{"id":"https://openalex.org/W4210371702","doi":"https://doi.org/10.3390/s22031136","title":"In Situ Flow Cytometer Calibration and Single-Molecule Resolution via Quantum Measurement","display_name":"In Situ Flow Cytometer Calibration and Single-Molecule Resolution via Quantum Measurement","publication_year":2022,"publication_date":"2022-02-02","ids":{"openalex":"https://openalex.org/W4210371702","doi":"https://doi.org/10.3390/s22031136","pmid":"https://pubmed.ncbi.nlm.nih.gov/35161882"},"language":"en","primary_location":{"is_oa":true,"landing_page_url":"https://doi.org/10.3390/s22031136","pdf_url":"https://www.mdpi.com/1424-8220/22/3/1136/pdf?version=1644475017","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true},"type":"article","type_crossref":"journal-article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1424-8220/22/3/1136/pdf?version=1644475017","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086746246","display_name":"Javier Sabines-Chesterking","orcid":null},"institutions":[{"id":"https://openalex.org/I4210151733","display_name":"Joint Quantum Institute","ror":"https://ror.org/04xz38214","country_code":"US","type":"facility","lineage":["https://openalex.org/I1321296531","https://openalex.org/I1343035065","https://openalex.org/I4210151733","https://openalex.org/I66946132"]},{"id":"https://openalex.org/I66946132","display_name":"University of Maryland, College Park","ror":"https://ror.org/047s2c258","country_code":"US","type":"education","lineage":["https://openalex.org/I66946132"]},{"id":"https://openalex.org/I1321296531","display_name":"National Institute of Standards and Technology","ror":"https://ror.org/05xpvk416","country_code":"US","type":"government","lineage":["https://openalex.org/I1321296531","https://openalex.org/I1343035065"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Javier Sabines-Chesterking","raw_affiliation_strings":["Joint Quantum Institute, University of Maryland, College Park, MD 20742, USA","National Institute of Standards and Technology, Gaithersburg, MD 20899, USA"],"affiliations":[{"raw_affiliation_string":"Joint Quantum Institute, University of Maryland, College Park, MD 20742, USA","institution_ids":["https://openalex.org/I4210151733","https://openalex.org/I66946132"]},{"raw_affiliation_string":"National Institute of Standards and Technology, Gaithersburg, MD 20899, USA","institution_ids":["https://openalex.org/I1321296531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017657634","display_name":"Ivan A. Burenkov","orcid":"https://orcid.org/0000-0001-5695-8339"},"institutions":[{"id":"https://openalex.org/I4210151733","display_name":"Joint Quantum Institute","ror":"https://ror.org/04xz38214","country_code":"US","type":"facility","lineage":["https://openalex.org/I1321296531","https://openalex.org/I1343035065","https://openalex.org/I4210151733","https://openalex.org/I66946132"]},{"id":"https://openalex.org/I66946132","display_name":"University of Maryland, College Park","ror":"https://ror.org/047s2c258","country_code":"US","type":"education","lineage":["https://openalex.org/I66946132"]},{"id":"https://openalex.org/I1321296531","display_name":"National Institute of Standards and Technology","ror":"https://ror.org/05xpvk416","country_code":"US","type":"government","lineage":["https://openalex.org/I1321296531","https://openalex.org/I1343035065"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ivan A. Burenkov","raw_affiliation_strings":["Joint Quantum Institute, University of Maryland, College Park, MD 20742, USA","National Institute of Standards and Technology, Gaithersburg, MD 20899, USA"],"affiliations":[{"raw_affiliation_string":"Joint Quantum Institute, University of Maryland, College Park, MD 20742, USA","institution_ids":["https://openalex.org/I4210151733","https://openalex.org/I66946132"]},{"raw_affiliation_string":"National Institute of Standards and Technology, Gaithersburg, MD 20899, USA","institution_ids":["https://openalex.org/I1321296531"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039864344","display_name":"Sergey V. Polyakov","orcid":"https://orcid.org/0000-0002-4601-0250"},"institutions":[{"id":"https://openalex.org/I66946132","display_name":"University of Maryland, College Park","ror":"https://ror.org/047s2c258","country_code":"US","type":"education","lineage":["https://openalex.org/I66946132"]},{"id":"https://openalex.org/I1321296531","display_name":"National Institute of Standards and Technology","ror":"https://ror.org/05xpvk416","country_code":"US","type":"government","lineage":["https://openalex.org/I1321296531","https://openalex.org/I1343035065"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sergey V. Polyakov","raw_affiliation_strings":["National Institute of Standards and Technology, Gaithersburg, MD 20899, USA","Physics Department, University of Maryland, College Park, MD 20742, USA"],"affiliations":[{"raw_affiliation_string":"Physics Department, University of Maryland, College Park, MD 20742, USA","institution_ids":["https://openalex.org/I66946132"]},{"raw_affiliation_string":"National Institute of Standards and Technology, Gaithersburg, MD 20899, USA","institution_ids":["https://openalex.org/I1321296531"]}]}],"institution_assertions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5039864344"],"corresponding_institution_ids":["https://openalex.org/I66946132","https://openalex.org/I1321296531"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2598,"provenance":"doaj"},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2598,"provenance":"doaj"},"fwci":0.385,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.573058,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":76,"max":80},"biblio":{"volume":"22","issue":"3","first_page":"1136","last_page":"1136"},"is_retracted":false,"is_paratext":false,"primary_topic":{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9993,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9993,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9925,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11393","display_name":"Biosensors and Analytical Detection","score":0.9917,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C165838908","wikidata":"https://www.wikidata.org/wiki/Q736777","display_name":"Calibration","level":2,"score":0.6539692},{"id":"https://openalex.org/C5297727","wikidata":"https://www.wikidata.org/wiki/Q786970","display_name":"Autocorrelation","level":2,"score":0.49728444},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.48713037},{"id":"https://openalex.org/C138268822","wikidata":"https://www.wikidata.org/wiki/Q1051925","display_name":"Resolution (logic)","level":2,"score":0.45238048},{"id":"https://openalex.org/C2779662365","wikidata":"https://www.wikidata.org/wiki/Q5416694","display_name":"Event (particle physics)","level":2,"score":0.43250224},{"id":"https://openalex.org/C99498987","wikidata":"https://www.wikidata.org/wiki/Q2210247","display_name":"Noise (video)","level":3,"score":0.4284938},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.4111834},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.33022818},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.29113203},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.2641709},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.17171821},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.13414645},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.10808131},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.102846265},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D017785","descriptor_name":"Photons","qualifier_ui":"","qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002138","descriptor_name":"Calibration","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059629","descriptor_name":"Signal-To-Noise Ratio","qualifier_ui":"","qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"is_oa":true,"landing_page_url":"https://doi.org/10.3390/s22031136","pdf_url":"https://www.mdpi.com/1424-8220/22/3/1136/pdf?version=1644475017","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":false,"landing_page_url":"https://doaj.org/article/c0d1f99241934299b61e39b1a5e00005","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false},{"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8839117","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":["National Institutes of Health"],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35161882","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":["National Institutes of Health"],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false}],"best_oa_location":{"is_oa":true,"landing_page_url":"https://doi.org/10.3390/s22031136","pdf_url":"https://www.mdpi.com/1424-8220/22/3/1136/pdf?version=1644475017","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true},"sustainable_development_goals":[],"grants":[],"datasets":[],"versions":[],"referenced_works_count":28,"referenced_works":["https://openalex.org/W1606579447","https://openalex.org/W1767380958","https://openalex.org/W1927190899","https://openalex.org/W1967534314","https://openalex.org/W1984748886","https://openalex.org/W2008685387","https://openalex.org/W2017204918","https://openalex.org/W2018426603","https://openalex.org/W2028044620","https://openalex.org/W2033948497","https://openalex.org/W2039109187","https://openalex.org/W2049201279","https://openalex.org/W2075164322","https://openalex.org/W2082947161","https://openalex.org/W2091068879","https://openalex.org/W2104437632","https://openalex.org/W2114961775","https://openalex.org/W2134867392","https://openalex.org/W2149042168","https://openalex.org/W2167656187","https://openalex.org/W2286340588","https://openalex.org/W2512004978","https://openalex.org/W2559076955","https://openalex.org/W2890636596","https://openalex.org/W3098507548","https://openalex.org/W3102954271","https://openalex.org/W4251108015","https://openalex.org/W4255297749"],"related_works":["https://openalex.org/W747394405","https://openalex.org/W3121354342","https://openalex.org/W2381153750","https://openalex.org/W2088220880","https://openalex.org/W2060952610","https://openalex.org/W2041235277","https://openalex.org/W2027411114","https://openalex.org/W2022021973","https://openalex.org/W1987236514","https://openalex.org/W174653542"],"abstract_inverted_index":{"Fluorescent":[0],"biomarkers":[1,15],"are":[2,16],"used":[3,59],"to":[4,25,38],"detect":[5,26],"target":[6],"molecules":[7],"within":[8],"inhomogeneous":[9],"populations":[10],"of":[11,50,68,75,87],"cells.":[12],"When":[13],"these":[14],"found":[17,63],"in":[18,29],"trace":[19],"amounts":[20],"it":[21],"becomes":[22],"extremely":[23],"challenging":[24],"their":[27],"presence":[28],"a":[30,36,40,51],"flow":[31,52],"cytometer.":[32],"Here,":[33],"we":[34],"present":[35],"framework":[37],"draw":[39],"detection":[41,61,77],"baseline":[42],"for":[43,78],"single":[44],"emitters":[45],"and":[46,62,104],"enable":[47],"absolute":[48],"calibration":[49],"cytometer":[53],"based":[54],"on":[55],"quantum":[56],"measurements.":[57],"We":[58,71,83],"single-photon":[60],"the":[64,73,88],"second-order":[65],"autocorrelation":[66],"function":[67],"fluorescent":[69],"light.":[70],"computed":[72],"success":[74],"rare-event":[76],"different":[79],"signal-to-noise":[80],"ratios":[81],"(SNR).":[82],"showed":[84],"high-accuracy":[85],"identification":[86],"events":[89],"with":[90],"occurrence":[91],"rates":[92],"below":[93],"10-5":[94],"even":[95],"at":[96],"modest":[97],"SNR":[98],"levels,":[99],"enabling":[100],"early":[101],"disease":[102],"diagnostics":[103],"post-disease":[105],"monitoring.":[106]},"cited_by_api_url":"https://api.openalex.org/works?filter=cites:W4210371702","counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2}],"updated_date":"2025-01-08T16:45:03.327557","created_date":"2022-02-08"}