{"id":"https://openalex.org/W4322628704","doi":"https://doi.org/10.32614/rj-2023-018","title":"pCODE: Estimating Parameters of ODE Models","display_name":"pCODE: Estimating Parameters of ODE Models","publication_year":2023,"publication_date":"2023-02-10","ids":{"openalex":"https://openalex.org/W4322628704","doi":"https://doi.org/10.32614/rj-2023-018"},"language":"en","primary_location":{"is_oa":true,"landing_page_url":"https://doi.org/10.32614/rj-2023-018","pdf_url":"https://journal.r-project.org/articles/RJ-2023-018/RJ-2023-018.pdf","source":{"id":"https://openalex.org/S2489169438","display_name":"The R Journal","issn_l":"2073-4859","issn":["2073-4859"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true},"type":"article","type_crossref":"journal-article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journal.r-project.org/articles/RJ-2023-018/RJ-2023-018.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004129270","display_name":"Haixu Wang","orcid":"https://orcid.org/0009-0000-4848-4890"},"institutions":[{"id":"https://openalex.org/I18014758","display_name":"Simon Fraser University","ror":"https://ror.org/0213rcc28","country_code":"CA","type":"education","lineage":["https://openalex.org/I18014758"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Haixu Wang","raw_affiliation_strings":["Simon Fraser University"],"affiliations":[{"raw_affiliation_string":"Simon Fraser University","institution_ids":["https://openalex.org/I18014758"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062483690","display_name":"Jiguo Cao","orcid":"https://orcid.org/0000-0001-7417-6330"},"institutions":[{"id":"https://openalex.org/I18014758","display_name":"Simon Fraser University","ror":"https://ror.org/0213rcc28","country_code":"CA","type":"education","lineage":["https://openalex.org/I18014758"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jiguo Cao","raw_affiliation_strings":["Simon Fraser University"],"affiliations":[{"raw_affiliation_string":"Simon Fraser University","institution_ids":["https://openalex.org/I18014758"]}]}],"institution_assertions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"fulltext_origin":"pdf","cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":0,"max":68},"biblio":{"volume":"14","issue":"4","first_page":"291","last_page":"304"},"is_retracted":false,"is_paratext":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9938,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9938,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9927,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.983,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ode","display_name":"Ode","score":0.96532124},{"id":"https://openalex.org/keywords/hessian-matrix","display_name":"Hessian matrix","score":0.8551791}],"concepts":[{"id":"https://openalex.org/C34862557","wikidata":"https://www.wikidata.org/wiki/Q178985","display_name":"Ode","level":2,"score":0.96532124},{"id":"https://openalex.org/C203616005","wikidata":"https://www.wikidata.org/wiki/Q620495","display_name":"Hessian matrix","level":2,"score":0.8551791},{"id":"https://openalex.org/C200331156","wikidata":"https://www.wikidata.org/wiki/Q506041","display_name":"Jacobian matrix and determinant","level":2,"score":0.66813296},{"id":"https://openalex.org/C51544822","wikidata":"https://www.wikidata.org/wiki/Q465274","display_name":"Ordinary differential equation","level":3,"score":0.62050956},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6124978},{"id":"https://openalex.org/C34146451","wikidata":"https://www.wikidata.org/wiki/Q5048094","display_name":"Cascade","level":2,"score":0.60498387},{"id":"https://openalex.org/C28826006","wikidata":"https://www.wikidata.org/wiki/Q33521","display_name":"Applied mathematics","level":1,"score":0.5631051},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.4758641},{"id":"https://openalex.org/C167928553","wikidata":"https://www.wikidata.org/wiki/Q1376021","display_name":"Estimation theory","level":2,"score":0.46392545},{"id":"https://openalex.org/C79379906","wikidata":"https://www.wikidata.org/wiki/Q3174497","display_name":"Dynamical systems theory","level":2,"score":0.4523833},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.35932487},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.32026777},{"id":"https://openalex.org/C78045399","wikidata":"https://www.wikidata.org/wiki/Q11214","display_name":"Differential equation","level":2,"score":0.28590712},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.08119303},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"is_oa":true,"landing_page_url":"https://doi.org/10.32614/rj-2023-018","pdf_url":"https://journal.r-project.org/articles/RJ-2023-018/RJ-2023-018.pdf","source":{"id":"https://openalex.org/S2489169438","display_name":"The R Journal","issn_l":"2073-4859","issn":["2073-4859"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true}],"best_oa_location":{"is_oa":true,"landing_page_url":"https://doi.org/10.32614/rj-2023-018","pdf_url":"https://journal.r-project.org/articles/RJ-2023-018/RJ-2023-018.pdf","source":{"id":"https://openalex.org/S2489169438","display_name":"The R Journal","issn_l":"2073-4859","issn":["2073-4859"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true},"sustainable_development_goals":[],"grants":[],"datasets":[],"versions":[],"referenced_works_count":20,"referenced_works":["https://openalex.org/W1544097513","https://openalex.org/W1575978816","https://openalex.org/W1750424384","https://openalex.org/W2015781727","https://openalex.org/W2020102996","https://openalex.org/W2037392129","https://openalex.org/W2051866702","https://openalex.org/W2062183865","https://openalex.org/W2065536645","https://openalex.org/W2090142805","https://openalex.org/W2092202824","https://openalex.org/W2094547604","https://openalex.org/W2136829296","https://openalex.org/W2168910593","https://openalex.org/W2554158543","https://openalex.org/W3023906401","https://openalex.org/W3098144642","https://openalex.org/W4247602145","https://openalex.org/W4292156489","https://openalex.org/W4399569404"],"related_works":["https://openalex.org/W4298147562","https://openalex.org/W4280491311","https://openalex.org/W3161724164","https://openalex.org/W3031379238","https://openalex.org/W2435809071","https://openalex.org/W2149675122","https://openalex.org/W2024851320","https://openalex.org/W1979854074","https://openalex.org/W1977478463","https://openalex.org/W1972505059"],"abstract_inverted_index":{"The":[0,72,195],"ordinary":[1],"differential":[2],"equation":[3],"(ODE)":[4],"models":[5,30,220],"are":[6,50,165,224],"prominent":[7],"to":[8,59,82,120,152,168,216,226],"characterize":[9],"the":[10,26,36,41,44,61,65,91,105,108,122,127,133,140,154,160,163,177,192,231],"mechanism":[11],"of":[12,28,40,46,56,67,87,132],"dynamical":[13,42],"systems":[14,69],"with":[15,104,187,201,205],"various":[16,206],"applications":[17],"in":[18,107,117,176],"biology,":[19],"engineering,":[20],"and":[21,130,135,190,199,228],"many":[22],"other":[23],"areas.":[24],"While":[25],"form":[27],"ODE":[29,47,62,88,184,219],"is":[31,55,80,101,126,197],"often":[32,51],"proposed":[33,77],"based":[34],"on":[35],"understanding":[37],"or":[38,172],"assumption":[39],"systems,":[43],"values":[45],"model":[48],"parameters":[49,63,89,185],"unknown.":[52],"Hence,":[53],"it":[54],"great":[57],"interest":[58],"estimate":[60,217],"once":[64],"observations":[66,93],"dynamic":[68],"become":[70],"available.":[71],"parameter":[73,123,155],"cascade":[74,124,156],"method":[75,100,125],"initially":[76],"by":[78,112,139],"[@parcascade]":[79],"shown":[81],"provide":[83,169],"an":[84,148,234],"accurate":[85],"estimation":[86],"from":[90],"noisy":[92],"at":[94,238],"a":[95,213],"low":[96],"computational":[97],"cost.":[98],"This":[99],"further":[102],"promoted":[103],"implementation":[106],"R":[109,149],"package":[110,150,179,196,232],"CollocInfer":[111,119],"[@CollocInfer].":[113],"However,":[114],"one":[115],"bottleneck":[116],"using":[118],"implement":[121,153],"tedious":[128],"derivations":[129],"coding":[131],"Jacobian":[134,171],"Hessian":[136,173],"matrices":[137],"required":[138,167],"objective":[141],"functions":[142,223],"for":[143,182],"doing":[144],"estimation.":[145],"We":[146,208],"develop":[147],"pCODE":[151,178,211],"method,":[157],"which":[158],"has":[159,233],"advantage":[161],"that":[162,210],"users":[164,181],"not":[166],"any":[170,218],"matrices.":[174],"Functions":[175],"accommodate":[180],"estimating":[183],"along":[186],"their":[188],"variances":[189],"tuning":[191],"smoothing":[193],"parameters.":[194],"demonstrated":[198],"assessed":[200],"four":[202],"simulation":[203],"examples":[204],"settings.":[207],"show":[209],"offers":[212],"derivative-free":[214],"procedure":[215],"where":[221],"its":[222],"easy":[225],"understand":[227],"apply.":[229],"Furthermore,":[230],"online":[235],"Shiny":[236],"app":[237],".":[239]},"cited_by_api_url":"https://api.openalex.org/works?filter=cites:W4322628704","counts_by_year":[],"updated_date":"2024-12-11T21:59:47.343667","created_date":"2023-03-01"}