乐胖代购免代理版

{"id":"https://openalex.org/W2811269698","doi":"https://doi.org/10.1515/jib-2017-0041","title":"Identification of Missing Carbon Fixation Enzymes as Potential Drug Targets in Mycobacterium Tuberculosis","display_name":"Identification of Missing Carbon Fixation Enzymes as Potential Drug Targets in Mycobacterium Tuberculosis","publication_year":2018,"publication_date":"2018-07-03","ids":{"openalex":"https://openalex.org/W2811269698","doi":"https://doi.org/10.1515/jib-2017-0041","mag":"2811269698","pmid":"https://pubmed.ncbi.nlm.nih.gov/30218604","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6340126"},"language":"en","primary_location":{"is_oa":true,"landing_page_url":"https://doi.org/10.1515/jib-2017-0041","pdf_url":"http://www.degruyter.com/downloadpdf/j/jib.2018.15.issue-3/jib-2017-0041/jib-2017-0041.xml","source":{"id":"https://openalex.org/S4393917359","display_name":"Berichte aus der medizinischen Informatik und Bioinformatik/Journal of integrative bioinformatics","issn_l":"1432-4385","issn":["1432-4385","1613-4516"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true},"type":"article","type_crossref":"journal-article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://www.degruyter.com/downloadpdf/j/jib.2018.15.issue-3/jib-2017-0041/jib-2017-0041.xml","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112036270","display_name":"Amit Katiyar","orcid":null},"institutions":[{"id":"https://openalex.org/I37048141","display_name":"Indian Council of Medical Research","ror":"https://ror.org/0492wrx28","country_code":"IN","type":"government","lineage":["https://openalex.org/I37048141"]},{"id":"https://openalex.org/I63739035","display_name":"All India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71","country_code":"IN","type":"education","lineage":["https://openalex.org/I63739035"]},{"id":"https://openalex.org/I4210106490","display_name":"All India Institute of Medical Sciences Bhopal","ror":"https://ror.org/01rs0zz87","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210106490"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Amit Katiyar","raw_affiliation_strings":["Department of Biophysics, All India Institute of Medical Sciences , Ansari Nagar, New Delhi-110029 , India","ICMR-AIIMS Computational Genomics Centre, Indian Council of Medical Research , Ansari Nagar , New Delhi-110029 , India"],"affiliations":[{"raw_affiliation_string":"ICMR-AIIMS Computational Genomics Centre, Indian Council of Medical Research , Ansari Nagar , New Delhi-110029 , India","institution_ids":["https://openalex.org/I37048141","https://openalex.org/I4210106490","https://openalex.org/I63739035"]},{"raw_affiliation_string":"Department of Biophysics, All India Institute of Medical Sciences , Ansari Nagar, New Delhi-110029 , India","institution_ids":["https://openalex.org/I63739035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019635241","display_name":"Harpreet Singh","orcid":"https://orcid.org/0000-0002-5838-1884"},"institutions":[{"id":"https://openalex.org/I4210106490","display_name":"All India Institute of Medical Sciences Bhopal","ror":"https://ror.org/01rs0zz87","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210106490"]},{"id":"https://openalex.org/I63739035","display_name":"All India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71","country_code":"IN","type":"education","lineage":["https://openalex.org/I63739035"]},{"id":"https://openalex.org/I37048141","display_name":"Indian Council of Medical Research","ror":"https://ror.org/0492wrx28","country_code":"IN","type":"government","lineage":["https://openalex.org/I37048141"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Harpreet Singh","raw_affiliation_strings":["Division of Informatics Systems and Research Management, Indian Council of Medical Research , Ansari Nagar , New Delhi-110029 , India , Phone: +91-11-26589556, Fax: +91-11-26588662","ICMR-AIIMS Computational Genomics Centre, Indian Council of Medical Research , Ansari Nagar , New Delhi-110029 , India"],"affiliations":[{"raw_affiliation_string":"ICMR-AIIMS Computational Genomics Centre, Indian Council of Medical Research , Ansari Nagar , New Delhi-110029 , India","institution_ids":["https://openalex.org/I4210106490","https://openalex.org/I63739035","https://openalex.org/I37048141"]},{"raw_affiliation_string":"Division of Informatics Systems and Research Management, Indian Council of Medical Research , Ansari Nagar , New Delhi-110029 , India , Phone: +91-11-26589556, Fax: +91-11-26588662","institution_ids":["https://openalex.org/I37048141"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032791959","display_name":"Krishna Kant Azad","orcid":null},"institutions":[{"id":"https://openalex.org/I37048141","display_name":"Indian Council of Medical Research","ror":"https://ror.org/0492wrx28","country_code":"IN","type":"government","lineage":["https://openalex.org/I37048141"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Krishna Kant Azad","raw_affiliation_strings":["Division of Informatics Systems and Research Management, Indian Council of Medical Research , Ansari Nagar , New Delhi-110029 , India"],"affiliations":[{"raw_affiliation_string":"Division of Informatics Systems and Research Management, Indian Council of Medical Research , Ansari Nagar , New Delhi-110029 , India","institution_ids":["https://openalex.org/I37048141"]}]}],"institution_assertions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5019635241"],"corresponding_institution_ids":["https://openalex.org/I4210106490","https://openalex.org/I63739035","https://openalex.org/I37048141"],"apc_list":{"value":0,"currency":"USD","value_usd":0,"provenance":"doaj"},"apc_paid":null,"fwci":0.736,"has_fulltext":true,"fulltext_origin":"ngrams","cited_by_count":8,"citation_normalized_percentile":{"value":0.650665,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":83,"max":84},"biblio":{"volume":"15","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9975,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9975,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9928,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9786,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carbon-fixation","display_name":"Carbon fixation","score":0.69276196},{"id":"https://openalex.org/keywords/metabolic-pathway","display_name":"Metabolic pathway","score":0.6082882},{"id":"https://openalex.org/keywords/tricarboxylic-acid","display_name":"Tricarboxylic acid","score":0.43759748}],"concepts":[{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.7389889},{"id":"https://openalex.org/C165135838","wikidata":"https://www.wikidata.org/wiki/Q133895","display_name":"Citric acid cycle","level":3,"score":0.7278736},{"id":"https://openalex.org/C199873434","wikidata":"https://www.wikidata.org/wiki/Q901921","display_name":"Carbon fixation","level":3,"score":0.69276196},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.65153},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.6082882},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5896155},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.5288561},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.5264305},{"id":"https://openalex.org/C146249460","wikidata":"https://www.wikidata.org/wiki/Q2914991","display_name":"Fixation (population genetics)","level":3,"score":0.4856123},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.45494768},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.44958073},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.44542542},{"id":"https://openalex.org/C2776441662","wikidata":"https://www.wikidata.org/wiki/Q2823314","display_name":"Tricarboxylic acid","level":4,"score":0.43759748},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.41811118},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31787091},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22939965},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.11881164},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10729101},{"id":"https://openalex.org/C183688256","wikidata":"https://www.wikidata.org/wiki/Q11982","display_name":"Photosynthesis","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D057486","descriptor_name":"Carbon Cycle","qualifier_ui":"","qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":"","qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002245","descriptor_name":"Carbon Dioxide","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002245","descriptor_name":"Carbon Dioxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false}],"locations_count":4,"locations":[{"is_oa":true,"landing_page_url":"https://doi.org/10.1515/jib-2017-0041","pdf_url":"http://www.degruyter.com/downloadpdf/j/jib.2018.15.issue-3/jib-2017-0041/jib-2017-0041.xml","source":{"id":"https://openalex.org/S4393917359","display_name":"Berichte aus der medizinischen Informatik und Bioinformatik/Journal of integrative bioinformatics","issn_l":"1432-4385","issn":["1432-4385","1613-4516"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":true,"landing_page_url":"https://europepmc.org/articles/pmc6340126","pdf_url":"https://europepmc.org/articles/pmc6340126?pdf=render","source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":["European Bioinformatics Institute"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340126","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":["National Institutes of Health"],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30218604","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":["National Institutes of Health"],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false}],"best_oa_location":{"is_oa":true,"landing_page_url":"https://doi.org/10.1515/jib-2017-0041","pdf_url":"http://www.degruyter.com/downloadpdf/j/jib.2018.15.issue-3/jib-2017-0041/jib-2017-0041.xml","source":{"id":"https://openalex.org/S4393917359","display_name":"Berichte aus der medizinischen Informatik und Bioinformatik/Journal of integrative bioinformatics","issn_l":"1432-4385","issn":["1432-4385","1613-4516"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/7","score":0.59,"display_name":"Affordable and clean energy"}],"grants":[],"datasets":[],"versions":[],"referenced_works_count":57,"referenced_works":["https://openalex.org/W1550203027","https://openalex.org/W1550702931","https://openalex.org/W160519681","https://openalex.org/W1696527058","https://openalex.org/W1787843819","https://openalex.org/W1893960647","https://openalex.org/W1974884542","https://openalex.org/W1975401101","https://openalex.org/W1978908521","https://openalex.org/W1984523365","https://openalex.org/W1989862935","https://openalex.org/W1996460207","https://openalex.org/W2006932434","https://openalex.org/W2009313526","https://openalex.org/W2018518196","https://openalex.org/W2023559593","https://openalex.org/W2024455490","https://openalex.org/W2025118032","https://openalex.org/W2033840976","https://openalex.org/W2034401433","https://openalex.org/W2037520128","https://openalex.org/W2038538152","https://openalex.org/W2045374991","https://openalex.org/W2047330514","https://openalex.org/W2052447488","https://openalex.org/W2055043387","https://openalex.org/W2056681832","https://openalex.org/W2063263528","https://openalex.org/W2093363647","https://openalex.org/W2094491295","https://openalex.org/W2101291993","https://openalex.org/W2103017472","https://openalex.org/W2106048103","https://openalex.org/W2111615726","https://openalex.org/W2119201072","https://openalex.org/W2124320287","https://openalex.org/W2128669068","https://openalex.org/W2133579817","https://openalex.org/W2137052779","https://openalex.org/W2143609452","https://openalex.org/W2146211839","https://openalex.org/W2146569411","https://openalex.org/W2147526198","https://openalex.org/W2148606804","https://openalex.org/W2155075775","https://openalex.org/W2158023121","https://openalex.org/W2159586303","https://openalex.org/W2164838993","https://openalex.org/W2166582198","https://openalex.org/W2170146596","https://openalex.org/W2172266455","https://openalex.org/W2331830050","https://openalex.org/W2395271934","https://openalex.org/W2409909770","https://openalex.org/W2417671150","https://openalex.org/W2513217862","https://openalex.org/W2735567798"],"related_works":["https://openalex.org/W4387311068","https://openalex.org/W4312221298","https://openalex.org/W4220904696","https://openalex.org/W3122253607","https://openalex.org/W2417621198","https://openalex.org/W2137042898","https://openalex.org/W2031825920","https://openalex.org/W2009871488","https://openalex.org/W2008370637","https://openalex.org/W1063595"],"abstract_inverted_index":{"Metabolic":[0],"adaptation":[1],"to":[2,121,187],"the":[3,16,23,37,59,72,92,101,105,113,136,145,154,160,166,169],"host":[4],"environment":[5],"has":[6],"been":[7],"recognized":[8],"as":[9,31,64,131,175],"an":[10,116],"essential":[11],"mechanism":[12],"of":[13,18,34,47,50,77,84,89,94,98,104,139,156,165,184],"pathogenicity":[14],"and":[15,66,75],"growth":[17],"Mycobacterium":[19],"tuberculosis":[20],"(Mtb)":[21],"in":[22,71,79,124,135,153],"lungs":[24],"for":[25],"decades.":[26],"The":[27],"Mtb":[28,90],"uses":[29],"CO2":[30,60,78,123,132,140,147,170],"a":[32,45,95,176,182,189],"source":[33],"carbon":[35],"during":[36],"dormant":[38,161],"or":[39],"non-replicative":[40],"state.":[41],"However,":[42],"there":[43],"is":[44,133],"lack":[46],"biochemical":[48],"knowledge":[49],"its":[51],"metabolic":[52],"networks.":[53],"In":[54,163],"this":[55,125],"study,":[56],"we":[57],"investigated":[58],"fixation":[61,141,148,171],"pathways":[62,142],"(such":[63],"ko00710":[65],"ko00720)":[67],"most":[68],"likely":[69],"involved":[70],"energy":[73],"production":[74],"conversion":[76],"Mtb.":[80,162],"Extensive":[81],"pathway":[82],"evaluation":[83],"23":[85],"completely":[86],"sequenced":[87],"strains":[88],"confirmed":[91,174],"existence":[93],"complete":[96],"list":[97],"genes":[99],"encoding":[100],"relevant":[102,146],"enzymes":[103,172],"reductive":[106],"tricarboxylic":[107],"acid":[108],"(rTCA)":[109],"cycle.":[110],"This":[111],"provides":[112],"evidence":[114],"that":[115,130],"rTCA":[117],"cycle":[118],"may":[119],"function":[120],"fix":[122],"bacterium.":[126],"We":[127],"also":[128],"proposed":[129],"plentiful":[134],"lungs,":[137],"inhibition":[138],"(by":[143],"targeting":[144],"enzymes)":[149],"could":[150],"be":[151,188],"used":[152],"expansion":[155],"new":[157],"drugs":[158],"against":[159],"support":[164],"suggested":[167],"hypothesis,":[168],"were":[173],"potential":[177],"drug":[178],"target":[179],"by":[180],"analyzing":[181],"number":[183],"attributes":[185],"necessary":[186],"good":[190],"bacterial":[191],"target.":[192]},"cited_by_api_url":"https://api.openalex.org/works?filter=cites:W2811269698","counts_by_year":[{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2}],"updated_date":"2025-01-07T03:22:50.500925","created_date":"2018-07-10"}