乐胖代购免代理版

{"id":"https://openalex.org/W4281647038","doi":"https://doi.org/10.3389/frai.2022.660581","title":"Targeted Screening for Alzheimer's Disease Clinical Trials Using Data-Driven Disease Progression Models","display_name":"Targeted Screening for Alzheimer's Disease Clinical Trials Using Data-Driven Disease Progression Models","publication_year":2022,"publication_date":"2022-05-26","ids":{"openalex":"https://openalex.org/W4281647038","doi":"https://doi.org/10.3389/frai.2022.660581","pmid":"https://pubmed.ncbi.nlm.nih.gov/35719690"},"language":"en","primary_location":{"is_oa":true,"landing_page_url":"https://doi.org/10.3389/frai.2022.660581","pdf_url":"https://www.frontiersin.org/articles/10.3389/frai.2022.660581/pdf","source":{"id":"https://openalex.org/S4210197006","display_name":"Frontiers in Artificial Intelligence","issn_l":"2624-8212","issn":["2624-8212"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true},"type":"article","type_crossref":"journal-article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/frai.2022.660581/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075265609","display_name":"Neil P. Oxtoby","orcid":"https://orcid.org/0000-0003-0203-3909"},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Neil P. Oxtoby","raw_affiliation_strings":["Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086174310","display_name":"Cameron Shand","orcid":"https://orcid.org/0000-0002-1299-890X"},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Cameron Shand","raw_affiliation_strings":["Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042212695","display_name":"David M. Cash","orcid":"https://orcid.org/0000-0001-7833-616X"},"institutions":[{"id":"https://openalex.org/I4210126463","display_name":"UK Dementia Research Institute","ror":"https://ror.org/02wedp412","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210126463"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I4210151618","display_name":"National Hospital for Neurology and Neurosurgery","ror":"https://ror.org/048b34d51","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1340918713","https://openalex.org/I4210151618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David M. Cash","raw_affiliation_strings":["Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom","institution_ids":["https://openalex.org/I4210126463","https://openalex.org/I45129253","https://openalex.org/I4210151618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033449704","display_name":"Daniel C. Alexander","orcid":"https://orcid.org/0000-0003-2439-350X"},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Daniel C. Alexander","raw_affiliation_strings":["Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064378373","display_name":"Frederik Barkhof","orcid":"https://orcid.org/0000-0003-3543-3706"},"institutions":[{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB","NL"],"is_corresponding":false,"raw_author_name":"Frederik Barkhof","raw_affiliation_strings":["Amsterdam University Medical Center, Amsterdam, Netherlands","Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Amsterdam University Medical Center, Amsterdam, Netherlands","institution_ids":["https://openalex.org/I4210151833"]},{"raw_affiliation_string":"Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]}],"institution_assertions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5075265609"],"corresponding_institution_ids":["https://openalex.org/I45129253"],"apc_list":{"value":1150,"currency":"USD","value_usd":1150,"provenance":"doaj"},"apc_paid":{"value":1150,"currency":"USD","value_usd":1150,"provenance":"doaj"},"fwci":2.647,"has_fulltext":true,"fulltext_origin":"pdf","cited_by_count":10,"citation_normalized_percentile":{"value":0.999911,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":92},"biblio":{"volume":"5","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9962,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9962,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.995,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.9886,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2780904820","wikidata":"https://www.wikidata.org/wiki/Q415081","display_name":"Donepezil","level":4,"score":0.79869986},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.7666775},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6806954},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.64751923},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.566179},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.47915763},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.4638799},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.38326973},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34938315},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.33868885},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.19354069}],"mesh":[],"locations_count":7,"locations":[{"is_oa":true,"landing_page_url":"https://doi.org/10.3389/frai.2022.660581","pdf_url":"https://www.frontiersin.org/articles/10.3389/frai.2022.660581/pdf","source":{"id":"https://openalex.org/S4210197006","display_name":"Frontiers in Artificial Intelligence","issn_l":"2624-8212","issn":["2624-8212"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":false,"landing_page_url":"https://doaj.org/article/3eddaef796fb49b5afff0bec1bc41404","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false},{"is_oa":true,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10150948/","pdf_url":"https://discovery.ucl.ac.uk/10150948/1/Barkhof_Targeted%20Screening%20for%20Alzheimer%27s%20Disease%20Clinical%20Trials%20Using%20Data-Driven%20Disease%20Progression%20Models_VoR.pdf","source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":["University College London"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":true,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10150948/1/Barkhof_Targeted%20Screening%20for%20Alzheimer%27s%20Disease%20Clinical%20Trials%20Using%20Data-Driven%20Disease%20Progression%20Models_VoR.pdf","pdf_url":"https://discovery.ucl.ac.uk/id/eprint/10150948/1/Barkhof_Targeted%20Screening%20for%20Alzheimer%27s%20Disease%20Clinical%20Trials%20Using%20Data-Driven%20Disease%20Progression%20Models_VoR.pdf","source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":["University College London"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9204250","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":["National Institutes of Health"],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.01.29.21250773","pdf_url":null,"source":{"id":"https://openalex.org/S4306400573","display_name":"medRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory"],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false},{"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35719690","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":["National Institutes of Health"],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false}],"best_oa_location":{"is_oa":true,"landing_page_url":"https://doi.org/10.3389/frai.2022.660581","pdf_url":"https://www.frontiersin.org/articles/10.3389/frai.2022.660581/pdf","source":{"id":"https://openalex.org/S4210197006","display_name":"Frontiers in Artificial Intelligence","issn_l":"2624-8212","issn":["2624-8212"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.71}],"grants":[{"funder":"https://openalex.org/F4320314731","funder_display_name":"UK Research and Innovation","award_id":"MR/S03546X/1"},{"funder":"https://openalex.org/F4320335254","funder_display_name":"Horizon 2020","award_id":"666992"},{"funder":"https://openalex.org/F4320335827","funder_display_name":"UCLH Biomedical Research Centre","award_id":null}],"datasets":[],"versions":[],"referenced_works_count":33,"referenced_works":["https://openalex.org/W1968698114","https://openalex.org/W2063808031","https://openalex.org/W2098931866","https://openalex.org/W2103440561","https://openalex.org/W2107820540","https://openalex.org/W2136195493","https://openalex.org/W2146249493","https://openalex.org/W2148020885","https://openalex.org/W2167840686","https://openalex.org/W2168818001","https://openalex.org/W2236030964","https://openalex.org/W2517281879","https://openalex.org/W2615239903","https://openalex.org/W2617072792","https://openalex.org/W2740614417","https://openalex.org/W2755089181","https://openalex.org/W2773092061","https://openalex.org/W2782660935","https://openalex.org/W2789238556","https://openalex.org/W2791743234","https://openalex.org/W2796149904","https://openalex.org/W2802652408","https://openalex.org/W2899192510","https://openalex.org/W2918066696","https://openalex.org/W2952686744","https://openalex.org/W2960505072","https://openalex.org/W2981108121","https://openalex.org/W3005937372","https://openalex.org/W3031318751","https://openalex.org/W3043145818","https://openalex.org/W3046738083","https://openalex.org/W3128740055","https://openalex.org/W4250105389"],"related_works":["https://openalex.org/W4300703342","https://openalex.org/W4243835735","https://openalex.org/W3004549232","https://openalex.org/W2746912932","https://openalex.org/W2384834241","https://openalex.org/W2358172777","https://openalex.org/W2255819722","https://openalex.org/W2054508901","https://openalex.org/W2053254879","https://openalex.org/W2027037947"],"abstract_inverted_index":{"Heterogeneity":[0],"in":[1,30,82,136],"Alzheimer's":[2],"disease":[3,84],"progression":[4,85],"contributes":[5],"to":[6,10,53,87,92,96],"the":[7,22,50,56,94,107,118,162],"ongoing":[8],"failure":[9],"demonstrate":[11,117],"efficacy":[12],"of":[13,33,49,112,120,134],"putative":[14],"disease-modifying":[15],"therapeutics":[16],"that":[17,65,78],"have":[18,45],"been":[19,46],"trialed":[20],"over":[21],"past":[23],"two":[24],"decades.":[25],"Any":[26],"treatment":[27,97,157],"effect":[28,98],"present":[29],"a":[31,74,113,122,129,146],"subgroup":[32,148],"trial":[34,133],"participants":[35],"(responders)":[36],"can":[37],"be":[38],"diluted":[39],"by":[40,99,126],"non-responders":[41],"who":[42,154],"ideally":[43],"should":[44],"screened":[47],"out":[48,101],"trial.":[51,115],"How":[52],"identify":[54],"(screen-in)":[55],"most":[57],"likely":[58],"potential":[59],"responders":[60],"is":[61,66],"an":[62,69],"important":[63],"question":[64],"still":[67],"without":[68],"answer.":[70],"Here,":[71],"we":[72],"pilot":[73],"computational":[75,123],"screening":[76,100,124],"tool":[77,125],"leverages":[79],"recent":[80],"advances":[81],"data-driven":[83,147],"modeling":[86],"improve":[88],"stratification.":[89],"This":[90],"aims":[91],"increase":[93],"sensitivity":[95],"non-responders,":[102],"which":[103],"will":[104],"ultimately":[105],"reduce":[106],"size,":[108],"duration,":[109],"and":[110],"cost":[111],"clinical":[114,132],"We":[116],"concept":[119],"such":[121],"retrospectively":[127],"analyzing":[128],"completed":[130],"double-blind":[131],"donepezil":[135],"people":[137],"with":[138],"amnestic":[139],"mild":[140],"cognitive":[141,152],"impairment":[142,153],"(clinicaltrials.gov:":[143],"NCT00000173),":[144],"identifying":[145],"having":[149],"more":[150],"severe":[151],"showed":[155],"clearer":[156],"response":[158],"than":[159],"observed":[160],"for":[161],"full":[163],"cohort.":[164]},"cited_by_api_url":"https://api.openalex.org/works?filter=cites:W4281647038","counts_by_year":[{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1}],"updated_date":"2024-12-10T04:35:10.834650","created_date":"2022-06-13"}