{"id":"https://openalex.org/W1459017627","doi":"https://doi.org/10.4018/ijsda.2015100103","title":"Extracting Biological Significant Subnetworks from Protein-Protein Interactions Induced by Differentially Expressed Genes of HIV-1 Vpr Variants","display_name":"Extracting Biological Significant Subnetworks from Protein-Protein Interactions Induced by Differentially Expressed Genes of HIV-1 Vpr Variants","publication_year":2015,"publication_date":"2015-09-01","ids":{"openalex":"https://openalex.org/W1459017627","doi":"https://doi.org/10.4018/ijsda.2015100103","mag":"1459017627"},"language":"en","primary_location":{"is_oa":false,"landing_page_url":"https://doi.org/10.4018/ijsda.2015100103","pdf_url":null,"source":{"id":"https://openalex.org/S4210210041","display_name":"International Journal of System Dynamics Applications","issn_l":"2160-9772","issn":["2160-9772","2160-9799"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320424","host_organization_name":"IGI Global","host_organization_lineage":["https://openalex.org/P4310320424"],"host_organization_lineage_names":["IGI Global"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false},"type":"article","type_crossref":"journal-article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112356400","display_name":"Bandana Barman","orcid":null},"institutions":[{"id":"https://openalex.org/I77501641","display_name":"University of Kalyani","ror":"https://ror.org/03v783k16","country_code":"IN","type":"education","lineage":["https://openalex.org/I77501641"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Bandana Barman","raw_affiliation_strings":["[Department of Electronics and Communication Engineering, Kalyani Government Engineering College, Kalyani, India]"],"affiliations":[{"raw_affiliation_string":"[Department of Electronics and Communication Engineering, Kalyani Government Engineering College, Kalyani, India]","institution_ids":["https://openalex.org/I77501641"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016363044","display_name":"Anirban Mukhopadhyay","orcid":"https://orcid.org/0000-0001-8128-3521"},"institutions":[{"id":"https://openalex.org/I77501641","display_name":"University of Kalyani","ror":"https://ror.org/03v783k16","country_code":"IN","type":"education","lineage":["https://openalex.org/I77501641"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Anirban Mukhopadhyay","raw_affiliation_strings":["(Department of Computer Science & Engineering, University of Kalyani, Kalyani, India)"],"affiliations":[{"raw_affiliation_string":"(Department of Computer Science & Engineering, University of Kalyani, Kalyani, India)","institution_ids":["https://openalex.org/I77501641"]}]}],"institution_assertions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.126,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.464166,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":73,"max":76},"biblio":{"volume":"4","issue":"4","first_page":"35","last_page":"51"},"is_retracted":false,"is_paratext":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9997,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9997,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9967,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9922,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kegg","display_name":"KEGG","score":0.73376703},{"id":"https://openalex.org/keywords/false-discovery-rate","display_name":"False Discovery Rate","score":0.47847745}],"concepts":[{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.7989304},{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.73376703},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7282175},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.62044847},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5138788},{"id":"https://openalex.org/C193244246","wikidata":"https://www.wikidata.org/wiki/Q5432696","display_name":"False discovery rate","level":3,"score":0.47847745},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.45691544},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4436713},{"id":"https://openalex.org/C2987395477","wikidata":"https://www.wikidata.org/wiki/Q135085","display_name":"Gene ontology","level":4,"score":0.40542528},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.397654},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.06482014}],"mesh":[],"locations_count":1,"locations":[{"is_oa":false,"landing_page_url":"https://doi.org/10.4018/ijsda.2015100103","pdf_url":null,"source":{"id":"https://openalex.org/S4210210041","display_name":"International Journal of System Dynamics Applications","issn_l":"2160-9772","issn":["2160-9772","2160-9799"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320424","host_organization_name":"IGI Global","host_organization_lineage":["https://openalex.org/P4310320424"],"host_organization_lineage_names":["IGI Global"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.72,"id":"https://metadata.un.org/sdg/3"}],"grants":[],"datasets":[],"versions":[],"referenced_works_count":17,"referenced_works":["https://openalex.org/W1963522244","https://openalex.org/W1965138864","https://openalex.org/W1967180093","https://openalex.org/W1971289666","https://openalex.org/W1982684047","https://openalex.org/W2032769021","https://openalex.org/W2048677619","https://openalex.org/W2065341127","https://openalex.org/W2097720487","https://openalex.org/W2106620396","https://openalex.org/W2110065044","https://openalex.org/W2114365110","https://openalex.org/W2121702961","https://openalex.org/W2123172482","https://openalex.org/W2141407136","https://openalex.org/W2143308156","https://openalex.org/W2144742689"],"related_works":["https://openalex.org/W4386401670","https://openalex.org/W4313887725","https://openalex.org/W4296124993","https://openalex.org/W4229451835","https://openalex.org/W2956207900","https://openalex.org/W2939010697","https://openalex.org/W2790781282","https://openalex.org/W2551839783","https://openalex.org/W2334025507","https://openalex.org/W1970486251"],"abstract_inverted_index":{"Identification":[0],"of":[1,30,73,139,151],"protein":[2],"interaction":[3,121],"network":[4,122],"is":[5],"very":[6],"important":[7],"to":[8,52,75],"find":[9],"the":[10,22,54,66,68,112,117,129,135,148],"cell":[11],"signaling":[12],"pathway":[13,150],"for":[14],"a":[15,82],"particular":[16],"disease.":[17],"The":[18],"authors":[19,69,118,136],"have":[20,70],"found":[21,47,85,103,119],"differentially":[23,87,114],"expressed":[24,88,115],"genes":[25,55,89,106,116],"between":[26,90],"two":[27],"sample":[28,92],"groups":[29],"HIV-1.":[31],"Samples":[32],"are":[33],"wild":[34,93],"type":[35,94],"HIV-1":[36,39,95,98],"Vpr":[37,96],"and":[38,46,97,107,125,145],"mutant":[40,99],"Vpr.":[41],"They":[42,102],"did":[43],"statistical":[44],"t-test":[45],"false":[48],"discovery":[49],"rate":[50],"(FDR)":[51],"identify":[53,76],"increased":[56],"in":[57,62],"expression":[58,63],"(up-regulated)":[59],"or":[60],"decreased":[61],"(down-regulated).":[64],"In":[65],"test,":[67],"computed":[71],"q-values":[72],"test":[74],"minimum":[77],"FDR":[78],"which":[79],"occurs.":[80],"As":[81],"result":[83],"they":[84],"172":[86,113],"their":[91],"Vpr,":[100],"R80A.":[101],"68":[104],"up-regulated":[105],"104":[108],"down-regulated":[109],"genes.":[110],"From":[111],"protein-protein":[120],"with":[123,132,141],"string-db":[124],"then":[126],"clustered":[127],"(subnetworks)":[128],"PPI":[130],"networks":[131],"cytoscape3.0.":[133],"Lastly,":[134],"studied":[137,147],"significance":[138],"subnetworks":[140],"performing":[142],"gene":[143],"ontology":[144],"also":[146],"KEGG":[149],"those":[152],"subnetworks.":[153]},"cited_by_api_url":"https://api.openalex.org/works?filter=cites:W1459017627","counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2024-12-11T19:10:24.949249","created_date":"2016-06-24"}