乐胖代购免代理版

{"id":"https://openalex.org/W4285794542","doi":"https://doi.org/10.1515/jib-2022-0003","title":"A hybrid of Bees algorithm and regulatory on/off minimization for optimizing lactate and succinate production","display_name":"A hybrid of Bees algorithm and regulatory on/off minimization for optimizing lactate and succinate production","publication_year":2022,"publication_date":"2022-07-19","ids":{"openalex":"https://openalex.org/W4285794542","doi":"https://doi.org/10.1515/jib-2022-0003","pmid":"https://pubmed.ncbi.nlm.nih.gov/35852123"},"language":"en","primary_location":{"is_oa":true,"landing_page_url":"https://doi.org/10.1515/jib-2022-0003","pdf_url":"https://www.degruyter.com/document/doi/10.1515/jib-2022-0003/pdf","source":{"id":"https://openalex.org/S4393917359","display_name":"Berichte aus der medizinischen Informatik und Bioinformatik/Journal of integrative bioinformatics","issn_l":"1432-4385","issn":["1432-4385","1613-4516"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true},"type":"article","type_crossref":"journal-article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.degruyter.com/document/doi/10.1515/jib-2022-0003/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086929033","display_name":"Mohd Izzat Yong","orcid":null},"institutions":[{"id":"https://openalex.org/I4576418","display_name":"University of Technology Malaysia","ror":"https://ror.org/026w31v75","country_code":"MY","type":"education","lineage":["https://openalex.org/I4576418"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Mohd Izzat Yong","raw_affiliation_strings":["Artificial Intelligence and Bioinformatics Research Group, Faculty of Computing , Universiti Teknologi Malaysia , 81310 Johor , Malaysia"],"affiliations":[{"raw_affiliation_string":"Artificial Intelligence and Bioinformatics Research Group, Faculty of Computing , Universiti Teknologi Malaysia , 81310 Johor , Malaysia","institution_ids":["https://openalex.org/I4576418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085034566","display_name":"Mohd Saberi Mohamad","orcid":"https://orcid.org/0000-0002-1079-4559"},"institutions":[{"id":"https://openalex.org/I201726411","display_name":"United Arab Emirates University","ror":"https://ror.org/01km6p862","country_code":"AE","type":"education","lineage":["https://openalex.org/I201726411"]}],"countries":["AE"],"is_corresponding":true,"raw_author_name":"Mohd Saberi Mohamad","raw_affiliation_strings":["Big Data Analytics Center , United Arab Emirates University , Al Ain , Abu Dhabi , United Arab Emirates","Health Data Science Lab Department of Genetics and Genomics,College of Medical and Health Sciences , United Arab Emirates University , P.O. Box 17666, Al Ain , Abu Dhabi , United Arab Emirates"],"affiliations":[{"raw_affiliation_string":"Health Data Science Lab Department of Genetics and Genomics,College of Medical and Health Sciences , United Arab Emirates University , P.O. Box 17666, Al Ain , Abu Dhabi , United Arab Emirates","institution_ids":["https://openalex.org/I201726411"]},{"raw_affiliation_string":"Big Data Analytics Center , United Arab Emirates University , Al Ain , Abu Dhabi , United Arab Emirates","institution_ids":["https://openalex.org/I201726411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081045152","display_name":"Yee Wen Choon","orcid":"https://orcid.org/0000-0003-0787-5945"},"institutions":[{"id":"https://openalex.org/I226432","display_name":"Universiti Malaysia Kelantan","ror":"https://ror.org/0463y2v87","country_code":"MY","type":"education","lineage":["https://openalex.org/I226432"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Yee Wen Choon","raw_affiliation_strings":["Department of Data Science , Universiti Malaysia Kelantan , City Campus, Pengkalan Chepa , 16100 Kota Bharu , Kelantan, Malaysia ,","Institute for Artificial Intelligence and Big Data , Universiti Malaysia Kelantan , Kota Bharu , 16100 , Kelantan , Malaysia"],"affiliations":[{"raw_affiliation_string":"Institute for Artificial Intelligence and Big Data , Universiti Malaysia Kelantan , Kota Bharu , 16100 , Kelantan , Malaysia","institution_ids":["https://openalex.org/I226432"]},{"raw_affiliation_string":"Department of Data Science , Universiti Malaysia Kelantan , City Campus, Pengkalan Chepa , 16100 Kota Bharu , Kelantan, Malaysia ,","institution_ids":["https://openalex.org/I226432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047121335","display_name":"Weng Howe Chan","orcid":"https://orcid.org/0000-0003-0612-3661"},"institutions":[{"id":"https://openalex.org/I4576418","display_name":"University of Technology Malaysia","ror":"https://ror.org/026w31v75","country_code":"MY","type":"education","lineage":["https://openalex.org/I4576418"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Weng Howe Chan","raw_affiliation_strings":["Artificial Intelligence and Bioinformatics Research Group, Faculty of Computing , Universiti Teknologi Malaysia , 81310 Johor , Malaysia"],"affiliations":[{"raw_affiliation_string":"Artificial Intelligence and Bioinformatics Research Group, Faculty of Computing , Universiti Teknologi Malaysia , 81310 Johor , Malaysia","institution_ids":["https://openalex.org/I4576418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042504883","display_name":"Hasyiya Karimah Adli","orcid":"https://orcid.org/0000-0001-8754-6206"},"institutions":[{"id":"https://openalex.org/I226432","display_name":"Universiti Malaysia Kelantan","ror":"https://ror.org/0463y2v87","country_code":"MY","type":"education","lineage":["https://openalex.org/I226432"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Hasyiya Karimah Adli","raw_affiliation_strings":["Department of Data Science , Universiti Malaysia Kelantan , City Campus, Pengkalan Chepa , 16100 Kota Bharu , Kelantan, Malaysia ,","Institute for Artificial Intelligence and Big Data , Universiti Malaysia Kelantan , Kota Bharu , 16100 , Kelantan , Malaysia"],"affiliations":[{"raw_affiliation_string":"Institute for Artificial Intelligence and Big Data , Universiti Malaysia Kelantan , Kota Bharu , 16100 , Kelantan , Malaysia","institution_ids":["https://openalex.org/I226432"]},{"raw_affiliation_string":"Department of Data Science , Universiti Malaysia Kelantan , City Campus, Pengkalan Chepa , 16100 Kota Bharu , Kelantan, Malaysia ,","institution_ids":["https://openalex.org/I226432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034002607","display_name":"Khairul Nizar Syazwan WSW","orcid":null},"institutions":[{"id":"https://openalex.org/I226432","display_name":"Universiti Malaysia Kelantan","ror":"https://ror.org/0463y2v87","country_code":"MY","type":"education","lineage":["https://openalex.org/I226432"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Khairul Nizar Syazwan WSW","raw_affiliation_strings":["Department of Data Science , Universiti Malaysia Kelantan , City Campus, Pengkalan Chepa , 16100 Kota Bharu , Kelantan, Malaysia ,","Institute for Artificial Intelligence and Big Data , Universiti Malaysia Kelantan , Kota Bharu , 16100 , Kelantan , Malaysia"],"affiliations":[{"raw_affiliation_string":"Institute for Artificial Intelligence and Big Data , Universiti Malaysia Kelantan , Kota Bharu , 16100 , Kelantan , Malaysia","institution_ids":["https://openalex.org/I226432"]},{"raw_affiliation_string":"Department of Data Science , Universiti Malaysia Kelantan , City Campus, Pengkalan Chepa , 16100 Kota Bharu , Kelantan, Malaysia ,","institution_ids":["https://openalex.org/I226432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101527870","display_name":"Nooraini Yusoff","orcid":"https://orcid.org/0000-0003-2703-2531"},"institutions":[{"id":"https://openalex.org/I226432","display_name":"Universiti Malaysia Kelantan","ror":"https://ror.org/0463y2v87","country_code":"MY","type":"education","lineage":["https://openalex.org/I226432"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Nooraini Yusoff","raw_affiliation_strings":["Department of Data Science , Universiti Malaysia Kelantan , City Campus, Pengkalan Chepa , 16100 Kota Bharu , Kelantan, Malaysia ,","Institute for Artificial Intelligence and Big Data , Universiti Malaysia Kelantan , Kota Bharu , 16100 , Kelantan , Malaysia"],"affiliations":[{"raw_affiliation_string":"Department of Data Science , Universiti Malaysia Kelantan , City Campus, Pengkalan Chepa , 16100 Kota Bharu , Kelantan, Malaysia ,","institution_ids":["https://openalex.org/I226432"]},{"raw_affiliation_string":"Institute for Artificial Intelligence and Big Data , Universiti Malaysia Kelantan , Kota Bharu , 16100 , Kelantan , Malaysia","institution_ids":["https://openalex.org/I226432"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031916282","display_name":"Muhammad Akmal Remli","orcid":"https://orcid.org/0000-0002-7800-0057"},"institutions":[{"id":"https://openalex.org/I226432","display_name":"Universiti Malaysia Kelantan","ror":"https://ror.org/0463y2v87","country_code":"MY","type":"education","lineage":["https://openalex.org/I226432"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Muhammad Akmal Remli","raw_affiliation_strings":["Department of Data Science , Universiti Malaysia Kelantan , City Campus, Pengkalan Chepa , 16100 Kota Bharu , Kelantan, Malaysia ,","Institute for Artificial Intelligence and Big Data , Universiti Malaysia Kelantan , Kota Bharu , 16100 , Kelantan , Malaysia"],"affiliations":[{"raw_affiliation_string":"Institute for Artificial Intelligence and Big Data , Universiti Malaysia Kelantan , Kota Bharu , 16100 , Kelantan , Malaysia","institution_ids":["https://openalex.org/I226432"]},{"raw_affiliation_string":"Department of Data Science , Universiti Malaysia Kelantan , City Campus, Pengkalan Chepa , 16100 Kota Bharu , Kelantan, Malaysia ,","institution_ids":["https://openalex.org/I226432"]}]}],"institution_assertions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5085034566"],"corresponding_institution_ids":["https://openalex.org/I201726411"],"apc_list":{"value":0,"currency":"USD","value_usd":0,"provenance":"doaj"},"apc_paid":null,"fwci":0.128,"has_fulltext":true,"fulltext_origin":"pdf","cited_by_count":1,"citation_normalized_percentile":{"value":0.351006,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":60,"max":70},"biblio":{"volume":"19","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9999,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9999,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9969,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10171","display_name":"Biofuel production and bioconversion","score":0.9942,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metabolic-engineering","display_name":"Metabolic Engineering","score":0.705846},{"id":"https://openalex.org/keywords/minification","display_name":"Minification","score":0.46083787}],"concepts":[{"id":"https://openalex.org/C2778348673","wikidata":"https://www.wikidata.org/wiki/Q739302","display_name":"Production (economics)","level":2,"score":0.7190653},{"id":"https://openalex.org/C6350086","wikidata":"https://www.wikidata.org/wiki/Q6822347","display_name":"Metabolic engineering","level":3,"score":0.705846},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.66501147},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.62847936},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.5708468},{"id":"https://openalex.org/C147764199","wikidata":"https://www.wikidata.org/wiki/Q6865248","display_name":"Minification","level":2,"score":0.46083787},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.4461551},{"id":"https://openalex.org/C137858568","wikidata":"https://www.wikidata.org/wiki/Q7239","display_name":"Organism","level":2,"score":0.44456312},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.4232471},{"id":"https://openalex.org/C18762648","wikidata":"https://www.wikidata.org/wiki/Q42213","display_name":"Work (physics)","level":2,"score":0.41825783},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.4132674},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.245657},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23450455},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.16464642},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12989515},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.11273241},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.08889985},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"","qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019802","descriptor_name":"Succinic Acid","qualifier_ui":"","qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D060847","descriptor_name":"Metabolic Engineering","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019802","descriptor_name":"Succinic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"is_oa":true,"landing_page_url":"https://doi.org/10.1515/jib-2022-0003","pdf_url":"https://www.degruyter.com/document/doi/10.1515/jib-2022-0003/pdf","source":{"id":"https://openalex.org/S4393917359","display_name":"Berichte aus der medizinischen Informatik und Bioinformatik/Journal of integrative bioinformatics","issn_l":"1432-4385","issn":["1432-4385","1613-4516"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":false,"landing_page_url":"https://doaj.org/article/b85134374f3a4f3cbcae7ce7c55e770a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false},{"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9521821","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":["National Institutes of Health"],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35852123","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":["National Institutes of Health"],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false}],"best_oa_location":{"is_oa":true,"landing_page_url":"https://doi.org/10.1515/jib-2022-0003","pdf_url":"https://www.degruyter.com/document/doi/10.1515/jib-2022-0003/pdf","source":{"id":"https://openalex.org/S4393917359","display_name":"Berichte aus der medizinischen Informatik und Bioinformatik/Journal of integrative bioinformatics","issn_l":"1432-4385","issn":["1432-4385","1613-4516"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true},"sustainable_development_goals":[],"grants":[{"funder":"https://openalex.org/F4320322810","funder_display_name":"Universiti Malaysia Kelantan","award_id":"R/FUND/A0100/01850A/001/2020/00816"},{"funder":"https://openalex.org/F4320329006","funder_display_name":"Kementerian Pendidikan Malaysia","award_id":"R/FRGS/A0800/01655A/003/2020/00720"}],"datasets":[],"versions":[],"referenced_works_count":17,"referenced_works":["https://openalex.org/W16088600","https://openalex.org/W173438993","https://openalex.org/W1975597731","https://openalex.org/W2006672203","https://openalex.org/W2025172803","https://openalex.org/W2026569515","https://openalex.org/W2041715942","https://openalex.org/W2051675700","https://openalex.org/W2064854032","https://openalex.org/W2067268731","https://openalex.org/W2077100702","https://openalex.org/W2111967267","https://openalex.org/W2130364940","https://openalex.org/W2163799837","https://openalex.org/W2170491665","https://openalex.org/W2171403356","https://openalex.org/W2980588688"],"related_works":["https://openalex.org/W4310964874","https://openalex.org/W3116476418","https://openalex.org/W3092335715","https://openalex.org/W2930102738","https://openalex.org/W2334293709","https://openalex.org/W2302077272","https://openalex.org/W2273625928","https://openalex.org/W2208076193","https://openalex.org/W2023600884","https://openalex.org/W1881146916"],"abstract_inverted_index":{"Metabolic":[0,24],"engineering":[1],"has":[2,47],"expanded":[3],"in":[4,8,17,31,42,54,97,123,126],"importance":[5],"and":[6,11,39,63,76,104],"employment":[7],"recent":[9],"years":[10],"is":[12,81],"now":[13],"extensively":[14],"applied":[15],"particularly":[16],"the":[18,49,69,88,91,106,134],"production":[19,38,107,125],"of":[20,73,95,108,137],"biomass":[21],"from":[22],"microbes.":[23],"network":[25],"models":[26],"have":[27],"been":[28,48],"employed":[29],"extravagantly":[30],"computational":[32],"processes":[33],"developed":[34],"to":[35,67,121,139],"enhance":[36],"metabolic":[37],"suggest":[40],"changes":[41],"organisms.":[43],"The":[44],"crucial":[45],"issue":[46],"unrealistic":[50],"flux":[51],"distribution":[52],"presented":[53],"prior":[55],"work":[56],"on":[57],"rational":[58],"modelling":[59],"framework":[60],"adopting":[61],"Optknock":[62],"OptGene.":[64],"In":[65],"order":[66],"address":[68],"problem,":[70],"a":[71],"hybrid":[72],"Bees":[74],"Algorithm":[75],"Regulatory":[77],"On/Off":[78],"Minimization":[79],"(BAROOM)":[80],"used.":[82],"By":[83],"employing":[84],"Escherichia":[85],"coli":[86,99,131],"as":[87],"model":[89,127],"organism,":[90],"most":[92],"excellent":[93],"set":[94,136],"genes":[96,138],"E.":[98,130],"that":[100,115],"can":[101,110],"be":[102,111,140],"removed":[103],"advance":[105],"succinate":[109,124],"decided.":[112],"Evidences":[113],"shows":[114],"BAROOM":[116],"outperforms":[117],"alternative":[118],"strategies":[119],"used":[120],"escalate":[122],"organisms":[128],"like":[129],"by":[132],"selecting":[133],"best":[135],"removed.":[141]},"cited_by_api_url":"https://api.openalex.org/works?filter=cites:W4285794542","counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2024-12-11T22:20:26.851684","created_date":"2022-07-19"}