{"id":"https://openalex.org/W4391404813","doi":"https://doi.org/10.3390/jimaging10020039","title":"Evaluation of Non-Invasive Methods for (R)-[11C]PK11195 PET Image Quantification in Multiple Sclerosis","display_name":"Evaluation of Non-Invasive Methods for (R)-[11C]PK11195 PET Image Quantification in Multiple Sclerosis","publication_year":2024,"publication_date":"2024-01-31","ids":{"openalex":"https://openalex.org/W4391404813","doi":"https://doi.org/10.3390/jimaging10020039","pmid":"https://pubmed.ncbi.nlm.nih.gov/38392087"},"language":"en","primary_location":{"is_oa":true,"landing_page_url":"https://doi.org/10.3390/jimaging10020039","pdf_url":"https://www.mdpi.com/2313-433X/10/2/39/pdf?version=1706693292","source":{"id":"https://openalex.org/S2736465063","display_name":"Journal of Imaging","issn_l":"2313-433X","issn":["2313-433X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true},"type":"article","type_crossref":"journal-article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2313-433X/10/2/39/pdf?version=1706693292","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072708004","display_name":"Dimitri Brigide de Almeida Mantovani","orcid":"https://orcid.org/0000-0003-4883-4680"},"institutions":[{"id":"https://openalex.org/I4210145268","display_name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo","ror":"https://ror.org/03se9eg94","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210145268"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Dimitri B. A. Mantovani","raw_affiliation_strings":["Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo 05403-911, Brazil"],"affiliations":[{"raw_affiliation_string":"Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo 05403-911, Brazil","institution_ids":["https://openalex.org/I4210145268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030013257","display_name":"Milena Sales Pitombeira","orcid":"https://orcid.org/0000-0002-3298-0264"},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Milena S. Pitombeira","raw_affiliation_strings":["Laboratory of Nuclear Medicine (LIM 43), Department of Radiology and Oncology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo 05403-911, Brazil"],"affiliations":[{"raw_affiliation_string":"Laboratory of Nuclear Medicine (LIM 43), Department of Radiology and Oncology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo 05403-911, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085359478","display_name":"Phelipi Nunes Schuck","orcid":"https://orcid.org/0000-0002-8864-8674"},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Phelipi N. Schuck","raw_affiliation_strings":["Weill Cornell Medical College, New York, NY 10065, USA"],"affiliations":[{"raw_affiliation_string":"Weill Cornell Medical College, New York, NY 10065, USA","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024769316","display_name":"Adriel Silva de Ara\u00fajo","orcid":"https://orcid.org/0000-0001-7537-1867"},"institutions":[{"id":"https://openalex.org/I45643870","display_name":"Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul","ror":"https://ror.org/025vmq686","country_code":"BR","type":"education","lineage":["https://openalex.org/I45643870"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Adriel S. de Ara\u00fajo","raw_affiliation_strings":["Graduate Program in Computer Science, Pontificia Universidade Catolica do Rio Grande do Sul PUCRS, Porto Alegre 90619-900, Brazil"],"affiliations":[{"raw_affiliation_string":"Graduate Program in Computer Science, Pontificia Universidade Catolica do Rio Grande do Sul PUCRS, Porto Alegre 90619-900, Brazil","institution_ids":["https://openalex.org/I45643870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055580205","display_name":"Carlos Alberto Buchpiguel","orcid":"https://orcid.org/0000-0003-0956-2790"},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Carlos Alberto Buchpiguel","raw_affiliation_strings":["Laboratory of Nuclear Medicine (LIM 43), Department of Radiology and Oncology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo 05403-911, Brazil"],"affiliations":[{"raw_affiliation_string":"Laboratory of Nuclear Medicine (LIM 43), Department of Radiology and Oncology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo 05403-911, Brazil","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007804149","display_name":"Daniele de Paula Faria","orcid":"https://orcid.org/0000-0002-1766-2786"},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Daniele de Paula Faria","raw_affiliation_strings":["Laboratory of Nuclear Medicine (LIM 43), Department of Radiology and Oncology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo 05403-911, Brazil"],"affiliations":[{"raw_affiliation_string":"Laboratory of Nuclear Medicine (LIM 43), Department of Radiology and Oncology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo 05403-911, Brazil","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I17974374"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016676023","display_name":"Ana Maria Marques da Silva","orcid":"https://orcid.org/0000-0002-5924-6852"},"institutions":[{"id":"https://openalex.org/I4210145268","display_name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo","ror":"https://ror.org/03se9eg94","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210145268"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ana Maria M. da Silva","raw_affiliation_strings":["Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo 05403-911, Brazil"],"affiliations":[{"raw_affiliation_string":"Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo 05403-911, Brazil","institution_ids":["https://openalex.org/I4210145268"]}]}],"institution_assertions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5007804149"],"corresponding_institution_ids":["https://openalex.org/I17974374"],"apc_list":{"value":1600,"currency":"CHF","value_usd":1732,"provenance":"doaj"},"apc_paid":{"value":1600,"currency":"CHF","value_usd":1732,"provenance":"doaj"},"fwci":0.0,"has_fulltext":true,"fulltext_origin":"pdf","cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":0,"max":83},"biblio":{"volume":"10","issue":"2","first_page":"39","last_page":"39"},"is_retracted":false,"is_paratext":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9959,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9959,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9561,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.9545,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/putamen","display_name":"Putamen","score":0.7692665},{"id":"https://openalex.org/keywords/caudate-nucleus","display_name":"Caudate nucleus","score":0.5194175}],"concepts":[{"id":"https://openalex.org/C2779714222","wikidata":"https://www.wikidata.org/wiki/Q550934","display_name":"Putamen","level":2,"score":0.7692665},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.6920346},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.6095216},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.575287},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.56537724},{"id":"https://openalex.org/C551621295","wikidata":"https://www.wikidata.org/wiki/Q182228","display_name":"Brainstem","level":2,"score":0.547572},{"id":"https://openalex.org/C2779246727","wikidata":"https://www.wikidata.org/wiki/Q184215","display_name":"Thalamus","level":2,"score":0.5376872},{"id":"https://openalex.org/C2781423529","wikidata":"https://www.wikidata.org/wiki/Q1132309","display_name":"Caudate nucleus","level":2,"score":0.5194175},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.35722542},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29633778},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.2657482}],"mesh":[],"locations_count":3,"locations":[{"is_oa":true,"landing_page_url":"https://doi.org/10.3390/jimaging10020039","pdf_url":"https://www.mdpi.com/2313-433X/10/2/39/pdf?version=1706693292","source":{"id":"https://openalex.org/S2736465063","display_name":"Journal of Imaging","issn_l":"2313-433X","issn":["2313-433X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10889702","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":["National Institutes of Health"],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38392087","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":["National Institutes of Health"],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false}],"best_oa_location":{"is_oa":true,"landing_page_url":"https://doi.org/10.3390/jimaging10020039","pdf_url":"https://www.mdpi.com/2313-433X/10/2/39/pdf?version=1706693292","source":{"id":"https://openalex.org/S2736465063","display_name":"Journal of Imaging","issn_l":"2313-433X","issn":["2313-433X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.63}],"grants":[],"datasets":[],"versions":[],"referenced_works_count":34,"referenced_works":["https://openalex.org/W1979473451","https://openalex.org/W2013254203","https://openalex.org/W2036527156","https://openalex.org/W2049546272","https://openalex.org/W2054929374","https://openalex.org/W2067347526","https://openalex.org/W2104595674","https://openalex.org/W2111352290","https://openalex.org/W2116138279","https://openalex.org/W2127325484","https://openalex.org/W2127897405","https://openalex.org/W2128526036","https://openalex.org/W2129965408","https://openalex.org/W2148602027","https://openalex.org/W2156612134","https://openalex.org/W2160879352","https://openalex.org/W2308891363","https://openalex.org/W2321904707","https://openalex.org/W2485658681","https://openalex.org/W2582092343","https://openalex.org/W2597697444","https://openalex.org/W2609200668","https://openalex.org/W2616489368","https://openalex.org/W2724559439","https://openalex.org/W2770089247","https://openalex.org/W2792364172","https://openalex.org/W2886053311","https://openalex.org/W2904004727","https://openalex.org/W3088997143","https://openalex.org/W3135575967","https://openalex.org/W3147457502","https://openalex.org/W3158189176","https://openalex.org/W4285589426","https://openalex.org/W4317107890"],"related_works":["https://openalex.org/W998151349","https://openalex.org/W4229952405","https://openalex.org/W3187281143","https://openalex.org/W2413912790","https://openalex.org/W2368029811","https://openalex.org/W2349665762","https://openalex.org/W2081178549","https://openalex.org/W1998309022","https://openalex.org/W1982205783","https://openalex.org/W174059960"],"abstract_inverted_index":{"This":[0],"study":[1,194],"aims":[2],"to":[3,134,211],"evaluate":[4],"non-invasive":[5,147],"PET":[6,32],"quantification":[7,108],"methods":[8,109,148],"for":[9,96,152,156,200,205],"(R)-[11C]PK11195":[10,31,165],"uptake":[11,166],"measurement":[12],"in":[13,22,50,118,143,209],"multiple":[14],"sclerosis":[15],"(MS)":[16],"patients":[17,131,173],"and":[18,33,43,62,75,87,98,100,127,149,154,174,179,191,214],"healthy":[19],"controls":[20],"(HC)":[21],"comparison":[23],"with":[24],"arterial":[25],"input":[26,68],"function":[27,69],"(AIF)":[28],"using":[29,64,92,176,203],"dynamic":[30],"magnetic":[34],"resonance":[35],"images.":[36],"The":[37],"total":[38],"volume":[39,45],"of":[40,129],"distribution":[41,44],"(VT)":[42],"ratio":[46],"(DVR)":[47],"were":[48,90,110,116,141],"measured":[49],"the":[51,66,72,103,106,119,135,162,197],"gray":[52,120],"matter,":[53,55,121,123],"white":[54,122],"caudate":[56],"nucleus,":[57],"putamen,":[58,124],"pallidum,":[59,125],"thalamus,":[60,126],"cerebellum,":[61],"brainstem":[63,128],"AIF,":[65],"image-derived":[67],"(IDIF)":[70],"from":[71,78,105],"carotid":[73],"arteries,":[74],"pseudo-reference":[76],"regions":[77],"supervised":[79],"clustering":[80],"analysis":[81],"(SVCA).":[82],"Uptake":[83],"differences":[84,115],"between":[85,102,146,171,189],"MS":[86,130,172],"HC":[88,136,175],"groups":[89],"tested":[91],"statistical":[93],"tests":[94],"adjusted":[95],"age":[97],"sex,":[99],"correlations":[101,140],"results":[104],"different":[107],"also":[111],"analyzed.":[112],"Significant":[113],"DVR":[114,144],"observed":[117],"when":[132],"compared":[133],"group.":[137],"Also,":[138],"strong":[139],"found":[142,188],"values":[145],"AIF":[150,201],"(0.928":[151],"IDIF":[153],"0.975":[155],"SVCA,":[157],"p":[158,184],"<":[159,185],"0.0001).":[160],"On":[161],"other":[163],"hand,":[164],"could":[167],"not":[168],"be":[169],"differentiated":[170],"VT":[177],"values,":[178],"a":[180,212],"weak":[181],"correlation":[182],"(0.356,":[183],"0.0001)":[186],"was":[187],"VTAIF":[190],"VTIDIF.":[192],"Our":[193],"shows":[195],"that":[196],"best":[198],"alternative":[199],"is":[202],"SVCA":[204],"reference":[206],"region":[207],"modeling,":[208],"addition":[210],"cautious":[213],"appropriate":[215],"methodology.":[216]},"cited_by_api_url":"https://api.openalex.org/works?filter=cites:W4391404813","counts_by_year":[],"updated_date":"2025-01-08T22:19:29.292310","created_date":"2024-02-01"}