C)Tj 0.001 Tc -0.002 Tw 0.673 0 Td [(l)2(a)-1(ss a)-1(n)-2(d)-2( i)2(t)2(s su)-2(b)-2(c)-1(l)2(a)-1(sse)-1(s)]TJ 0 Tc 0 Tw 8.831 0 Td (:)Tj 0.277 0 Td ( )Tj 0.003 Tc -0.003 Tw -13.093 -1.707 Td (1\))Tj /TT1 1 Tf 0 Tc 0 Tw 0.836 0 Td ( )Tj 0.084 Tw 0.334 0 Td [(In)-3(p)-3(u)-3(t)1( C)-6(r)-1(i)1(t)1(e)-2(r)-1(i)1(a)]TJ 0 Tw 5.688 0 Td (: )Tj /TT0 1 Tf 0.002 Tc -0.002 Tw 0.668 0 Td [(en)-1(c)]TJ 0.139 Tw [(o)-1(m)-5(p)-1(as)1(s)1(es)1( t)3(h)-1(e cr)2(i)3(t)3(er)2(i)3(a t)3(h)-1(at)3( d)-1(i)3(r)2(ect)3(l)3(y)-1( af)1(f)1(ect)3( )]TJ 0.003 Tc 0.167 Tw -6.612 -1.122 Td [(t)4(he)1( w)-4(a)1(y e)1(vi)4(de)1(nc)1(e)1( i)4(s)2( i)4(nput)4( t)4(o t)4(he)1( s)2(ys)2(t)4(e)1(m)-4(.)4( I)3(t)4( f)2(oc)1(us)2(e)1(s)2( on t)4(he)1( )]TJ 0.285 Tw 0 -1.098 TD [(s)2(our)3(c)1(e)1( of)3( i)4(nput)4( da)1(t)4(a)1( or)3( e)1(vi)4(de)1(nc)1(e)1(,)4( w)-3(hi)4(c)1(h c)1(a)1(n be)1( t)4(a)1(ngi)4(bl)4(e)1( )]TJ 0 Tc 0.111 Tw 0 -1.122 TD [(\(s)-1(e)-2(n)-3(s)-1(i)1(n)-3(g)-3( o)-3(r p)-3(h)-3(y)-3(s)-1(i)1(c)-2(a)-2(l)1(\),)1( t)1(e)-2(s)-1(t)1(i)1(m)-7(o)-3(n)-3(i)1(a)-2(l)1( \(h)-3(u)-3(m)-7(a)-2(n)-3(\))]TJ 0.003 Tc 0.108 Tw 17.424 0 Td [(,)4( doc)1(um)-4(e)1(nt)4(a)1(r)3(y,)4( or)3( )]TJ -0.004 Tw -17.424 -1.098 Td [(know)-4(n m)-4(i)4(s)2(s)2(i)4(ng)]TJ 0 Tc 0 Tw 6.117 0 Td (.)Tj 0.249 0 Td ( )Tj /C2_0 1 Tf -5.817 -1.805 Td <0001>Tj /TT2 1 Tf 0.462 0 Td ( )Tj /TT1 1 Tf 0.002 Tc 0.103 Tw 0.361 0 Td [(R)-3(el)2(eva)-1(n)-1(ce t)2(o)-1( P)-3(ro)-1(b)-1(l)2(em)]TJ /TT0 1 Tf 0 Tc 0 Tw 9.082 0 Td ( )Tj 0.002 Tc -0.002 Tw 0.412 0 Td (as)Tj 0.001 Tc -0.001 Tw 0.836 0 Td [(se)-1(ss)]TJ 0.002 Tc -0.002 Tw (es)Tj 0 Tc 0 Tw 2.454 0 Td ( )Tj 0.003 Tc 0.159 Tw 0.412 0 Td [(how)-4( a)1( gi)4(ve)1(n unc)1(e)1(r)3(t)4(a)1(i)4(nt)4(y )]TJ 0 Tc 0 Tw -12.189 -1.098 Td [(re)-2(p)-3(re)]TJ 0.003 Tc 0.13 Tw 2.062 0 Td [(s)2(e)1(nt)4(a)1(t)4(i)4(on i)4(s)2( a)1(bl)4(e)1( t)4(o c)1(a)1(pt)4(ur)3(e)1( )]TJ -0.003 Tw 11.614 0 Td [(w)-4(hy)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc 0.13 Tw 2.118 0 Td [(a)1( gi)4(ve)1(n i)4(nput)4( i)4(s)2( )]TJ 0 Tc 0.038 Tw -15.794 -1.122 Td [(re)-2(l)1(e)-2(v)-3(a)-2(n)-3(t)1( t)1(o)-3( t)1(h)-3(e)-2( p)-3(ro)-3(b)-3(l)1(e)-2(m)]TJ 0 Tw 9.453 0 Td ( )Tj 0.003 Tc 0.035 Tw 0.288 0 Td [(a)1(nd w)-4(ha)1(t)]TJ 0 Tc 0 Tw 3.695 0 Td ( )Tj 0.002 Tc 0.036 Tw 0.288 0 Td [(w)-5(as t)3(h)-1(e so)-1(u)-1(r)2(ce o)-1(f)1( t)3(h)-1(e )]TJ -0.003 Tw -13.724 -1.098 Td [(d)-1(at)3(a r)2(eq)-1(u)-1(es)1(t)3(.)3( )]TJ 0 Tc 0 Tw 5.318 0 Td ( )Tj /C2_0 1 Tf -7.148 -1.805 Td <0001>Tj /TT2 1 Tf 0.462 0 Td ( )Tj /TT1 1 Tf 0.003 Tc 0.294 Tw 0.361 0 Td [(W)-5(e)2(i)4(g)1(h)1(t)4( )1(o)1(r)2( )1(F)-1(o)1(r)2(c)2(e)2( )1(o)1(f)4( )1(E)-1(v)2(i)4(d)1(e)2(n)1(c)2(e)]TJ /TT0 1 Tf 0 Tc 0 Tw 12.791 0 Td ( )Tj 0.003 Tc -0.003 Tw 0.603 0 Td [(m)-4(e)1(a)1(s)2(ur)3(e)1(s)]TJ 0 Tc 0 Tw 3.741 0 Td ( )Tj 0.003 Tc 0.35 Tw 0.603 0 Td [(how)-4( a)1( gi)4(ve)1(n )]TJ 0.058 Tw -16.733 -1.098 Td [(unc)1(e)1(r)3(t)4(a)1(i)4(nt)4(y r)3(e)1(pr)3(e)]TJ 0.057 Tw [(s)2(e)1(nt)4(a)1(t)4(i)4(on i)4(s)2( a)1(bl)4(e)1( t)4(o c)1(a)1(pt)4(ur)3(e)1( )]TJ 0 Tc 0.06 Tw 18.138 0 Td [(t)1(h)-3(e)-2( d)]TJ 0.002 Tc -0.002 Tw 2.04 0 Td [(eg)-1(r)2(ee )]TJ 0 Tc 0.163 Tw -20.178 -1.122 Td [(t)1(o)-3( w)-7(h)-3(i)1(c)-2(h)]TJ 0 Tw 3.652 0 Td ( )Tj 0.003 Tc 0.16 Tw 0.413 0 Td [(a)1( gi)4(ve)1(n i)4(nput)4( c)1(a)1(n a)1(f)2(f)2(e)1(c)1(t)4( t)4(he)1( pr)3(oc)1(e)1(s)2(s)2(i)4(ng a)1(nd )]TJ 0.059 Tw -4.065 -1.098 Td [(out)4(put)4( of)2( )]TJ [(t)4(he)1( f)2(us)2(i)4(on s)2(ys)2(t)4(e)1(m)-4(.)4( I)3(de)1(a)1(l)4(l)4(y,)4( )]TJ 15.088 0 Td [(t)4(he)1( w)-4(e)1(i)4(ght)]TJ 0 Tc 0 Tw 4.274 0 Td ( )Tj 0.003 Tc -0.003 Tw 0.312 0 Td [(s)2(houl)4(d )]TJ 0.002 Tc 0.406 Tw -19.673 -1.122 Td [(b)-1(e an)-1( o)-1(b)-1(j)2(ect)3(i)3(v)-1(e as)1(s)1(es)1(s)1(m)-5(en)-1(t)3( an)-1(d)-1( t)3(h)-1(e r)2(ep)-1(r)2(es)1(en)-1(t)3(at)3(i)3(o)-1(n)-1( )]TJ 0.003 Tc 0.071 Tw 0 -1.098 TD [(a)1(ppr)3(oa)1(c)1(h m)-4(us)2(t)4( pr)3(ovi)4(de)1( a)1( m)-4(e)1(a)1(ns)2( t)4(o m)-4(e)1(a)1(s)2(ur)3(e)1( t)4(he)1( de)1(gr)3(e)1(e)1( )]TJ 0.123 Tw 0 -1.122 TD [(of)2( i)4(m)-4(pa)1(c)1(t)4( of)2( a)1(n e)1(vi)4(de)]TJ -0.001 Tc 0.127 Tw [(n)-4(c)-3(e)-3( ite)-3(m)-8( w)-8(ith)-4( a)-3( n)-4(u)]TJ 0.003 Tc 0.123 Tw 16.96 0 Td [(m)-4(e)1(r)3(i)4(c)1(a)1(l)4( s)2(c)1(a)1(l)4(e)]TJ 0 Tc 0 Tw 5.393 0 Td ( )Tj 0.003 Tc -0.004 Tw -22.353 -1.098 Td [(s)2(uc)1(h a)1(s)]TJ 0 Tc 0 Tw 2.928 0 Td ( )Tj 0.003 Tc -0.004 Tw 0.249 0 Td [(va)1(l)4(ue)1( of)2( i)4(nf)2(or)3(m)-4(a)1(t)4(i)4(on)]TJ 0 Tc 0 Tw 8.253 0 Td ( )Tj 0.249 0 Td ([)Tj 0.003 Tc -0.003 Tw (24)Tj 0 Tc 0 Tw (])Tj (.)Tj 1.922 0 Td ( )Tj /C2_0 1 Tf -15.429 -1.805 Td <0001>Tj /TT2 1 Tf 0.462 0 Td ( )Tj /TT1 1 Tf -0.001 Tc 0.001 Tw 0.361 0 Td [(C)-7(r)-3(e)-3(d)-4(ib)-4(ility)-3(, )]TJ /TT0 1 Tf 0.003 Tc 0.257 Tw 5.05 0 Td [(a)1(l)4(s)2(o know)-4(n a)1(s)2( be)1(l)4(i)4(e)1(va)1(bi)4(l)4(i)4(t)4(y,)4( c)1(om)-4(pr)3(i)4(s)2(e)1(s)2( t)4(he)1( )]TJ 0.002 Tc 0.055 Tw -4.044 -1.098 Td [(as)1(p)-1(ect)3(s)1( t)3(h)-1(at)3( d)-1(i)3(r)2(ect)3(l)3(y)-1( af)1(f)1(ect)3( a s)1(en)-1(s)1(o)-1(r)2( \()2(s)1(o)-1(f)1(t)3( o)-1(r)2( h)-1(ar)2(d)-1(\))2( i)3(n)-1( i)3(t)3(s)1( )]TJ 0.059 Tw T* [(ab)-1(i)3(l)3(i)3(t)3(y)-1( t)3(o)-1( cap)-1(t)3(u)-1(r)2(e ev)-1(i)3(d)-1(en)-1(ce.)3( I)2(t)3(s)1( s)1(u)-1(b)-1(cl)3(as)1(s)1(es)1( ar)2(e )]TJ /TT1 1 Tf -0.002 Tw 18.702 0 Td [(V)-3(era)-1(ci)2(t)2(y)]TJ /TT0 1 Tf -0.001 Tc 0.001 Tw (, )Tj /TT1 1 Tf -18.702 -1.098 Td [(O)-8(b)-4(je)-3(c)-3(tiv)-3(ity)]TJ /TT0 1 Tf 4.402 0 Td (, )Tj /TT1 1 Tf 0.003 Tc 0.778 Tw 1.337 0 Td [(O)-4(bs)1(e)1(r)1(v)1(at)4(i)4(onal)4( Se)1(ns)1(i)]TJ 0 Tc 0 Tw 8.899 0 Td [(t)1(i)1(v)-2(i)1(t)1(y)]TJ /TT0 1 Tf 0.003 Tc 0.835 Tw 2.001 0 Td [(,)4( a)1(nd )]TJ /TT1 1 Tf -0.001 Tc 0.001 Tw [(S)-4(e)-3(lf)]TJ 0 Tc 0 Tw 5.38 0 Td (-)Tj 0.003 Tc -0.003 Tw -22.019 -1.122 Td [(C)-3(onf)4(i)4(de)1(nc)1(e)]TJ 0 Tc 0 Tw 4.577 0 Td (.)Tj /TT0 1 Tf 0.249 0 Td ( )Tj 0.003 Tc -0.003 Tw -8.119 -1.707 Td (2\))Tj /TT1 1 Tf 0 Tc 0 Tw 0.836 0 Td ( )Tj 0.002 Tc 0.444 Tw 0.695 0 Td [(R)-3(ep)-1(resen)-1(t)2(a)-1(t)2(i)2(o)-1(n)-1( C)-4(ri)2(t)2(eri)2(a)]TJ 0 Tc 0 Tw (: )Tj /TT0 1 Tf 0.002 Tc 0.501 Tw 11.04 0 Td [(en)-1(co)-1(m)-5(p)-1(as)1(s)1(es)1( t)3(h)-1(e cr)2(i)3(t)3(er)2(i)3(a t)3(h)-1(at)3( )]TJ 0.003 Tc 0.391 Tw -11.657 -1.122 Td [(di)4(r)3(e)1(c)1(t)4(l)4(y a)1(f)2(f)2(e)1(c)1(t)4( t)4(he)1( w)-4(a)1(y i)4(nf)2(or)3(m)-4(a)1(t)4(i)4(on i)4(s)2( c)1(a)1(pt)4(ur)3(e)1(d by a)1(nd )]TJ 0 Tc 0.203 Tw 0 -1.098 TD [(t)1(ra)-2(n)-3(s)-1(m)-7(i)1(t)1(t)1(e)-2(d)-3( t)1(h)-3(ro)-3(u)-3(g)-3(h)-3( t)1(h)-3(e)-2( s)-1(y)-3(s)-1(t)1(e)-2(m)-7(.)1( )]TJ 0.002 Tc 0.201 Tw 13.721 0 Td [(T)-3(h)-1(ese cr)1(i)2(t)2(er)1(i)2(a )]TJ 6.143 0 Td [(can)-1( al)3(s)1(o)-1( b)-1(e )]TJ -0.001 Tc 0.106 Tw -19.864 -1.122 Td [(c)-3(a)-3(lle)-3(d)-4( in)-4(te)-3(r)-1(f)-2(a)-3(c)-3(in)-4(g)-4( o)-4(r)-1( tr)-1(a)-3(n)-4(s)-2(p)-4(o)-4(r)-1(t c)-3(r)-1(ite)-3(r)-1(ia)-3(, a)-3(s)-2( )]TJ 0 Tc 0.105 Tw 17.196 0 Td [(t)1(h)-3(e)-2(y)-3( re)-2(l)1(a)-2(t)]TJ -0.001 Tc 0.106 Tw 3.864 0 Td [(e)-3( to)]TJ 0 Tc 0 Tw 1.581 0 Td ( )Tj 0.003 Tc -0.003 Tw 0.355 0 Td [(how)-4( )]TJ 0 Tc 0.443 Tw -22.996 -1.122 Td [(t)1(h)-3(e)-2( re)-2(p)-3(re)-2(s)-1(e)-2(n)-3(t)1(a)-2(t)1(i)1(o)-3(n)-3(a)-2(l)1( m)-7(o)-3(d)-3(e)-2(l)1( )]TJ 0.001 Tc 0.442 Tw 12.229 0 Td [(t)2(r)1(a)-1(n)-2(sfe)-1(r)1(s,)2( p)-2(a)-1(sse)-1(s,)2( a)-1(n)-2(d)-2( r)1(o)-2(u)-2(t)2(e)-1(s)]TJ 0 Tc 0 Tw 12.502 0 Td ( )Tj -0.001 Tw -24.731 -1.098 Td [(i)1(n)-3(f)-1(o)-3(rm)-7(a)-2(t)1(i)1(o)-3(n)-3( w)-7(i)1(t)1(h)-3(i)1(n)-3( t)1(h)-3(e)-2( s)-1(y)-3(s)-1(t)1(e)-2(m)-7(.)1( )]TJ 0 Tw 12.573 0 Td ( )Tj /C2_0 1 Tf -13.03 -1.805 Td <0001>Tj /TT2 1 Tf 0.462 0 Td ( )Tj /TT1 1 Tf 0.003 Tc 0.076 Tw 0.452 0 Td [(E)-2(v)1(i)3(de)1(nc)1(e)1( H)-4(andl)3(i)3(ng)]TJ 0 Tc 0 Tw 7.81 0 Td (:)Tj /TT0 1 Tf ( )Tj 0.135 Tw 0.719 0 Td [(i)1(s)-1( a)-2( s)-1(u)-3(b)-3(c)-2(l)1(a)-2(s)-1(s)-1( o)-3(f)-1( re)-2(p)-3(re)-2(s)-1(e)-2(n)-3(t)1(a)-2(t)1(i)1(o)-3(n)-3( c)-2(ri)1(t)1(e)-2(ri)1(a)-2( )]TJ 0.614 Tw -7.614 -1.098 Td [(t)1(h)-3(a)-2(t)1( a)-2(p)-3(p)-3(l)1(y)-3( p)-3(a)-2(rt)1(i)1(c)-2(u)-3(l)1(a)-2(rl)1(y)-3( t)1(o)-3( t)1(h)-3(e)-2( a)-2(b)-3(i)1(l)1(i)1(t)1(y)-3( o)-3(f)-1( a)-2( g)-3(i)1(v)-3(e)-2(n)-3( )]TJ 0.843 Tw 0 -1.122 TD [(re)-2(p)-3(re)-2(s)-1(e)-2(n)-3(t)1(a)-2(t)1(i)1(o)-3(n)-3( o)-3(f)-1( u)-3(n)-3(c)-2(e)-2(rt)1(a)-2(i)1(n)-3(t)1(y)-3( t)1(o)-3( c)-2(a)-2(p)-3(t)1(u)-3(re)-2( s)-1(p)-3(e)-2(c)-2(i)1(f)-1(i)]TJ 0.002 Tc -0.002 Tw 22.913 0 Td (c )Tj 0.148 Tw -22.913 -1.098 Td [(ch)-1(ar)2(act)3(er)2(i)3(s)1(t)3(i)3(cs)1( o)-1(f)1( i)3(n)-1(co)-1(m)-5(p)-1(l)3(et)3(e ev)-1(i)3(d)-1(en)-1(ce t)3(h)-1(at)3( ar)2(e )]TJ -0.002 Tw 19.737 0 Td [(av)-1(ai)3(l)3(ab)-1(l)3(e )]TJ 0 Tc 0 Tw -19.737 -1.122 Td [(t)1(o)-3( )]TJ 0.003 Tc 0.229 Tw 1.262 0 Td [(or)3( pr)3(oduc)1(e)1(d by )]TJ 0 Tc 0.232 Tw 7.029 0 Td [(t)1(h)-3(e)-2( s)-1(y)-3(s)-1(t)1(e)-2(m)-7(.)1( )]TJ 0.003 Tc 0.229 Tw 5.714 0 Td [(T)-2(he)1( m)-5(a)1(i)3(n f)2(oc)1(us)1( i)3(s)1( on )]TJ ET endstream endobj 5 0 obj <>stream Adobed              L     1Q!"1AQa#$3BERq %&'()*2456789:CDFGHIJSTUVWXYZbcdefghijrstuvwxyz w!1AQRa"#23BCSq4 $%&'()*56789:DEFGHIJTUVWXYZbcdefghijrstuvwxyz? 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gi)4(ve)1(n r)3(e)1(pr)3(e)1(s)2(e)1(nt)4(a)1(t)4(i)4(ona)1(l)4( t)4(e)1(c)1(hni)4(que)1( t)4(o pr)3(oduc)1(e)1( )]TJ 0 Tc -0.001 Tw T* [(i)1(t)1(s)-1( re)-2(s)-1(u)-3(l)1(t)1(s)-1(.)]TJ 0 Tw 4.061 0 Td ( )Tj /C2_1 1 Tf 21.598 38.366 Td <0001>Tj /TT2 1 Tf 0.462 0 Td ( )Tj /TT1 1 Tf 0.002 Tc -0.002 Tw 0.452 0 Td [(P)-3(erf)2(o)-1(rm)-5(a)-1(n)-1(ce )]TJ /TT0 1 Tf 0.003 Tc -0.003 Tw 5.56 0 Td [(i)4(nc)1(l)4(ude)]TJ 0 Tc 0 Tw 2.956 0 Td (s)Tj 0.39 0 Td ( )Tj 0.001 Tc 0.117 Tw 0.368 0 Td [(m)-6(e)-1(t)2(r)1(i)2(c)-1(s t)2(o)-2( a)-1(sse)-1(ss )]TJ 0 Tc 0 Tw 7.293 0 Td [(t)1(h)-3(e)]TJ 1.226 0 Td ( )Tj 0.003 Tc -0.003 Tw 0.368 0 Td [(c)1(ont)4(r)3(i)4(but)4(i)]TJ 3.901 0 Td (on)Tj 0 Tc 0 Tw ( )Tj 0.003 Tc -0.003 Tw 1.374 0 Td (of)Tj 0 Tc 0 Tw 0.837 0 Td ( )Tj 0.064 Tw -23.359 -1.122 Td [(t)1(h)-3(e)-2( re)-2(p)-3(re)-2(s)-1(e)-2(n)-3(t)1(a)-2(t)1(i)1(o)-3(n)-3(a)-2(l)1( m)-7(o)-3(d)-3(e)-2(l)1( )]TJ 11.091 0 Td [(t)1(o)-3(w)-7(a)-2(rd)-3( m)-7(e)-2(e)-2(t)1(i)1(n)-3(g)-3( t)1(h)-3(e)]TJ 0 Tw 7.884 0 Td ( )Tj 0.003 Tc -0.003 Tw 0.314 0 Td [(f)2(unc)1(t)4(i)4(ona)1(l)4( )]TJ 0.371 Tw -19.289 -1.098 Td [(r)3(e)1(qui)4(r)3(e)1(m)-4(e)1(nt)4(s)2( of)2( a)1(n i)4(nf)2(or)3(m)-4(a)1(t)4(i)4(on f)2(us)2(i)4(on s)2(ys)2(t)4(e)1(m)-4(.)4( O)]TJ 0 Tc 0 Tw 21.799 0 Td [(t)1(h)-3(e)-2(r )]TJ 0.003 Tc 0.054 Tw -21.799 -1.122 Td [(s)2(ys)2(t)4(e)1(m)-4( a)1(r)3(c)1(hi)4(t)4(e)1(c)1(t)4(ur)3(e)1( f)3(a)1(c)1(t)4(or)3(s)2( a)1(l)4(s)2(o a)1(f)3(f)3(e)1(c)1(t)4( )]TJ 0.002 Tc -0.002 Tw 15.691 0 Td [(t)3(h)-1(es)1(e )]TJ 0 Tc 0 Tw 2.37 0 Td [(m)-7(e)-2(t)1(ri)1(c)]TJ -0.001 Tc 0.001 Tw 2.565 0 Td [(s)-2(. )]TJ 0 Tc 0 Tw 0.946 0 Td [(T)-5(h)-3(is)-2( )]TJ -0.001 Tc 0.001 Tw -21.572 -1.098 Td [(c)-3(r)-1(ite)-3(r)-1(io)-4(n)-4( )]TJ 0.003 Tc 0.545 Tw 4.195 0 Td [(i)4(s)2( di)4(vi)4(de)1(d i)4(nt)4(o s)2(ubc)1(l)4(a)1(s)2(s)2(e)1(s)2( )]TJ /TT1 1 Tf -0.001 Tc 0.001 Tw 12.617 0 Td [(T)-5(im)-8(e)-3(lin)-4(e)-3(s)-2(s)]TJ /TT0 1 Tf 0 Tc 0 Tw 4.297 0 Td ( )Tj 0.003 Tc -0.003 Tw 0.798 0 Td [(a)1(nd )]TJ /TT1 1 Tf -21.907 -1.122 Td [(T)-1(hr)2(oughput)]TJ /TT0 1 Tf 0 Tc 0 Tw 4.749 0 Td (.)Tj 0.249 0 Td ( )Tj 0.003 Tc -0.003 Tw -7.285 -1.707 Td (4\))Tj /TT1 1 Tf 0 Tc 0 Tw 0.836 0 Td ( )Tj 0.003 Tc -0.003 Tw 0.261 0 Td [(O)-4(ut)]TJ -0.001 Tc 0.012 Tw 1.509 0 Td [(p)-4(u)-4(t C)-7(r)-2(ite)-3(r)-2(ia)]TJ /TT0 1 Tf 0 Tc 0 Tw 4.779 0 Td ( )Tj 0.318 0 Td [(re)-2(l)1(a)-2(t)1(e)]TJ 2.226 0 Td (s)Tj 0.39 0 Td ( )Tj 0.068 Tw 0.318 0 Td [(t)1(o)-3( t)1(h)-3(e)-2( s)-1(y)-3(s)-1(t)1(e)-2(m)-7(\222s)-1( re)-2(s)-1(u)-3(l)1(t)1(s)-1( a)-2(n)-3(d)-3( i)1(t)1(s)-1( a)-2(b)-3(i)1(l)1(i)1(t)1(y)-3( )]TJ 0.136 Tw -9.723 -1.122 Td [(t)1(o)-3( c)-2(o)-3(m)-7(m)-7(u)-3(n)-3(i)1(c)-2(a)-2(t)1(e)-2( i)1(t)1( t)1(o)-3( i)1(t)1(s)-1( u)-3(s)-1(e)-2(rs)-1( i)1(n)-3( a)-2( c)-2(l)1(e)-2(a)-2(r f)-1(a)-2(s)-1(h)-3(i)1(o)-3(n)-3(.)1( It)1( h)-3(a)-2(s)-1( t)1(h)-3(e)-2( )]TJ 0.002 Tc -0.003 Tw 0 -1.098 TD [(f)1(o)-1(l)3(l)3(o)-1(w)-5(i)3(n)-1(g)-1( su)-1(b)-1(cl)3(asses:)]TJ 0 Tc 0 Tw ( )Tj /C2_1 1 Tf 0.549 -1.805 Td <0001>Tj /TT2 1 Tf 0.462 0 Td ( )Tj /TT1 1 Tf -0.001 Tc 0.001 Tw 0.361 0 Td [(Q)-8(u)-4(a)-4(lity)-3( )]TJ /TT0 1 Tf 0.003 Tc -0.003 Tw 3.336 0 Td [(s)2(e)1(r)3(ve)1(s)]TJ 0 Tc 0 Tw 2.509 0 Td ( )Tj 0.131 Tw 0.381 0 Td [(t)1(o)-3( a)-2(s)-1(s)-1(e)-2(s)-1(s)-1( t)1(h)-3(e)-2( i)1(n)-3(f)-1(o)-3(rm)-7(a)-2(t)1(i)1(o)-3(n)-3(a)-2(l)1( )]TJ 0.001 Tc -0.001 Tw 11.449 0 Td [(a)-1(sse)-1(ssm)-6(e)-1(n)-2(t)]TJ 0 Tc 0 Tw ( )Tj 0.001 Tc -0.001 Tw 4.846 0 Td [(o)-2(f )]TJ 0.003 Tc 0.678 Tw -21.516 -1.098 Td [(t)4(he)1( s)2(ys)2(t)4(e)1(m)-4(\222)3(s)2( out)4(put)4(.)4( )]TJ 0 Tc 0.681 Tw 10.353 0 Td [(It)1( i)1(n)-3(c)-2(l)1(u)-3(d)-3(e)-2(s)-1( )]TJ /TT1 1 Tf 0.002 Tc -0.002 Tw 5.82 0 Td [(A)-3(ccu)-1(ra)-1(cy)]TJ /TT0 1 Tf 0 Tc 0 Tw 3.796 0 Td ( )Tj 0.003 Tc -0.003 Tw 0.932 0 Td [(a)1(nd )]TJ /TT1 1 Tf 0.002 Tc -0.002 Tw -20.901 -1.122 Td [(P)-3(reci)2(si)2(o)]TJ 0 Tc 0 Tw (n)Tj /TT0 1 Tf 3.849 0 Td ( )Tj 0.001 Tc 0.234 Tw 0.485 0 Td [(a)-1(s su)-2(b)-2(c)-1(l)2(a)-1(sse)-1(s.)2( )]TJ 0 Tc 6.238 0 Td [(It)1( i)1(s)-1( c)-2(o)-3(m)-7(m)-7(o)-3(n)-3( t)1(o)-3( s)-1(e)-2(e)-2( i)1(n)-3( t)1(h)-3(e)-2( )]TJ 0.103 Tw -10.571 -1.098 Td [(l)1(i)1(t)1(e)-2(ra)-2(t)1(u)-3(re)-2( t)1(h)-3(e)-2( s)-1(a)-2(m)-7(e)-2( c)-2(o)-3(n)-3(c)-2(e)-2(p)-3(t)1(s)-1( w)-7(i)1(t)1(h)-3( d)-3(i)1(f)-1(f)-1(e)-2(re)-2(n)-3(t)1( n)-3(a)-2(m)-7(e)-2(s)-1(.)1( F)-4(o)-3(r )]TJ 0.002 Tc -0.002 Tw 0 -1.122 TD [(ex)-1(am)-5(p)-1(l)3(e,)3( )]TJ 0 Tc 0 Tw 3.969 0 Td (a)Tj 0.003 Tc 0.06 Tw 0.446 0 Td [(c)1(c)1(ur)3(a)1(c)1(y s)2(om)-4(e)1(t)4(i)4(m)-4(e)1(s)2( i)4(s)2( us)2(e)1(d a)1(s)2( a)1( s)2(ynonym)-4( of)2( )]TJ -0.001 Tc 0.001 Tw -4.415 -1.098 Td [(p)-4(r)-1(e)-3(c)-3(is)-2(io)-4(n)-4(; )]TJ 0.003 Tc -0.003 Tw 4.337 0 Td [(a)1(nd )]TJ 1.832 0 Td [(s)2(om)-4(e)1(t)4(i)4(m)-4(e)1(s)2( )]TJ 0.002 Tc 0.128 Tw 4.681 0 Td [(p)-1(r)2(eci)3(s)1(i)3(o)-1(n)-1( i)3(s)1( a r)2(ef)1(i)3(n)-1(em)-5(en)-1(t)3( o)-1(f)1( )]TJ -0.002 Tw -10.851 -1.122 Td [(accu)-1(r)2(acy)]TJ 0.003 Tc 0.199 Tw 3.569 0 Td [(.)4( A)-4(s)2( one)1( m)-4(a)1(ke)1(s)2( t)4(he)1( gr)3(a)1(nul)4(a)1(r)3(i)4(t)4(y c)1(oa)1(r)3(s)2(e)1(r)3(,)4( one)]TJ 0 Tc 0 Tw 18.783 0 Td ( )Tj 0.002 Tc 0.06 Tw -22.353 -1.098 Td [(can)-1( ex)-1(p)-1(ect)3( t)3(h)-1(at)3( t)3(h)-1(e s)1(y)-1(s)1(t)3(em)-5( w)-5(i)3(l)3(l)3( h)-1(av)-1(e a b)-1(et)3(t)3(er)2( accu)-1(r)2(acy)-1(.)3( )]TJ 0.003 Tc 0.067 Tw 0 -1.122 TD [(P)-1(r)3(e)1(c)1(i)4(s)2(i)4(on c)1(a)1(n a)1(l)4(s)2(o be)1( us)2(e)1(d t)4(o )]TJ -0.001 Tc 0.001 Tw 12.238 0 Td [(d)-4(e)-3(te)-3(r)-1(m)-8(in)-4(e)]TJ 0 Tc 0 Tw 4.017 0 Td ( )Tj 0.003 Tc -0.003 Tw 0.32 0 Td (bounds)Tj 0 Tc 0 Tw 2.906 0 Td ( )Tj 0.003 Tc 0.067 Tw 0.32 0 Td [(on t)4(he)1( )]TJ -0.004 Tw -19.801 -1.098 Td [(c)1(e)1(r)3(t)4(a)1(i)4(nt)4(y of)2( t)4(he)1( r)3(e)1(por)3(t)4(e)1(d r)3(e)1(s)2(ul)4(t)]TJ 0 Tc 0 Tw 12.141 0 Td (.)Tj 0.249 0 Td ( )Tj /C2_1 1 Tf -14.219 -1.805 Td <0001>Tj /TT2 1 Tf 0.462 0 Td ( )Tj /TT1 1 Tf 0.361 0 Td [(In)-3(t)1(e)-2(r)-1(p)-3(r)-1(e)-2(t)1(a)-3(t)1(i)1(o)-3(n)]TJ /TT0 1 Tf 5.63 0 Td ( )Tj 0.649 Tw 0.9 0 Td [(re)-2(f)-1(e)-2(rs)-1( t)1(o)-3( )]TJ 0.003 Tc 0.646 Tw [(t)4(he)1( de)1(gr)3(e)1(e)1( t)4(o w)-4(hi)4(c)1(h t)4(he)]TJ 0 Tc 0 Tw 16.829 0 Td ( )Tj 0.003 Tc 0.008 Tw -22.353 -1.098 Td [(unc)1(e)1(r)3(t)4(a)1(i)4(nt)4(y r)3(e)1(pr)3(e)1(s)2(e)1(nt)4(a)1(t)4(i)4(on a)1(nd r)3(e)1(a)1(s)2(oni)4(ng)]TJ 0 Tc 0 Tw 16.341 0 Td ( )Tj 0.002 Tc -0.002 Tw 0.261 0 Td (can)Tj 0 Tc 0 Tw 1.395 0 Td ( )Tj 0.003 Tc 0.008 Tw 0.261 0 Td [(be)1( us)2(e)1(d t)4(o )]TJ -0.003 Tw -18.258 -1.122 Td [(gui)4(de)1( )]TJ 0.001 Tc -0.001 Tw 2.545 0 Td [(a)-1(sse)-1(ssm)-6(e)-1(n)-2(t)2(,)2( )]TJ 0 Tc 0 Tw 5.026 0 Td [(t)1(o)-3( )]TJ 0.003 Tc 0.059 Tw 1.093 0 Td [(unde)1(r)3(s)2(t)4(a)1(nd t)4(he)1( c)1(onc)1(l)4(us)2(i)4(ons)2( of)2( t)4(he)1( )]TJ 0.283 Tw -8.664 -1.098 Td [(s)2(ys)2(t)4(e)1(m)-4( a)1(nd us)2(e)1( t)4(he)1(m)-4( a)1(s)2( a)1( ba)1(s)2(i)4(s)2( f)3(or)3( a)1(c)1(t)4(i)4(on,)4( a)1(nd t)4(o )]TJ 0.701 Tw T* [(s)2(uppor)3(t)4( t)4(he)1( r)3(ul)4(e)1(s)2( f)3(or)3( c)1(om)-4(bi)4(ni)4(ng a)1(nd upda)1(t)4(i)4(ng )]TJ -0.003 Tw 0 -1.098 TD [(m)-4(e)1(a)1(s)2(ur)3(e)1(s)2(.)]TJ 0 Tc 0 Tw 3.989 0 Td ( )Tj 0.002 Tc 0.596 Tw -5.819 -1.732 Td [(T)-3(h)-1(e ab)-1(o)-1(v)-1(e co)-1(n)-1(cep)-1(t)2(s ar)1(e )]TJ 0.003 Tc -0.003 Tw 12.098 0 Td [(be)1(i)4(ng)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc 0.595 Tw 3.08 0 Td [(e)1(xpl)4(or)3(e)1(d w)-4(i)4(t)4(hi)4(n t)4(he)1( )]TJ 0.192 Tw -16.642 -1.098 Td [(E)-2(T)-2(U)-4(R)-3(W)-7(G)-4(,)4( w)-4(hi)3(c)1(h i)3(s)1( m)-5(a)1(ki)3(ng us)1(e)1( of)2( t)3(hi)3(s)1( ont)3(ol)3(ogy )]TJ -0.003 Tw 21.459 0 Td [(\()3(s)2(how)-4(n )]TJ 0 Tc 0 Tw 3.406 0 Td [(i)1(n)-3( )]TJ 0.003 Tc 0.052 Tw -24.865 -1.122 Td [(F)-1(i)4(gur)3(e)1( 4\))3( )]TJ [(t)4(o s)2(uppor)3(t)4( t)4(he)1( de)1(ve)1(l)4(opm)-4(e)1(nt)4( of)2( unc)1(e)1(r)3(t)4(a)1(i)4(nt)4(y e)1(va)1(l)4(ua)1(t)4(i)4(on )]TJ -0.001 Tc 0.001 Tw 0 -1.098 TD [(c)-3(r)-1(ite)-3(r)-1(ia)-3( )]TJ 0.003 Tc -0.003 Tw 3.514 0 Td [(ove)1(r)]TJ 0 Tc 0 Tw 1.785 0 Td ( )Tj 0.003 Tc 0.425 Tw 0.678 0 Td [(a)1( s)2(e)1(t)4( of)2( i)4(nf)2(or)3(m)-4(a)1(t)4(i)4(on f)2(us)2(i)4(on us)2(e)1( c)1(a)1(s)2(e)1(s)2(.)4( T)-2(he)1( )]TJ 0 Tc 0.115 Tw -5.978 -1.122 Td [(i)1(n)-3(t)1(e)-2(re)-2(s)-1(t)1(e)-2(d)-3( re)-2(a)-2(d)-3(e)-2(r s)-1(h)-3(o)-3(u)-3(l)1(d)-3( re)-2(f)-1(e)-2(r t)1(o)-3( t)1(h)-3(e)-2( g)-3(ro)-3(u)-3(p)-3(\222s)-1( w)-7(e)-2(b)-3(s)-1(i)1(t)1(e)-2( f)-1(o)-3(r m)-7(o)-3(re)-2( )]TJ 0.003 Tc 0.102 Tw T* [(s)2(pe)1(c)1(i)4(f)3(i)4(c)1( de)1(t)4(a)1(i)4(l)4(s)]TJ 0 Tc 0 Tw 6.092 0 Td ( )Tj 0.355 0 Td (\()Tj 0.931 0.793 0 0 k -0.001 Tc 0.001 Tw [(h)-4(ttp)-4(://e)-3(tu)-4(r)-1(w)-8(g)-4(.g)]TJ 0.003 Tc -0.003 Tw 6.269 0 Td [(m)-4(u.)4(e)1(du)]TJ 0.75 0.68 0.655 0.902 k 0 Tc 0 Tw 2.989 0 Td (\))Tj -0.001 Tc 0.106 Tw (. N)Tj 1.667 0 Td [(o)-4(te)-3( th)-4(a)-3(t th)-4(e)-3( U)-8(R)-7(R)-7(E)-6(F)]TJ 0 Tc 0 Tw 8.272 0 Td ( )Tj ET 0.931 0.793 0 0 k 381.72 374.04 87.84 0.24 re f BT 0.75 0.68 0.655 0.902 k /TT0 1 Tf 0.003 Tc -0.003 Tw 9.84 0 0 9.84 315 364.68 Tm [(ont)4(ol)4(ogy)]TJ 0 Tc 0 Tw 3.573 0 Td ( )Tj 0.003 Tc 0.353 Tw 0.606 0 Td [(i)4(s)2( not)4( s)2(uppos)2(e)1(d t)4(o be)1( )]TJ 0.002 Tc 0.354 Tw 10.454 0 Td [(a d)-1(ef)1(i)3(n)-1(i)3(t)3(i)3(v)-1(e r)2(ef)1(er)2(en)-1(ce f)1(o)-1(r)2( )]TJ -0.002 Tw -14.633 -1.122 Td (ev)Tj -0.001 Tc 0.187 Tw 0.949 0 Td [(a)-3(lu)-4(a)-3(tio)-4(n)-4( c)-3(r)-1(ite)-3(r)-1(ia)-3(, )]TJ 0.003 Tc 0.183 Tw 7.191 0 Td [(but)4( s)2(i)4(m)-4(pl)4(y )]TJ 0.002 Tc 0.184 Tw 4.892 0 Td [(an)-1( es)1(t)3(ab)-1(l)3(i)3(s)1(h)-1(ed)-1( b)-1(as)1(el)3(i)3(n)-1(e)]TJ 0 Tc 0 Tw 9.57 0 Td ( )Tj 0.186 Tw 0.436 0 Td [(t)1(h)-3(a)-2(t)1( i)1(s)-1( )]TJ ET endstream endobj 9 0 obj <> endobj 10 0 obj <>stream H:` endstream endobj 11 0 obj <>stream HW{pTWn6Ldk0 71#$мR͆E <E V)ZXY(e(Vt3V1N&wνl2_};lc$8a$Pv(`X o2-ٛٶB(H:y-K!a˽X1bply(gbP|dŇ5>|vڿ"mIS﹄d)Pxt`;? 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([)Tj (1)Tj 0.836 0 Td (])Tj (.)Tj 0.582 0 Td ( )Tj 0.002 Tc 0.049 Tw 0.301 0 Td [(A)-5(l)3(so)-1(,)3( t)3(h)-1(e st)3(r)2(u)-1(ct)3(u)-1(r)2(e an)-1(d)-1( )]TJ 0 Tc 0 Tw -16.405 -1.122 Td (v)Tj 0.003 Tc 0.301 Tw 0.503 0 Td [(i)4(e)1(w)-4(poi)4(nt)4( a)1(dopt)4(e)1(d i)4(n t)4(he)1( ont)4(ol)4(ogy de)1(ve)1(l)4(opm)-4(e)1(nt)4( )]TJ 0.002 Tc 0.302 Tw 20.792 0 Td [(h)-1(av)-1(e b)-1(een)-1( )]TJ 0.003 Tc 0.08 Tw -21.295 -1.098 Td [(t)4(une)1(d t)4(o a)1(ddr)3(e)1(s)2(s)2(i)4(ng)]TJ 0 Tc 0 Tw 7.975 0 Td ( )Tj 0.333 0 Td [(t)1(h)-3(e)-2( )]TJ 0.003 Tc 0.08 Tw 1.559 0 Td [(unc)1(e)1(r)3(t)4(a)1(i)4(nt)4(y e)1(va)1(l)4(ua)1(t)4(i)4(on )]TJ -0.003 Tw 9.364 0 Td [(pr)3(obl)4(e)1(m)-4( )]TJ 3.684 0 Td [(a)1(nd )]TJ 0 Tc 0 Tw 1.785 0 Td [(i)1(t)1(s)-1( )]TJ 0.002 Tc 0.073 Tw -24.7 -1.122 Td [(as)1(s)1(o)-1(ci)3(at)3(ed)-1( p)-1(er)2(s)1(p)-1(ect)3(i)3(v)-1(e \()2(e.)3(g)]TJ 0.003 Tc 0.072 Tw 10.878 0 Td [(.)4( how)]TJ 0 Tc 0 Tw 2.309 0 Td ( )Tj 0.325 0 Td [(i)1(n)-3(f)-1(o)-3(rm)-7(a)-2(t)]TJ 0.075 Tw 3.459 0 Td [(i)1(o)-3(n)-3( i)1(s)-1( )]TJ 0.003 Tc -0.003 Tw 2.601 0 Td [(ha)1(ndl)4(e)1(d )]TJ -0.001 Tc 0.001 Tw 3.506 0 Td [(w)-8(ith)-4(in)-4( )]TJ 0.003 Tc 0.121 Tw -23.079 -1.098 Td [(a)1( f)2(us)2(i)4(on )]TJ 0.001 Tc -0.001 Tw 3.705 0 Td [(sy)-2(st)2(e)-1(m)]TJ -0.001 Tc 0.001 Tw 2.792 0 Td [(\))-1(. )]TJ 0.002 Tc 0.122 Tw 0.956 0 Td [(N)-5(ex)-1(t)3(,)3( w)-5(e p)-1(r)2(esen)-1(t)3( si)3(m)-6(u)-1(l)3(t)3(an)-1(eo)-1(u)-1(s t)3(r)2(ack)-1(i)3(n)-1(g)-1( an)-1(d)-1( )]TJ 0 Tc 0 Tw -7.454 -1.122 Td [(i)1(d)-3(e)-2(n)-3(t)1(i)1(f)-1(i)1(c)-2(a)-2(t)1(i)1(o)-3(n)]TJ 5.348 0 Td ( )Tj 0.249 0 Td [(\(ID)-7(\) )]TJ 0.003 Tc -0.004 Tw 1.978 0 Td [(a)1(ppl)4(i)4(c)1(a)1(t)4(i)4(on us)2(i)4(ng t)4(he)1( U)-4(R)-3(R)-3(E)-2(F)-1(.)]TJ 0 Tc 0 Tw 12.108 0 Td ( )Tj 0.005 Tc -0.005 Tw -12.213 -2.561 Td [(IV)-6(.)]TJ /TT1 1 Tf 0 Tc 0 Tw ( )Tj /TT0 1 Tf 0.01 Tc -0.01 Tw 2.492 0 Td [(EX)-2(A)-2(M)-5(P)1(LE)]TJ 0 Tc 0 Tw 7.92 0 0 7.92 189.7649 490.68 Tm ( )Tj 9.84 0 0 9.84 191.7649 490.68 Tm (\226)Tj 7.92 0 0 7.92 196.7649 490.68 Tm ( )Tj 0.012 Tc -0.012 Tw 9.84 0 0 9.84 198.7649 490.68 Tm [(W)-3(AM)-2(I)]TJ 0 Tc 0 Tw 2.935 0 Td ( )Tj 0.008 Tc 0.067 Tw -18.61 -1.585 Td [(W)-7(i)4(de)1( a)1(r)3(e)1(a)1( m)-4(ot)4(i)4(on i)4(m)-4(a)1(ge)1(r)3(y \()3(W)-7(A)-4(M)-6(I)3(\))3( s)2(ys)2(t)4(e)1(m)-4(s)2( pr)3(ovi)4(de)1( i)4(m)-4(a)1(ge)1(r)3(y )]TJ -0.004 Tw 0 -1.171 TD [(a)1(nd vi)4(de)1(o s)2(ur)3(ve)1(i)4(l)4(l)4(a)1(nc)1(e)1( of)2( l)4(a)1(r)3(ge)1( )]TJ 0.007 Tc -0.007 Tw 12.783 0 Td [(ar)2(eas)]TJ 0.004 Tc -0.004 Tw (. )Tj 0 Tc 0 Tw 2.595 0 Td ( )Tj /TT2 1 Tf 0.012 Tc -0.012 Tw -15.378 -2.39 Td (A.)Tj /TT3 1 Tf 0 Tc 0 Tw 0.988 0 Td ( )Tj /TT2 1 Tf 0.007 Tc -0.007 Tw 0.841 0 Td [(S)-2(ch)-2(em)-6(a)]TJ 0 Tc 0 Tw 3.387 0 Td ( )Tj /TT0 1 Tf -5.216 -1.463 Td (A)Tj 0.734 0 Td ( )Tj /TT4 1 Tf 0.008 Tc -0.008 Tw 0.376 0 Td [(s)2(c)1(he)1(m)-3(a)]TJ /TT0 1 Tf 0 Tc 0 Tw 3.048 0 Td ( )Tj 0.008 Tc 0.118 Tw 0.376 0 Td [(f)2(or)3( i)4(m)-5(a)1(ge)1( pr)3(oc)1(e)1(s)1(s)1(i)4(ng i)4(s)1( s)1(how)-4(n )]TJ 13.227 0 Td [(i)4(n F)-1(i)4(gur)3(e)1( 5 f)2(or)3( )]TJ 0.005 Tc -0.005 Tw 6.642 0 Td [(t)1(h)-3(e)-2( )]TJ 0.008 Tc 0.014 Tw -24.404 -1.171 Td [(C)-3(ur)2(s)1(or)2( on T)-2(a)1(r)2(ge)1(t)4( )]TJ 0.005 Tc -0.005 Tw 7.251 0 Td [(\(C)-5(o)-3(T)-4(\) )]TJ 0.008 Tc -0.008 Tw 2.756 0 Td [(pr)3(ogr)3(a)1(m)]TJ 0 Tc 0 Tw 3.443 0 Td ( )Tj 0.272 0 Td ([)Tj 0.008 Tc -0.008 Tw 0.338 0 Td (44)Tj 0 Tc 0 Tw (])Tj 0.007 Tc 0.015 Tw 1.355 0 Td [(.)3( A)-5(s)1( d)-1(et)3(ai)3(l)3(ed)-1(,)3( t)3(h)-1(e s)1(ch)-1(em)-5(a )]TJ 0.004 Tc 0.213 Tw -15.414 -1.171 Td [(p)-4(r)-1(o)-4(v)-4(id)-4(e)-3(s)-2( ta)-3(r)-1(g)-4(e)-3(t ty)-4(p)-4(e)-3( a)-3(n)-4(d)-4( id)-4(e)-3(n)-4(tif)-2(ic)-3(a)-3(tio)-4(n)-4( \()-1(I)-1(D)-8(\))-1( a)-3(lle)-3(g)-4(ia)-3(n)-4(c)-3(e)-3(, tim)-8(e)-3( )]TJ 0.009 Tc 0.142 Tw T* [(s)3(t)5(a)2(m)-3(p)1(s)3(,)5( )1(a)2(n)1(d)1( )1(c)2(o)1(o)1(r)4(d)1(i)5(n)1(a)2(t)5(e)2( )1(l)5(o)1(c)1(a)2(t)5(i)5(o)1(n)1(s)3( )]TJ 0.008 Tc 14.104 0 Td [(\()3(m)-4(uc)1(h a)1(s)2( t)4(he)1( D)-3(F)-1(I)3(G)-3( l)4(e)1(ve)1(l)4( 1)]TJ 0 Tc 0 Tw 11.541 0 Td ( )Tj 0.008 Tc 0.217 Tw -25.645 -1.171 Td [(obj)3(e)1(c)1(t)4( a)1(s)2(s)2(e)1(s)2(s)2(m)-4(e)1(nt)4( i)4(nf)2(or)3(m)-4(a)1(t)4(i)4(on of)2( )]TJ 0.005 Tc -0.005 Tw 14.546 0 Td [(t)1(a)-2(rg)-3(e)-2(t)]TJ 0 Tc 0 Tw 2.313 0 Td ( )Tj 0.008 Tc 0.217 Tw 0.475 0 Td [(t)4(r)3(a)1(c)1(k a)1(nd I)3(D)-4( i)4(nf)2(or)]TJ 0 Tc 0 Tw 7.972 0 Td (-)Tj 0.005 Tc -0.005 Tw -25.307 -1.171 Td [(m)-7(a)-2(t)1(i)1(o)-3(n)]TJ 0 Tc 0 Tw 2.823 0 Td (\))Tj 0.004 Tc 0.146 Tw 0.338 0 Td [(. W)-11(h)-4(ile)-3( th)-4(e)-3( s)-2(c)-3(h)-4(e)-3(m)-8(a)-3( is)-2( s)-2(im)-8(p)-4(le)]TJ 0.008 Tc 0.142 Tw 12.416 0 Td [(,)4( a)1(nd w)-4(or)3(ke)1(d )]TJ 0.004 Tc 0.147 Tw 5.971 0 Td [(w)-8(e)-3(ll [)]TJ 0.008 Tc -0.008 Tw 2.489 0 Td (45)Tj 0.005 Tc -0.005 Tw (],)Tj 0 Tc 0 Tw 1.609 0 Td ( )Tj 0.008 Tc 0.008 Tw -25.645 -1.171 Td [(f)2(or)3( pur)3(pos)1(e)1(s)1( of)2( i)4(nf)2(or)3(m)-5(a)1(t)4(i)4(on t)4(r)3(a)1(ns)1(m)-5(i)4(s)1(s)1(i)4(on)]TJ 16.646 0 Td [(,)4( pr)3(oc)1(e)1(s)2(s)2(i)4(ng,)4( e)1(xpl)4(oi)4(t)4(a)]TJ 0 Tc 0 Tw 8.66 0 Td (-)Tj 0.008 Tc 0.262 Tw -25.307 -1.171 Td [(t)4(i)4(on,)4( a)1(nd di)4(s)2(s)2(e)1(m)-4(i)4(na)1(t)4(i)4(on)]TJ 9.989 0 Td [(,)4( f)2(ut)4(ur)3(e)1( de)1(ve)1(l)4(opm)-4(e)1(nt)4(s)2( c)1(oul)4(d i)4(nc)1(l)4(ude)1( )]TJ -0.008 Tw -9.989 -1.171 Td [(unc)1(e)1(r)3(t)4(a)1(i)4(nt)4(y )]TJ 0.004 Tc -0.004 Tw 4.839 0 Td [(f)-2(ie)-3(ld)-4(s)-3( )]TJ 0.008 Tc 0.01 Tw 2.527 0 Td [(f)2(r)3(om)-5( t)4(he)]TJ 0 Tc 0 Tw 3.486 0 Td ( )Tj 0.008 Tc 0.01 Tw 0.268 0 Td [(U)-4(R)-3(R)-3(E)-2(F)-1( ont)4(ol)4(ogy)]TJ 0.004 Tc 0.014 Tw 7.157 0 Td (. I)Tj 0.005 Tc 0.013 Tw 0.861 0 Td [(t)1( i)1(s)-1( i)1(m)-7(p)-3(o)-3(rt)1(a)-2(n)-3(t)1( t)]TJ 0.008 Tc -0.008 Tw 5.999 0 Td (o )Tj 0.006 Tc -0.006 Tw -25.137 -1.171 Td [(a)-1(sse)-1(ss )]TJ 0.007 Tc 0.042 Tw 2.783 0 Td [(w)-5(h)-1(i)3(ch)-1( sem)-6(an)-1(t)3(i)3(c co)-1(n)-1(t)2(en)]TJ 0.005 Tc 0.044 Tw 9.402 0 Td [(t)1( i)1(s)-1( m)-7(o)-3(s)-1(t)1( re)-2(l)1(e)-2(v)-3(a)-2(n)-3(t)1( f)-1(o)]TJ 0.008 Tc 0.041 Tw 8.252 0 Td [(r)3( ope)1(r)3(a)]TJ 0.005 Tc -0.005 Tw 2.894 0 Td [(t)1(i)1(o)-3(n)-3(a)-2(l)1( )]TJ 0.008 Tc -0.004 Tw -23.331 -1.171 Td [(i)4(nf)2(or)3(m)-4(a)1(t)4(i)4(on f)2(us)2(i)4(on )]TJ -0.003 Tw 7.848 0 Td [(m)-4(a)1(na)1(ge)1(m)-4(e)1(nt)4( )1(and )]TJ 0.006 Tc -0.001 Tw 7.167 0 Td [(sy)-2(st)2(e)-1(m)-6(s )1(d)-3(e)-1(si)2(g)-2(n)-2(.)]TJ 0 Tc 0 Tw 6.38 0 Td ( )Tj -21.395 -1.171 Td ( )Tj 0.254 0 Td ( )Tj ET q 44.52 190.44 253.679 106.32 re W n q /Perceptual ri 253.679995 0 0 106.3199997 44.5200005 190.4400025 cm /Im0 Do Q Q BT /TT0 1 Tf 9.84 0 0 9.84 298.302 190.44 Tm ( )Tj -0.001 Tc 0.001 Tw 7.92 0 0 7.92 105.5752 183.48 Tm [(Fi)3(g)1(u)1(r)2(e)2( )]TJ 0 Tc 0 Tw 2.846 0 Td (5)Tj 0.499 0 Td ( )Tj 0.246 0 Td (\226)Tj 0.499 0 Td ( )Tj -0.002 Tc -0.002 Tw 0.246 0 Td [(C)-2(ur)1(s)1(or)1( on T)-1(ar)1(get)2( S)-1(chem)-3(a)]TJ 0 Tc 0 Tw 10.205 0 Td ( )Tj 0.246 0 Td ([)Tj -0.001 Tc 0.001 Tw 0.33 0 Td (46)Tj 0 Tc 0 Tw (])Tj 1.328 0 Td ( )Tj 0.304 Tw 9.84 0 0 9.84 53.52 167.16 Tm [(In)-3( o)-3(rd)-3(e)-2(r t)1(o)-3( d)-3(e)-2(t)1(e)-2(rm)-7(i)1(n)-3(e)-2( w)-7(h)-3(a)-2(t)1( )]TJ -0.001 Tc 0.305 Tw 12.478 0 Td [(u)-4(n)-4(c)-3(e)-3(r)-1(ta)-3(in)-4(ty)-4( a)-3(ttr)-1(ib)-4(u)-4(te)-3(s)]TJ 0 Tc 0 Tw 8.8 0 Td ( )Tj 0.002 Tc 0.302 Tw 0.554 0 Td [(can)-1( b)-1(e )]TJ 0.003 Tc 0.033 Tw -22.747 -1.122 Td [(a)1(dde)1(d t)4(o s)2(uc)1(h a)1( m)-4(e)1(s)2(s)2(a)1(ge)1( pa)1(s)2(s)2(i)4(ng)]TJ 0 Tc 0 Tw 13.318 0 Td ( )Tj 0.003 Tc -0.003 Tw 0.286 0 Td [(s)2(c)1(he)1(m)-4(a)]TJ 0.002 Tc 0.034 Tw 3.017 0 Td [(,)3( t)3(h)-1(er)2(e ar)2(e t)3(h)-1(r)2(ee i)3(s)1(s)1(u)-1(es)1( )]TJ 0 Tc 0.127 Tw -16.62 -1.098 Td [(\(1)-3(\) w)-7(h)-3(a)-2(t)1(,)1( \(2)-3(\) h)]TJ 0.003 Tc 0.124 Tw [(ow)-4( m)-4(uc)1(h,)4( a)1(nd \()3(3\))3( w)-4(hi)4(c)1(h one)1(s)]TJ 0 Tc 0 Tw 18.701 0 Td (.)Tj 0.249 0 Td ( )Tj 0.002 Tc 0.125 Tw 0.377 0 Td [(F)-2(o)-1(r)2( t)3(h)-1(e cas)1(e o)-1(f)1( )]TJ 0.003 Tc -0.003 Tw -19.327 -1.122 Td [(phys)2(i)4(c)1(s)]TJ 0 Tc 0 Tw 3.013 0 Td (-)Tj 0.003 Tc 0.235 Tw [(ba)1(s)2(e)1(d \()3(vi)4(de)1(o\))3( a)1(nd t)4(e)1(xt)4(ua)1(l)]TJ 0 Tc 0 Tw (-)Tj 0.003 Tc 0.236 Tw [(ba)1(s)2(e)1(d r)3(e)1(por)3(t)4(s)2(,)4( w)-4(e)1( ne)1(e)1(d t)4(o )]TJ 0.11 Tw -3.013 -1.098 Td [(de)1(t)4(e)1(r)3(m)-4(i)4(ne)1( w)-4(ha)1(t)4( s)2(e)1(m)-4(a)1(nt)4(i)4(c)1( c)1(ont)4(e)1(nt)4( c)1(oul)4(d be)1( us)2(e)1(f)2(ul)4(.)4( O)-4(ne)1( s)2(i)4(m)-4(pl)4(e)1( )]TJ 0.002 Tc 0.008 Tw 0 -1.122 TD [(cas)1(e i)3(s)1( t)3(h)-1(at)3( ei)3(t)3(h)-1(er)2( a h)-1(u)-1(m)-5(an)-1( an)-1(al)]TJ [(y)-1(s)1(t)3( can)-1( r)2(ep)-1(o)-1(r)2(t)3( a \223f)1(r)2(i)3(en)-1(d)-1(l)3(y)]TJ -0.001 Tc 0.011 Tw 22.673 0 Td [(\224)-3( in)-4( th)-4(e)-3( )]TJ /TT4 1 Tf 0.001 Tw -22.673 -1.098 Td [(u)-4(id)]TJ /TT0 1 Tf 0 Tc 0 Tw 1.283 0 Td ( )Tj 0.002 Tc 0.178 Tw 0.43 0 Td [(f)1(i)3(el)3(d)-1(,)3( o)-1(r)2( a m)-6(ach)-1(i)3(n)-1(e )]TJ 0 Tc 0.18 Tw 8.496 0 Td [(t)1(ra)-2(c)-2(k)-3(e)-2(r c)-2(o)-3(u)-3(l)1(d)-3( e)-2(x)-3(t)1(ra)-2(c)-2(t)1( t)1(h)-3(e)-2( i)1(n)-3(f)-1(o)-3(rm)-7(a)-2(t)1(i)1(o)-3(n)-3( )]TJ 0.003 Tc 0.306 Tw -10.21 -1.122 Td [(f)2(r)3(om)-5( )-1(t)4(he)1( vi)4(de)1(o t)4(o )]TJ 8.432 0 Td [(upda)1(t)4(e)1( t)4(he)1( )]TJ /TT4 1 Tf -0.001 Tc 0.001 Tw 5.023 0 Td [(u)-4(id)]TJ /TT0 1 Tf 0 Tc 0 Tw 1.283 0 Td ( )Tj 0.003 Tc 0.306 Tw 0.559 0 Td [(f)2(i)4(e)1(l)4(d of)2( \223f)2(r)3(i)4(e)1(ndl)4(y)]TJ -0.001 Tc 0.001 Tw 7.416 0 Td [(\224)-3(. )]TJ 0.002 Tc -0.002 Tw 1.254 0 Td [(O)-5(n)-1(e )]TJ 0.003 Tc 0.117 Tw -23.967 -1.122 Td [(e)1(xa)1(m)-4(pl)4(e)1( of)2( \223f)2(r)3(i)4(e)1(ndl)4(y\224)1( c)1(oul)4(d be)1( f)2(r)3(om)-4( e)1(xt)4(r)3(a)1(c)1(t)4(e)1(d t)4(e)1(xt)4( a)1(nd vi)4(de)1(o )]TJ 0.058 Tw 27.488 66.049 Td [(e)1(xpl)4(oi)4(t)4(a)1(t)4(i)4(on of)2( a)1( bl)4(ue)1( ve)1(hi)4(c)1(l)4(e)1(.)]TJ 0 Tc 0 Tw 12.197 0 Td ( )Tj 0.003 Tc 0.058 Tw 0.311 0 Td [(W)-7(ha)1(t)4( i)4(s)2( obvi)4(ous)2(l)4(y m)-4(i)4(s)2(s)2(i)4(ng f)2(r)3(om)-4( )]TJ 0.401 Tw -12.508 -1.122 Td [(t)4(he)1( C)-3(oT)-1( s)2(c)1(he)1(m)-4(a)1( i)4(s)2( s)2(om)-4(e)1( not)4(i)4(on of)2( unc)]TJ -0.001 Tc 0.405 Tw 18.261 0 Td [(e)-3(r)-1(ta)-3(in)-4(ty)-4( w)-8(ith)-4( th)-4(e)-3( )]TJ 0.003 Tc 0.015 Tw -18.261 -1.098 Td [(m)-4(e)1(a)1(s)2(ur)3(e)1(m)-4(e)1(nt)4(s)2( a)1(nd i)4(nf)3(or)3(m)-4(a)1(t)4(i)4(on a)1(s)2( t)4(o t)4(he)1( c)1(onf)3(i)4(de)1(nc)1(e)1(,)4( t)4(i)4(m)-4(e)1(l)4(i)4(ne)1(s)2(s)2(,)4( )]TJ 0.19 Tw 0 -1.122 TD [(a)1(nd pos)2(i)4(t)4(i)4(on a)1(c)1(c)1(ur)3(a)1(c)1(y.)4( W)-7(hi)4(l)4(e)1( t)4(he)1( e)1(nt)4(i)4(r)3(e)1( U)-4(R)-3(R)-3(E)-2(F)-1( c)1(a)1(nnot)4(,)4( a)1(nd )]TJ 0.018 Tw 0 -1.098 TD [(s)2(houl)4(d not)4(,)4( be)1( c)1(ons)2(i)4(de)1(r)3(e)1(d f)3(or)3( t)4(he)1( s)2(c)1(he)1(m)-4(a)1( upda)1(t)4(e)1(s)2(,)4( a)1(s)2( a)1( m)-4(e)1(s)2(s)2(a)1(ge)1( )]TJ 0.118 Tw 0 -1.122 TD [(pa)1(s)2(s)2(i)4(ng s)2(e)1(r)3(vi)4(c)1(e)1( f)2(or)3( t)4(he)1( ont)4(ol)4(ogy,)4( t)4(he)1( f)2(i)4(r)3(s)2(t)4( i)4(s)2(s)2(ue)1( i)4(s)2( t)]TJ 0.002 Tc 0.119 Tw 21.206 0 Td [(o)-1( cal)3(cu)-1(l)3(at)3(e )]TJ 0.003 Tc -0.004 Tw -21.206 -1.098 Td [(pos)2(s)2(i)4(bl)4(e)1( unc)1(e)1(r)3(t)4(a)1(i)4(nt)4(y m)-4(e)1(t)4(r)3(i)4(c)1(s)2( t)4(ha)1(t)4( c)1(oul)4(d go i)4(nt)4(o t)4(he)1( s)2(c)1(he)1(m)-4(a)1(.)4( )]TJ 0 Tc 0 Tw 7.92 0 0 7.92 549.1601 663.96 Tm ( )Tj /TT2 1 Tf 0.011 Tc -0.011 Tw 9.84 0 0 9.84 315 640.44 Tm (B.)Tj /TT3 1 Tf 0 Tc 0 Tw 0.932 0 Td ( )Tj /TT2 1 Tf 0.007 Tc -0.007 Tw 0.897 0 Td [(M)-8(et)2(ri)3(cs)]TJ 0 Tc 0 Tw 3.329 0 Td ( )Tj 0.009 Tc -0.005 Tw 0.254 0 Td [(t)4(o)1( Suppo)1(r)]TJ 0 Tc 0 Tw 4.321 0 Td (t)Tj 0.338 0 Td ( )Tj 0.008 Tc -0.004 Tw 0.254 0 Td [(t)3(h)-1(e)1( U)-3(R)-3(R)-3(E)-2(F)-1( O)-4(n)-1(t)3(ol)4(ogy)]TJ 0 Tc 0 Tw ( )Tj /TT0 1 Tf 0.007 Tc 0.064 Tw -10.325 -1.463 Td [(F)-2(o)-1(r)2( t)3(h)-1(e m)-5(et)3(r)2(i)3(cs)1( av)-1(ai)3(l)3(ab)-1(l)3(e i)3(n)-1( t)3(h)-1(e C)-4(u)-1(r)2(s)1(o)-1(r)2( o)-1(n)-1( T)-3(ar)2(g)-1(et)3( S)-2(ch)-1(em)-5(a,)3( w)-5(e )]TJ 0.008 Tc 0.306 Tw 0 -1.171 TD [(s)2(e)1(e)1(k )1(m)-4(e)1(a)1(s)1(ur)3(e)1(s)2( )1(of)3( )1(c)1(onf)3(i)4(de)1(nc)1(e)1(,)4( )1(a)1(c)1(c)1(u)-1(r)3(a)1(cy,)4( )1(a)1(nd )1(t)4(i)4(m)-4(e)1(l)4(i)4(ne)1(s)2(s)]TJ 0.004 Tc 0.31 Tw 23.981 0 Td [(, a)-3(s)-2( )]TJ 0.008 Tc -0.004 Tw -23.981 -1.171 Td [(r)3(e)1(l)4(a)1(t)4(e)1(d t)4(o )]TJ /TT4 1 Tf 0.004 Tc 4.063 0 Td [(u)-4(id)]TJ /TT0 1 Tf 1.299 0 Td (, )Tj /TT4 1 Tf 0.005 Tc -0.005 Tw 0.508 0 Td [(t)1(i)1(m)-7(e)]TJ /TT0 1 Tf 0.008 Tc -0.004 Tw 1.75 0 Td [(,)4( a)1(nd )]TJ /TT4 1 Tf -0.008 Tw [(poi)4(nt)]TJ /TT0 1 Tf 0.005 Tc -0.001 Tw 4.319 0 Td [(;)1( re)-2(s)-1(p)-3(e)-2(c)-2(t)1(i)1(v)-3(e)-2(l)1(y)]TJ 0 Tc 0 Tw 5.446 0 Td (.)Tj 0.254 0 Td ( )Tj -17.638 -1.171 Td ( )Tj /C2_0 1 Tf 0.457 -1.244 Td <0001>Tj /TT1 1 Tf 0.467 0 Td ( )Tj /TT0 1 Tf 0.008 Tc 0.032 Tw 0.447 0 Td [(C)-3(r)2(e)1(di)4(bi)4(l)4(i)4(t)4(y /)4( C)-3(onf)2(i)3(de)1(nc)1(e)]TJ 0.005 Tc -0.005 Tw 9.95 0 Td [(:)1( )]TJ 0.007 Tc -0.007 Tw 0.572 0 Td [(ev)-1(al)3(u)-1(at)3(es)1( )]TJ 0.005 Tc 0.034 Tw 4.07 0 Td [(t)1(h)-3(e)-2( a)-2(b)-3(i)1(l)1(i)1(t)1(y)-3( t)1(o)-3( d)-3(i)1(s)-1(c)-2(e)-2(rn)-3( a)-2(n)-3( )]TJ ET 328.44 577.56 97.92 0.24 re f BT /TT0 1 Tf 0.008 Tc 0.273 Tw 9.84 0 0 9.84 337.5 567.72 Tm [(obj)3(e)1(c)1(t)4( ba)1(s)2(e)1(d on a)1( know)-4(n t)4(a)1(r)3(ge)1(t)]TJ 0.004 Tc -0.004 Tw 14.002 0 Td (. )Tj 0.278 Tw 0.786 0 Td [(C)-7(la)-3(s)-3(s)-3(if)-2(ic)-3(a)-3(tio)-4(n)-4( is)-3( th)-4(e)-3( )]TJ 0.005 Tc 0.019 Tw -14.788 -1.146 Td [(t)1(a)-2(rg)-3(e)-2(t)1( m)-7(a)-2(t)1(c)-2(h)-3(,)1( w)-7(h)-3(i)1(l)1(e)-2( i)1(d)-3(e)-2(n)-3(t)1(i)1(t)1(y)-3( )]TJ 11.511 0 Td [(i)1(s)-1( t)1(a)-2(rg)-3(e)-2(t)1( )]TJ 0.007 Tc 0.017 Tw [(al)3(l)3(eg)-1(i)3(an)-1(ce.)3( I)2(f)1( t)3(ar)2(g)-1(et)3(s)1( )]TJ 0.084 Tw -11.511 -1.171 Td [(ar)2(e o)-1(f)1( k)-1(n)-1(o)-1(w)-5(n)-1( en)-1(t)3(i)3(t)3(i)3(es)1(,)3( i)3(t)3( can)-1( b)-1(e as)1(s)1(u)-1(m)-5(ed)-1( t)3(h)-1(at)3( t)3(h)-1(e t)3(ar)2(g)-1(et)]TJ 0.006 Tc -0.006 Tw 22.963 0 Td (s )Tj 0.008 Tc 0.288 Tw -22.963 -1.171 Td [(not)4( c)1(l)4(a)1(s)2(s)2(i)4(f)2(i)4(e)1(d c)1(oul)4(d pos)2(e)1( a)1(n )]TJ 0.005 Tc -0.005 Tw [(ID)-6( )]TJ 0.008 Tc 0.288 Tw 14.563 0 Td [(unc)1(e)1(r)3(t)4(a)1(i)4(nt)4(y.)4( U)-4(s)2(i)4(ng a)1( )]TJ 0.007 Tc 0.182 Tw -14.563 -1.171 Td [(B)-4(ay)-1(esi)3(an)-1( ap)-1(p)-1(r)1(o)-1(ach)-1( f)1(o)-1(r)1( t)2(h)-1(i)2(s ex)-1(am)-6(p)-1(l)3(e,)3( w)-5(e d)-1(et)2(er)1(m)-6(i)2(n)-1(e t)2(h)-1(e )]TJ 0.008 Tc 0.289 Tw 0 -1.171 TD [(r)3(e)1(l)4(a)1(t)4(i)4(ve)1( pr)3(oba)1(bi)4(l)4(i)4(t)4(y f)2(r)3(om)-4( t)4(he)1( l)4(i)4(ke)1(l)4(i)4(hood va)1(l)4(ue)1(s)2( of)2( t)4(he)1( )]TJ 0.002 Tc 0.012 Tw 0 -1.366 TD [(o)-4(b)-4(j)-1(e)-3(c)-3(t, v)-4(e)-3(r)-1(s)-2(u)-4(s)-2( o)-4(f)-2( ta)-3(r)-1(g)-4(e)-3(t c)-3(lu)-4(tte)-3(r)-1( )]TJ /C2_1 1 Tf 0 Tc 0 Tw <0001>Tj /TT0 1 Tf -0.003 Tc 6.48 0 0 6.48 464.8286 495.48 Tm [(O)-2( | c)]TJ 0 Tc 9.84 0 0 9.84 476.8386 496.92 Tm ( )Tj 0.005 Tc 0.009 Tw 0.264 0 Td [(,)3( w)-5(h)-1(er)2(e )]TJ /TT4 1 Tf 0 Tc 0 Tw (c)Tj /TT0 1 Tf 3.698 0 Td ( )Tj 6.96 0 0 6.96 518.4158 495.48 Tm (j)Tj 9.84 0 0 9.84 520.3406 496.92 Tm ( )Tj 0.004 Tc 0.01 Tw 0.264 0 Td [(i)2(s fo)-2(r)1( )]TJ /TT4 1 Tf 0 Tc 0 Tw 2.379 0 Td (j)Tj /TT0 1 Tf 0.28 0 Td ( )Tj 0.002 Tc 0.012 Tw 0.264 0 Td [(=)-5( 1)-4(, )]TJ 0.004 Tc -0.004 Tw -21.767 -1.366 Td (..., )Tj /TT4 1 Tf 0 Tc 0 Tw 1.27 0 Td (n)Tj /TT0 1 Tf 0.508 0 Td ( )Tj 0.004 Tc 0.254 0 Td [(c)-3(lu)-4(tte)-3(r)-1( ty)-4(p)-4(e)-3(s)-2(: )]TJ 0 Tc 5.531 0 Td ( )Tj /TT4 1 Tf 0.011 Tc -0.011 Tw 10.8 0 0 10.8 351 460.92 Tm (Pr)Tj /TT0 1 Tf 0.001 Tc 0 Tw 6.96 0 0 6.96 362 459.48 Tm [(O)-3( | c)]TJ 0 Tc 10.8 0 0 10.8 375.0601 460.92 Tm ( )Tj 0.01 Tc -0.006 Tw 0.255 0 Td (= )Tj 0.006 Tc 2.802 0.844 Td ([ )Tj /C2_1 1 Tf 0 Tc 0 Tw 9.84 0 0 9.84 414.4843 470.04 Tm <0001>Tj /TT0 1 Tf 10.8 0 0 10.8 420.3877 470.04 Tm ( )Tj 0.001 Tc 6.96 0 0 6.96 423.1377 468.6 Tm [(O)-3( | C)]TJ 0 Tc 10.8 0 0 10.8 437.7598 470.04 Tm ( )Tj 0.255 0 Td (])Tj -4.722 -1.444 Td ( )Tj /C2_2 1 Tf 0.255 0 Td <0003>Tj /TT0 1 Tf 0.603 0 Td ( )Tj 6.96 0 0 6.96 401.5234 453 Tm (c)Tj 0.446 0 Td ( )Tj 0.002 Tc -0.002 Tw 0.251 -0.31 Td (j )Tj /C2_2 1 Tf 0 Tc 0 Tw 3.36 0 0 3.36 410.0786 453.48 Tm <0002>Tj /TT0 1 Tf 6.96 0 0 6.96 412.5737 453 Tm ( )Tj 0.251 0 Td (C)Tj 10.8 0 0 10.8 418.9927 454.44 Tm ( )Tj 0.255 0 Td ( )Tj 0.255 0 Td ([)Tj 0.339 0 Td ( )Tj /C2_1 1 Tf 9.84 0 0 9.84 430.9058 454.44 Tm <0001>Tj /TT0 1 Tf 10.8 0 0 10.8 436.8091 454.44 Tm ( )Tj 0.001 Tc 6.96 0 0 6.96 439.5591 453 Tm [(O)-3( | )]TJ 0.003 Tc -0.003 Tw [(c)1( )]TJ 0 Tc 0 Tw 2.128 -0.31 Td (j)Tj 10.8 0 0 10.8 456.3174 454.44 Tm ( )Tj 0.255 0 Td (])Tj ET 0.75 0.68 0.655 0.902 K 0.72 w q 1 0 0 1 389.64 465.6 cm 0 0 m 73.2 0 l S Q BT /TT0 1 Tf 10.8 0 0 10.8 462.7304 460.92 Tm ( )Tj 0.255 0 Td ( )Tj 0.006 Tc -0.006 Tw 7.733 0 Td (\(1)Tj 0 Tc 0 Tw 0.848 0 Td (\))Tj 0.339 0 Td ( )Tj -20.771 -2.022 Td ( )Tj 0.004 Tc 9.84 0 0 9.84 337.5 427.56 Tm [(U)-8(s)-3(in)-4(g)-4( p)-4(la)-3(u)-4(s)-3(ib)-4(ili)-1(ty)]TJ 0 Tc 7.255 0 Td (,)Tj 0.254 0 Td ( )Tj 0.004 Tc -0.004 Tw 0.254 0 Td [(u)-4(n)-4(c)-3(e)-3(r)-1(ta)-3(in)-4(ty)]TJ 0 Tc 0 Tw 4.571 0 Td ( )Tj 0.008 Tc -0.004 Tw 0.254 0 Td [(i)4(s)2( e)1(ve)1(r)3(yt)4(hi)4(ng unknow)-4(n)]TJ 0 Tc 0 Tw 9.315 0 Td ( )Tj 10.8 0 0 10.8 337.5 415.08 Tm ( )Tj /TT4 1 Tf 1.25 -1.178 Td (U)Tj /TT0 1 Tf 6.96 0 0 6.96 358.9438 400.92 Tm (L)Tj 10.8 0 0 10.8 363.2197 402.36 Tm ( )Tj 0.009 Tc -0.005 Tw 0.255 0 Td [(=)-1( 1 )]TJ 0 Tc 0 Tw 1.593 0 Td (-)Tj 0.339 0 Td ( )Tj /TT4 1 Tf 0.011 Tc -0.011 Tw 0.255 0 Td (Pr)Tj /TT0 1 Tf 0.001 Tc 0 Tw 6.96 0 0 6.96 400.5864 400.92 Tm [(O)-3( | c)]TJ 0 Tc 1.876 0 Td ( )Tj 0.006 Tc -0.006 Tw 10.8 0 0 10.8 549 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t)4(hi)4(s)2( a)1(na)1(l)4(ys)2(i)4(s)2( w)]TJ 0.004 Tc 0.165 Tw 12.085 0 Td [(e)-3( s)-2(im)-8(u)-4(la)-3(te)-3( )]TJ 0.007 Tc 0.057 Tw -19.046 -1.146 Td [(t)3(h)-1(e d)-1(ead)-1(t)3(i)3(m)-5(e f)1(o)-1(r)2( an)-1( )]TJ /TT4 1 Tf 0.005 Tc 0.002 Tw 8.367 0 Td [(i)1(n)-3(p)-3(u)-3(t)1( t)1(i)1(m)-7(e)-2( d)-3(e)-2(l)1(a)-3(y)]TJ /TT0 1 Tf 0 Tc 0 Tw ( )Tj 6.867 0 Td (\()Tj /TT4 1 Tf 0.009 Tc -0.009 Tw 0.338 0 Td (TD)Tj /TT0 1 Tf 0 Tc 0 Tw 6.48 0 0 6.48 503.5166 341.64 Tm (i)Tj 0.008 Tc 0.056 Tw 9.84 0 0 9.84 505.3225 343.08 Tm [(\))3( f)2(or)3( a)1( de)1(c)1(i)4(s)2(i)4(on )]TJ /TT4 1 Tf 0 Tc 0 Tw -17.055 -1.171 Td (i)Tj /TT0 1 Tf 0.007 Tc 0.03 Tw 0.282 0 Td [(,)3( as)1( r)2(el)3(at)3(ed)-1( t)3(o)-1( t)3(h)-1(e u)-1(s)1(er)2( ach)-1(i)3(ev)-1(i)3(n)-1(g)-1( a co)-1(n)-1(t)3(r)2(o)-1(l)3( d)-1(eci)3(s)1(i)3(o)-1(n)]TJ 0 Tc 0 Tw 20.842 0 Td ( )Tj 0.008 Tc -0.008 Tw 0.287 0 Td [([)3(46])]TJ 0.004 Tc -0.004 Tw 1.693 0 Td (. )Tj 0.007 Tc 0.504 Tw -23.105 -1.171 Td 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ga)1(i)4(ne)1(d i)4(n popul)4(a)1(r)3(i)4(t)4(y a)1(s)2( i)4(t)4( a)1(f)2(f)2(or)3(ds)2( a)1(dva)1(nc)1(e)1(d )]TJ 0.007 Tc 0.174 Tw T* [(cap)-1(ab)-1(i)3(l)3(i)3(t)3(i)3(es)1( i)3(n)-1( p)-1(er)2(s)1(i)3(s)1(t)3(en)-1(ce,)3( i)3(n)-1(cr)2(eas)1(ed)-1( t)3(r)2(ack)-1( l)3(i)3(f)1(e)]TJ 0.004 Tc 0.177 Tw 19.562 0 Td [(, a)-3(n)-4(d)-4( s)-2(itu)-4(a)-3(tio)-4(n)-4( )]TJ 0.007 Tc 0.03 Tw -19.562 -1.171 Td [(aw)-5(ar)2(en)-1(es)1(s)1(,)3( b)-1(u)-1(t)3( i)3(t)3( al)3(s)1(o)-1( p)-1(o)-1(s)1(es)1( n)-1(ew)-5( ch)-1(al)3(l)3(en)-1(g)-1(es)1( )]TJ 0.006 Tc 0.032 Tw 18.18 0 Td [(su)-2(c)-1(h)-2( )1(a)-1(s )1(l)2(o)-2(w)-5( f)1(ra)-1(m)-6(e)-1( )]TJ 0.004 Tc 0.071 Tw -18.18 -1.171 Td [(u)-4(p)-4(d)-4(a)-3(te)-3(s)-2( \()-1(tim)-8(e)-3(lin)-4(e)-3(s)-2(s)-2(\))]TJ 0 Tc 0 Tw 8.228 0 Td ( )Tj 0.325 0 Td ([)Tj 0.008 Tc -0.008 Tw 0.338 0 Td (47)Tj 0 Tc 0 Tw (,)Tj 1.27 0 Td ( )Tj 0.008 Tc -0.008 Tw 0.325 0 Td (48)Tj 0 Tc 0 Tw (])Tj 0.008 Tc 0.067 Tw 1.355 0 Td [(.)4( L)-2(e)1(ve)1(r)3(a)1(gi)4(ng de)1(ve)1(l)4(opm)-4(e)1(nt)4(s)2( f)2(r)3(om)-4( )]TJ 0.337 Tw -11.842 -1.171 Td [(c)1(om)-4(put)4(e)1(r)3( vi)4(s)2(i)4(on [)]TJ -0.008 Tw 7.85 0 Td (49)Tj 0 Tc 0 Tw (,)Tj 1.27 0 Td ( )Tj 0.008 Tc -0.008 Tw 0.595 0 Td (50)Tj 0 Tc 0 Tw (,)Tj 1.27 0 Td ( )Tj 0.008 Tc -0.008 Tw 0.595 0 Td (51)Tj 0 Tc 0 Tw (,)Tj 1.27 0 Td ( )Tj 0.008 Tc -0.008 Tw 0.595 0 Td (52)Tj 0.004 Tc -0.004 Tw (, )Tj 0.008 Tc -0.008 Tw 1.865 0 Td (53)Tj 0 Tc 0 Tw (])Tj 0.004 Tc 0.341 Tw 1.355 0 Td [(, m)-8(e)]TJ 0.008 Tc 0.336 Tw 2.09 0 Td [(t)4(hods)2( a)1(r)3(e)1( be)1(i)4(ng )]TJ 0.007 Tc 0.05 Tw -18.755 -1.171 Td [(ap)-1(p)-1(l)3(i)3(ed)-1( as)1( p)-1(ar)2(t)3( o)-1(f)1( t)3(h)-1(e E)-3(T)-3(U)-5(W)-8(G)-5( [)2(2)-1(9)-1(])2(.)3( T)-3(h)-1(e p)-1(er)2(s)1(i)3(s)1(t)3(en)-1(ce co)-1(v)-1(er)2(ag)-1(e )]TJ 0.008 Tc 0.189 Tw T* [(a)1(f)2(f)2(or)3(ds)2( s)2(uc)1(h m)-4(e)1(t)4(hods)2( a)1(s)2( m)-4(ul)4(t)4(i)4(pl)4(e)1( obj)3(e)1(c)1(t)4( a)1(nd gr)3(oup t)4(r)3(a)1(c)1(ki)4(ng )]TJ 0 Tc 0 Tw T* ([)Tj 0.008 Tc -0.008 Tw 0.338 0 Td (54)Tj 0 Tc 0 Tw (,)Tj 1.27 0 Td ( )Tj 0.008 Tc -0.008 Tw 0.288 0 Td (55)Tj 0 Tc 0 Tw (,)Tj 1.27 0 Td ( )Tj 0.008 Tc -0.008 Tw 0.288 0 Td (56)Tj 0.029 Tw [(])3(,)4( r)3(oa)1(d a)1(s)2(s)2(e)1(s)2(s)2(m)-4(e)1(nt)4( a)1(nd t)4(r)3(a)1(c)1(ki)4(ng [)]TJ -0.008 Tw 14.504 0 Td (57)Tj 0 Tc 0 Tw (,)Tj 1.27 0 Td ( )Tj 0.008 Tc -0.008 Tw 0.288 0 Td (58)Tj 0.029 Tw [(])3(,)4( c)1(ont)4(e)1(xt)4(ua)1(l)4( )]TJ 0.005 Tc -0.005 Tw -19.516 -1.171 Td [(t)1(r)]TJ 0.008 Tc 0.139 Tw [(a)1(c)1(ki)4(ng [)]TJ -0.008 Tw 4.066 0 Td (59)Tj 0 Tc 0 Tw (,)Tj 1.27 0 Td ( )Tj 0.008 Tc -0.008 Tw 0.398 0 Td (60)Tj 0.139 Tw [(])3(,)4( a)1(nd )]TJ 0.004 Tc 0.143 Tw 3.871 0 Td [(a)-3(d)-4(v)-4(a)-3(n)-4(c)-3(e)-3(s)-2( in)-4( p)-4(a)-3(r)-1(tic)-3(le)-3( f)-2(ilte)-3(r)-1(in)-4(g)-4( [)-1(5)-4(9)-4(, )]TJ 0.008 Tc -0.008 Tw 14.432 0 Td (61)Tj 0 Tc 0 Tw (])Tj 1.355 0 Td (.)Tj 0.254 0 Td ( )Tj 0.007 Tc 0.116 Tw -25.645 -1.171 Td [(B)-4(ecau)-1(se o)-1(f)1( t)3(h)-1(e n)-1(u)-1(m)-6(er)1(o)-1(u)-1(s o)-1(b)-1(j)2(ect)2(s an)-1(d)-1( t)2(h)-1(ei)2(r)1( )]TJ 0.009 Tc -0.009 Tw 18.302 0 Td [(m)-3(o)1(v)1(e)2(m)-3(e)2(n)1(t)5(s)]TJ 0.004 Tc 0.119 Tw 4.685 0 Td [(, th)-4(e)-3(r)-1(e)-3( )]TJ 0.008 Tc 0.148 Tw -22.987 -1.171 Td [(a)1(r)3(e)1( oppor)3(t)4(uni)4(t)4(i)4(e)1(s)2( f)2(or)3( l)4(i)4(ne)1(a)1(r)3( r)3(oa)1(d t)4(r)3(a)1(c)1(ki)4(ng,)4( but)4( a)1(l)4(s)2(o t)4(he)1(r)3(e)1( i)4(s)2( a)1( )]TJ 0.591 Tw T* [(ne)1(e)1(d f)2(or)3( nonl)4(i)4(ne)1(a)1(r)3( t)4(r)3(a)1(c)1(k e)1(va)1(l)4(ua)1(t)4(i)4(on [)]TJ -0.008 Tw 17.791 0 Td (62)Tj 0.005 Tc -0.005 Tw (] )Tj 0.008 Tc 0.592 Tw 2.204 0 Td [(s)2(uc)1(h )1(a)1(s)1( )1(t)4(he)1( )]TJ 0.62 Tw -19.995 -1.146 Td [(r)3(a)1(ndom)-4(i)4(z)1(e)1(d uns)2(c)1(e)1(nt)4(e)1(d t)4(r)3(a)1(ns)2(f)2(or)3(m)-4( \()3(R)-2(U)-3(T)-1(\))3( f)2(i)4(l)4(t)4(e)1(r)3( [)]TJ -0.008 Tw 22.227 0 Td (63)Tj 0 Tc 0 Tw (])Tj 1.355 0 Td ( )Tj 0.005 Tc -0.005 Tw 0.878 0 Td [(f)-1(o)-3(r )]TJ 0.007 Tc 0.031 Tw -24.46 -1.171 Td [(accu)-1(r)2(acy)-1( as)1(s)1(es)1(s)1(m)-5(en)-1(t)]TJ 0.004 Tc 0.034 Tw 8.414 0 Td [(. T)-6(h)-4(e)-3(s)-2(e)-3( is)-2(s)-2(u)-4(e)-3(s)-2( w)-8(ill b)-4(e)-3( im)-8(p)-4(o)-4(r)-1(ta)-3(n)-4(t f)-2(o)-4(r)-1( f)-2(u)-4(tu)-4(r)-1(e)-3( )]TJ 0.008 Tc -0.008 Tw -8.414 -1.171 Td [(w)-4(or)2(k.)]TJ 0 Tc 0 Tw 2.343 0 Td ( )Tj 0.004 Tc 0.355 Tw -1.428 -1.78 Td [(W)-11(e)-3( )-1(u)-4(tiliz)-3(e)-3( )-1(th)-4(e)-3( )-1(r)-1(e)-3(s)-2(u)-4(lts)-2( f)-2(r)-1(o)-4(m)-8( a)-3( W)-11(A)-8(M)-10(I)-1( )]TJ 0.005 Tc 0.354 Tw 17.474 0 Td [(t)1(ra)-2(c)-2(k)-3(e)-2(r f)-1(o)-3(r)]TJ 0 Tc 0 Tw ( )Tj 0.005 Tc -0.005 Tw 5.225 0 Td [(t)1(ra)-2(c)-2(k)-3( )]TJ 0.008 Tc 0.214 Tw -23.614 -1.171 Td [(l)4(oc)1(a)1(t)4(i)4(on a)1(c)1(c)1(ur)3(a)1(c)1(y,)4( t)4(he)1( pi)4(xe)1(l)4(s)2( on t)4(a)1(r)3(ge)1(t)4( f)2(or)3( )]TJ 0.004 Tc 0.218 Tw 18.626 0 Td [(c)-3(la)-3(s)-2(s)-2(if)-2(ic)-3(a)-3(tio)-4(n)-4( f)-2(o)-4(r)-1( )]TJ 0.005 Tc 0.12 Tw -18.626 -1.171 Td [(t)1(a)-2(rg)-3(e)-2(t)1( i)1(d)-3(e)-2(n)-3(t)1(i)1(t)1(y)-3( )]TJ 0.008 Tc -0.008 Tw [(\()3(e)1(.)4(g.)]TJ 0 Tc 0 Tw 7.975 0 Td ( )Tj 0.004 Tc -0.004 Tw 0.376 0 Td [(c)-3(r)-1(e)-3(d)-4(ib)-4(ility)]TJ 0 Tc 0 Tw 4.177 0 Td (\))Tj 0.004 Tc 0.121 Tw 0.338 0 Td [(, a)-3(n)-4(d)-4( th)-4(e)-3( tim)-8(e)-3(lin)-4(e)-3(s)-2(s)-2( to)-4( )-1(m)-8(a)-3(k)-4(e)-3( )-1(a)-3( )]TJ 0.008 Tc -0.008 Tw -12.866 -1.171 Td [(de)1(c)1(i)4(s)2(i)4(on.)]TJ 0 Tc 0 Tw 3.641 0 Td ( )Tj 0.007 Tc 0.012 Tw 0.269 0 Td [(W)-8(e ar)2(e t)3(r)2(ack)-1(i)3(n)-1(g)-1( f)1(o)]TJ 0.008 Tc 0.011 Tw [(ur)3( t)4(a)1(r)3(ge)1(t)4(s)2( w)-4(i)4(t)4(h a)1(n on)]TJ 0 Tc 0 Tw 16.048 0 Td (-)Tj 0.008 Tc -0.008 Tw 0.338 0 Td [(r)3(oa)1(d )]TJ 0.004 Tc -0.004 Tw 2.075 0 Td [(a)-3(n)-4(a)-3(ly)-4(s)-2(is)-2( )]TJ 0.008 Tc 0.241 Tw -22.371 -1.171 Td [(w)-4(i)4(t)4(h a)1( nom)-5(i)4(na)1(t)3(e)1(d t)3(a)1(r)2(ge)1(t)4( of)2( i)3(nt)3(e)1(r)2(e)1(s)1(t)4(,)4( a)1(s)1( s)1(how)-4(n i)3(n F)-1(i)]TJ 22.579 0 Td [(gur)3(e)1( 6.)4( )]TJ 0.007 Tc 0.017 Tw -22.579 -1.171 Td [(V)-5(eh)-1(i)3(cl)3(es t)3(u)-1(r)1(n)]TJ 0.008 Tc 0.016 Tw 5.466 0 Td [(i)4(ng of)2(f)2( r)3(oa)1(d a)1(r)3(e)1( not)4( c)1(ons)2(i)4(de)1(r)3(e)1(d a)1(s)2( p)]TJ 0.007 Tc 0.017 Tw 14.504 0 Td [(ar)2(t)3( o)-1(f)1( t)3(h)-1(e u)-1(s)1(er)2( )]TJ 0.008 Tc 0.171 Tw -19.97 -1.171 Td [(de)1(f)2(i)4(ne)1(d t)4(a)1(r)3(ge)1(t)4(s)2( of)2( i)4(nt)4(e)1(r)3(e)1(s)2(t)4(.)4( N)-4(ot)4(e)1(:)4( t)4(he)1( e)1(nt)4(i)4(r)3(e)1( C)-3(ol)4(um)-4(bus)2( L)-2(a)1(r)3(ge)1( )]TJ 0.398 Tw T* [(I)3(m)-4(a)1(ge)1( F)-1(or)3(m)-4(a)1(t)4( \()3(C)-2(L)-1(I)3(F)-1(\))3( W)-7(A)-3(M)-6(I)3( i)4(m)-4(a)1(ge)1( c)1(ol)4(l)4(e)1(c)1(t)4(i)4(on ha)1(s)2( be)1(e)1(n )]TJ 0.118 Tw 0 -1.146 TD [(pr)3(e)1(s)2(e)1(nt)4(e)1(d i)4(n pr)3(e)1(vi)4(ous)2( pa)1(pe)1(r)3(s)2( w)-4(i)4(t)4(h)]TJ 0 Tc 0 Tw 14.148 0 Td ( )Tj 0.004 Tc 0.122 Tw 0.376 0 Td [(d)-4(is)-2(c)-3(u)-4(s)-2(s)-2(io)-4(n)-4(s)-2( w)-8(ith)-4( th)-4(e)-3( e)-3(n)-4(tir)-1(e)-3( )]TJ 0.008 Tc -0.004 Tw -14.525 -1.171 Td [(vi)4(de)1(o da)1(t)4(a)1( s)]TJ 0.007 Tc -0.007 Tw 4.854 0 Td (et)Tj 0 Tc 0 Tw 0.733 0 Td ( )Tj 0.254 0 Td ([)Tj 0.008 Tc -0.008 Tw 0.338 0 Td (27)Tj 0 Tc 0 Tw (])Tj 1.355 0 Td ( )Tj 0.005 Tc -0.005 Tw 0.254 0 Td [(\(s)-1(e)-2(e)]TJ 0 Tc 0 Tw 1.636 0 Td ( )Tj 0.005 Tc -0.005 Tw 0.254 0 Td [(t)1(h)-3(e)-2( )]TJ 0.012 Tc -0.008 Tw 1.496 0 Td [(E)2(T)2(UR)1(W)-3(G we)5(b)4(s)5(i)7(t)7(e)]TJ 0 Tc 0 Tw 7.705 0 Td (\))Tj 0.338 0 Td (.)Tj 0.254 0 Td ( )Tj -19.472 -1.171 Td ( )Tj ET q /Perceptual ri 121.4400024 0 0 108.4800042 44.5200005 115.7999946 cm /Im0 Do Q BT /TT0 1 Tf 9.84 0 0 9.84 166.0559 115.8 Tm ( )Tj ET q 168.6 115.8 117.121 107.519 re W n q /Perceptual ri 117.1200011 0 0 107.5199965 168.6000061 115.8000108 cm /Im1 Do Q Q BT /TT0 1 Tf 9.84 0 0 9.84 285.6519 115.8 Tm ( )Tj -24.505 -0.951 Td ( )Tj -0.001 Tc 0.001 Tw 7.92 0 0 7.92 125.887 97.08 Tm [(Fi)3(g)1(u)1(r)2(e)2( )]TJ 0 Tc 0 Tw 2.845 0 Td (6)Tj 0.499 0 Td ( )Tj 0.246 0 Td (\226)Tj 0.499 0 Td ( )Tj -0.001 Tc -0.003 Tw 0.246 0 Td [(W)-4(A)-2(M)-4(I)2( T)-1(r)2(a)1(c)1(ki)3(ng.)]TJ 0 Tc 0 Tw 6.98 0 Td ( )Tj 9.84 0 0 9.84 44.52 80.28 Tm ( )Tj ET /CS0 cs 1 scn 354.62 581.89 181.354 142.864 re f* q 0.4167038 0 0 0.417049 0 0 cm /CS0 CS 1 SCN 0.14 w 1 j 851.013 1737.814 435.206 -342.559 re S Q q 0.4167038 0 0 0.417049 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 851.0128 1395.2554 cm 0 0 m 435.206 0 l S Q Q q 0.4167038 0 0 0.417049 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 1286.7188 1394.7563 cm 0 0 m 1 0 l S Q Q q 0.4167038 0 0 0.417049 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 851.0128 1395.2554 cm 0 0 m 0 342.559 l S Q Q q 0.4167038 0 0 0.417049 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 851.5128 1737.3143 cm 0 0 m 1.001 0 l S Q Q q 0.4167038 0 0 0.417049 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 851.0128 1395.2554 cm 0 0 m 0 5.021 l S Q Q q 0.4167038 0 0 0.417049 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 851.5128 1399.7762 cm 0 0 m 1.001 0 l S Q Q q 324.12 562.68 234 175.44 re W n BT 0 scn /TT5 1 Tf 5.4326 0 0 5.4371 353.3689 576.4623 Tm (0)Tj ET Q q 0.4167038 0 0 0.417049 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 894.1288 1395.2554 cm 0 0 m 0 5.021 l S Q Q q 0.4167038 0 0 0.417049 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 894.6287 1399.7762 cm 0 0 m 1.03 0 l S Q Q q 324.12 562.68 234 175.44 re W n BT 0 scn /TT5 1 Tf 5.4326 0 0 5.4371 371.3367 576.4623 Tm (2)Tj ET Q q 0.4167038 0 0 0.417049 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 937.2687 1395.2554 cm 0 0 m 0 5.021 l S Q Q q 0.4167038 0 0 0.417049 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 937.7687 1399.7762 cm 0 0 m 1 0 l S Q Q q 324.12 562.68 234 175.44 re W n BT 0 scn /TT5 1 Tf 5.4326 0 0 5.4371 389.3008 576.4623 Tm (4)Tj ET Q q 0.4167038 0 0 0.417049 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 981.3888 1395.2554 cm 0 0 m 0 5.021 l S Q Q q 0.4167038 0 0 0.417049 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 981.8887 1399.7762 cm 0 0 m 1 0 l S Q Q q 324.12 562.68 234 175.44 re W n BT 0 scn /TT5 1 Tf 5.4326 0 0 5.4371 407.6941 576.4623 Tm (6)Tj ET Q q 0.4167038 0 0 0.417049 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 1024.4988 1395.2554 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1213.0288 1651.6643 cm 0 0 m 0 79.13 l S Q Q q 0.4167038 0 0 0.417049 0 0 cm /CS1 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 1213.5288 1730.2943 cm 0 0 m 1 0 l S Q Q q 0.4167038 0 0 0.417049 0 0 cm /CS1 CS 0 SCN 0.14 w 1 j q 1 0 0 1 1213.0288 1651.6643 cm 0 0 m 67.19 0 l S Q Q q 0.4167038 0 0 0.417049 0 0 cm /CS1 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 1280.7188 1651.1643 cm 0 0 m 1 0 l S Q Q q 0.4167038 0 0 0.417049 0 0 cm /CS1 CS 0 SCN 0.14 w 1 j q 1 0 0 1 1213.0288 1651.6643 cm 0 0 m 0 79.13 l S Q Q q 0.4167038 0 0 0.417049 0 0 cm /CS1 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 1213.5288 1730.2943 cm 0 0 m 1 0 l S Q Q q 0.4167038 0 0 0.417049 0 0 cm /CS1 CS 0 SCN 0.14 w 1 j q 1 0 0 1 1213.0288 1730.7943 cm 0 0 m 67.19 0 l S Q Q q 0.4167038 0 0 0.417049 0 0 cm /CS1 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 1280.7188 1730.2943 cm 0 0 m 1 0 l S Q Q q 0.4167038 0 0 0.417049 0 0 cm /CS1 CS 0 SCN 0.14 w 1 j q 1 0 0 1 1213.0288 1651.6643 cm 0 0 m 67.19 0 l S Q Q q 0.4167038 0 0 0.417049 0 0 cm /CS1 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 1280.7188 1651.1643 cm 0 0 m 1 0 l S Q Q q 0.4167038 0 0 0.417049 0 0 cm /CS1 CS 0 SCN 0.14 w 1 j q 1 0 0 1 1280.2188 1651.6643 cm 0 0 m 0 79.13 l S Q Q q 0.4167038 0 0 0.417049 0 0 cm /CS1 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 1280.7188 1730.2943 cm 0 0 m 1 0 l S Q Q q 0.4167038 0 0 0.417049 0 0 cm /CS1 CS 0 SCN 0.14 w 1 j q 1 0 0 1 1213.0288 1651.6643 cm 0 0 m 0 79.13 l S Q Q q 0.4167038 0 0 0.417049 0 0 cm /CS1 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 1213.5288 1730.2943 cm 0 0 m 1 0 l S Q Q q 324.12 562.68 234 175.44 re W n BT 0 scn /TT5 1 Tf 5.4326 0 0 5.4371 527.6215 715.9832 Tm (A)Tj ET Q q 0.4167038 0 0 0.417049 0 0 cm 0.931 0.793 0 0 K 4.004 w 1 j [4.004 4.004]0 d q 1 0 0 1 1221.0388 1719.7844 cm 0 0 m 40.11 0 l S Q Q q 324.12 562.68 234 175.44 re W n BT 0 scn /TT5 1 Tf 5.4326 0 0 5.4371 527.6215 708.0425 Tm (B)Tj ET Q q 0.4167038 0 0 0.417049 0 0 cm 0.655 0 1 0 K 0.14 w 1 j [0.14 0.14]0 d q 1 0 0 1 1221.0388 1700.7444 cm 0 0 m 40.11 0 l S Q Q q 324.12 562.68 234 175.44 re W n BT 0 scn /TT5 1 Tf 5.4326 0 0 5.4371 527.6215 700.5231 Tm (C)Tj ET Q q 0.4167038 0 0 0.417049 0 0 cm 0 1 1 0 K 0.14 w 1 j [0.14 0.14]0 d q 1 0 0 1 1221.0388 1682.7343 cm 0 0 m 40.11 0 l S Q Q q 324.12 562.68 234 175.44 re W n BT 0 scn /TT5 1 Tf 5.4326 0 0 5.4371 527.6215 692.5867 Tm (D)Tj ET Q q 0.4167038 0 0 0.417049 0 0 cm 0.531 0 0.128 0 K 0.14 w 1 j [0.14 0.14]0 d q 1 0 0 1 1221.0388 1663.7043 cm 0 0 m 40.11 0 l S Q Q BT 0.75 0.68 0.655 0.902 k /TT0 1 Tf 9.84 0 0 9.84 558.145 562.68 Tm ( )Tj -0.001 Tc 0.001 Tw 7.92 0 0 7.92 397.6225 555.72 Tm [(Fi)3(g)1(u)1(r)2(e)2( )]TJ 0 Tc 0 Tw 2.846 0 Td (7)Tj 0.499 0 Td ( )Tj 0.246 0 Td (\226)Tj 0.499 0 Td ( )Tj -0.003 Tc 0.003 Tw 0.246 0 Td [(T)-3(a)-1(rg)-2(e)-1(t )]TJ -0.002 Tc 0.002 Tw 2.844 0 Td [(A)-3(ccu)-1(r)1(acy)]TJ 0 Tc 0 Tw ( )Tj 0.008 Tc 0.132 Tw 9.84 0 0 9.84 324 538.92 Tm [(F)-1(i)4(gur)3(e)1( 7 pl)4(ot)4(s)2( t)4(he)1( t)4(a)1(r)3(ge)1(t)4( a)1(c)1(c)1(ur)3(a)1(c)1(y \()3(w)-4(hi)4(c)1(h i)4(s)2( t)4(he)1( i)4(nve)1(r)3(s)2(e)1( of)2( )]TJ 0.005 Tc 0.083 Tw -0.915 -1.171 Td [(t)1(h)-3(e)-2( t)1(y)-3(p)-3(i)1(c)-2(a)-2(l)1( p)-3(l)1(o)-3(t)1(s)-1( t)1(h)-3(a)-2(t)1( s)-1(h)-3(o)-3(w)-7( t)1(h)-3(e)-2( t)1(a)-2(rg)-3(e)-2(t)1( t)1(ra)-2(c)-2(k)-3(i)1(n)-3(g)-3( e)-2(rro)-3(r\).)1( F)-4(i)1(g)-3(u)-3(re)-2( 8)-3( )]TJ 0.008 Tc 0.052 Tw 0 -1.171 TD [(c)1(om)-4(bi)4(ne)1(s)2( t)4(he)1( t)4(r)3(a)1(c)1(k a)1(c)1(c)1(ur)3(a)1(c)1(y i)4(n a)1( uni)4(f)2(i)4(e)1(d di)4(s)2(pl)4(a)1(y pl)4(ot)4( s)2(how)-4(i)4(ng )]TJ 0.005 Tc -0.005 Tw T* [(t)1(h)-3(e)]TJ 0 Tc 0 Tw 1.242 0 Td ( )Tj 0.007 Tc 0.006 Tw 0.263 0 Td [(t)3(ar)2(g)-1(et)3( co)-1(n)-1(f)1(i)3(d)-1(en)-1(ce \()2(u)-1(i)3(d)-1(\))2( an)-1(d)-1( t)3(h)-1(e accu)-1(r)2(acy)-1(.)]TJ 0 Tc 0 Tw 16.635 0 Td ( )Tj 0.007 Tc 0.006 Tw 0.263 0 Td [(T)-3(h)-1(e co)-1(n)-1(f)1(i)3(d)-1(en)-1(ce i)3(s )]TJ 0.009 Tc 0.065 Tw -18.403 -1.171 Td [(s)3(h)1(o)1(w)-2(n)1( )1(a)2(s)3( )1(s)3(o)1(l)5(i)5(d)1( )1(l)5(i)5(n)1(e)2(s)3( )1(a)2(n)1(d )1(t)5(h)1(e)2( )1(t)5(i)5(m)-3(e)2(l)5(i)5(n)1(e)2(s)3(s)3( )1(p)1(r)4(e)2(s)3(e)2(n)1(t)5(e)2(d)1( )1(a)2(s)3( )1(t)5(h)1(e)2( )1(b)1(l)5(a)2(c)2(k)1( )]TJ 0.008 Tc 0.079 Tw T* [(hum)-4(ps)2( w)-4(he)1(r)3(e)1( t)4(he)1( t)4(i)4(m)-4(e)1( i)4(nt)4(e)1(r)3(va)1(l)4(s)2( a)1(r)3(e)1( s)2(how)-4(n a)1(s)2(:)4( or)3(i)4(e)1(nt)4( \()]TJ /TT1 1 Tf 0 Tc 0 Tw 22.507 0 Td (t)Tj /TT0 1 Tf 0.282 0 Td ( )Tj 0.004 Tc 0.083 Tw 0.337 0 Td [(=)-5( 2)-4(.5)]TJ 0 Tc 0 Tw 2.181 0 Td (-)Tj 0.008 Tc 0.132 Tw -25.307 -1.171 Td [(5\))3(,)4( obs)2(e)1(r)3(ve)1( \()]TJ /TT1 1 Tf 0.005 Tc -0.005 Tw 5.38 0 Td [(t)1( )]TJ /TT0 1 Tf 0.009 Tc 0.131 Tw 0.615 0 Td (= 5)Tj 0 Tc 0 Tw 1.471 0 Td (-)Tj 0.008 Tc 0.132 Tw 0.338 0 Td [(10\))3(,)4( de)1(c)1(i)4(de)1( \()]TJ /TT1 1 Tf 0 Tc 0 Tw 5.379 0 Td (t)Tj /TT0 1 Tf 0.282 0 Td ( )Tj 0.008 Tc 0.132 Tw 0.39 0 Td [(=)-1( 10)]TJ 0 Tc 0 Tw (-)Tj 0.008 Tc 0.132 Tw 2.318 0 Td [(13\))3( a)1(nd a)1(c)1(t)4( \()]TJ /TT1 1 Tf 0 Tc 0 Tw 5.515 0 Td (t)Tj /TT0 1 Tf 0.282 0 Td ( )Tj 0.008 Tc -0.008 Tw 0.39 0 Td [(=)-1(13)]TJ 0 Tc 0 Tw (-)Tj 0.008 Tc -0.008 Tw 1.928 0 Td [(18\))3( )]TJ 0.005 Tc -0.001 Tw -24.291 -1.171 Td [(t)1(i)1(m)-7(e)-2( s)-1(t)1(e)-2(p)]TJ 0.006 Tc -0.006 Tw 3.697 0 Td (s.)Tj 0 Tc 0 Tw 0.65 0 Td ( )Tj ET /CS0 cs 1 scn 347.846 281.708 195.304 154.004 re f* q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 1 SCN 0.14 w 1 j 775.131 969.177 435.206 -342.559 re S Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 775.1315 969.1766 cm 0 0 m 435.206 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 1210.8376 968.6767 cm 0 0 m 1 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 775.1315 626.6177 cm 0 0 m 435.206 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 1210.8376 626.1187 cm 0 0 m 1 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 1210.3375 626.6177 cm 0 0 m 0 342.559 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 1210.8376 968.6767 cm 0 0 m 1 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 775.1315 626.6177 cm 0 0 m 0 342.559 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 775.6315 968.6767 cm 0 0 m 1.001 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 775.1315 626.6177 cm 0 0 m 435.206 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 1210.8376 626.1187 cm 0 0 m 1 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 775.1315 626.6177 cm 0 0 m 0 342.559 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 775.6315 968.6767 cm 0 0 m 1.001 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 775.1315 626.6177 cm 0 0 m 0 5.021 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 775.6315 631.1387 cm 0 0 m 1.001 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 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5.861 442.353 275.8569 Tm (10)Tj ET Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 1035.8475 626.6177 cm 0 0 m 0 5.021 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 1036.3475 631.1387 cm 0 0 m 1.01 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 1035.8475 969.1766 cm 0 0 m 0 -4.02 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 1036.3475 964.6566 cm 0 0 m 1.01 0 l S Q Q q 315 261 252 189.12 re W n BT 0 scn /TT6 1 Tf -0.017 Tc 0.017 Tw 5.8505 0 0 5.861 461.7034 275.8569 Tm (12)Tj ET Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 1078.9875 626.6177 cm 0 0 m 0 5.021 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 1079.4875 631.1387 cm 0 0 m 1.01 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 1078.9875 969.1766 cm 0 0 m 0 -4.02 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 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797.8967 cm 0 0 m -5 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 1205.8375 797.3966 cm 0 0 m 1 0 l S Q Q q 315 261 252 189.12 re W n BT 0 scn /TT6 1 Tf -0.017 Tc 0.017 Tw 5.8505 0 0 5.861 336.6054 357.8101 Tm (250)Tj ET Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 775.1315 832.9666 cm 0 0 m 4.028 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 779.6605 832.4666 cm 0 0 m 1.001 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 1210.3375 832.9666 cm 0 0 m -5 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 1205.8375 832.4666 cm 0 0 m 1 0 l S Q Q q 315 261 252 189.12 re W n BT 0 scn /TT6 1 Tf -0.017 Tc 0.017 Tw 5.8505 0 0 5.861 336.6054 373.5674 Tm (300)Tj ET Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 775.1315 867.0166 cm 0 0 m 4.028 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J 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Q Q Q q 0.4487579 0 0 0.4495685 0 0 cm 0.743 0 0.318 0 K 4.004 w 1 j q 1 0 0 1 796.2005 695.7367 cm 0 0 m 11.037 29.05 l 22.047 -6 l 33.077 23.03 l 44.117 3.02 l 54.147 33.04 l 65.187 -2 l 76.197 27.05 l 87.237 6.02 l 98.267 -16.014 l 109.307 -9.02 l 120.337 -34.049 l 130.347 -49.086 l 141.387 -49.086 l 152.417 -58.079 l 163.457 -63.099 l 174.487 -66.097 l 185.497 -67.096 l S Q Q q 315 261 252 189.12 re W n BT 0 scn /TT6 1 Tf -0.017 Tc 0.045 Tw 0 5.861 -5.8505 0 558.0069 331.2406 Tm [(T)-21(ar)9(get)-45( I)-45(D)12( C)12(onf)-45(i)-24(denc)-55(e)]TJ 0 Tc -0.006 Tw 9.9041 0 0 9.922 364.0492 442.4594 Tm [(C)-4(o)-34(n)56(f)-40(i)-4(d)11(e)11(n)56(ce)11(-)14(A)-13(ccu)56(r)14(a)11(cy-)14(T)-24(i)-4(m)16(e)11(l)41(i)-4(n)56(e)11(ss P)-13(l)41(o)-34(t)]TJ 0 Tw 5.8505 0 0 5.861 346.4988 279.9106 Tm ( )Tj 33.459 26.352 Td ( )Tj ET Q q 0.4487579 0 0 0.4495685 0 0 cm /CS1 CS 0 SCN 0.14 w 1 j [0.14 0.14]0 d q 1 0 0 1 796.2005 661.6876 cm 0 0 m 22.047 0 l 44.117 0 l 65.187 0 l 87.237 0 l 109.307 0 l 130.347 0 l 152.417 0 l 174.487 0 l 196.537 0 l 217.607 0 l 239.647 0 l 261.717 0 l 282.787 0 l 304.837 0 l 326.907 0 l 347.957 0 l 370.027 0 l 392.097 0 l 414.137 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm 0 1 1 0 K 0.14 w 1 j [0.14 0.14]0 d q 1 0 0 1 796.2005 763.8466 cm 0 0 m 22.047 0 l 44.117 0 l 65.187 0 l 87.237 0 l 109.307 0 l 130.347 0 l 152.417 0 l 174.487 0 l 196.537 0 l 217.607 0 l 239.647 0 l 261.717 0 l 282.787 0 l 304.837 0 l 326.907 0 l 347.957 0 l 370.027 0 l 392.097 0 l 414.137 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm 0.531 0 0.128 0 K 0.14 w 1 j [0.14 0.14]0 d q 1 0 0 1 796.2005 832.9666 cm 0 0 m 22.047 0 l 44.117 0 l 65.187 0 l 87.237 0 l 109.307 0 l 130.347 0 l 152.417 0 l 174.487 0 l 196.537 0 l 217.607 0 l 239.647 0 l 261.717 0 l 282.787 0 l 304.837 0 l 326.907 0 l 347.957 0 l 370.027 0 l 392.097 0 l 414.137 0 l S Q Q q 347.792 281.664 195.403 154.081 re W n q 0.4487579 0 0 0.4495685 0 0 cm 0.931 0.793 0 0 K 4.004 w 1 j [4.004 4.004]0 d q 1 0 0 1 796.2005 884.0466 cm 0 0 m 22.047 0 l 44.117 0 l 65.187 0 l 87.237 0 l 109.307 0 l 130.347 0 l 152.417 0 l 174.487 0 l 196.537 0 l 217.607 0 l 239.647 0 l 261.717 0 l 282.787 0 l 304.837 0 l 326.907 0 l 347.957 0 l 370.027 0 l 392.097 0 l 414.137 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm 0.066 0 1 0 K 4.004 w 1 j [4.004 4.004]0 d q 1 0 0 1 796.2005 918.0966 cm 0 0 m 22.047 0 l 44.117 0 l 65.187 0 l 87.237 0 l 109.307 0 l 130.347 0 l 152.417 0 l 174.487 0 l 196.537 0 l 217.607 0 l 239.647 0 l 261.717 0 l 282.787 0 l 304.837 0 l 326.907 0 l 347.957 0 l 370.027 0 l 392.097 0 l 414.137 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm 0.655 0 1 0 K 4.004 w 1 j [4.004 4.004]0 d q 1 0 0 1 796.2005 952.1467 cm 0 0 m 22.047 0 l 44.117 0 l 65.187 0 l 87.237 0 l 109.307 0 l 130.347 0 l 152.417 0 l 174.487 0 l 196.537 0 l 217.607 0 l 239.647 0 l 261.717 0 l 282.787 0 l 304.837 0 l 326.907 0 l 347.957 0 l 370.027 0 l 392.097 0 l 414.137 0 l S Q Q Q q 315 261 252 189.12 re W n BT 0 scn /TT6 1 Tf 5.6808 8.1276 -8.1129 5.691 369.0035 357.3605 Tm [(T)20(a)-34(r)14(g)11(e)-34(t)6( )6(I)6(D)-4( )6(C)-4(o)11(n)11(f)]TJ 0 1 1 0 k 0 0 TD [(T)20(a)-34(r)14(g)11(e)-34(t)6( )6(I)6(D)-4( )6(C)-4(o)11(n)11(f)]TJ 0.931 0.793 0 0 k T* [(T)20(a)-34(r)14(g)11(e)-34(t)6( )6(I)6(D)-4( )6(C)-4(o)11(n)11(f)]TJ ET Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 775.1315 969.1766 cm 0 0 m 435.206 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 1210.8376 968.6767 cm 0 0 m 1 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 775.1315 626.6177 cm 0 0 m 435.206 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 1210.8376 626.1187 cm 0 0 m 1 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 1210.3375 626.6177 cm 0 0 m 0 342.559 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 1210.8376 968.6767 cm 0 0 m 1 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 775.1315 626.6177 cm 0 0 m 0 342.559 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 775.6315 968.6767 cm 0 0 m 1.001 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 775.1315 626.6177 cm 0 0 m 435.206 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 1210.8376 626.1187 cm 0 0 m 1 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 1210.3375 626.6177 cm 0 0 m 0 342.559 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 1210.8376 968.6767 cm 0 0 m 1 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 775.1315 626.6177 cm 0 0 m 0 5.021 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 775.6315 631.1387 cm 0 0 m 1.001 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 775.1315 969.1766 cm 0 0 m 0 -4.02 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 775.6315 964.6566 cm 0 0 m 1.001 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 818.2475 626.6177 cm 0 0 m 0 5.021 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 818.7475 631.1387 cm 0 0 m 1.03 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 818.2475 969.1766 cm 0 0 m 0 -4.02 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 818.7475 964.6566 cm 0 0 m 1.03 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 861.3875 626.6177 cm 0 0 m 0 5.021 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 861.8875 631.1387 cm 0 0 m 1 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 861.3875 969.1766 cm 0 0 m 0 -4.02 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 861.8875 964.6566 cm 0 0 m 1 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 905.5075 626.6177 cm 0 0 m 0 5.021 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 906.0075 631.1387 cm 0 0 m 1 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 905.5075 969.1766 cm 0 0 m 0 -4.02 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 906.0075 964.6566 cm 0 0 m 1 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 948.6175 626.6177 cm 0 0 m 0 5.021 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 949.1175 631.1387 cm 0 0 m 1 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 948.6175 969.1766 cm 0 0 m 0 -4.02 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 949.1175 964.6566 cm 0 0 m 1 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 992.7375 626.6177 cm 0 0 m 0 5.021 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 993.2375 631.1387 cm 0 0 m 1 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 992.7375 969.1766 cm 0 0 m 0 -4.02 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 993.2375 964.6566 cm 0 0 m 1 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 1035.8475 626.6177 cm 0 0 m 0 5.021 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 1036.3475 631.1387 cm 0 0 m 1.01 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 1035.8475 969.1766 cm 0 0 m 0 -4.02 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 1036.3475 964.6566 cm 0 0 m 1.01 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 1078.9875 626.6177 cm 0 0 m 0 5.021 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 1079.4875 631.1387 cm 0 0 m 1.01 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 1078.9875 969.1766 cm 0 0 m 0 -4.02 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 1079.4875 964.6566 cm 0 0 m 1.01 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 1123.1075 626.6177 cm 0 0 m 0 5.021 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 1123.6075 631.1387 cm 0 0 m 1 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 1123.1075 969.1766 cm 0 0 m 0 -4.02 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 1123.6075 964.6566 cm 0 0 m 1 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 1166.2275 626.6177 cm 0 0 m 0 5.021 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 1166.7275 631.1387 cm 0 0 m 1 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 1166.2275 969.1766 cm 0 0 m 0 -4.02 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 1166.7275 964.6566 cm 0 0 m 1 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 1210.3375 626.6177 cm 0 0 m 0 5.021 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 1210.8376 631.1387 cm 0 0 m 1 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 1210.3375 969.1766 cm 0 0 m 0 -4.02 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 1210.8376 964.6566 cm 0 0 m 1 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 1210.3375 626.6177 cm 0 0 m -5 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 1205.8375 626.1187 cm 0 0 m 1 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 775.1315 626.6177 cm 0 0 m 4.028 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 779.6605 626.1187 cm 0 0 m 1.001 0 l S Q Q q 315 261 252 189.12 re W n BT /CS1 cs 0 scn /TT6 1 Tf 5.8505 0 0 5.861 544.4993 280.8093 Tm (0)Tj ET Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 1210.3375 661.6876 cm 0 0 m -5 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 1205.8375 661.1887 cm 0 0 m 1 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 775.1315 661.6876 cm 0 0 m 4.028 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 779.6605 661.1887 cm 0 0 m 1.001 0 l S Q Q q 315 261 252 189.12 re W n BT /CS1 cs 0 scn /TT6 1 Tf -0.017 Tc 0.017 Tw 5.8505 0 0 5.861 544.4993 296.5757 Tm [(0.)-45(1)]TJ ET Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 1210.3375 695.7367 cm 0 0 m -5 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 1205.8375 695.2366 cm 0 0 m 1 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 775.1315 695.7367 cm 0 0 m 4.028 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 779.6605 695.2366 cm 0 0 m 1.001 0 l S Q Q q 315 261 252 189.12 re W n BT /CS1 cs 0 scn /TT6 1 Tf -0.017 Tc 0.017 Tw 5.8505 0 0 5.861 544.4993 311.8822 Tm [(0.)-45(2)]TJ ET Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 1210.3375 729.8067 cm 0 0 m -5 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 1205.8375 729.3067 cm 0 0 m 1 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 775.1315 729.8067 cm 0 0 m 4.028 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 779.6605 729.3067 cm 0 0 m 1.001 0 l S Q Q q 315 261 252 189.12 re W n BT /CS1 cs 0 scn /TT6 1 Tf -0.017 Tc 0.017 Tw 5.8505 0 0 5.861 544.4993 327.19 Tm [(0.)-45(3)]TJ ET Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 1210.3375 763.8466 cm 0 0 m -5 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 1205.8375 763.3467 cm 0 0 m 1 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 775.1315 763.8466 cm 0 0 m 4.028 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 779.6605 763.3467 cm 0 0 m 1.001 0 l S Q Q q 315 261 252 189.12 re W n BT /CS1 cs 0 scn /TT6 1 Tf -0.017 Tc 0.017 Tw 5.8505 0 0 5.861 544.4993 342.5068 Tm [(0.)-45(4)]TJ ET Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 1210.3375 797.8967 cm 0 0 m -5 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 1205.8375 797.3966 cm 0 0 m 1 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 775.1315 797.8967 cm 0 0 m 4.028 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 779.6605 797.3966 cm 0 0 m 1.001 0 l S Q Q q 315 261 252 189.12 re W n BT /CS1 cs 0 scn /TT6 1 Tf -0.017 Tc 0.017 Tw 5.8505 0 0 5.861 544.4993 357.8101 Tm [(0.)-45(5)]TJ ET Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 1210.3375 832.9666 cm 0 0 m -5 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 1205.8375 832.4666 cm 0 0 m 1 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 775.1315 832.9666 cm 0 0 m 4.028 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 779.6605 832.4666 cm 0 0 m 1.001 0 l S Q Q q 315 261 252 189.12 re W n BT /CS1 cs 0 scn /TT6 1 Tf -0.017 Tc 0.017 Tw 5.8505 0 0 5.861 544.4993 373.5674 Tm [(0.)-45(6)]TJ ET Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 1210.3375 867.0166 cm 0 0 m -5 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 1205.8375 866.5166 cm 0 0 m 1 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 775.1315 867.0166 cm 0 0 m 4.028 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 779.6605 866.5166 cm 0 0 m 1.001 0 l S Q Q q 315 261 252 189.12 re W n BT /CS1 cs 0 scn /TT6 1 Tf -0.017 Tc 0.017 Tw 5.8505 0 0 5.861 544.4993 388.8842 Tm [(0.)-45(7)]TJ ET Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 1210.3375 901.0566 cm 0 0 m -5 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 1205.8375 900.5567 cm 0 0 m 1 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 775.1315 901.0566 cm 0 0 m 4.028 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 779.6605 900.5567 cm 0 0 m 1.001 0 l S Q Q q 315 261 252 189.12 re W n BT /CS1 cs 0 scn /TT6 1 Tf -0.017 Tc 0.017 Tw 5.8505 0 0 5.861 544.4993 404.1921 Tm [(0.)-45(8)]TJ ET Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 1210.3375 935.1266 cm 0 0 m -5 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 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0 m 81.23 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 1192.7975 664.1856 cm 0 0 m 1 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 1111.0676 664.6857 cm 0 0 m 0 79.131 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 1111.5675 743.3167 cm 0 0 m 1.01 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 1111.0676 743.8166 cm 0 0 m 81.23 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 1192.7975 743.3167 cm 0 0 m 1 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 1111.0676 664.6857 cm 0 0 m 81.23 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 1192.7975 664.1856 cm 0 0 m 1 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 1192.2975 664.6857 cm 0 0 m 0 79.131 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 1192.7975 743.3167 cm 0 0 m 1 0 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 1111.0676 664.6857 cm 0 0 m 0 79.131 l S Q Q q 0.4487579 0 0 0.4495685 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 1111.5675 743.3167 cm 0 0 m 1.01 0 l S Q Q q 315 261 252 189.12 re W n BT 0 scn /TT6 1 Tf -0.026 Tc 0.026 Tw 5.8505 0 0 5.861 522.4518 328.0981 Tm [(A)-51(-c)-64(f)]TJ ET Q q 0.4487579 0 0 0.4495685 0 0 cm 0.931 0.793 0 0 K 4.004 w 1 j q 1 0 0 1 1119.0775 732.8067 cm 0 0 m 40.11 0 l S Q Q q 315 261 252 189.12 re W n BT 0 scn /TT6 1 Tf -0.026 Tc 0.026 Tw 5.8505 0 0 5.861 522.4518 319.5383 Tm [(B)-51(-c)-64(f)]TJ ET Q q 0.4487579 0 0 0.4495685 0 0 cm 0.927 0.247 1 0.159 K 4.004 w 1 j q 1 0 0 1 1119.0775 713.7666 cm 0 0 m 40.11 0 l S Q Q q 315 261 252 189.12 re W n BT 0 scn /TT6 1 Tf -0.029 Tc 0.029 Tw 5.8505 0 0 5.861 522.4518 311.4326 Tm [(C-)-3(c)-67(f)]TJ ET Q q 0.4487579 0 0 0.4495685 0 0 cm 0 1 1 0 K 4.004 w 1 j q 1 0 0 1 1119.0775 695.7367 cm 0 0 m 40.11 0 l S Q Q q 315 261 252 189.12 re W n BT 0 scn /TT6 1 Tf -0.029 Tc 0.029 Tw 5.8505 0 0 5.861 522.4518 302.8755 Tm [(D-)-3(c)-67(f)]TJ ET Q q 0.4487579 0 0 0.4495685 0 0 cm 0.743 0 0.318 0 K 4.004 w 1 j q 1 0 0 1 1119.0775 676.7007 cm 0 0 m 40.11 0 l S Q Q BT 0.75 0.68 0.655 0.902 k /TT0 1 Tf 9.84 0 0 9.84 567 261 Tm ( )Tj -0.001 Tc 0.001 Tw 7.92 0 0 7.92 357.2251 254.04 Tm [(Fi)3(g)1(u)1(r)2(e)2( )]TJ 0 Tc 0 Tw 2.846 0 Td (8)Tj 0.499 0 Td ( )Tj 0.246 0 Td (\226)Tj 0.499 0 Td ( )Tj 0.246 0 Td (C)Tj -0.001 Tc 0.001 Tw [(onf)1(i)2(de)1(nc)1(e)]TJ 0 Tc 0 Tw 4.593 0 Td (-)Tj -0.002 Tc 0.002 Tw 0.33 0 Td [(A)-3(ccu)-1(r)1(acy)]TJ 0 Tc 0 Tw (-)Tj -0.003 Tc 0.003 Tw 4.149 0 Td [(T)-3(im)-5(e)-1(lin)-2(e)-1(s)-1(s)]TJ 0 Tc 0 Tw ( )Tj -0.003 Tc 0.003 Tw 4.616 0 Td [(R)-3(e)-1(su)-1(l)1(t)1(s.)]TJ 0 Tc 0 Tw ( )Tj 0.008 Tc 0.239 Tw 9.84 0 0 9.84 324 237 Tm [(U)-4(s)1(i)4(ng t)4(he)1( a)1(bove)1( i)3(nf)2(or)2(m)-5(a)1(t)3(i)3(on,)4( w)-4(e)1( c)1(om)-5(bi)3(ne)1( t)4(he)1( 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Tw 7.92 0 0 7.92 438.5139 142.68 Tm [(I)2(SC)-1(U)-2(SSI)2(O)-2(N)]TJ 0 Tc 0 Tw 9.84 0 0 9.84 479.8577 142.68 Tm ( )Tj 0.008 Tc 0.015 Tw -16.754 -1.585 Td [(F)-1(i)4(gur)3(e)1( 9 s)2(how)-4(s)2( a)1( c)1(a)1(s)2(e)1( f)2(or)3( )]TJ 0.004 Tc -0.004 Tw 10.725 0 Td [(u)-4(n)-4(if)-2(ie)-3(d)]TJ 0 Tc 0 Tw 2.879 0 Td ( )Tj 0.008 Tc -0.008 Tw 0.273 0 Td (un)Tj 0.004 Tc 0.019 Tw [(c)-3(e)-3(r)-1(ta)-3(in)-4(ty)-4( e)-3(s)-2(tim)-8(a)-3(ti)]TJ 0.008 Tc 0.015 Tw 8.062 0 Td [(on a)1(nd i)4(s)2( )]TJ 0.009 Tc 0.104 Tw -21.938 -1.171 Td [(m)-3(e)2(a)2(n)1(t)5( )1(f)4(o)1(r)4( d)1(i)5(s)3(c)2(u)1(s)2(s)3(i)5(o)1(n)1(.)]TJ 0 Tc 0 Tw 8.883 0 Td ( )Tj 0.007 Tc 0.106 Tw 0.363 0 Td [(G)-5(i)3(v)-1(en)-1( t)3(h)-1(e ch)-1(o)-1(i)3(ce t)3(o)-1( u)-1(t)2(i)3(l)2(i)2(ze t)2(h)-1(e U)-5(R)-4(R)-4(E)-3(F)-2( )]TJ 0.008 Tc 0.523 Tw -9.245 -1.171 Td [(ont)4(ol)4(ogy,)4( t)4(he)1(r)3(e)1( a)1(r)3(e)1( i)4(s)2(s)2(ue)1(s)2( a)1(s)2(s)2(oc)1(i)4(a)1(t)4(e)1(d w)-4(i)4(t)4(h c)1(hoos)2(i)4(ng a)1(n )]TJ 0.422 Tw T* 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[(Ti)-79(m)-84(e)]TJ -0.017 Tc 0.017 Tw 0 5.5561 -5.5496 0 60.743 556.5541 Tm [(U)12(nc)-55(er)9(t)-45(ai)-24(nt)-45(y)]TJ 0.004 Tc -0.01 Tw 9.3947 0 0 9.4057 126.0503 650.4579 Tm [(CA)-9(T)-20( Un)60(c)4(e)15(t)10(a)15(in)60(t)10(y)4( P)-9(l)45(o)-30(t)]TJ 0 Tc 0 Tw 5.5496 0 0 5.5561 74.3988 496.3668 Tm ( )Tj 33.459 26.352 Td ( )Tj ET Q 228.064 602.649 28.601 34.15 re f* q 0.4256789 0 0 0.4261773 0 0 cm /CS0 CS 1 SCN 0.14 w 1 j 535.766 1494.222 67.19 -80.14 re S Q q 0.4256789 0 0 0.4261773 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 535.7659 1494.2216 cm 0 0 m 67.19 0 l S Q Q q 0.4256789 0 0 0.4261773 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 603.4559 1493.7216 cm 0 0 m 1 0 l S Q Q q 0.4256789 0 0 0.4261773 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 535.7659 1414.0815 cm 0 0 m 67.19 0 l S Q Q q 0.4256789 0 0 0.4261773 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 603.4559 1413.5815 cm 0 0 m 1 0 l S Q Q q 0.4256789 0 0 0.4261773 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 602.9559 1414.0815 cm 0 0 m 0 80.14 l S Q Q q 0.4256789 0 0 0.4261773 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 603.4559 1493.7216 cm 0 0 m 1 0 l S Q Q q 0.4256789 0 0 0.4261773 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 535.7659 1414.0815 cm 0 0 m 0 80.14 l S Q Q q 0.4256789 0 0 0.4261773 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 536.2659 1493.7216 cm 0 0 m 1.03 0 l S Q Q q 0.4256789 0 0 0.4261773 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 535.7659 1414.0815 cm 0 0 m 67.19 0 l S Q Q q 0.4256789 0 0 0.4261773 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 603.4559 1413.5815 cm 0 0 m 1 0 l S Q Q q 0.4256789 0 0 0.4261773 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 535.7659 1414.0815 cm 0 0 m 0 80.14 l S Q Q q 0.4256789 0 0 0.4261773 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 2 J q 1 0 0 1 536.2659 1493.7216 cm 0 0 m 1.03 0 l S Q Q q 0.4256789 0 0 0.4261773 0 0 cm /CS0 CS 0 SCN 0.14 w 1 j q 1 0 0 1 535.7659 1494.2216 cm 0 0 m 67.19 0 l S Q Q q 0.4256789 0 0 0.4261773 0 0 cm /CS0 CS 0 SCN 0.999 w 1 j 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/TT1 1 Tf 5.5496 0 0 5.5561 250.6891 622.7181 Tm (B)Tj ET Q q 0.4256789 0 0 0.4261773 0 0 cm 0.655 0 1 0 K 0.14 w 1 j [0.14 0.14]0 d q 1 0 0 1 543.7959 1464.1715 cm 0 0 m 40.12 0 l S Q Q q 0.4256789 0 0 0.4261773 0 0 cm 0.655 0 1 0 K 0.999 w 1 j 2 J q 1 0 0 1 584.4159 1463.6715 cm 0 0 m 1 0 l S Q Q q 44.52 478.44 239.04 179.28 re W n BT 0 scn /TT1 1 Tf 5.5496 0 0 5.5561 250.6891 614.6037 Tm (C)Tj ET Q q 0.4256789 0 0 0.4261773 0 0 cm 0 1 1 0 K 0.14 w 1 j [0.42 0.14]0 d q 1 0 0 1 543.7959 1445.1316 cm 0 0 m 40.12 0 l S Q Q q 0.4256789 0 0 0.4261773 0 0 cm 0 1 1 0 K 0.999 w 1 j 2 J q 1 0 0 1 584.4159 1444.6316 cm 0 0 m 1 0 l S Q Q q 44.52 478.44 239.04 179.28 re W n BT 0 scn /TT1 1 Tf 5.5496 0 0 5.5561 250.6891 606.4935 Tm (D)Tj ET Q q 0.4256789 0 0 0.4261773 0 0 cm 0.531 0 0.128 0 K 0.14 w 1 j q 1 0 0 1 543.7959 1426.1216 cm 0 0 m 40.12 0 l S Q Q q 0.4256789 0 0 0.4261773 0 0 cm 0.531 0 0.128 0 K 0.999 w 1 j 2 J q 1 0 0 1 584.4159 1425.6216 cm 0 0 m 1 0 l S Q Q BT 0.75 0.68 0.655 0.902 k /TT0 1 Tf 9.84 0 0 9.84 283.5 478.44 Tm ( )Tj -0.001 Tc 0.001 Tw 7.92 0 0 7.92 97.7273 471.48 Tm [(Fi)3(g)1(u)1(r)2(e)2( )]TJ 0 Tc 0 Tw 2.846 0 Td (9)Tj 0.499 0 Td ( )Tj 0.246 0 Td (\226)Tj 0.499 0 Td ( )Tj -0.002 Tc -0.002 Tw 0.246 0 Td [(O)-3(b)-1(j)1(ect)2(i)2(v)-1(e S)-1(em)-3(an)-1(t)2(i)2(c o)-1(f)1( U)-3(n)-1(cer)1(t)2(ai)2(n)-1(t)2(y)-1(.)]TJ 0 Tc 0 Tw 14.091 0 Td ( )Tj 0.006 Tc -0.006 Tw 9.84 0 0 9.84 131.8982 446.52 Tm [(V)-6(I.)]TJ /TT2 1 Tf 0 Tc 0 Tw 1.326 0 Td ( )Tj /TT0 1 Tf 1.166 0 Td (C)Tj 0.007 Tc -0.007 Tw 7.92 0 0 7.92 163.094 446.52 Tm [(ONC)1(L)2(US)2(I)4(ONS)]TJ 0 Tc 0 Tw 9.84 0 0 9.84 213.7659 446.52 Tm ( )Tj -15.736 -1.537 Td (C)Tj 0.673 0 Td (h)Tj -0.001 Tc 0.157 Tw 0.503 0 Td [(a)-3(r)-1(a)-3(c)-3(te)-3(r)-1(iz)-3(in)-4(g)-4( th)-4(e)-3( u)-4(n)-4(c)-3(e)-3(r)-1(ta)-3(in)-4(ty)-4( is)-2( im)-8(p)-4(o)-4(r)-1(ta)-3(n)-4(t in)-4( in)-4(f)-2(o)-4(r)-1(m)-8(a)-3(tio)-4(n)-4( )]TJ 0.003 Tc 0.451 Tw -2.639 -1.098 Td [(f)2(us)1(i)4(on \()3(I)]TJ 0 Tc 0 Tw 3.881 0 Td [(F)-4(\) )]TJ 0.002 Tc -0.002 Tw 1.597 0 Td [(p)-1(r)2(o)-1(ces)1(s)1(es)]TJ -0.001 Tc 0.454 Tw 3.849 0 Td (. E)Tj 0.003 Tc 0.45 Tw 1.568 0 Td [(va)1(l)4(ua)1(t)4(i)4(on of)2( I)3(F)-1( s)2(ys)2(t)4(e)1(m)-4(s)2( pr)3(e)1(s)2(e)1(nt)]TJ 0 Tc 0 Tw 14.361 0 Td (s)Tj 0.39 0 Td ( )Tj 0.003 Tc 0.024 Tw -25.645 -1.122 Td [(va)1(r)3(i)4(ous)2( c)1(ha)1(l)4(l)4(e)1(nge)1(s)2( due)1( t)4(o t)4(he)1( c)1(om)-4(pl)4(e)1(xi)4(t)4(y of)2( )]TJ -0.003 Tw 17.947 0 Td [(f)2(us)1(i)4(on )]TJ 0.023 Tw 2.787 0 Td [(s)2(ys)2(t)4(e)1(m)-4(s)2( a)1(nd )]TJ 0.18 Tw -20.734 -1.098 Td [(t)4(he)1( s)2(he)1(e)1(r)3( num)-4(be)1(r)3( of)2( va)1(r)3(i)4(a)1(bl)4(e)]TJ 0 Tc 0 Tw 12.219 0 Td (s)Tj 0.39 0 Td ( )Tj 0.003 Tc -0.003 Tw 0.433 0 Td [(i)4(nf)2(l)4(ue)1(nc)1(i)4(ng )]TJ 0 Tc 0 Tw 5.006 0 Td [(t)1(h)-3(e)-2(i)1(r )]TJ 0.002 Tc -0.002 Tw 2.27 0 Td [(p)-1(er)2(f)1(o)-1(r)2(m)-5(an)-1(ce.)]TJ 0 Tc 0 Tw 5.328 0 Td ( )Tj 0.002 Tc 0.248 Tw -25.645 -1.122 Td [(D)-5(ev)-1(el)3(o)-1(p)-1(i)3(n)-1(g)-1( t)3(h)-1(e o)-1(p)-1(er)2(at)3(i)3(o)-1(n)-1(al)3( sem)-6(an)-1(t)3(i)3(cs w)-5(i)3(l)3(l)3( i)3(n)-1(cl)3(u)-1(d)-1(e i)3(ssu)-1(es o)-1(f)1( )]TJ 0 Tc 0.537 Tw 0 -1.098 TD [(re)-2(p)-3(re)-2(s)-1(e)-2(n)-3(t)1(a)-2(t)1(i)1(o)-3(n)-3(,)1( re)-2(a)-2(s)-1(o)-3(n)-3(i)1(n)]TJ 0 Tw 10.123 0 Td (g)Tj 0.503 0 Td (,)Tj 0.249 0 Td ( )Tj 0.003 Tc 0.534 Tw 0.787 0 Td [(a)1(nd pol)4(i)4(c)1(y w)-4(hi)4(c)1(h ne)1(e)1(d t)4(o be)1( )]TJ 0.519 Tw -11.662 -1.122 Td [(c)1(ons)2(i)4(de)1(r)3(e)1(d f)2(or)3( c)1(om)-4(m)-4(a)1(nd a)1(nd c)1(ont)4(r)3(ol)4( )]TJ 0 Tc 0 Tw 17.65 0 Td ([)Tj 0.003 Tc -0.003 Tw (64)Tj 0 Tc 0 Tw (])Tj -0.001 Tc 0.523 Tw [(. R)-7(e)]TJ 0.003 Tc -0.003 Tw 3.813 0 Td [(pr)3(e)1(s)2(e)1(nt)4(i)4(ng)]TJ 0 Tc 0 Tw 4.182 0 Td ( )Tj 0.003 Tc -0.003 Tw -25.645 -1.098 Td [(unc)1(e)1(r)3(t)4(a)1(i)4(nt)4(y )]TJ 0.002 Tc -0.002 Tw 4.768 0 Td [(h)-1(as)]TJ 0 Tc 0 Tw 1.339 0 Td ( )Tj 0.003 Tc 0.252 0 Td [(a)1(n ove)1(r)3(a)1(l)4(l)4( i)4(m)-4(pa)1(c)1(t)4( on )]TJ 0.001 Tc -0.001 Tw [(sy)-2(st)2(e)-1(m)-6( )]TJ 0.002 Tc 0 Tw 11.531 0 Td [(p)-1(er)2(f)1(o)-1(r)2(m)-5(an)-1(ce t)3(h)-1(at)3( i)3(s)1( )]TJ 0.003 Tc 0.033 Tw -17.89 -1.122 Td [(ha)1(r)3(d t)4(o qua)1(nt)4(i)4(f)2(y or)3( e)1(ve)1(n t)4(o a)1(s)2(s)2(e)1(s)2(s)2( f)2(r)3(om)-4( a)1( qua)1(l)4(i)4(t)4(a)1(t)4(i)4(ve)1( vi)4(e)1(w)-4(poi)4(nt)4(.)4( )]TJ -0.003 Tw 0 -1.098 TD [(T)-2(he)]TJ 0 Tc 0 Tw 1.565 0 Td ( )Tj 0.005 Tc -0.005 Tw 0.291 0 Td [(ETU)-2(R)-1(W)-5(G)]TJ 0 Tc 0 Tw 4.316 0 Td ( )Tj 0.002 Tc 0.039 Tw 0.291 0 Td [(t)3(ech)-1(n)-1(i)3(cal)3( co)-1(n)-1(s)1(i)3(d)-1(er)2(at)]TJ 0.003 Tc -0.003 Tw 8.038 0 Td [(i)4(ons)2( )]TJ 1.965 0 Td [(une)1(a)1(r)3(t)4(he)1(d )]TJ 0.038 Tw 4.252 0 Td [(m)-4(a)1(ny i)4(s)2(s)2(ue)1(s)2( )]TJ 0 Tc 0 Tw -20.719 -1.122 Td [(t)1(h)-3(a)-2(t)1( )]TJ 0.003 Tc 0.127 Tw 1.884 0 Td [(de)1(m)-4(a)1(nd a)1( c)1(om)-4(m)-4(on unde)1(r)3(s)2(t)4(a)1(ndi)4(ng t)4(ha)1(t)4( i)4(s)2( onl)4(y a)1(c)1(hi)4(e)1(va)1(bl)4(e)1( )]TJ -0.004 Tw -1.884 -1.098 Td [(by a)1( f)2(or)3(m)-4(a)1(l)4( s)2(pe)1(c)1(i)4(f)2(i)4(c)1(a)1(t)4(i)4(on of)2( t)4(he)1( s)2(e)1(m)-4(a)1(nt)4(i)4(c)1(s)2( i)4(nvol)4(ve)1(d)]TJ 0 Tc 0 Tw 20.541 0 Td ( )Tj 0.249 0 Td ([)Tj 0.003 Tc -0.003 Tw (65)Tj -0.001 Tc 0.001 Tw (, )Tj 0.003 Tc -0.003 Tw 1.837 0 Td (66)Tj 0 Tc 0 Tw (])Tj (.)Tj 1.588 0 Td ( )Tj 0.249 0 Td ( )Tj 0.17 Tw -23.001 -1.732 Td [(In)-3( t)1(h)-3(e)-2( p)-3(a)-2(p)-3(e)-2(r,)1( w)-7(e)-2( u)-3(t)1(i)1(l)1(i)1(z)-2(e)-2(d)-3( t)1(h)-3(e)-2( c)-2(u)-3(rre)-2(n)-3(t)1( U)-7(R)-6(R)-6(E)-4(F)-4( )]TJ 0.003 Tc -0.003 Tw 19.408 0 Td [(ont)4(ol)4(ogy )]TJ 0 Tc 0 Tw 3.993 0 Td [(i)1(n)-3( )]TJ 0.033 Tw -24.865 -1.098 Td [(re)-2(l)1(a)-2(t)1(i)1(o)-3(n)-3( t)1(o)-3( a)-2(n)-3( e)-2(s)-1(t)1(a)-2(b)-3(l)1(i)1(s)-1(h)-3(e)-2(d)-3( s)-1(c)]TJ 0.002 Tc -0.002 Tw [(h)-1(em)-5(a )]TJ 0 Tc 0.033 Tw 13.687 0 Td [(\(C)-6(u)-3(rs)-1(o)-3(r o)-3(n)-3( T)-4(a)-2(rg)-3(e)-2(t)1(\) )]TJ 0.003 Tc 0.03 Tw [(t)4(o s)2(uppor)3(t)4( )]TJ 0.166 Tw -13.687 -1.122 Td [(t)4(he)1( de)1(ve)1(l)4(opm)-4(e)1(nt)4( )]TJ 0.002 Tc 0.168 Tw 7.259 0 Td [(o)-1(f)1( a s)1(p)-1(eci)3(f)1(i)3(c u)-1(s)1(e cas)1(e f)1(o)-1(r)]TJ 0 Tc 0 Tw 10.739 0 Td ( )Tj -0.001 Tc 0.001 Tw 0.42 0 Td [(w)-8(id)-4(e)]TJ 0 Tc 0 Tw 1.955 0 Td (-)Tj 0.002 Tc 0.168 Tw [(ar)2(ea m)-5(o)-1(t)3(i)3(o)-1(n)-1( )]TJ 0 Tc 0 Tw -20.372 -1.098 Td [(i)1(m)-7(a)-2(g)-3(e)-2(ry)]TJ 3.294 0 Td ( )Tj 0.038 Tw 0.288 0 Td [(\(W)-10(A)-7(M)-9(I\) s)-1(i)1(m)-7(u)-3(l)1(t)1(a)-2(n)-3(e)-2(o)-3(u)-3(s)-1( t)1(ra)-2(c)-2(k)-3(i)1(n)-3(g)-3( a)-2(n)-3(d)-3( i)1(d)-3(e)-2(n)-3(t)1(i)1(f)-1(i)1(c)-2(a)-2(t)1(i)1(o)-3(n)]TJ -0.001 Tc 0.039 Tw 20.126 0 Td [(. W)-11(e)-3( )]TJ 0.002 Tc 0.061 Tw -23.708 -1.122 Td [(al)3(s)1(o)-1( p)-1(r)2(es)1(en)-1(t)3(ed)-1( a )]TJ -0.001 Tc 0.064 Tw 6.849 0 Td [(v)-4(is)-2(u)-4(a)-3(l a)-3(n)-4(a)-3(ly)-4(tic)]TJ 0 Tc 0 Tw 5.886 0 Td ( )Tj 0.003 Tc 0.06 Tw 0.313 0 Td [(m)-4(e)1(t)4(hod f)3(or)3( unc)1(e)1(r)3(t)4(a)1(i)4(nt)4(y m)-4(e)1(t)4(r)3(i)4(c)1(s)2( )]TJ -0.001 Tc 0.244 Tw -13.048 -1.098 Td [(a)-3(n)-4(d)-4( a)-3(n)-4(a)-3(ly)-4(tic)-3(s)-2(. )]TJ 0.003 Tc 0.24 Tw 6.253 0 Td [(F)-1(ut)4(ur)3(e)1( w)-4(or)3(k i)4(nc)1(l)4(ude)1(s)2( g)]TJ 0 Tc 0.243 Tw [(ro)-3(u)-3(p)-3( t)1(ra)-2(c)-2(k)-3(i)1(n)-3(g)-3(,)1( a)-2(c)-2(t)1(i)1(v)-3(i)1(t)1(y)-3( )]TJ -0.001 Tc 0 Tw -6.253 -1.122 Td [(a)-3(n)-4(a)-3(ly)-4(s)-2(is)-2(, h)-4(a)-3(r)-1(d)]TJ 0 Tc 5.517 0 Td (-)Tj 0.003 Tc -0.004 Tw [(s)2(of)3(t)4( f)3(us)2(i)4(on,)4( a)1(nd c)1(ont)4(e)1(xt)4(ua)1(l)4( unde)1(r)3(s)2(t)4(a)1(ndi)4(ng.)]TJ 0 Tc 0 Tw 17.168 0 Td ( )Tj -21.221 -1.707 Td (M)Tj 0.002 Tc 0.154 Tw 0.899 0 Td [(o)-1(r)2(e s)1(p)-1(eci)3(f)1(i)3(c r)2(eq)-1(u)-1(i)3(r)2(em)-5(en)-1(t)3(s)1( t)3(o)-1( ev)-1(al)3(u)-1(at)3(e a s)1(et)3( o)-1(f)1( u)-1(s)1(e cas)1(es)1( )]TJ 0.003 Tc 0.44 Tw -2.362 -1.122 Td [(a)1(nd a)1(s)2(s)2(oc)1(i)4(a)1(t)4(e)1(d da)1(t)4(a)1( s)2(e)1(t)4(s)2( de)1(s)2(i)4(gne)1(d by t)4(he)1( )]TJ 0.005 Tc 0.439 Tw 19.411 0 Td [(ETU)-2(R)-1(W)-5(G)-2( a)3(r)4(e)]TJ 0 Tc 0 Tw 6.234 0 Td ( )Tj 0.003 Tc 0.302 Tw -25.645 -1.098 Td [(a)1(c)1(c)1(e)1(s)2(s)2(i)4(bl)4(e)1( t)4(hr)3(ough our)3( w)-4(e)1(bpa)1(ge)1( [)]TJ -0.001 Tc 0.001 Tw 14.662 0 Td [(h)-4(ttp)-4(://e)-3(tu)-4(r)-1(w)-8(g)-4(.c)-3(4)-4(i.g)-4(m)-8(u)-4(.e)-3(d)-4(u)]TJ 0 Tc 0 Tw 10.401 0 Td (])Tj -0.001 Tc 0.001 Tw (. )Tj -25.063 -1.122 Td [(A)-8(lth)]TJ 0.003 Tc 0.009 Tw 1.786 0 Td [(ough i)4(t)4( i)4(s)2( c)1(l)4(e)1(a)1(r)3( t)4(ha)1(t)4( t)4(he)1( U)-4(R)-3(R)-3(E)-2(F)-1( ont)4(ol)4(ogy i)4(s)2( not)4( a)1( de)1(f)2(i)4(ni)4(t)4(i)4(ve)1( )]TJ 0.002 Tc -0.002 Tw -1.786 -1.098 Td [(r)2(ef)1(er)2(en)-1(ce )]TJ 0 Tc 0 Tw 4.152 0 Td [(f)-1(o)-3(r )]TJ -0.001 Tc 0.001 Tw 1.589 0 Td [(a)-3(ll)]TJ 0 Tc 0 Tw ( )Tj 0.003 Tc 0.166 Tw 1.419 0 Td [(t)4(ype)1(s)2( of)2( )]TJ 3.795 0 Td [(i)4(nf)2(or)3(m)-4(a)1(t)4(i)4(on f)2(us)2(i)4(on )]TJ -0.001 Tc 0.17 Tw 8.091 0 Td [(a)-3(c)-3(tiv)-4(itie)-3(s)-2(, it h)-4(a)-3(s)-2( )]TJ 0.003 Tc -0.003 Tw -19.047 -1.122 Td [(pr)3(ove)]TJ 0 Tc 0 Tw 2.288 0 Td (n)Tj 0.503 0 Td ( )Tj 0.002 Tc -0.003 Tw 0.249 0 Td [(t)3(o)-1( b)-1(e a )]TJ 0.003 Tc -0.004 Tw 2.922 0 Td [(di)4(s)2(c)1(us)2(s)2(i)4(on t)4(ow)-4(a)1(r)3(ds)2( a)1( )]TJ -0.003 Tw 8.559 0 Td [(c)1(om)-4(m)-4(on )]TJ 0 Tc 0 Tw [(f)-1(ra)-2(m)-8(e)-2(w)-7(o)-3(rk)-3(.)]TJ 8.437 0 Td ( )Tj 0.249 0 Td ( )Tj -14.522 -2.561 Td (A)Tj 0.008 Tc -0.008 Tw 7.92 0 0 7.92 137.2004 132.12 Tm [(C)1(KNOW)-2(L)2(E)2(DGM)-1(E)2(NT)]TJ 0 Tc 0 Tw 9.84 0 0 9.84 211.4114 132.12 Tm ( )Tj 0.002 Tc -0.002 Tw -15.497 -1.537 Td [(T)-3(h)-1(e )]TJ 0.003 Tc 0.078 Tw 1.895 0 Td [(a)1(ut)4(hor)3(s)2( r)3(e)1(c)1(ogni)4(z)1(e)1( t)4(he)1( )]TJ 9.078 0 Td [(c)1(ont)4(r)3(i)4(but)4(i)4(ons)2( of)2( t)4(he)1( m)-4(e)1(m)-4(be)1(r)3(s)2( of)2( )]TJ 0 Tc 0 Tw -12.436 -1.122 Td [(t)1(h)]TJ 0.003 Tc 0.045 Tw 0.78 0 Td [(e)1( I)3(nt)4(e)1(r)3(na)1(t)4(i)4(ona)1(l)4( S)-1(oc)1(i)4(e)1(t)4(y of)2( I)3(nf)2(or)3(m)-4(a)1(t)4(i)4(on F)-1(us)2(i)4(on\222)3(s)2( E)-2(T)-2(U)-4(R)-3(W)-7(G)-4( )]TJ 0 Tc 0 Tw 24.085 0 Td [(i)1(n)-3( )]TJ 0.003 Tc -0.003 Tw -24.865 -1.098 Td [(f)2(or)3(m)-5(ul)4(a)1(t)4(i)4(ng )]TJ 0 Tc 0 Tw 5.307 0 Td [(t)1(h)]TJ 0.006 Tc 0.309 Tw 0.78 0 Td [(e)4( U)-1(RRE)1(F)]TJ 0 Tc 0 Tw 4.261 0 Td ( )Tj 0.003 Tc 0.312 Tw 0.564 0 Td [(ont)4(ol)4(ogy,)4( w)-4(hi)4(c)1(h w)-4(a)1(s)2( di)4(s)2(c)1(us)2(s)2(e)1(d i)4(n )]TJ -0.004 Tw -10.912 -1.122 Td [(s)2(e)1(ve)1(r)3(a)1(l)4( of)3( i)4(t)4(s)2( m)-4(e)1(e)1(t)4(i)4(ngs)]TJ 0 Tc 0 Tw 8.999 0 Td ( )Tj 0.002 Tc -0.003 Tw 0.249 0 Td [(an)-1(d)-1( i)3(n)-1(cl)3(u)-1(d)-1(es)1( t)3(h)-1(e W)-8(A)-5(M)-8(I)2( u)-1(s)1(e cas)1(e)]TJ 0 Tc 0 Tw 13.252 0 Td (.)Tj 0.249 0 Td ( )Tj 14.941 65.537 Td (R)Tj 0.006 Tc -0.006 Tw 7.92 0 0 7.92 422.0627 729 Tm [(EFER)-1(EN)-2(C)-1(ES)]TJ 0 Tc 0 Tw 9.84 0 0 9.84 466.9572 729 Tm ( )Tj 7.92 0 0 7.92 315 715.32 Tm ([)Tj 0.336 0 Td (1)Tj 0.505 0 Td (])Tj 8.88 0 0 8.88 324.3281 715.32 Tm ( )Tj 0.253 0 Td ( )Tj 0.003 Tc 0.14 Tw 7.92 0 0 7.92 333 715.32 Tm [(K)-4(.)1(B)-3(.)1( )1(L)-2(a)-1(s)-1(k)-2(e)-1(y)-2(,)1( )1(K)-4(.)1(J)-1(.)1( )1(L)-2(a)-1(s)-1(k)-1(e)-1(y)-2(,)1( )1(P)-2(.)1(C)-3(.G)-4(.)1( )1(C)-3(o)-2(s)-1(t)1(a)-1(,)1( )1(M)-6(.)1( )1(K)-4(o)-1(k)-2(a)-1(r,)1( )1(T)-2(.)1( )1(M)-6(a)-1(rt)]TJ 0.006 Tc 0.136 Tw 25.439 0 Td [(i)3(n,)3( a)1(nd T.)3( )]TJ 0.004 Tc 0.167 Tw -25.439 -1.121 Td [(L)-2(u)-1(k)-1(asi)1(ew)-4(i)1(cz \()1(ed)-1(s.)2(\))1( \223)]TJ 0.005 Tc 0.166 Tw 8.666 0 Td [(U)-2(nc)1(e)1(r)2(t)3(a)1(i)3(nt)3(y )1(R)-1(e)1(a)1(s)1(oni)3(ng)1( )1(f)2(or)2( )1(t)3(h)1(e)1( )1(W)-4(o)1(r)2(l)3(d )1(W)-4(i)3(de)1( )1(W)-4(e)1(b)]TJ 0.003 Tc -0.003 Tw 20.643 0 Td (: )Tj 0.005 Tc 0.582 Tw -29.309 -1.152 Td [(W)-4(3C)-1( I)2(nc)1(uba)1(t)3(or)2( G)-2(r)2(oup R)-1(e)1(por)2(t)]TJ 0.006 Tc 13.843 0 Td [(.)4(\224)2( )1(W)-3(o)1(r)3(l)4(d)1( )1(W)-3(i)4(d)1(e)2( )1(W)-3(e)2(b)1( )1(C)-1(o)1(n)1(s)2(o)1(r)3(t)4(i)4(u)1(m)-1(.)4( )586( )]TJ 0.003 Tc 0 Tw -13.843 -1.121 Td [(A)-4(v)-2(a)-1(i)1(l)1(a)-1(b)-2(l)1(e)-2( )1(a)-1(t)1( )]TJ 0.931 0.793 0 0 k 0.005 Tc -0.005 Tw 5.16 0 Td [(ht)3(t)3(p:)3(/)3(/)3(w)-2(w)-2(w)-2(.)3(w)-2(3.)3(or)2(g/)3(2005/)3(I)2(nc)1(uba)1(t)3(or)2(/)3(ur)2(w)-2(3/)3(X)-2(G)-2(R)]TJ 0 Tc 0 Tw 18.909 0 Td (-)Tj 0.003 Tc -0.003 Tw 0.336 0 Td [(u)-2(rw)]TJ 0.005 Tc -0.005 Tw 1.571 0 Td (3/)Tj 0.75 0.68 0.655 0.902 k 0 Tc 0 Tw 0.786 0 Td (.)Tj 0.253 0 Td ( )Tj ET 0.931 0.793 0 0 k 373.8 686.76 171.121 0.239 re f BT 0.75 0.68 0.655 0.902 k /TT0 1 Tf 7.92 0 0 7.92 315 676.92 Tm ([)Tj 0.336 0 Td (2)Tj 0.505 0 Td (])Tj 8.88 0 0 8.88 324.3281 676.92 Tm ( )Tj 0.253 0 Td ( )Tj 0.004 Tc 0.242 Tw 7.92 0 0 7.92 333 676.92 Tm [(E)-2(.)2( P)-2(.)2( B)-3(l)1(asch)-1(,)2( E)-2(.)2( B)-3(o)-1(sse,)2( an)-1(d)-1( D)-4(.)2( A)-4(.)2( L)-2(am)-4(b)-1(er)1(t)1(,)2( )]TJ /TT3 1 Tf 0.003 Tc -0.003 Tw 19.78 0 Td [(H)-4(i)1(g)-2(h)]TJ 0 Tc 0 Tw 2.02 0 Td (-)Tj 0.004 Tc 0.185 Tw 0.336 0 Td [(L)-2(evel)1( I)]TJ 0.005 Tc -0.005 Tw 2.963 0 Td [(nf)3(or)1(m)-2(at)3(i)3(on )]TJ -25.1 -1.121 Td [(F)-1(us)1(i)2(on )]TJ 3.058 0 Td [(M)-3(anage)1(m)-2(e)1(nt)3( )]TJ 5.526 0 Td (and )Tj 0.004 Tc -0.002 Tw 1.768 0 Td [(S)-1(yst)2(em)-3(s D)-3(esi)2(g)-1(n)]TJ /TT0 1 Tf 0.006 Tc -0.003 Tw 6.312 0 Td [(,)4( )1(A)-1(r)3(t)4(e)2(c)2(h)1( )1(H)-1(o)1(us)2(e)2(,)4( )1(2)1(0)1(1)1(2)1(.)]TJ 0 Tc 0 Tw 8.865 0 Td ( )Tj -27.801 -1.455 Td ([)Tj 0.336 0 Td (3)Tj 0.505 0 Td (])Tj 8.88 0 0 8.88 324.3281 656.52 Tm ( )Tj 0.253 0 Td ( )Tj 0.003 Tc 0.067 Tw 7.92 0 0 7.92 333 656.52 Tm [(P)-3(. C)-4(. G)-5(. C)-4(o)-2(s)-1(ta)-1(, K)-5(. B)-4(. L)-3(a)-1(s)-1(k)-2(e)-1(y)-2(, E)-3(. B)-4(la)-1(s)-1(c)-1(h)-2( a)-1(n)-2(d)-2( )]TJ 0 Tc 0 Tw (A)Tj 19.356 0 Td (-)Tj 0.004 Tc 0.066 Tw 0.336 0 Td [(L)-2(.)2( Jo)-1(u)-1(ssel)1(m)-4(e,)2( \223)-1(T)-2(o)-1(w)-4(ar)1(d)-1(s )]TJ 0.006 Tc 0.016 Tw -19.693 -1.152 Td [(U)-1(n)1(b)1(i)4(a)2(s)2(e)2(d)1( )1(E)1(v)1(a)2(l)4(u)1(a)2(t)3(i)4(o)1(n)1( )1(of)3( U)-1(n)1(c)]TJ 0.005 Tc 11.53 0 Td [(e)1(r)2(t)3(a)1(i)3(nt)3(y R)-1(e)1(a)1(s)1(oni)3(ng:)3( T)-1(he)1( U)-2(R)-1(R)-1(E)-1(F)-1( O)-2(nt)3(ol)3(ogy,)3(\224)1( )]TJ /TT3 1 Tf -0.003 Tw -11.53 -1.121 Td [(I)2(nt)3(.)3( C)-1(onf)3(.)3( on I)2(nf)3(o F)-1(us)1(i)3(on)]TJ /TT0 1 Tf 0.006 Tc 10.045 0 Td [(,)4( )1(2)1(0)1(1)1(2)1(.)]TJ 0 Tc 0 Tw 2.778 0 Td ( )Tj -15.095 -1.455 Td ([)Tj 0.336 0 Td (4)Tj 0.505 0 Td (])Tj 8.88 0 0 8.88 324.3281 627 Tm ( )Tj 0.253 0 Td ( )Tj 0.004 Tc 0.201 Tw 7.92 0 0 7.92 333 627 Tm [(E)-2(.)2( P)-2(.)2( B)-3(l)1(asch)-1( an)-1(d)-1( P)-2(.)2( H)-4(an)-1(sel)1(m)-4(an)-1(,)2( "I)1(n)-1(fo)-1(r)1(m)-4(at)1(i)1(o)-1(n)]TJ 0 Tc 0 Tw 19.47 0 Td ( )Tj 0.005 Tc 0.2 Tw 0.455 0 Td [(F)-1(us)1(i)2(on f)1(or)1( I)1(nf)1(or)1(m)-3(a)1(t)2(i)2(on )]TJ 0.003 Tc -0.003 Tw -19.925 -1.152 Td [(S)-3(u)-2(p)-2(e)-1(r)-1(io)-2(r)-1(ity)-2(,")-1( )]TJ /TT3 1 Tf 0.007 Tc -0.005 Tw 5.462 0 Td [(I)4(E)1(E)1(E)1( N)]TJ 0.005 Tc 3.114 0 Td (at)Tj 0.003 Tc -0.003 Tw 0.786 0 Td [(.)1( )]TJ 0 Tc 0 Tw 0.505 0 Td ( )Tj 0.004 Tc -0.002 Tw 0.253 0 Td [(A)-2(ero)-1(sp)-1(a)-1(ce a)-1(n)-1(d)-1( E)-2(l)1(ect)1(ro)-1(n)-1(i)1(cs C)-3(o)-1(n)-1(f)1(eren)-1(ce,)2( )]TJ /TT0 1 Tf 0.005 Tc -0.005 Tw 16.297 0 Td (2000)Tj 0 Tc 0 Tw (.)Tj 2.273 0 Td ( )Tj -30.962 -1.455 Td ([)Tj 0.336 0 Td (5)Tj 0.505 0 Td (])Tj 8.88 0 0 8.88 324.3281 606.36 Tm ( )Tj 0.004 Tc 0.198 Tw 7.92 0 0 7.92 333 606.36 Tm [(E)-2(.)2( B)-3(l)1(asch)-1(,)2( \223)-1(L)-2(ev)]TJ 0.003 Tc 6.794 0 Td [(e)-1(l)1( 5)-2( \(U)-4(s)-1(e)-1(r R)-3(e)-1(f)-1(i)1(n)-2(e)-1(m)-4(e)-1(n)-2(t)1(\) i)1(s)-1(s)-1(u)-2(e)-1(s)-1( s)-1(u)-2(p)-2(p)-2(o)-2(rt)1(i)1(n)-2(g)-2( In)-2(f)-1(o)-2(rm)-4(a)-1(t)1(i)1(o)-2(n)-2( )]TJ 0.004 Tc -0.001 Tw -6.794 -1.121 Td [(F)-2(u)-1(si)1(o)-1(n)-1( M)-5(an)-1(ag)-1(em)-4(en)-1(t)1(\224 )]TJ /TT3 1 Tf 0.005 Tc -0.003 Tw 8.977 0 Td [(I)2(nt)3(.)3( C)-1(onf)3(.)3( on I)2(nf)3(o F)-1(us)1(i)3(on)]TJ /TT0 1 Tf 0.003 Tc 10.045 0 Td [(,)1( )]TJ 0.005 Tc -0.005 Tw 0.505 0 Td (2006.)Tj 0 Tc 0 Tw 2.273 0 Td ( )Tj -24.072 -1.455 Td ([)Tj 0.336 0 Td (6)Tj 0.505 0 Td (])Tj 8.88 0 0 8.88 324.3281 585.96 Tm ( )Tj 0.004 Tc 0.302 Tw 7.92 0 0 7.92 333 585.96 Tm [(E)-2(.)2( B)-3(l)1(asch)-1(,)2( "U)-4(ser)1( r)1(efi)1(n)-1(em)-4(en)-1(t)1( i)1(n)-1( I)1(n)-1(fo)-1(r)1(m)-4(at)1(i)1(o)-1(n)-1( F)-2(u)-1(si)1(o)-1(n)-1(",)2( C)-3(h)-1(ap)-1(t)1(er)1( 1)-1(9)-1( i)1(n)-1( )]TJ /TT3 1 Tf 0.006 Tc 0.13 Tw 0 -1.152 TD [(H)-1(a)1(n)1(d)1(b)1(o)1(o)1(k)2( )1(o)1(f)4( )1(M)-2(u)1(l)4(t)4(i)4(s)2(e)2(ns)2(o)1(r)2( )1(D)-1(a)1(t)4(a)1( )1(F)1(u)1(s)2(i)4(o)1(n)1( )1(2)]TJ 0.021 Tc -0.021 Tw 4.8 0 0 4.8 468.2781 580.44 Tm (nd)Tj 0 Tc 0 Tw 7.92 0 0 7.92 473.278 576.84 Tm ( )Tj 0.002 Tc -0.002 Tw 0.386 0 Td [(E)-4(d)-3(, )]TJ /TT0 1 Tf 0 Tc 0 Tw 1.761 0 Td ( )Tj 0.005 Tc 0.187 Tw 0.443 0 Td [(\()2(E)-1(ds)1(.)3(\))2( D)-2(.)3( H)-2(a)1(l)3(l)3(,)3( a)1(nd J)1(.)3( )]TJ 0.006 Tc -0.006 Tw -20.301 -1.121 Td (Ll)Tj -0.003 Tw 0.898 0 Td [(i)3(na)1(s)1(,)3( C)-1(R)-1(C)-1( Pr)2(e)1(s)1(s)1(,)3( 2008)1(.)]TJ 0 Tc 0 Tw 9.316 0 Td ( )Tj -12.487 -1.455 Td ([)Tj 0.336 0 Td (7)Tj 0.505 0 Td (])Tj 8.88 0 0 8.88 324.3281 556.44 Tm ( )Tj 0.253 0 Td ( )Tj 0.003 Tc 0.288 Tw 7.92 0 0 7.92 333 556.44 Tm [(D)-4(.)1( )1(L)-2(.)1( )1(H)-4(a)-1(l)1(l)1( )1(a)-1(n)-2(d)-2( )]TJ 0.004 Tc 0.287 Tw [(J.)2( M)-5(.)2( Jo)-1(r)1(d)-1(an)]TJ 0.003 Tc -0.003 Tw 12.783 0 Td [(,)1( )]TJ /TT3 1 Tf 0.006 Tc 0.229 Tw 0.793 0 Td [(H)-1(u)1(m)-1(a)1(n)1( )1(Ce)2(n)1(t)4(e)2(r)1(e)2(d)1( )1(I)2(n)2(f)4(o)2(r)2(m)-1(a)2(t)4(i)4(o)1(n)2( )1(F)1(u)1(s)2(i)4(o)1(n)]TJ /TT0 1 Tf 0.003 Tc -0.003 Tw 15.761 0 Td [(,)1( )]TJ 0.005 Tc -0.005 Tw -29.337 -1.152 Td [(A)-2(r)2(t)3(e)1(c)1(h)]TJ 0 Tc 0 Tw ( )Tj 0.006 Tc -0.003 Tw 3.001 0 Td [(H)-1(o)1(u)1(s)2(e)2(,)4( )1(2)1(0)1(1)1(0)]TJ 0 Tc 0 Tw 5.106 0 Td (.)Tj 0.253 0 Td ( )Tj -10.632 -1.424 Td ([)Tj 0.336 0 Td (8)Tj 0.505 0 Td (])Tj 8.88 0 0 8.88 324.3281 536.04 Tm ( )Tj 0.004 Tc 0.051 Tw 7.92 0 0 7.92 333 536.04 Tm [(E)-2(.)2( B)-3(l)1(asch)-1(,)2( M)-5(.)2( P)-2(r)1(i)1(b)-1(i)1(l)1(sk)-1(i)1(,)2( B)-3(.)2( R)-3(o)-1(sco)-1(e,)2( )]TJ /TT3 1 Tf 0.003 Tc -0.001 Tw 14.68 0 Td [(e)-1(t)1(.)1( a)-2(l)1(.)]TJ /TT0 1 Tf 0.005 Tc 0.051 Tw [(,)3( )1(\223Fus)1(i)3(on )1(M)-4(e)1(t)3(r)2(i)3(c)1(s)1( )1(f)2(or)2( )1(D)-2(ynam)-2(i)3(c)1( )]TJ 0.003 Tc 0 Tw -14.68 -1.152 Td [(S)-3(itu)-2(a)-1(tio)-2(n)-2( A)-5(n)-2(a)-1(ly)-2(s)-1(is)-1(,\224)-1( )]TJ /TT3 1 Tf 0.004 Tc -0.002 Tw 8.389 0 Td [(P)-2(ro)-1(c S)-1(P)-2(I)1(E)]TJ 0.003 Tc -0.003 Tw 4.291 0 Td [(,)1( )]TJ /TT0 1 Tf 0.006 Tc 0.505 0 Td [(V)-1(o)1(l)4(.)4( )1(5)1(4)1(2)1(9)1(,)]TJ 0 Tc 0 Tw 4.293 0 Td ( )Tj 0.007 Tc -0.007 Tw 0.253 0 Td (Au)Tj 0.005 Tc -0.003 Tw 1.235 0 Td (g 2004.)Tj 0 Tc 0 Tw 3.03 0 Td ( )Tj -24.269 -1.455 Td ([)Tj 0.336 0 Td (9)Tj 0.505 0 Td (])Tj 8.88 0 0 8.88 324.3281 515.4 Tm ( )Tj 0.002 Tc 0.072 Tw 7.92 0 0 7.92 333 515.4 Tm [(E)-4(. B)-5(l)-1(a)-2(s)-2(c)-2(h)-3(, I)-1(. K)-6(a)-2(d)-3(a)-2(r)-1(, J)-2(. S)-4(a)-2(l)-1(e)-2(r)-1(n)-3(o)-3(, M)-7(. M)-7(. K)-6(o)-3(k)-3(a)-2(r)-1(, S)-4(. D)-6(a)-2(s)-2(, G)-6(. M)-7(. P)-4(o)-3(w)-6(e)-2(l)-1(l)-1(, D)-6(. )]TJ 0.003 Tc 0.296 Tw 0 -1.121 TD [(D)-4(.)1( )1(C)-3(o)-2(rk)-2(i)1(l)1(l)1(,)1( )1(a)-1(n)-2(d)-2( )1(E)-2(.)1( )1(H)-4(.)1( )1(R)-3(u)-2(s)-1(p)-2(i)1(n)-2(i)1(,)1( )1(\223)]TJ 0.005 Tc 0.294 Tw 14.545 0 Td [(I)2(s)1(s)1(ue)1(s)1( a)1(nd C)-1(ha)1(l)3(l)3(e)1(nge)1(s)1( i)3(n Si)3(t)3(ua)1(t)3(i)3(on )]TJ 0.004 Tc 0.207 Tw -14.545 -1.152 Td [(A)-3(ssessm)-3(e)-1(n)-1(t)2( )1(\(L)-1(ev)-1(el)2( 2)-1( )1(F)-2(u)-1(si)2(o)-1(n)-1(\))1(,)]TJ -0.004 Tw 12.633 0 Td (\224 )Tj /TT3 1 Tf 0.005 Tc 0.149 Tw 0.909 0 Td [(J)1(.)3( of)3( A)-1(dv)1(anc)1(e)1(s)1( i)3(n I)2(nf)3(or)1(m)-2(at)3(i)3(on F)-1(us)1(i)3(on,)]TJ /TT0 1 Tf 0 Tc 0 Tw 16.048 0 Td ( )Tj 0.006 Tc -0.003 Tw -29.59 -1.121 Td [(V)-1(o)1(l)4(.)4( )1(1)1(,)4( )1(N)-1(o)1(.)3( )1(2)1(,)4( )1(p)1(p)1(.)4( )1(1)2(2)1(2)1( )]TJ 0 Tc 0 Tw 9.063 0 Td (-)Tj 0.336 0 Td ( )Tj 0.005 Tc -0.005 Tw 0.253 0 Td (13)Tj -0.003 Tw [(9,)3( D)-2(e)1(c)1(.)3( 2006.)]TJ 0 Tc 0 Tw ( )Tj -11.924 -1.455 Td ([)Tj 0.005 Tc -0.005 Tw 0.336 0 Td (10)Tj 0 Tc 0 Tw (])Tj 8.88 0 0 8.88 328.3281 477 Tm ( )Tj 0.002 Tc -0.002 Tw 7.92 0 0 7.92 333 477 Tm [(E)-4(. )]TJ 0.005 Tc 0.009 Tw 1.134 0 Td [(W)-4(a)1(l)3(t)3(z)1( a)1(nd J)1(.)3( L)-1(l)3(i)3(na)1(s)1(,)3( \223)1(Sys)1(t)3(e)1(m)-2( M)-4(ode)1(l)3(i)3(ng a)1(nd Pe)1(r)2(f)1(or)2(m)-2(a)1(nc)1(e)1( E)-1(va)1(l)3(ua)1(t)3(i)3(on,)3(\224)1( )]TJ -0.002 Tw -1.134 -1.152 Td [(C)-2(h 11 i)2(n )]TJ /TT3 1 Tf -0.003 Tw [(M)-3(ul)3(t)3(i)3(s)1(e)1(ns)1(or)1( D)-2(at)3(a F)-1(us)1(i)3(on Sy)1(s)1(t)3(e)1(m)-2(s)]TJ /TT0 1 Tf 0.006 Tc 17.34 0 Td [(,)4( )1(A)-1(r)3(t)4(e)2(c)2(h)1( )1(H)-1(o)1(u)1(s)1(e)2( )1(1)1(9)1(9)1(0)1(.)]TJ 0 Tc 0 Tw 8.612 0 Td ( )Tj -28.225 -1.455 Td ([)Tj 0.005 Tc -0.005 Tw 0.336 0 Td (11)Tj 0 Tc 0 Tw (])Tj 8.88 0 0 8.88 328.3281 456.36 Tm ( )Tj 0.004 Tc 0.025 Tw 7.92 0 0 7.92 333 456.36 Tm [(J.)2( L)-2(l)2(i)2(n)-1(as,)2( \223)-1(A)-3(ssessi)2(n)-1(g)-1( t)2(h)-1(e P)-2(er)1(fo)-1(r)1(m)-4(an)-1(ce o)-1(f M)-5(u)-1(l)2(t)2(i)2(sen)-1(so)-1(r)1( F)-2(u)-1(si)2(o)-1(n)-1( P)-2(r)1(o)-1(cesses,)2(\224 )]TJ 0.005 Tc 0.135 Tw 0 -1.121 TD [(C)-2(h 20 i)]TJ -0.005 Tw 3.249 0 Td (n )Tj /TT3 1 Tf 0.006 Tc 0.078 Tw 0.895 0 Td [(H)-1(a)1(n)1(d)1(b)1(o)1(o)1(k)2( )1(o)1(f)4( )1(M)-2(u)1(l)4(t)4(i)4(s)2(e)1(n)1(s)2(o)1(r)2( )1(D)-1(a)1(t)4(a)1( )1(F)1(u)1(s)2(i)4(o)1(n)]TJ /TT0 1 Tf 0.003 Tc 0.137 Tw 15.978 0 Td [(,)1( )1(\(E)-3(d)-2(s)-1(.)1(\) D)-4(.)1( )1(H)-4(a)-1(l)1(l)1( )1(a)-1(n)-2(d)-2( )1(J)-1(.)1( )]TJ 0.004 Tc -0.002 Tw -20.122 -1.152 Td [(L)-2(l)1(i)1(n)-1(as,)2( C)-3(R)-3(C)-3( P)-2(r)1(ess,)2( 2)-1(0)-1(0)-1(1)-1(.)]TJ 0 Tc 0 Tw 10.214 0 Td ( )Tj -12.487 -1.455 Td ([)Tj 0.005 Tc -0.005 Tw 0.336 0 Td (12)Tj 0 Tc 0 Tw (])Tj 8.88 0 0 8.88 328.3281 426.84 Tm ( )Tj 0.253 0 Td ( )Tj 0.004 Tc 0.147 Tw 7.92 0 0 7.92 333 426.84 Tm [(P)-2(.)1( H)-4(an)-1(sel)1(m)-4(an)-1(,)1( C)-3(.)1( L)-2(aw)-4(ren)-1(ce,)1( E)-2(.)1( F)-2(o)-1(rt)1(u)-1(n)-1(an)-1(o)-1(,)1( B)-3(.)1( T)-2(en)-1(n)-1(ey)-1(,)1( an)-1(d)-1( E)-2(.)1( B)-3(l)1(asch)-1(,)1( )]TJ -0.001 Tw T* [(\223)-1(D)-4(y)-1(n)-1(am)-4(i)1(c T)-2(act)1(i)1(cal)1( T)-2(arg)-1(et)1(i)1(n)-1(g)-1(,)1(\224)]TJ /TT3 1 Tf 0 Tc 0 Tw 12.536 0 Td ( )Tj 0.005 Tc -0.003 Tw 0.253 0 Td [(P)-1(r)1(oc)1(.)3( of)2( SP)-1(I)2(E)-1(,)]TJ 0 Tc 0 Tw ( )Tj /TT0 1 Tf 0.003 Tc -0.003 Tw 6.087 0 Td [(V)-4(o)-2(l)1(.)]TJ /TT3 1 Tf 0 Tc 0 Tw 1.768 0 Td ( )Tj /TT0 1 Tf 0.005 Tc -0.003 Tw 0.253 0 Td [(5441,)3( 2004.)]TJ 0 Tc 0 Tw 4.798 0 Td ( )Tj -27.967 -1.455 Td ([)Tj 0.005 Tc -0.005 Tw 0.336 0 Td (13)Tj 0 Tc 0 Tw (])Tj 8.88 0 0 8.88 328.3281 406.44 Tm ( )Tj 0.253 0 Td ( )Tj 0.003 Tc 0.081 Tw 7.92 0 0 7.92 333 406.44 Tm [(K)-4(.)1( )1(C)-3(.)1( )1(C)]TJ 0.005 Tc 0.078 Tw 3.248 0 Td [(ha)1(ng a)1(nd R)-2(obe)1(r)2(t)3( M)-4(.)3( F)-1(ung,)3( \223T)-1(a)1(r)2(ge)1(t)3( I)2(de)1(nt)3(i)3(f)1(i)3(c)1(a)1(t)3(i)3(on w)-2(i)3(t)3(h B)-2(a)1(ye)1(s)1(i)3(a)1(n )]TJ 0.61 Tw -3.248 -1.152 Td [(N)-2(e)1(t)3(w)-2(or)2(ks)1( )1(i)3(n)-1( )1(a)1( )1(M)-4(u)1(l)3(t)3(i)3(pl)3(e)1( )1(H)-2(y)1(pot)3(he)1(s)1(i)3(s)1( )1(T)-1(r)2(a)1(c)1(k)1(i)3(n)1(g )1(Sy)1(s)1(t)3(e)1(m)-2(\224)1(,)]TJ 0 Tc 0 Tw 25.695 0 Td ( )Tj /TT3 1 Tf 0.003 Tc -0.003 Tw 0.865 0 Td [(O)-4(p)-2(t)1(i)1(c)-1(a)-2(l)1( )]TJ 0.005 Tc -0.005 Tw -26.56 -1.121 Td [(E)-1(ngi)2(ne)1(e)1(r)1(i)2(ng)]TJ /TT0 1 Tf 0.006 Tc -0.003 Tw [(,)4( V)-1(o)1(l)4(.)4( )1(3)1(6)1(,)4( )1(N)-1(o)1(.)4( )1(3)1(,)4( )1(p)1(p)1(.)4(6)1(8)1(4)]TJ 0 Tc 0 Tw 14.561 0 Td (-)Tj 0.005 Tc -0.003 Tw 0.336 0 Td [(691,)3( M)-4(a)1(r)2(c)1(h,)3( 1997.)]TJ 0 Tc 0 Tw 8.88 0 0 8.88 509.8672 388.44 Tm ( )Tj 7.92 0 0 7.92 315 376.92 Tm ([)Tj 0.005 Tc -0.005 Tw 0.336 0 Td (14)Tj 0 Tc 0 Tw (])Tj 1.346 0 Td ( )Tj 0.004 Tc 0.31 Tw 0.59 0 Td [(E)-2(.)2( B)-3(l)1(asch)-1(,)2( )]TJ /TT3 1 Tf 0.003 Tc 0.255 Tw 4.999 0 Td [(D)-4(e)-1(r)-1(i)1(v)-1(a)-2(t)1(i)1(o)-2(n)-2( )1(o)-2(f)1( )1(A)-2( )1(B)-2(e)-1(l)1(i)1(e)-1(f)1( )1(F)-2(i)1(l)1(t)1(e)-1(r)-1( )1(f)1(o)-1(r)-1( )1(H)-4(i)1(g)-1(h)-2( )1(R)-2(a)-1(n)-2(g)-2(e)-1( )1(R)-2(e)-1(s)-1(o)-1(l)1(u)-2(t)1(i)]TJ 0.005 Tc -0.005 Tw 23.581 0 Td (on )Tj 0.697 Tw -28.58 -1.121 Td [(R)-1(adar)1( Si)2(m)-3(ul)2(t)2(ane)1(ous)1( T)-1(ar)1(ge)1(t)2( T)-1(r)1(ac)1(k)1(i)2(ng and I)2(de)1(nt)2(i)2(f)2(i)2(c)1(at)2(i)2(on)]TJ /TT0 1 Tf 0.003 Tc 0.756 Tw 26.027 0 Td [(,)1( )1(P)-2(h)-2(.)1(D)-4(.)1( )]TJ 0 Tw -26.027 -1.152 Td [(D)-4(i)1(s)-1(s)-1(e)-1(rt)1(a)-1(t)1(i)1(o)-2(n)-2(,)1( )1(W)-6(ri)1(g)-2(h)-2(t)1( )1(S)-2(t)1(a)-1(t)1(e)-1( )1(U)-4(n)-1(i)1(v)-1(e)-1(rs)-1(i)1(t)1(y)-2(,)1( )1(1)-2(9)-2(9)-2(9)-2(.)]TJ 0 Tc 17.814 0 Td ( )Tj -20.087 -1.485 Td ([)Tj 0.005 Tc -0.005 Tw 0.336 0 Td (15)Tj 0 Tc 0 Tw (])Tj 1.346 0 Td ( )Tj 0.005 Tc 0.094 Tw 0.59 0 Td [(C)-2(.)2( Y)-3(ang and E)-1(.)2( B)-2(l)2(as)1(ch,)2( \223P)-1(os)1(e A)-3(ngul)2(ar)]TJ 0 Tc 0 Tw 16.202 0 Td (-)Tj 0.006 Tc 0.093 Tw 0.336 0 Td [(A)-1(i)4(d)1(i)4(n)1(g)1( )1(f)3(o)1(r)3( )1(M)-3(a)2(n)1(e)2(u)1(v)1(e)2(r)3(i)3(n)2(g )1(T)1(a)1(r)3(g)1(e)1(t)4( )]TJ 0.004 Tc -0.004 Tw -16.539 -1.152 Td [(T)-2(r)1(ack)-1(i)1(n)-1(g)-1(\224,)2( )]TJ /TT3 1 Tf 0.005 Tc -0.003 Tw 4.599 0 Td [(I)2(nt)3(.)3( C)-1(onf)3(.)3( on I)2(nf)3(o F)-1(us)1(i)3(on)]TJ /TT0 1 Tf 0.006 Tc 10.045 0 Td [(,)4( )1(J)2(u)1(l)4(y)1( 2)1(00)1(5.)]TJ 0 Tc 0 Tw 4.714 0 Td ( )Tj -21.631 -1.152 Td ([)Tj 0.005 Tc -0.005 Tw 0.336 0 Td (16)Tj 0 Tc 0 Tw (])Tj 1.346 0 Td ( )Tj 0.005 Tc 0.058 Tw 0.59 0 Td [(G)-2(.)3( )1(C)-1(he)1(n,)3( )1(D)-2(.)3( )1(She)1(n,)3( )1(C)-1(.)3( )1(K)-2(w)-2(a)1(n)1(,)3( )1(J)1(.)3( )1(C)-1(r)2(uz)1(,)3( )1(M)-5(.)3( )1(K)-2(r)2(uge)1(r)2(,)3( )1(a)1(nd )1(E.)3( )1(B)-1(l)3(a)1(s)1(c)1(h)1(,)3( )1(\223)1(G)-2(a)1(m)-2(e)1( )]TJ 0.004 Tc 0.023 Tw T* [(T)-2(h)-1(eo)-1(r)1(et)1(i)1(c A)-3(p)-1(p)-1(r)1(o)-1(ach)-1( t)1(o)-1( T)-2(h)-1(r)1(eat)1( P)-2(r)1(ed)-1(i)1(ct)2(i)1(o)-1(n)-1( an)-1(d)-1( S)-2(i)1(t)1(u)-1(at)1(i)1(o)-1(n)-1( A)-3(w)-3(ar)1(en)-1(ess,)2(\224 )]TJ /TT3 1 Tf 0 Tc 0 Tw 27.853 0 Td (J)Tj 0.448 0 Td (.)Tj 0.252 0 Td ( )Tj 0.003 Tc -0.003 Tw 0.252 0 Td [(o)-2(f )]TJ 0.005 Tc -28.805 -1.152 Td [(A)-1(dv)1(anc)1(e)1(s)1( i)2(n I)2(nf)2(or)1(m)-3(at)2(i)2(on F)-1(us)1(i)2(on,)]TJ /TT0 1 Tf 0 Tc 0 Tw 13.298 0 Td ( )Tj 0.003 Tc 0.253 0 Td [(V)-4(o)-2(l)1(.)1( )1(2)-2(,)1( )1(N)-5(o)-2(.)1( )1(1)-2(,)1( )1(1)]TJ 0 Tc (-)Tj 0.005 Tc -0.003 Tw 6.621 0 Td [(14,)3( J)1(une)1( 2007.)]TJ 0 Tc 0 Tw 5.892 0 Td ( )Tj -28.337 -1.424 Td ([)Tj 0.005 Tc -0.005 Tw 0.336 0 Td (17)Tj 0 Tc 0 Tw (])Tj 1.346 0 Td ( )Tj 0.002 Tc 0.255 Tw 0.59 0 Td [(E)-4(. B)-5(l)-1(a)-2(s)-2(c)-2(h)-3(, I)-1(. K)-6(a)-2(d)-3(a)-2(r)-1(, K)-6(. H)-6(i)-1(n)-3(t)-1(z)-2(, J)-2(. 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P)-4(. B)-5(l)-1(a)-2(s)-2(c)-2(h)-3(, O)-6(. S)-4(t)-1(r)-1(a)-2(k)-3(a)-2(, J)-2(. 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W)-7(a)-1(lle)-1(y)-2(, \223)]TJ 0.004 Tc -0.004 Tw 5.525 0 Td [(M)-5(easu)-1(r)1(es )]TJ 0 Tc 0 Tw 4.417 0 Td (o)Tj 0.003 Tc 0.294 Tw 0.505 0 Td [(f)-1( U)-5(n)-2(c)-1(e)-1(rta)-1(in)-2(ty)-2( In)-2( E)-3(x)-2(p)-2(e)-1(rt S)-3(y)-2(s)-1(te)-1(m)-5(s)]TJ -0.003 Tw 14.192 0 Td [(,)1(\224)]TJ 0 Tc 0 Tw 0.701 0 Td ( )Tj 0.547 0 Td (A)Tj 0.003 Tc -0.003 Tw 0.729 0 Td [(rt)1(i)1(f)-1(i)1(c)-1(i)1(a)-1(l)1( )]TJ 0.005 Tc -26.617 -1.121 Td [(I)2(nt)3(e)1(l)3(l)3(i)3(ge)1(nc)1(e)1(,)3( 83\()2(1\))2(,)3( M)-4(a)1(y 1996,)3( pp.)3( 1)]TJ 0 Tc 0 Tw 14.615 0 Td (-)Tj 0.005 Tc -0.005 Tw 0.336 0 Td (58.)Tj 0 Tc 0 Tw 1.263 0 Td ( )Tj -18.487 -1.455 Td ([)Tj 0.005 Tc -0.005 Tw 0.336 0 Td (33)Tj 0 Tc 0 Tw (])Tj 8.88 0 0 8.88 57.8481 495 Tm ( )Tj 0.005 Tc 0.036 Tw 7.92 0 0 7.92 62.52 495 Tm [(L)-1(.)3( M)-4(.)3( K)-3(a)1(pl)2(a)1(n,)3( S)-1(.)3( C)-2(ha)1(kr)2(a)1(bor)2(t)2(y,)3( a)1(nd C)-2(.)3( B)-2(i)2(s)1(di)2(ki)2(a)1(n,)3( \223S)-1(ubj)2(e)1(c)1(t)2(i)2(ve)1( L)-1(ogi)2(c)1( w)-3(i)2(t)2(h )]TJ -0.002 Tw 0 -1.152 TD [(U)-2(nc)1(e)1(r)2(t)3(a)1(i)3(n )1(Pa)1(r)2(t)3(i)3(a)1(l)3( )1(O)-2(bs)1(e)1(r)2(va)1(t)3(i)3(ons)1(,)3(\224)1( )]TJ /TT1 1 Tf -0.003 Tw 13.408 0 Td [(I)2(nt)3(.)3( C)-1(onf)3(.)3( on I)2(nf)3(or)1(m)-2(at)3(i)3(on F)-1(us)1(i)3(on)]TJ /TT0 1 Tf 0.006 Tc 13.244 0 Td [(,)4( )1(2)1(0)1(1)1(2)1(.)]TJ 0 Tc 0 Tw 2.778 0 Td ( )Tj -31.702 -1.455 Td ([)Tj 0.005 Tc -0.005 Tw 0.336 0 Td (34)Tj 0 Tc 0 Tw (])Tj 8.88 0 0 8.88 57.8481 474.36 Tm ( )Tj 0.003 Tc 0.017 Tw 7.92 0 0 7.92 62.52 474.36 Tm [(A)-4(.)1( )1(J)]TJ /C2_0 1 Tf 0 Tc 0 Tw 1.645 0 Td <0004>Tj /TT0 1 Tf 0.005 Tc 0.015 Tw 0.832 0 Td [(s)1(a)1(ng a)1(nd R)-2(.)3( H)-2(a)1(nki)3(n,)3( \223I)2(nt)]TJ 0.014 Tw 10.111 0 Td [(e)1(r)2(pr)2(e)1(t)3(a)1(t)3(i)3(on a)1(nd F)-1(us)1(i)3(on of)1( H)-2(ype)1(r)2( O)-2(pi)3(ni)3(ons)1( )]TJ 0.006 Tc -0.003 Tw -12.588 -1.121 Td [(i)3(n Subj)2(e)1(c)1(t)3(i)3(ve)1( Lo)1(gi)3(c)1(,)3(\224)1( )]TJ /TT1 1 Tf 0.005 Tc 8.865 0 Td [(I)2(nt)3(.)3( C)-1(onf)3(.)3( on I)2(nf)3(or)1(m)-2(at)3(i)3(on F)-1(us)1(i)3(on)]TJ /TT0 1 Tf 0.006 Tc 13.244 0 Td [(,)4( )1(2)1(0)1(1)1(2)1(.)]TJ 0 Tc 0 Tw 2.778 0 Td ( )Tj -27.159 -1.455 Td ([)Tj 0.005 Tc -0.005 Tw 0.336 0 Td (35)Tj 0 Tc 0 Tw (])Tj 8.88 0 0 8.88 57.8481 453.96 Tm ( )Tj 0.002 Tc 0.356 Tw 7.92 0 0 7.92 62.52 453.96 Tm [(J)-2(. D)-5(e)-2(z)-2(e)-2(r)-1(t, D)-5(. H)-5(a)-2(n)-3(, Z)]TJ 0 Tc 0 Tw 9.558 0 Td (-)Tj 0.005 Tc 0.353 Tw 0.336 0 Td [(g.)3( L)-1(,)3( a)1(nd J)]TJ 0 Tc 0 Tw 5.304 0 Td (-)Tj 0.004 Tc 0.354 Tw 0.336 0 Td [(M)-5(.)2( T)-2(acn)-1(et)2(,)2( \223)-1(H)-3(i)2(er)1(ar)1(ch)-1(i)2(cal)2( D)-3(S)-2(m)-4(P)-2( )]TJ 0.275 Tw -15.535 -1.152 Td [(t)1(ra)-1(n)-2(s)-1(fo)-2(rm)-4(a)-1(t)1(i)1(o)-2(n)-2( fo)-2(r d)-2(e)-1(c)-1(i)1(s)-1(i)1(o)-2(n)]TJ 0 Tc 0 Tw 11.549 0 Td (-)Tj 0.005 Tc 0.274 Tw 0.336 0 Td [(m)-3(aki)2(ng under)1( uncer)1(t)2(ai)2(nt)2(y,)2(\224 )]TJ /TT1 1 Tf 0.216 Tw 12.159 0 Td [(I)2(nt)3(.)3( C)-1(onf)3(.)3( on )]TJ 0.003 Tc -0.003 Tw -24.044 -1.121 Td [(In)-2(f)1(o)-2(r)]TJ 0.006 Tc 2.02 0 Td [(m)-1(a)1(t)4(i)4(o)1(n)1( )1(F)1(u)1(s)2(i)4(on)]TJ /TT0 1 Tf 5.864 0 Td [(,)4( )1(2)1(0)1(1)1(2)1(.)4( )]TJ 0 Tc 0 Tw 3.03 0 Td ( )Tj -13.188 -1.455 Td ([)Tj 0.005 Tc -0.005 Tw 0.336 0 Td (36)Tj 0 Tc 0 Tw (])Tj 8.88 0 0 8.88 57.8481 424.44 Tm ( )Tj 0.005 Tc 0.146 Tw 7.92 0 0 7.92 62.52 424.44 Tm [(A)-2(.)3( )1(A)-2(uge)1(r)2( )1(and )1(J)1(.)3( )1(R)-1(oy)1(,)3( )1(\223)1(Expr)2(e)1(s)1(s)1(i)3(on )1(o)1(f)2( )1(U)-2(n)1(c)1(e)1(r)2(t)3(a)1(i)3(n)1(t)3(y)1( )1(i)3(n)1( )1(Li)3(ngu)1(i)2(s)1(t)3(i)3(c)1( )1(D)-2(a)1(t)3(a)1(,)3(\224)1( )]TJ /TT1 1 Tf -0.003 Tw T* [(I)2(nt)3(.)3( C)-1(onf)3(e)1(r)1(e)1(nc)1(e)1( on I)2(nf)3(or)1(m)-2(at)3(i)3(on F)-1(us)1(i)3(on)]TJ /TT0 1 Tf 0.006 Tc 15.683 0 Td [(,)4( )1(2)1(0)1(0)1(8)1(.)]TJ 0 Tc 0 Tw 2.778 0 Td ( )Tj -20.733 -1.455 Td ([)Tj 0.005 Tc -0.005 Tw 0.336 0 Td (37)Tj 0 Tc 0 Tw (])Tj 8.88 0 0 8.88 57.8481 403.8 Tm ( )Tj 0.005 Tc 0.017 Tw 7.92 0 0 7.92 60.4949 403.8 Tm [(H)-2(.)3( )1(Li)3(ng,)3( )1(L.)3( )1(B)-1(a)1(i)3(,)3( )1(E.)3( )1(B)-1(l)3(a)1(s)1(c)1(h)1(,)3( )1(a)1(n)1(d )1(X)-2(.)3( )1(M)-5(e)1(i)3(,)3( )1(\223)1(R)-1(o)1(bus)1(t)3( )1(i)3(nf)2(r)2(a)1(r)2(e)1(d)1( )1(ve)1(h)1(i)3(c)1(l)3(e)1( )1(t)3(r)2(a)1(c)1(k)1(i)3(n)1(g )]TJ 0.004 Tc 0.366 Tw 0.256 -1.121 Td [(acr)1(o)-1(ss t)2(ar)1(g)-1(et)2( )]TJ 0.005 Tc 0.365 Tw [(pos)1(e)1( c)1(ha)1(nge)1( us)1(i)3(ng )]TJ 0.003 Tc 0.367 Tw 14.825 0 Td [(L)-3(1)-2( re)-1(g)-2(u)-2(la)-1(riz)-1(a)-1(tio)-2(n)-2(,)1(\224)-1( )]TJ /TT1 1 Tf -0.003 Tw 8.672 0 Td [(In)-2(t)]TJ 1.122 0 Td [(\222l)1( )]TJ 0.005 Tc -0.005 Tw 1.18 0 Td [(C)-2(onf)]TJ 0 Tc 0 Tw 1.964 0 Td (.)Tj 0.253 0 Td ( )Tj 0.005 Tc -0.005 Tw 0.563 0 Td (on )Tj -0.003 Tw -28.58 -1.152 Td [(I)2(nf)3(or)1(m)-2(at)3(i)3(on F)-1(us)1(i)3(on)]TJ /TT0 1 Tf 0.003 Tc 7.885 0 Td [(,)1( )]TJ 0.005 Tc -0.005 Tw 0.505 0 Td (2010.)Tj 0 Tc 0 Tw 2.273 0 Td ( )Tj -12.935 -1.424 Td ([)Tj 0.005 Tc -0.005 Tw 0.336 0 Td (38)Tj 0 Tc 0 Tw (])Tj 1.346 0 Td ( )Tj 0.005 Tc 0.071 Tw 0.59 0 Td [(A)-2(.)3( )1(Pr)2(e)1(e)1(c)1(e,)3( )1(D)-2(.)3( )1(Pi)3(z)1(z)1(o)1(c)1(a)1(r)2(o,)3( )1(D)-2(.)3( )1(B)-1(r)2(a)1(i)3(n)1(e)1(s)1(,)3( )1(D)-2(.)3( )1(M)-4(o)1(t)3(t)3(,)3( )1(G)-2(.)3( )1(d)1(e)1( )1(M)-4(e)1(l)2(,)3( )1(a)1(nd)1( )1(T.)3( )1(Pha)1(m)-2(,)3( )]TJ 0.004 Tc 0.541 Tw T* [(\223)-1(In)-1(t)1(eg)-1(rat)1(i)1(n)-1(g)-1( h)-1(ard)-1( an)-1(d)-1( so)-1(ft)1( In)-1(fo)-1(rm)-4(at)1(i)1(o)-1(n)-1( S)-2(o)-1(u)-1(rces fo)-1(r D)-4(2)-1(D)-4( U)-4(si)1(n)-1(g)-1( )]TJ 0.005 Tc -0.002 Tw 0 -1.121 TD [(C)-2(ont)2(r)1(ol)2(l)2(ed N)-3(at)2(ur)1(al)2( L)-1(anguage,)2(\224 )]TJ /TT1 1 Tf -0.003 Tw 12.79 0 Td [(I)2(nt)3(.)3( C)-1(onf)3(.)3( on I)2(nf)3(or)1(m)-2(at)3(i)3(on F)-1(us)1(i)3(on)]TJ /TT0 1 Tf 0.006 Tc 13.244 0 Td [(,)4( )1(2)1(0)1(1)1(2)1(.)]TJ 0 Tc 0 Tw 2.778 0 Td ( )Tj -31.084 -1.455 Td ([)Tj 0.005 Tc -0.005 Tw 0.336 0 Td (39)Tj 0 Tc 0 Tw (])Tj 8.88 0 0 8.88 57.8481 345 Tm ( )Tj 0.005 Tc 0.483 Tw 7.92 0 0 7.92 62.52 345 Tm [(W)-4(.)3( Pe)1(r)2(r)2(y,)3( D)-2(.)3( Si)3(gnor)2(i)3(,)3( a)1(nd J)1(.)3( B)-1(oon,)3( \223)1(E)-1(xpl)3(or)2(i)3(ng t)3(he)1( I)2(nf)1(or)2(m)-2(a)1(t)3(i)3(on )]TJ 0.141 Tw 0 -1.152 TD [(S)-1(upe)1(r)1(i)2(or)1(i)2(t)2(y:)2( A)-3( M)-4(e)1(t)2(hodol)2(ogy f)1(or)1( M)-4(e)1(a)1(s)1(ur)1(i)2(ng t)2(he)1( Q)-3(ua)1(l)2(i)2(t)2(y of)1( I)1(nf)1(or)1(m)-3(a)1(t)2(i)2(on )]TJ 0.004 Tc -0.002 Tw 0 -1.121 TD [(an)-1(d)-1( i)2(t)2(s I)1(m)-3(p)-1(act)2( o)-1(n)-1( S)-2(h)-1(ar)1(ed)-1( A)-3(w)-3(ar)1(en)-1(ess,)2(\224 )]TJ /TT1 1 Tf 0.005 Tc -0.003 Tw 15.68 0 Td [(R)-1(A)-1(N)-2(D)-3( C)-2(or)1(por)1(at)2(i)2(on)]TJ /TT0 1 Tf 0.006 Tc 7.941 0 Td [(,)4( )1(2)1(0)1(0)1(4)1(.)]TJ 0 Tc 0 Tw 2.778 0 Td ( )Tj -28.671 -1.455 Td ([)Tj 0.005 Tc -0.005 Tw 0.336 0 Td (40)Tj 0 Tc 0 Tw (])Tj 8.88 0 0 8.88 57.8481 315.48 Tm ( )Tj 0.005 Tc 0.27 Tw 7.92 0 0 7.92 62.52 315.48 Tm [(M)-4(.)3( E)-1(.)3( J)1(ohns)1(on a)1(nd K)-2(.)3( C)-2(.)3( C)-2(ha)1(ng,)3( \223Q)-2(ua)1(l)3(i)3(t)3(y of)1( I)2(nf)1(or)2(m)-3(a)1(t)3(i)3(on f)1(or)2( D)-2(a)1(t)3(a)1( )]TJ 0.004 Tc 0.132 Tw 0 -1.152 TD [(F)-2(u)-1(si)1(o)-1(n)-1( i)1(n)-1( N)-4(et)1( C)-3(en)-1(t)1(ri)1(c P)-2(u)-1(b)-1(l)1(i)1(sh)-1( an)-1(d)-1( S)-2(u)-1(b)-1(scri)1(b)-1(e A)-4(rch)-1(i)1(t)1(ect)1(u)-1(res,)1(\224 )]TJ /TT1 1 Tf 0.003 Tc 0.076 Tw 25.669 0 Td [(In)-2(t)1(.)1( C)-3(o)-2(n)-2(f)1(.)]TJ 0 Tc 0 Tw 3.921 0 Td ( )Tj 0.005 Tc -0.003 Tw -29.59 -1.121 Td [(on I)2(nf)3(or)1(m)-2(at)3(i)3(on F)-1(us)1(i)3(on)]TJ /TT0 1 Tf 0.006 Tc 9.147 0 Td [(,)4( )1(2)1(0)1(0)1(5)1(.)]TJ 0 Tc 0 Tw 2.778 0 Td ( )Tj -14.198 -1.455 Td ( )Tj 0.253 0 Td ([)Tj 0.005 Tc -0.005 Tw 0.336 0 Td (41)Tj 0 Tc 0 Tw (])Tj 8.88 0 0 8.88 59.8481 285.96 Tm ( )Tj 0.002 Tc 0.161 Tw 7.92 0 0 7.92 62.52 285.96 Tm [(M)-7(. A)-5(. H)-5(o)-3(s)-2(s)-2(a)-2(in)-3(, P)-4(. K)-5(. A)-5(tr)-1(e)-2(y)-3(, a)-2(n)-3(d)-3( A)-5(. E)-4(l S)-4(a)-2(d)-3(d)-3(ik)-3(, \223)-3(M)-7(o)-3(d)-3(e)-2(lin)-3(g)-3( Q)-5(u)-3(a)-2(lity)-3( o)-3(f)-2( )]TJ 0 Tc 0 Tw 0 -1.152 TD (I)Tj 0.005 Tc 0.109 Tw 0.336 0 Td [(nf)1(or)2(m)-3(a)1(t)3(i)3(on i)3(n M)-4(ul)3(t)3(i)]TJ 0 Tc 0 Tw (-)Tj 0.004 Tc 0.11 Tw 8.584 0 Td [(S)-2(en)-1(so)-1(r S)-2(u)-1(rv)-1(ei)1(l)1(l)1(an)-1(ce S)-2(y)-1(st)1(em)-4(s,)1(\224 )]TJ /TT1 1 Tf 0.005 Tc 0.052 Tw 12.959 0 Td [(I)2(E)-1(E)-1(E)-1( I)2(nt)3(.)3( C)-1(onf)3(.)3( on )]TJ 0.006 Tc -0.003 Tw -21.879 -1.121 Td [(D)-1(a)1(t)4(a)1( )1(E)1(n)1(g)1(i)4(n)1(e)2(e)2(r)2(i)3(n)1(g)1( )1(W)-2(o)1(r)2(k)2(s)2(h)1(o)1(p)]TJ /TT0 1 Tf 11.615 0 Td [(,)4( )1(2)1(0)1(0)1(7)1(.)4( )]TJ 0 Tc 0 Tw 3.03 0 Td ( )Tj -16.918 -1.455 Td ([)Tj 0.005 Tc -0.005 Tw 0.336 0 Td (42)Tj 0 Tc 0 Tw (])Tj 8.88 0 0 8.88 57.8481 256.44 Tm ( )Tj 0.005 Tc 0.165 Tw 7.92 0 0 7.92 62.52 256.44 Tm [(C)-2(.)2( B)-2(i)2(s)1(di)2(ki)2(an and L)-1(.)2( M)-4(.)2( K)-3(apl)2(an,)2( )]TJ 0.002 Tc 0.168 Tw 13.967 0 Td [(M)-7(. B)-5(. S)-4(r)-1(iv)-3(a)-2(s)-2(ta)-2(v)-3(a)-2(, D)-5(. J)-2(. T)-4(h)-3(o)-3(r)-1(n)-3(le)-2(y)-3(, D)-5(. )]TJ 0.006 Tc 0.482 Tw -13.967 -1.152 Td [(V)-1(e)2(r)3(m)-1(a)2(,)4( )1(a)2(n)1(d)1( )1(R.)3( )1(I)3(.)4( )1(Y)-1(o)1(u)1(n)2(g)1(,)4( )]TJ 0 Tc 0 Tw 12.662 0 Td (\223)Tj 0.005 Tc 0.482 Tw 0.449 0 Td [(B)-2(ui)2(l)2(di)2(ng pr)1(i)2(nci)2(pl)2(es)1( f)1(or)1( a qual)2(i)2(t)2(y of)1( )]TJ 0.004 Tc -0.004 Tw -13.111 -1.121 Td [(i)1(n)-2(fo)-2(rm)-4(a)]TJ 0.173 Tw 3.198 0 Td [(t)1(i)1(o)-2(n)-2( s)-1(p)-2(e)-1(c)-1(i)1(fi)1(c)-1(a)-1(t)1(i)1(o)-2(n)-2( )1(fo)-2(r s)-1(e)-1(n)-2(s)-1(o)-2(r)1( f)1(u)-1(s)-1(i)1(o)-2(n)-1(,)]TJ -0.004 Tw 14.978 0 Td (\224 )Tj /TT1 1 Tf 0.005 Tc 0.115 Tw 0.875 0 Td [(I)2(nt)3(.)3( C)-1(onf)3(.)3( on I)2(nf)3(or)1(m)-2(at)3(i)3(on )]TJ -0.005 Tw -19.051 -1.152 Td [(F)-1(us)1(i)2(on)]TJ /TT0 1 Tf 0.006 Tc -0.003 Tw [(,)4( )1(2)1(0)1(0)1(9)1(.)]TJ 0 Tc 0 Tw 5.584 0 Td ( )Tj -7.856 -1.455 Td ([)Tj 0.005 Tc -0.005 Tw 0.336 0 Td (43)Tj 0 Tc 0 Tw (])Tj 8.88 0 0 8.88 57.8481 217.8 Tm ( )Tj 0.004 Tc 0.331 Tw 7.92 0 0 7.92 62.52 217.8 Tm [(E)-2(.)2( P)-2(.)2( B)-3(l)1(asch)-1(,)2( \223)-1(O)-4(n)-1(t)1(o)-1(l)1(o)-1(g)-1(i)1(cal)1( I)1(ssu)-1(es i)1(n)-1( H)-4(i)1(g)-1(h)-1(er)1( L)-2(ev)-1(el)1(s o)-1(f I)1(n)-1(fo)-1(r)1(m)-4(at)1(i)1(o)-1(n)-1( )]TJ 0.273 Tw 0 -1.121 TD [(F)-2(u)-1(si)1(o)-1(n)-1(:)1( U)-4(ser R)-3(efi)1(n)-1(em)-4(en)-1(t)1( o)-1(f t)1(h)-1(e F)-2(u)-1(si)1(o)-1(n)-1( P)-2(ro)-1(cess)]TJ 0.003 Tc -0.003 Tw 20.724 0 Td [(,)1(\224)-1( )]TJ /TT1 1 Tf 0.005 Tc 0.215 Tw 1.227 0 Td [(I)2(nt)3(.)3( C)-1(onf)3(.)3( on I)2(nf)3(o )]TJ -0.005 Tw -21.951 -1.152 Td [(F)-1(us)1(i)2(on)]TJ 0.003 Tc -0.003 Tw [(,)1( )]TJ /TT0 1 Tf 0.005 Tc -0.005 Tw 3.311 0 Td (2003.)Tj 0 Tc 0 Tw 2.273 0 Td ( )Tj -7.856 -1.424 Td ([)Tj 0.005 Tc -0.005 Tw 0.336 0 Td (44)Tj 0 Tc 0 Tw (])Tj 8.88 0 0 8.88 57.8481 188.52 Tm ( )Tj 7.92 0 0 7.92 62.52 188.52 Tm (R)Tj 0.003 Tc 0.413 Tw 0.674 0 Td [(.)1( )1(C)-3(a)-1(rv)-2(a)-1(l)1(h)-2(o)-2(,)1( )1(P)-2(.)1( )1(C)-3(o)-2(s)-1(t)1(a)-1(,)1( )1(K)-4(.)]TJ 0 Tc 0 Tw 11.221 0 Td ( )Tj 0.005 Tc 0.411 Tw 0.666 0 Td [(L)-1(a)1(s)1(ke)1(y,)3( a)1(nd K)-3(C)-2( C)-2(ha)1(ng,)3( \223P)-1(R)-2(O)-3(G)-3(N)-3(O)-3(S)-1(:)2( )]TJ 0.003 Tc 0.242 Tw -12.561 -1.152 Td [(P)-3(r)-1(e)-1(d)-2(ic)-1(tiv)-2(e)-1( S)-3(itu)-2(a)-1(tio)-2(n)-2(a)-1(l A)-5(w)-5(a)-1(r)-1(e)-1(n)-2(e)-1(s)-1(s)-1( w)-5(ith)-2( P)-3(r)-1(o)-2(b)-2(a)-1(b)-2(ilis)-1(tic)-1( O)-5(n)-2(to)-2(lo)-2(g)-2(ie)-1(s)]TJ -0.003 Tw 26.712 0 Td [(,)1(\224)]TJ /TT1 1 Tf 0 Tc 0 Tw 0.701 0 Td ( )Tj 0.003 Tc -0.001 Tw 0.438 0 Td [(In)-2(t)1(\222l)1( )]TJ 0.005 Tc -0.002 Tw -27.851 -1.121 Td [(C)-2(onf)2(.)2( on I)1(nf)2(or)1(m)-3(at)2(i)2(on F)-1(us)1(i)2(on)]TJ /TT0 1 Tf 0.006 Tc -0.003 Tw 11.617 0 Td [(,)4( )1(2)1(0)1(1)1(0)1(.)]TJ 0 Tc 0 Tw 2.778 0 Td ( )Tj -16.667 -1.455 Td ([)Tj 0.005 Tc -0.005 Tw 0.336 0 Td (45)Tj 0 Tc 0 Tw (])Tj 8.88 0 0 8.88 57.8481 159 Tm ( )Tj 0.002 Tc 0.26 Tw 7.92 0 0 7.92 62.4028 159 Tm [(M)-7( J)-2(. K)-5(r)-1(is)-2(ta)-2(n)-3(, J)-2(. T)-4(. H)-5(a)-2(m)-6(a)-2(la)-2(in)-3(e)-2(n)-3(, D)-5(. P)-4(. R)-5(o)-3(b)-3(b)-3(in)-3(s)-2(, a)-2(n)-3(d)-3( P)-4(. J)-2(. N)-5(e)-2(w)-5(e)-2(r)-1(, , )]TJ 0.005 Tc -0.005 Tw 0.015 -1.152 Td [(\223C)-2(ur)1(s)1(or)]TJ 0 Tc 0 Tw 3.198 0 Td (-)Tj 0.005 Tc -0.005 Tw 0.336 0 Td (on)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.227 Tw 1.346 0 Td [(T)-2(ar)1(g)-1(et)1( M)-5(essag)-1(e R)-3(o)-1(u)-1(t)1(er)1( U)-4(ser)1(\222)1(s G)-4(u)-1(i)1(d)-1(e,)2(\224 )]TJ /TT1 1 Tf 0.005 Tc 0.168 Tw 17.128 0 Td [(M)-3(I)2(TR)-1(E)-1( P)-1(r)1(oduc)1(t)3( )]TJ 0 Tc 0 Tw 7.075 0 Td (\226)Tj 0.505 0 Td ( )Tj 0.005 Tc -0.005 Tw -29.59 -1.121 Td [(M)-3(P)-1(090284,)]TJ /TT0 1 Tf 0 Tc 0 Tw 4.741 0 Td ( )Tj 0.004 Tc -0.002 Tw 0.253 0 Td [(2)-1(0)-1(0)-1(9)-1(.)2( \()1(accessed)-1( o)-1(n)-1( l)2(i)2(n)-1(e\))]TJ 0 Tc 0 Tw 9.761 0 Td ( )Tj -17.027 -1.455 Td ([)Tj 0.005 Tc -0.005 Tw 0.336 0 Td (46)Tj 0 Tc 0 Tw (])Tj 1.346 0 Td ( )Tj 0.005 Tc 0.701 Tw 0.956 0 Td [(R)-2(.)2( A)-3(.)2( S)-1(hul)2(s)1(t)2(ad,)2( \223C)-2(ur)1(s)1(or)1( on T)-1(ar)1(get)2(:)2( I)1(ns)1(pi)2(r)1(i)2(ng I)1(nnovat)2(i)2(on t)2(o )]TJ 0.355 Tw -0.366 -1.152 Td [(R)-2(evol)2(ut)2(i)2(oni)2(zi)2(ng A)-3(i)2(r)1( F)-1(or)1(ce C)-2(om)-3(m)-3(and and C)-2(ont)2(r)1(ol)2(,)2(\224 )]TJ /TT1 1 Tf 0.298 Tw [(A)-1(i)2(r)1( and Spac)1(e)1( )]TJ -0.003 Tw T* [(P)-1(ow)-2(e)1(r)1( J)1(our)1(nal)2(.)]TJ /TT0 1 Tf 0 Tc 0 Tw 6.285 0 Td ( )Tj 0.003 Tc 0.253 0 Td [(V)-4(o)-2(l)1(.)1( )1(4)-2(,)1( )1(D)-5(e)-1(c)-1(.)]TJ 0.006 Tc -0.003 Tw 4.909 0 Td [(,)4( )1(2)1(0)1(1)1(1)1(.)]TJ 0 Tc 0 Tw 2.778 0 Td ( )Tj 0.253 0 Td ( )Tj -16.749 -1.455 Td ([)Tj 0.005 Tc -0.005 Tw 0.336 0 Td (47)Tj 0 Tc 0 Tw (])Tj 8.88 0 0 8.88 57.8481 99.96 Tm ( )Tj 0.005 Tc 0.068 Tw 7.92 0 0 7.92 62.52 99.96 Tm [(E)-1(.)3( B)-2(l)2(a)1(s)1(c)1(h,)3( R)-2(.)3( B)-2(r)2(e)1(t)2(on,)3( P)-1(.)3( V)-3(a)1(l)2(i)2(n,)3( a)1(nd E)-1(.)3( B)-2(os)1(s)1(e)1(,)3( \223U)-3(s)1(e)1(r)2( I)2(nf)1(or)2(m)-3(a)1(t)2(i)2(on F)-1(us)1(i)2(on )]TJ 0.041 Tw 0 -1.152 TD [(D)-2(e)1(c)1(i)3(s)1(i)3(on M)-4(a)1(ki)3(ng A)-2(na)1(l)3(ys)1(i)3(s)1( w)-2(i)3(t)3(h t)3(he)1( C)]TJ 0 Tc 0 Tw 15.436 0 Td (-)Tj 0.007 Tc 0.039 Tw 0.336 0 Td [(OODA M)-2(o)2(d)2(e)3(l)5(,)5(\224)3( )]TJ /TT1 1 Tf 0.005 Tc -0.003 Tw 6.842 0 Td [(I)2(nt)3(.)3( C)-1(onf)3(.)3( on I)2(nf)3(o )]TJ -0.005 Tw -22.614 -1.121 Td [(F)-1(us)1(i)2(on)]TJ /TT0 1 Tf 0.006 Tc -0.003 Tw [(,)4( )1(2)1(0)1(1)1(1)1(.)]TJ 0 Tc 0 Tw 5.584 0 Td ( )Tj 26.295 81.939 Td ([)Tj 0.005 Tc -0.005 Tw 0.336 0 Td (48)Tj 0 Tc 0 Tw (])Tj 1.346 0 Td ( )Tj 0.005 Tc 0.035 Tw 0.59 0 Td [(E)-1(.)3( B)-2(l)2(a)1(s)1(c)1(h a)1(nd P)-1(.)3( V)-3(a)1(l)2(i)2(n,)3( \223T)-1(r)2(a)1(c)1(k P)-1(ur)2(i)2(t)2(y a)1(nd C)-2(ur)2(r)2(e)1(nt)2( A)-3(s)1(s)1(i)2(gnm)-3(e)1(nt)2( R)]TJ 0.003 Tc 0.037 Tw 26.607 0 Td [(a)-1(t)1(i)1(o)-2( f)-1(o)-2(r )]TJ 0.005 Tc 0.404 Tw -26.607 -1.152 Td [(T)-1(a)1(r)2(ge)1(t)2( T)-1(r)2(a)1(c)1(ki)2(ng a)1(nd I)2(de)1(nt)2(i)2(f)1(i)2(c)1(a)1(t)2(i)2(on E)-1(va)1(l)2(ua)1(t)2(i)2(on,)3(\224)1( )]TJ /TT1 1 Tf 0.347 Tw 21.554 0 Td [(I)2(nt)3(.)3( C)-1(onf)3(.)3( on I)2(nf)3(o )]TJ -0.005 Tw -21.554 -1.121 Td [(F)-1(us)1(i)2(on)]TJ /TT0 1 Tf 0.006 Tc -0.003 Tw [(,)4( )1(2)1(0)1(1)1(1)1(.)]TJ 0 Tc 0 Tw 5.584 0 Td ( )Tj -7.856 -1.455 Td ([)Tj 0.005 Tc -0.005 Tw 0.336 0 Td (49)Tj 0 Tc 0 Tw (])Tj 8.88 0 0 8.88 328.3281 701.4 Tm ( )Tj 0.005 Tc 0.025 Tw 7.92 0 0 7.92 331.0427 701.4 Tm [(K)-2(.)3( )1(Pa)1(l)3(a)1(ni)3(a)1(pp)-1(a)1(n,)3( )1(F.)3( )1(B)-1(u)1(nya)1(k)1(,)3( )1(P.)3( )1(K)-2(um)-2(a)1(r)2(,)3( )1(e)1(t)3( )1(a)1(l)3(.)3(,)3( )1(\223)1(Ef)2(f)2(i)3(c)1(i)3(e)1(nt)3( )1(f)2(e)1(a)1(t)3(u)1(r)2(e)1( )1(e)1(xt)3(r)2(a)1(c)1(t)3(i)3(on )]TJ 0.202 Tw 0.247 -1.121 Td [(a)1(nd l)3(i)3(ke)1(l)3(i)3(hood f)1(us)1(i)3(on f)1(or)2( ve)1(hi)3(c)1(l)3(e)1( t)3(r)2(a)1(c)1(ki)3(ng i)3(n l)3(ow)-2( f)1(r)2(a)1(m)-2(e)1( r)2(a)1(t)3(e)1( a)1(i)3(r)2(bor)2(ne)1( )]TJ -0.005 Tw 0 -1.152 TD [(vi)3(de)1(o)]TJ 0.003 Tc -0.003 Tw 2.244 0 Td [(,)1(\224)]TJ 0 Tc 0 Tw 0.701 0 Td ( )Tj /TT1 1 Tf 0.005 Tc -0.003 Tw 0.253 0 Td [(I)2(nt)3(.)3( C)-1(onf)3(.)3( on I)2(nf)3(or)1(m)-2(at)3(i)3(on F)-1(us)1(i)3(on)]TJ /TT0 1 Tf 0.003 Tc 13.244 0 Td [(,)1( )]TJ 0.005 Tc -0.005 Tw 0.505 0 Td (2010.)Tj 0 Tc 0 Tw 2.273 0 Td ( )Tj -21.492 -1.455 Td ([)Tj 0.005 Tc -0.005 Tw 0.336 0 Td (50)Tj 0 Tc 0 Tw (])Tj 8.88 0 0 8.88 328.3281 671.88 Tm ( )Tj 0.005 Tc 0.061 Tw 7.92 0 0 7.92 331.3228 671.88 Tm [(K)-2(.)3( )1(Pa)1(l)3(a)1(ni)3(appa)1(n,)3( )1(R)-1(.)3( )1(R)-1(a)1(o,)3( )1(G)-2(.)3( )1(Se)1(e)1(t)2(ha)1(r)2(a)1(m)-2(a)1(n,)3( )1(")1(W)-4(i)3(d)1(e)]TJ 0 Tc 0 Tw 19.917 0 Td (-)Tj 0.003 Tc 0.062 Tw 0.336 0 Td [(a)-1(re)-1(a)-1( p)-2(e)-1(rs)-1(i)1(s)-1(t)1(e)-1(n)-2(t)1( a)-1(i)1(rb)-2(o)-2(rn)-2(e)]TJ 0 Tc 0 Tw 9.548 0 Td ( )Tj 0.003 Tc 0.023 Tw -29.59 -1.121 Td [(v)-1(i)1(d)-1(eo)-1(:)1( A)-3(r)1(ch)-1(i)1(t)1(ect)1(u)-1(r)1(e an)-1(d)-1( ch)-1(al)1(l)1(en)-1(g)-1(es,)2(" )]TJ /TT1 1 Tf -0.002 Tw 15.018 0 Td [(D)-3(i)2(st)2(ri)2(b)-1(u)-1(t)2(ed)-1( V)-2(i)2(d)-1(eo)-1( S)-1(en)-1(so)-1(r N)-2(et)2(w)-2(o)-1(rks:)]TJ 0 Tc 0 Tw 14.571 0 Td ( )Tj 0.004 Tc 0.089 Tw -29.59 -1.152 Td [(R)-2(esea)-1(rch)-1( C)-3(h)-1(a)-1(l)1(l)1(en)-1(g)-1(es a)-1(n)-1(d)-1( F)-2(u)-1(t)1(u)-1(re D)-4(i)1(rect)1(i)1(o)-1(n)-1(s)]TJ /TT0 1 Tf 0.003 Tc 0.147 Tw 18.202 0 Td [(,)1( )1(S)-2(p)-2(ri)1(n)-2(g)-2(e)-1(r,)1( )1(P)]TJ 0.146 Tw 5.344 0 Td [(a)-1(rt)1( V)-4(,)1( C)-3(h)-2(a)-1(p)-2(t)1(e)-1(r )]TJ 0.005 Tc -0.003 Tw -23.546 -1.121 Td [(24,)3( pp.)3( 349 )]TJ 0 Tc 0 Tw 4.798 0 Td (\226)Tj 0.505 0 Td ( )Tj 0.005 Tc -0.003 Tw 0.253 0 Td [(371,)3( 2011.)]TJ 0 Tc 0 Tw 4.293 0 Td ( )Tj -12.121 -1.455 Td ([)Tj 0.005 Tc -0.005 Tw 0.336 0 Td (51)Tj 0 Tc 0 Tw (])Tj 8.88 0 0 8.88 328.3281 633.48 Tm ( )Tj 0.003 Tc 0.035 Tw 7.92 0 0 7.92 331.1069 633.48 Tm [(Y)-4(.)1( )1(W)-6(u)-2(,)1( )1(H)-4(.)1( )1(L)-2(i)1(n)-2(g)-2(,)1( )1(E)-2(.)1( )1(B)-3(l)1(a)-1(s)-1(c)-1(h)-2(,)1( )1(G)-4(.)1( )1(C)-3(h)-1(e)-1(n)-2(,)1( )1(a)-1(n)-1(d)-2( )1(L)-2(.)1( )1(B)-3(a)-1(i)1(,)1( )1(\223)-1(V)-4(i)1(s)-1(u)-2(a)-1(l)1( )1(T)-2(ra)-1(c)-1(k)-2(i)1(n)-2(g)-1( )1(b)-1(a)-1(s)]TJ 0.004 Tc -0.004 Tw 28.875 0 Td [(ed)-1( )]TJ 0.005 Tc 0.25 Tw -28.636 -1.152 Td [(on L)-1(og)]TJ 0 Tc 0 Tw 3.142 0 Td (-)Tj 0.004 Tc 0.251 Tw 0.336 0 Td [(E)-2(u)-1(cl)1(i)1(d)-1(ean)-1( R)-3(i)1(em)-4(an)-1(n)-1(i)1(an)-1( )]TJ [(S)-2(p)-1(arse R)-3(ep)-1(resen)-1(t)1(at)1(i)1(o)-1(n)-1(,)1(\224 )]TJ /TT1 1 Tf 0.005 Tc 0.193 Tw 20.39 0 Td [(I)2(nt)3(.)3( Sy)1(m)-2(p.)3( on )]TJ -0.003 Tw -23.869 -1.121 Td [(A)-1(dv)1(.)3( i)2(n V)-1(i)2(s)1(ual)2( C)-2(om)-3(put)2(i)2(ng )]TJ 0 Tc 0 Tw 10.69 0 Td (-)Tj 0.336 0 Td ( )Tj 0.004 Tc -0.001 Tw 0.253 0 Td [(L)-2(ect)1(u)-1(re N)-3(o)-1(t)1(es i)1(n)-1( C)-3(o)-1(m)-4(p)-1(u)-1(t)1(er S)-1(ci)1(en)-1(ce)]TJ /TT0 1 Tf 0.003 Tc 0 Tw 14.307 0 Td [(,)1( )1(2)]TJ 0.005 Tc -0.005 Tw 1.01 0 Td (011.)Tj 0 Tc 0 Tw 1.768 0 Td ( )Tj -30.636 -1.455 Td ([)Tj 0.005 Tc -0.005 Tw 0.336 0 Td (52)Tj 0 Tc 0 Tw (])Tj 8.88 0 0 8.88 328.3281 603.96 Tm ( )Tj 0.003 Tc 0.185 Tw 7.92 0 0 7.92 332.2959 603.96 Tm [(X)-4(.)1( )1(M)-6(e)-1(i)1(,)1( )1(H)-4(.)1( )1(L)-2(i)1(n)-2(g)-2(,)1( )1(Y)-4(.)1( )1(W)-6(u)-2(,)1( )1(E)-2(.)1( )1(P)-2(.)1( )1(B)-3(l)1(a)-1(s)-1(c)-1(h)-2(,)1( )1(a)-1(n)-1(d)-2( )1(L)-2(.)1( )1(B)-3(a)-1(i)1(,)1( )1(\223)-1(M)-6(i)1(n)-2(i)1(m)-4(u)-2(m)-4( )1(E)-2(rro)-2(r )]TJ 0.005 Tc 0.522 Tw 0.089 -1.152 Td [(B)-2(ounded )-1(E)-1(f)1(f)1(i)2(ci)2(ent)2( L)-1(1 T)-1(r)1(acker)1( w)-3(i)2(t)2(h O)-3(ccl)2(us)1(i)2(on D)-3(et)2(ect)2(i)2(on,)2(\224 )]TJ /TT1 1 Tf 0.007 Tc -0.007 Tw 27.402 0 Td [(I)4(E)1(E)1(E)1( )]TJ 0.005 Tc -0.002 Tw -27.402 -1.121 Td [(C)-2(om)-3(put)2(er)1( V)-1(i)2(s)1(i)2(on and P)-1(at)2(t)2(er)1(n R)-1(ecogni)2(t)2(i)2(on)]TJ /TT0 1 Tf 0.006 Tc -0.003 Tw 17.058 0 Td [(,)4( )1(2)1(0)1(1)1(1)1(.)]TJ 0 Tc 0 Tw 2.778 0 Td ( )Tj -22.108 -1.455 Td ([)Tj 0.005 Tc -0.005 Tw 0.336 0 Td (53)Tj 0 Tc 0 Tw (])Tj 8.88 0 0 8.88 328.3281 574.44 Tm ( )Tj 0.003 Tc 0.063 Tw 7.92 0 0 7.92 331.3288 574.44 Tm [(Y)-4(.)1( )1(W)-6(u)-2(,)1( )1(E)-2(.)1( )1(B)-3(l)1(a)-1(s)-1(c)-1(h)-2(,)1( )1(G)-4(.)1( )1(C)-3(h)-2(e)-1(n)-1(,)1( )1(L)-2(.)1( )1(B)-3(a)-1(i)1(,)1( )1(a)-1(n)-2(d)-2( )1(H)-5(.)1( )1(L)-2(i)1(n)-1(g)]TJ 0.005 Tc 0.061 Tw 19.961 0 Td [(,)3( )1(\223)1(M)-4(ul)3(t)3(i)3(pl)3(e)1( )1(Sour)2(c)1(e)1( )1(D)-2(a)1(t)3(a)1( )]TJ 0.004 Tc 0.303 Tw -19.75 -1.152 Td [(F)-2(u)-1(si)1(o)-1(n)-1( v)-1(i)1(a S)-2(p)-1(arse R)-3(ep)-1(resen)-1(t)1(at)1(i)1(o)-1(n)-1( fo)-1(r R)-3(o)-1(b)-1(u)-1(st)1( V)-4(i)1(su)-1(al)1( T)-2(rack)-1(i)1(n)-1(g)-1(,)1(\224 )]TJ /TT1 1 Tf 0.003 Tc -0.003 Tw 28.215 0 Td [(In)-2(t)1(.)1( )]TJ 0.005 Tc -0.002 Tw -28.215 -1.121 Td [(C)-2(onf)2(.)2( on I)1(nf)2(o F)-1(us)1(i)2(on)]TJ /TT0 1 Tf 0.006 Tc -0.003 Tw 8.418 0 Td [(,)4( )1(2)1(0)1(1)1(1)1(.)]TJ 0 Tc 0 Tw 2.778 0 Td ( )Tj -13.468 -1.455 Td ([)Tj 0.005 Tc -0.005 Tw 0.336 0 Td (54)Tj 0 Tc 0 Tw (])Tj 8.88 0 0 8.88 328.3281 544.92 Tm ( )Tj 7.92 0 0 7.92 331.0994 544.92 Tm (Y)Tj 0.003 Tc -0.003 Tw 0.729 0 Td [(.)1( )]TJ 0.002 Tc 0.034 Tw 0.539 0 Td [(W)-7(u)-3(, J)]TJ 0 Tc 0 Tw 2.391 0 Td (.)Tj 0.253 0 Td ( )Tj 0.005 Tc 0.031 Tw 0.287 0 Td [(W)-4(a)1(ng,)3( J)]TJ 0 Tc 0 Tw 3.344 0 Td (.)Tj 0.253 0 Td ( )Tj 0.005 Tc 0.032 Tw 0.287 0 Td [(C)-2(heng,)2( H)]TJ 0 Tc 0 Tw 3.906 0 Td (.)Tj 0.253 0 Td ( )Tj 0.002 Tc 0.035 Tw 0.287 0 Td [(L)-4(u)-3(, E)]TJ 0 Tc 0 Tw 2.278 0 Td (.)Tj 0.253 0 Td ( )Tj 0.005 Tc 0.032 Tw 0.287 0 Td [(B)-2(l)2(as)1(ch,)2( L)]TJ ET BT /TT0 1 Tf 0 Tc 0 Tw 7.92 0 0 7.92 483.5669 544.92 Tm (.)Tj 0.253 0 Td ( )Tj 0.005 Tc 0.032 Tw 0.287 0 Td [(B)-2(ai)2(,)2( and H)]TJ 0 Tc 0 Tw 4.417 0 Td (.)Tj 0.253 0 Td ( )Tj 0.005 Tc 0.032 Tw 0.287 0 Td [(L)-1(i)2(ng,)3( \223R)-2(e)1(a)1(l)]TJ 0 Tc 0 Tw 4.747 0 Td (-)Tj 0.003 Tc 0.107 Tw -29.253 -1.152 Td [(T)-3(im)-5(e)-1( P)-3(ro)-2(b)-2(a)-1(b)-2(ilis)-1(tic)-1( C)-4(o)-2(v)-2(a)-1(ria)-1(n)-2(c)-1(e)-1( T)-3(ra)-1(c)-1(k)-2(in)-2(g)-2( w)-5(ith)-2( E)-3(f)-1(f)-1(ic)-1(i)]TJ 0.004 Tc 0.106 Tw [(en)-1(t)2( M)-5(o)-1(d)-1(el)2( U)-3(p)-1(d)-1(at)2(e,)2(\224 )]TJ /TT1 1 Tf 0.005 Tc -0.003 Tw 0 -1.121 TD [(I)2(E)-1(E)-1(E)-1( Tr)1(ans)1(.)3( on I)2(m)-2(age)1( P)-1(r)1(oc)1(e)1(s)1(s)1(i)3(ng)]TJ /TT0 1 Tf 0.003 Tc 13.831 0 Td [(,)1( )]TJ /TT2 1 Tf 0.005 Tc -0.005 Tw 0.505 0 Td (21)Tj /TT0 1 Tf [(\()2(5\))2(:)3(2824)]TJ 0 Tc 0 Tw 4.489 0 Td (-)Tj 0.005 Tc -0.003 Tw 0.336 0 Td [(2837,)3( 2012.)3( )]TJ 0 Tc 0 Tw 5.051 0 Td ( )Tj -26.485 -1.485 Td ([)Tj 0.005 Tc -0.005 Tw 0.336 0 Td (55)Tj 0.098 Tw [(])2( X)-2(.)3( Z)-1(ha)1(ng,)3( W)-4(.)3( L)-1(i)3(,)3( W)-4(.)3( H)-2(u,)3( H)-2(.)3( L)-1(i)3(ng,)3( a)1(nd S.)3( M)-4(a)1(yba)1(nk,)3( \223)1(B)-1(l)3(oc)1(k c)1(ova)1(r)2(i)3(a)1(nc)1(e)1( )]TJ 0.004 Tc 0.671 Tw 1.936 -1.152 Td [(b)-1(ased)-1( L)-2(1)-1( t)2(r)1(ack)-1(er)1( w)-3(i)2(t)2(h)-1( a su)-1(b)-1(t)2(l)2(e t)2(em)-4(p)-1(l)2(at)2(e d)-1(i)2(ct)2(i)2(o)-1(n)-1(ar)1(y)-1(,)2(\224 )]TJ /TT1 1 Tf 0.003 Tc -0.003 Tw 26.56 0 Td [(P)-3(a)-2(tte)-1(r)-1(n)-2( )]TJ 0.005 Tc -0.005 Tw -26.56 -1.182 Td [(R)-1(e)1(c)1(ogni)2(t)2(i)2(on)]TJ /TT0 1 Tf 0.006 Tc -0.003 Tw [(,)4( )1(2)1(0)1(1)1(2)1(.)4( )]TJ 0 Tc 0 Tw 7.911 0 Td ( )Tj -10.184 -1.121 Td ([)Tj 0.005 Tc -0.005 Tw 0.336 0 Td (56)Tj 0 Tc 0 Tw (])Tj 1.346 0 Td ( )Tj 0.005 Tc 0.134 Tw 0.59 0 Td [(E)-1(.)3( P)-1(.)3( B)-2(l)2(a)1(s)1(c)1(h a)1(nd T)-1(.)3( C)-2(onna)1(r)2(e)1(,)3( \223I)2(m)-3(pr)2(ovi)2(ng T)-1(r)2(a)1(c)1(k m)-3(a)1(i)2(nt)2(e)1(na)1(nc)1(e)1( T)-1(hr)2(ough )]TJ 0.006 Tc 0.181 Tw 0 -1.121 TD [(G)-1(r)3(o)1(u)1(p)1( )1(T)1(r)3(a)2(c)2(k)1(i)4(n)1(g)1(,)4(\224)2( )]TJ /TT1 1 Tf 0.005 Tc 0.124 Tw 7.8 0 Td [(P)-1(r)1(oc)1( of)2( t)2(he)1( W)-3(or)1(k)1(s)1(hop on E)-1(s)1(t)2(i)2(m)-3(at)2(i)2(on,)3( T)-1(r)1(ac)1(k)1(i)2(ng,)3( and )]TJ -0.003 Tw -7.8 -1.152 Td [(F)-1(us)1(i)2(on;)2( A)-1( T)-1(r)1(i)2(but)2(e)1( t)2(o Y)-1(aak)1(ov)1( B)-1(ar)1( Shal)2(om)]TJ /TT0 1 Tf 0.006 Tc 16.554 0 Td [(,)4( )1(3)1(6)1(0)1( )]TJ 0 Tc 0 Tw 2.273 0 Td (\226)Tj 0.005 Tc -0.003 Tw 0.505 0 Td [(371,)3( M)-4(a)1(y 2001.)]TJ 0 Tc 0 Tw 6.397 0 Td ( )Tj -28.001 -1.455 Td ([)Tj 0.005 Tc -0.005 Tw 0.336 0 Td (57)Tj 0 Tc 0 Tw (])Tj 1.346 0 Td ( )Tj 0.004 Tc 0.013 Tw 0.59 0 Td [(T)-2(.)2( C)-3(o)-1(n)-1(n)-1(ar)1(e,)2( E)-2(.)2( B)-3(l)1(asch)-1(,)2( J.)2( S)-2(ch)-1(m)-4(i)1(t)1(z,)2( F)-2(.)2( S)-2(al)1(v)-1(at)1(o)-1(r)1(e)]TJ 0.006 Tc 0.012 Tw 19.123 0 Td [(,)4( )1(a)2(n)1(d)1( )1(F)1(.)4( S)1(c)2(a)1(r)3(p)1(i)4(n)1(o)1(,)4( )1(\223)2(G)-1(r)3(o)1(u)1(p)1( )]TJ 0.005 Tc 0.146 Tw -19.123 -1.121 Td [(I)2(M)-4(M)-4( t)3(r)2(a)1(c)1(ki)3(ng ut)3(i)3(l)3(i)3(z)1(i)3(ng T)-1(r)2(a)1(c)1(k a)1(nd I)2(de)1(nt)3(i)3(f)1(i)3(c)1(a)1(t)3(i)3(on Fus)1(i)3(on,)3(\224)1( )]TJ /TT1 1 Tf 0.004 Tc 0.09 Tw 24.321 0 Td [(P)-2(ro)-1(c.)2( o)-1(f)1( t)1(h)-1(e )]TJ 0.005 Tc 0.183 Tw -24.321 -1.152 Td [(W)-3(or)1(k)1(s)1(hop on E)-1(s)1(t)3(i)3(m)-2(at)3(i)3(on,)3( Tr)1(ac)1(k)1(i)3(ng,)3( and F)-1(us)1(i)3(on;)2( A)-1( Tr)1(i)3(but)3(e)1( t)3(o Yaak)1(ov)1( )]TJ -0.003 Tw T* [(B)-1(ar)1( Shal)2(om)-3(,)3( )]TJ /TT0 1 Tf 5.303 0 Td [(M)-4(ont)3(e)1(r)2(e)1(y,)3( C)-2(A)-2(,)3( 205 )]TJ 0 Tc 0 Tw 8.108 0 Td (-)Tj 0.005 Tc -0.003 Tw 0.336 0 Td [(220,)3( M)-4(a)1(y 2001.)]TJ 0 Tc 0 Tw 6.397 0 Td ( )Tj -22.417 -1.485 Td ([)Tj 0.005 Tc -0.005 Tw 0.336 0 Td (58)Tj 0 Tc 0 Tw (])Tj 1.346 0 Td ( )Tj 0.005 Tc 0.132 Tw 0.59 0 Td [(M)-4(.)3( W)-4(i)3(e)1(ne)1(ke)1( a)1(nd W)-4(.)3( K)-2(oc)1(h,)3( \223A)-2( P)-1(M)-4(H)-2(T)]TJ 0 Tc 0 Tw 16.15 0 Td ( )Tj 0.006 Tc 0.131 Tw 0.387 0 Td [(A)-1(p)1(p)1(r)3(o)1(a)2(c)2(h)1( )1(f)3(o)1(r)3( )1(e)2(x)1(t)4(e)2(n)1(de)2(d)2( )1(O)-2(b)1(j)3(e)2(c)2(t)4(s)2( )]TJ 0.004 Tc 0.198 Tw -16.536 -1.182 Td [(an)-1(d)-1( O)-3(b)-1(j)1(ect)2( G)-3(r)1(o)-1(u)-1(p)-1(s,)2(\224 )]TJ /TT1 1 Tf 0.005 Tc 0.14 Tw 9.182 0 Td [(I)2(E)-1(E)-1(E)-1( T.)3( A)-1(e)1(r)1(os)1(pac)1(e)1( and E)-1(l)3(e)1(c)1(t)3(r)1(oni)3(c)1( Sy)1(s)1(t)3(e)1(m)-2(s)]TJ /TT0 1 Tf 0.003 Tc 0.199 Tw 18.161 0 Td [(,)1( )1(v)-2(o)-2(l)1(.)1( )]TJ 0.005 Tc -0.003 Tw -27.342 -1.152 Td [(48,)3( no.)3( 3,)3( J)1(ul)3(y 2012)]TJ 0.003 Tc 7.997 0 Td [(.)1( )]TJ 0 Tc 0 Tw 0.505 0 Td ( )Tj -10.775 -1.152 Td ([)Tj 0.005 Tc -0.005 Tw 0.336 0 Td (59)Tj 0.055 Tw [(])2( C)-1(.)3( Y)-2(a)1(ng a)1(nd E)-1(.)3( B)-1(l)3(a)1(s)1(c)1(h,)3( \223)1(Fus)1(i)3(on of)1( T)-1(r)2(a)1(c)1(ks)1( w)-2(i)3(t)3(h R)-1(oa)1(d C)-1(ons)1(t)3(r)2(a)1(i)3(nt)3(s)1(,)3(\224)1( )]TJ /TT1 1 Tf 0.002 Tc 0.001 Tw 29.533 0 Td [(J)-2(. o)-3(f. )]TJ 0.005 Tc -0.003 Tw -27.597 -1.182 Td [(A)-1(dv)1(anc)1(e)1(s)1( i)2(n I)2(nf)2(or)1(m)-3(at)2(i)2(on F)-1(us)1(i)2(on,)]TJ /TT0 1 Tf 0 Tc 0 Tw 13.298 0 Td ( )Tj 0.003 Tc 0.253 0 Td [(V)-4(o)-2(l)1(.)1( )1(3)-2(,)1( )1(N)-5(o)-2(.)1( )1(1)-2(,)1( )]TJ 0.005 Tc -0.005 Tw 5.78 0 Td (14)Tj 0 Tc 0 Tw (-)Tj 0.005 Tc -0.003 Tw 1.346 0 Td [(32,)3( J)1(une)1( 2008.)]TJ 0 Tc 0 Tw 5.892 0 Td ( )Tj -28.842 -1.121 Td ([)Tj 0.005 Tc -0.005 Tw 0.336 0 Td (60)Tj 0 Tc 0 Tw (])Tj 8.88 0 0 8.88 328.3281 373.8 Tm ( )Tj 0.003 Tc 0.018 Tw 7.92 0 0 7.92 330.9673 373.8 Tm [(X)-4(.)1( )1(S)-2(h)-2(i)1(,)1( )1(H)-4(.)1( )1(L)-2(i)1(n)-2(g)-2(,)1( )1(E)-2(.)1( )1(B)-3(l)1(a)-1(s)-1(c)-1(h)-1(,)1( )1(a)-1(n)-2(d)-1( )1(W)-6(.)1( )1(H)-4(u)-2(,)1( )1(\223)-1(C)-3(o)-1(n)-2(t)1(e)-1(x)-2(t)]TJ 0 Tc 0 Tw 19.825 0 Td (-)Tj 0.006 Tc 0.015 Tw 0.336 0 Td [(D)-1(r)3(i)4(v)1(e)2(n)1( )1(M)-3(o)1(v)1(i)4(n)1(g)1( V)-1(e)2(h)1(i)4(c)2(l)4(e)2( )]TJ 0.005 Tc 0.425 Tw -19.905 -1.121 Td [(D)-2(e)1(t)3(e)1(c)1(t)3(i)3(on )1(i)3(n )1(W)-4(i)3(de)1( )1(A)-2(r)2(e)1(a)1( )1(M)-4(ot)3(i)3(on)-1( )1(I)2(m)-2(a)1(g)1(e)1(r)2(y,)3(\224)1( )]TJ /TT1 1 Tf 0.367 Tw 19.979 0 Td [(I)2(nt)3(\222)2(l)3( C)-1(onf)3( on P)-1(at)3(t)3(e)1(r)1(n )]TJ 0.003 Tc -0.001 Tw -19.979 -1.152 Td [(R)-3(e)-1(c)-1(o)-2(g)-2(n)-2(itio)-2(n)-2( \(IC)-4(P)-3(R)-3(\),)]TJ /TT0 1 Tf 0 Tc 0 Tw 8.303 0 Td ( )Tj 0.005 Tc -0.005 Tw 0.253 0 Td (2012.)Tj 0 Tc 0 Tw 2.273 0 Td ( )Tj -13.101 -1.455 Td ([)Tj 0.005 Tc -0.005 Tw 0.336 0 Td (61)Tj 0 Tc 0 Tw (])Tj 1.346 0 Td ( )Tj 0.004 Tc 0.146 Tw 0.4 0 Td [(E)-2(.)2( D)-4(.)2( M)-5(ar)1(t)1(i)1(,)2( J.)2( G)-4(ar)1(ci)1(a,)2( an)-1(d)-1( J.)2( L)-2( C)-3(r)1(assi)1(d)-1(i)1(s,)2( \223)-1(I)1(m)-4(p)]TJ 0.003 Tc 0.147 Tw 20.29 0 Td [(ro)-2(v)-2(i)1(n)-2(g)-2( M)-6(u)-2(l)1(t)1(i)1(p)-2(l)1(e)]TJ 0 Tc 0 Tw (-)Tj 0.005 Tc -0.005 Tw 6.853 0 Td [(M)-4(ode)1(l)3( )]TJ -26.952 -1.121 Td [(C)-2(ont)2(ext)]TJ 0 Tc 0 Tw 3.198 0 Td (-)Tj 0.005 Tc 0.311 Tw 0.336 0 Td [(A)-2(i)3(de)1(d )1(Tr)2(a)1(c)1(ki)3(ng )1(t)3(h)1(r)2(ou)1(gh )1(an )1(A)-2(ut)3(oc)1(o)1(r)2(r)2(e)1(l)3(a)1(t)3(i)3(o)1(n )1(A)-2(p)1(pr)2(o)1(a)1(c)1(h,)3(\224)1( )]TJ /TT1 1 Tf 0.003 Tc -0.003 Tw 24.68 0 Td [(In)-2(t)1(.)1( )]TJ 0.005 Tc -0.002 Tw -28.215 -1.152 Td [(C)-2(onf)2(.)2( on I)1(nf)2(o F)-1(us)1(i)2(on)]TJ /TT0 1 Tf 0.006 Tc -0.003 Tw 8.418 0 Td [(,)4( )1(2)1(0)1(1)1(2)]TJ 0 Tc 0 Tw 2.525 0 Td (.)Tj 0.253 0 Td ( )Tj -13.468 -1.455 Td ([)Tj 0.005 Tc -0.005 Tw 0.336 0 Td (62)Tj 0 Tc 0 Tw (])Tj 1.346 0 Td ( )Tj 0.005 Tc 0.173 Tw 0.59 0 Td [(L)-1(.)3( S)-1(ni)2(da)1(r)2(o,)3( I)2(.)3( V)-3(i)2(s)1(e)1(nt)2(i)2(ni)2(,)3( K)-3(.)3( B)-2(r)2(ya)1(n,)3( a)1(nd G)-3(.)3( L)-1(.)3( F)-1(or)2(e)1(s)1(t)2(i)2(,)3( \223M)-4(a)1(r)2(kov L)-1(ogi)2(c)1( )]TJ 0.103 Tw 0 -1.121 TD [(N)-2(e)1(t)3(w)-2(or)2(k )1(f)2(or)2( )1(c)1(ont)3(e)1(xt)3( )1(i)3(n)1(t)3(e)1(g)1(r)2(a)1(t)3(i)3(o)1(n )1(a)1(nd )1(s)1(i)3(t)3(ua)1(t)3(i)3(on )1(a)1(s)1(s)1(e)1(s)1(s)1(m)-2(e)1(n)]TJ 0.003 Tc 0.105 Tw 23.355 0 Td [(t in)-3( a)-2( m)-5(a)-2(ritim)-5(e)-2( )]TJ 0.005 Tc -0.005 Tw -23.355 -1.152 Td [(dom)-3(a)1(i)3(n,)3(\224)1( )]TJ /TT1 1 Tf -0.003 Tw 3.983 0 Td [(I)2(nt)3(.)3( C)-1(onf)3(.)3( on I)2(nf)3(o F)-1(us)1(i)3(on)]TJ /TT0 1 Tf 0.006 Tc 10.045 0 Td [(,)4( )1(2)1(0)1(1)1(2)]TJ 0 Tc 0 Tw 2.525 0 Td (.)Tj 0.253 0 Td ( )Tj -19.078 -1.455 Td ([)Tj 0.336 0 Td (6)Tj 0.505 0 Td (3)Tj 0.505 0 Td (])Tj 0.336 0 Td ( )Tj 0.003 Tc 0.096 Tw 0.59 0 Td [(F)-3(. P)-3(a)-1(p)-2(i. M)-6(. P)-3(o)-2(d)-2(t, Y)-5(. B)-4(o)-2(e)-1(r)-1(s)-1(, G)-5(. B)-4(a)-1(ttis)-1(te)-1(llo)-2(, a)-1(n)-2(d)-2( M)-6(. U)-5(lm)-5(k)-2(a)-1(, \223)-2(C)-4(o)-2(n)-2(s)-1(tr)-1(a)-1(in)-2(ts)-1( )]TJ 0.09 Tw 0 -1.121 TD [(E)-3(x)-2(p)-2(lo)-2(ita)-1(tio)-2(n)-2( f)-1(o)-2(r P)-3(a)-1(rtic)-1(le)-1( F)-3(ilte)-1(rin)-2(g)-2( b)-2(a)-1(s)-1(e)-1(d)-2( T)-3(a)-1(g)-2(re)-1(t T)-3(ra)-1(c)-1(k)-2(in)-2(g)-2(,)1(\224)-1( )]TJ /TT1 1 Tf 0.005 Tc 0.03 Tw 24.416 0 Td [(I)2(nt)3(.)3( C)-1(onf)3(.)3( on )]TJ -0.003 Tw -24.416 -1.152 Td [(I)2(nf)3(o F)-1(us)1(i)3(on)]TJ /TT0 1 Tf 0.006 Tc 4.686 0 Td [(,)4( )1(2)1(0)1(1)1(2)]TJ 0 Tc 0 Tw 2.525 0 Td (.)Tj 0.253 0 Td ( )Tj -9.736 -1.485 Td ([)Tj 0.005 Tc -0.005 Tw 0.336 0 Td (64)Tj 0 Tc 0 Tw (])Tj 1.346 0 Td ( )Tj 0.006 Tc -0.006 Tw 0.59 0 Td (Z.)Tj 0 Tc 0 Tw 0.87 0 Td ( )Tj 0.006 Tc 0.255 Tw 0.511 0 Td [(D)-1(u)1(a)2(n)1(,)4( )1(X)-1(.)4( )1(Ro)1(n)1(g)1( )1(L)1(i)4(,)4( )1(a)2(nd)2( )1(J)1(.)4( )]TJ 0.007 Tc -0.007 Tw (Ru)Tj 0 Tc 0 Tw 13.11 0 Td (,)Tj /TT2 1 Tf 0.253 0 Td ( )Tj /TT0 1 Tf 0.511 0 Td ( )Tj 0.004 Tc 0.257 Tw 0.511 0 Td [(\223)-1(D)-4(esi)1(g)-1(n)-1( an)-1(d)-1( A)-4(n)-1(al)1(y)-1(si)1(s o)-1(f L)-2(i)1(n)-1(ear )]TJ 0.354 Tw -15.764 -1.152 Td [(E)-2(q)-1(u)-1(al)1(i)1(t)1(y)-1( C)-3(o)-1(n)-1(st)1(r)1(ai)1(n)-1(ed)-1( D)-4(y)-1(n)-1(am)-4(i)1(c S)-2(y)-1(st)1(em)-4(s,)2(\224 )]TJ /TT1 1 Tf 0.005 Tc 0.296 Tw [(I)2(nt)3(.)3( C)-1(onf)3(.)3( on I)2(nf)3(or)1(m)-2(at)3(i)3(on )]TJ -0.005 Tw 0 -1.152 TD [(F)-1(us)1(i)2(on)]TJ /TT0 1 Tf 0.003 Tc -0.003 Tw [(,)1( )]TJ 0.005 Tc -0.005 Tw 3.311 0 Td (2012.)Tj 0 Tc 0 Tw 2.273 0 Td ( )Tj -7.856 -1.182 Td ([)Tj 0.005 Tc -0.005 Tw 0.336 0 Td (65)Tj 0 Tc 0 Tw (])Tj 1.346 0 Td ( )Tj 0.003 Tc 0.058 Tw 0.59 0 Td [(O)-4(.)1( )1(S)-2(t)1(ra)-1(k)-2(a)-1(,)1( )1(J)-1(.)1( )1(D)-4(u)-2(n)-2(\355)1(k)-2(,)1( )1(a)-1(n)-1(d)-2( )1(M)-6(.)1( )]TJ /C2_1 1 Tf 0 Tc 0 Tw 11.712 0 Td <0003>Tj /TT0 1 Tf 0.003 Tc -0.003 Tw 0.562 0 Td [(im)-5(a)-2(n)-3(d)-3(l,)]TJ /TT2 1 Tf 0 Tc 0 Tw 3.058 0 Td ( )Tj /TT0 1 Tf 0.311 0 Td ( )Tj 0.004 Tc 0.057 Tw 0.311 0 Td [(\223)-1(R)-3(an)-1(d)-1(o)-1(m)-4(i)1(zed)-1( U)-4(n)-1(scen)-1(t)1(ed)-1( K)-4(al)1(m)-4(an)-1( )]TJ -0.001 Tw -15.953 -1.152 Td [(F)-2(i)1(l)1(t)1(er i)1(n)-1( T)-2(arg)-1(et)1( T)-2(rack)-1(i)1(n)-1(g)-1(,)1(\224 )]TJ /TT1 1 Tf 0.003 Tc -0.003 Tw 10.967 0 Td [(In)-2(t)1(.)]TJ 0 Tc 0 Tw 1.375 0 Td ( )Tj 0.005 Tc -0.002 Tw 0.253 0 Td [(C)-2(onf)2(.)2( on I)1(nf)2(or)1(m)-3(at)2(i)2(on F)-1(us)1(i)2(on)]TJ /TT0 1 Tf 0.003 Tc -0.003 Tw 11.617 0 Td [(,)1( )]TJ 0.005 Tc -0.005 Tw 0.505 0 Td (2012.)Tj 0 Tc 0 Tw 2.273 0 Td ( )Tj -29.261 -1.121 Td ([)Tj 0.005 Tc -0.005 Tw 0.336 0 Td (66)Tj 0 Tc 0 Tw (])Tj 1.346 0 Td ( )Tj 0.005 Tc 0.221 Tw 0.59 0 Td [(L)-1(.)3( S)-1(c)1(hol)2(z)1(,)3( D)-3(.)3( L)-1(a)1(m)-3(be)1(r)2(t)2(,)3( D)-3(.)3( G)-3(os)1(s)1(i)2(nk,)3( a)1(nd G)-3(.)3( S)-1(m)-3(i)2(t)2(h,)3( \223A)-3( B)-2(l)2(ue)1(pr)2(i)2(nt)2( f)1(or)2( )]TJ 0.181 Tw T* [(C)-2(om)-3(m)-3(and and C)-2(ont)2(r)1(ol)2(:)2( A)-3(ut)2(om)-3(at)2(i)2(on and I)1(nt)2(er)1(f)1(ace,)2(\224 )]TJ /TT1 1 Tf 0.124 Tw 22.223 0 Td [(I)2(nt)3(.)3( C)-1(onf)3(.)3( on I)2(nf)3(o )]TJ -0.005 Tw -22.223 -1.121 Td [(F)-1(us)1(i)2(on)]TJ /TT0 1 Tf 0.006 Tc -0.003 Tw [(,)4( )1(2)1(0)1(1)1(2)]TJ 0 Tc 0 Tw 5.331 0 Td (.)Tj 0.253 0 Td ( )Tj -7.856 -1.485 Td ([)Tj 0.005 Tc -0.005 Tw 0.336 0 Td (67)Tj 0 Tc 0 Tw (])Tj 1.346 0 Td ( )Tj 0.002 Tc 0.152 Tw 0.59 0 Td [(E)-4(. B)-5(l)-1(a)-2(s)-2(c)-2(h)-3(, P)-4(. C)-5(. G)-6(. C)-5(o)-3(s)-2(t)-1(a)-2(, K)-6(. B)-5(. L)-4(a)-2(s)-2(k)-3(e)-2(y)-3(, )]TJ 0.003 Tc 17.861 0 Td [(D)-4(.)1( )1(S)-2(t)1(a)-1(m)-4(p)-2(o)-2(u)-3(l)1(i)1(,)1( )1(G)-4(.)1( )1(W)-6(.)1( )1(N)-4(g)-1(,)1( )1(J)-1(.)1( )]TJ 0.004 Tc 0.008 Tw -17.861 -1.152 Td [(S)-2(ch)-1(u)-1(b)-1(ert)1(,)1( R)-3(.)1( N)-4(ag)-1(i)1(,)1( an)-1(d)-1( P)-2( V)-4(al)1(i)1(n)-1(,)1( \223)-1(Issu)-1(es o)-1(f U)-4(n)-1(cert)1(ai)1(n)-1(t)1(y)-1( A)-4(n)-1(al)1(y)-1(si)1(s i)1(n)-1( H)-4(i)1(g)-1(h)]TJ 0 Tc 0 Tw 29.253 0 Td (-)Tj 0.004 Tc 0.031 Tw -29.253 -1.182 Td [(L)-1(e)1(ve)1(l)2( I)2(nf)1(or)2(m)-3(a)1(t)2(i)2(on F)-1(us)1(i)2(on )]TJ 0 Tc 0 Tw 10.716 0 Td (\226)Tj 0.504 0 Td ( )Tj 0.004 Tc 0.031 Tw 0.285 0 Td [(F)-1(us)1(i)2(on2012 P)-1(anel)2( D)-3(i)2(s)1(cus)1(s)1(i)2(on,)2(\224 )]TJ /TT1 1 Tf 0.005 Tc -0.003 Tw 12.986 0 Td [(I)2(nt)3(.)3( C)-1(onf)3(.)3( on )]TJ -24.492 -1.152 Td [(I)2(nf)3(o F)-1(us)1(i)3(on)]TJ /TT0 1 Tf 0.006 Tc 4.686 0 Td [(,)4( )1(2)1(0)1(1)1(2)1(.)4( )]TJ 0 Tc 0 Tw 3.03 0 Td ( )Tj -9.989 -1.152 Td ([)Tj 0.005 Tc -0.005 Tw 0.336 0 Td (68)Tj 0 Tc 0 Tw (])Tj 1.346 0 Td ( )Tj 0.003 Tc 0.115 Tw 0.59 0 Td [(P)-3(. C)-4(. G)-5(. C)-4(o)-2(s)-1(ta)-1(, E)-3(. P)-3(. B)-4(la)-1(s)-1(c)-1(h)-2(, K)-5(. B)-4(. L)-3(a)-1(s)-1(k)-2(e)-1(y)-2(, S)-3(. A)-5(n)-2(d)]TJ 0.116 Tw 21.642 0 Td [(le)-2(r)-1(, J)-2(. 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