乐胖代购免代理版

{"id":"https://openalex.org/W3007090700","doi":"https://doi.org/10.1371/journal.pcbi.1007701","title":"Individualized genetic network analysis reveals new therapeutic vulnerabilities in 6,700 cancer genomes","display_name":"Individualized genetic network analysis reveals new therapeutic vulnerabilities in 6,700 cancer genomes","publication_year":2020,"publication_date":"2020-02-26","ids":{"openalex":"https://openalex.org/W3007090700","doi":"https://doi.org/10.1371/journal.pcbi.1007701","mag":"3007090700","pmid":"https://pubmed.ncbi.nlm.nih.gov/32101536","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7062285"},"language":"en","primary_location":{"is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007701","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007701&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_indexed_in_scopus":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true},"type":"article","type_crossref":"journal-article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007701&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100326618","display_name":"Chuang Liu","orcid":"https://orcid.org/0000-0003-0431-2856"},"institutions":[{"id":"https://openalex.org/I163151501","display_name":"Hangzhou Normal University","ror":"https://ror.org/014v1mr15","country_code":"CN","type":"funder","lineage":["https://openalex.org/I163151501"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chuang Liu","raw_affiliation_strings":["Alibaba Research Center for Complexity Sciences, Hangzhou Normal University, Hangzhou, Zhejiang, China"],"affiliations":[{"raw_affiliation_string":"Alibaba Research Center for Complexity Sciences, Hangzhou Normal University, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I163151501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023153659","display_name":"Junfei Zhao","orcid":"https://orcid.org/0000-0002-4569-9797"},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"funder","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Junfei Zhao","raw_affiliation_strings":["Department of Biomedical Informatics, Columbia University, New York, New York, United States of America","Department of Systems Biology, Columbia University, New York, New York, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, Columbia University, New York, New York, United States of America","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Systems Biology, Columbia University, New York, New York, United States of America","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021219842","display_name":"Weiqiang L\u00fc","orcid":"https://orcid.org/0000-0003-1349-6597"},"institutions":[{"id":"https://openalex.org/I66867065","display_name":"East China Normal University","ror":"https://ror.org/02n96ep67","country_code":"CN","type":"funder","lineage":["https://openalex.org/I66867065"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Weiqiang Lu","raw_affiliation_strings":["Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China","institution_ids":["https://openalex.org/I66867065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102366942","display_name":"Yao Dai","orcid":null},"institutions":[{"id":"https://openalex.org/I163151501","display_name":"Hangzhou Normal University","ror":"https://ror.org/014v1mr15","country_code":"CN","type":"funder","lineage":["https://openalex.org/I163151501"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yao Dai","raw_affiliation_strings":["Alibaba Research Center for Complexity Sciences, Hangzhou Normal University, Hangzhou, Zhejiang, China"],"affiliations":[{"raw_affiliation_string":"Alibaba Research Center for Complexity Sciences, Hangzhou Normal University, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I163151501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001096479","display_name":"Jennifer Hockings","orcid":null},"institutions":[{"id":"https://openalex.org/I36373038","display_name":"Cleveland Clinic Lerner College of Medicine","ror":"https://ror.org/02x4b0932","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750","https://openalex.org/I36373038"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jennifer Hockings","raw_affiliation_strings":["Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America"],"affiliations":[{"raw_affiliation_string":"Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America","institution_ids":["https://openalex.org/I36373038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076504705","display_name":"Yadi Zhou","orcid":"https://orcid.org/0000-0002-6049-0545"},"institutions":[{"id":"https://openalex.org/I36373038","display_name":"Cleveland Clinic Lerner College of Medicine","ror":"https://ror.org/02x4b0932","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750","https://openalex.org/I36373038"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yadi Zhou","raw_affiliation_strings":["Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America"],"affiliations":[{"raw_affiliation_string":"Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America","institution_ids":["https://openalex.org/I36373038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025357844","display_name":"Ruth Nussinov","orcid":"https://orcid.org/0000-0002-8115-6415"},"institutions":[{"id":"https://openalex.org/I114662689","display_name":"Leidos (United States)","ror":"https://ror.org/012cvds63","country_code":"US","type":"funder","lineage":["https://openalex.org/I114662689"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"funder","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"funder","lineage":["https://openalex.org/I16391192"]}],"countries":["IL","US"],"is_corresponding":true,"raw_author_name":"Ruth Nussinov","raw_affiliation_strings":["Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland, United States of America","Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"],"affiliations":[{"raw_affiliation_string":"Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland, United States of America","institution_ids":["https://openalex.org/I114662689","https://openalex.org/I4210140884","https://openalex.org/I4210130649"]},{"raw_affiliation_string":"Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038322204","display_name":"Charis Eng","orcid":"https://orcid.org/0000-0002-3693-5145"},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"funder","lineage":["https://openalex.org/I58956616"]},{"id":"https://openalex.org/I4210153792","display_name":"University School","ror":"https://ror.org/05ap66461","country_code":"US","type":"education","lineage":["https://openalex.org/I4210153792"]},{"id":"https://openalex.org/I36373038","display_name":"Cleveland Clinic Lerner College of Medicine","ror":"https://ror.org/02x4b0932","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750","https://openalex.org/I36373038"]},{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Charis Eng","raw_affiliation_strings":["Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America","Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America","Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America","Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America","Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America","institution_ids":["https://openalex.org/I58956616","https://openalex.org/I36373038"]},{"raw_affiliation_string":"Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America","institution_ids":["https://openalex.org/I58956616","https://openalex.org/I4210153792"]},{"raw_affiliation_string":"Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America","institution_ids":["https://openalex.org/I36373038"]},{"raw_affiliation_string":"Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America","institution_ids":["https://openalex.org/I58956616","https://openalex.org/I4210153792"]},{"raw_affiliation_string":"Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, United States of America","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021122269","display_name":"Feixiong Cheng","orcid":"https://orcid.org/0000-0002-1736-2847"},"institutions":[{"id":"https://openalex.org/I36373038","display_name":"Cleveland Clinic Lerner College of Medicine","ror":"https://ror.org/02x4b0932","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750","https://openalex.org/I36373038"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"funder","lineage":["https://openalex.org/I58956616"]},{"id":"https://openalex.org/I4210153792","display_name":"University School","ror":"https://ror.org/05ap66461","country_code":"US","type":"education","lineage":["https://openalex.org/I4210153792"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Feixiong Cheng","raw_affiliation_strings":["Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America","Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America","Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America","institution_ids":["https://openalex.org/I36373038","https://openalex.org/I58956616"]},{"raw_affiliation_string":"Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America","institution_ids":["https://openalex.org/I36373038"]},{"raw_affiliation_string":"Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America","institution_ids":["https://openalex.org/I58956616","https://openalex.org/I4210153792"]}]}],"institution_assertions":[],"countries_distinct_count":3,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5100326618","https://openalex.org/A5023153659","https://openalex.org/A5021219842","https://openalex.org/A5102366942","https://openalex.org/A5001096479","https://openalex.org/A5076504705","https://openalex.org/A5025357844","https://openalex.org/A5038322204","https://openalex.org/A5021122269"],"corresponding_institution_ids":["https://openalex.org/I163151501","https://openalex.org/I78577930","https://openalex.org/I66867065","https://openalex.org/I163151501","https://openalex.org/I36373038","https://openalex.org/I36373038","https://openalex.org/I114662689","https://openalex.org/I4210140884","https://openalex.org/I4210130649","https://openalex.org/I16391192","https://openalex.org/I58956616","https://openalex.org/I4210153792","https://openalex.org/I36373038","https://openalex.org/I1316902750","https://openalex.org/I36373038","https://openalex.org/I58956616","https://openalex.org/I4210153792"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.764,"has_fulltext":true,"fulltext_origin":"pdf","cited_by_count":47,"citation_normalized_percentile":{"value":0.999984,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"16","issue":"2","first_page":"e1007701","last_page":"e1007701"},"is_retracted":false,"is_paratext":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9978,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9978,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9973,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9945,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/druggability","display_name":"Druggability","score":0.61466235},{"id":"https://openalex.org/keywords/nonsynonymous-substitution","display_name":"Nonsynonymous substitution","score":0.59500796},{"id":"https://openalex.org/keywords/pharmacogenomics","display_name":"Pharmacogenomics","score":0.43361747},{"id":"https://openalex.org/keywords/synthetic-lethality","display_name":"Synthetic Lethality","score":0.42869183}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.65640795},{"id":"https://openalex.org/C10679952","wikidata":"https://www.wikidata.org/wiki/Q5308937","display_name":"Druggability","level":3,"score":0.61466235},{"id":"https://openalex.org/C149904235","wikidata":"https://www.wikidata.org/wiki/Q7049620","display_name":"Nonsynonymous substitution","level":4,"score":0.59500796},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5422945},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.530031},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.50823116},{"id":"https://openalex.org/C98108389","wikidata":"https://www.wikidata.org/wiki/Q412563","display_name":"CRISPR","level":3,"score":0.5070517},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4632676},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4469638},{"id":"https://openalex.org/C170734499","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenomics","level":2,"score":0.43361747},{"id":"https://openalex.org/C2778502085","wikidata":"https://www.wikidata.org/wiki/Q7662767","display_name":"Synthetic lethality","level":4,"score":0.42869183},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.40376246},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.27211124}],"mesh":[{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"","qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D024682","descriptor_name":"BRCA2 Protein","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024682","descriptor_name":"BRCA2 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064113","descriptor_name":"CRISPR-Cas Systems","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059472","descriptor_name":"Exome","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005820","descriptor_name":"Genetic Testing","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020128","descriptor_name":"Inhibitory Concentration 50","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010597","descriptor_name":"Pharmacogenetics","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":6,"locations":[{"is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007701","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007701&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_indexed_in_scopus":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":false,"landing_page_url":"https://doaj.org/article/2f2cba8bf9d540278cdbc4739978b35f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_indexed_in_scopus":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false},{"is_oa":true,"landing_page_url":"https://europepmc.org/articles/pmc7062285","pdf_url":"https://europepmc.org/articles/pmc7062285?pdf=render","source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_indexed_in_scopus":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":["European Bioinformatics Institute"],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062285","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_indexed_in_scopus":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":["National Institutes of Health"],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Individualized_genetic_network_analysis_reveals_new_therapeutic_vulnerabilities_in_6_700_cancer_genomes/11904765","pdf_url":"https://figshare.com/ndownloader/files/21831978","source":{"id":"https://openalex.org/S4306400572","display_name":"OPAL (Open@LaTrobe) (La Trobe University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_indexed_in_scopus":false,"is_core":false,"host_organization":"https://openalex.org/I196829312","host_organization_name":"La Trobe University","host_organization_lineage":["https://openalex.org/I196829312"],"host_organization_lineage_names":["La Trobe University"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false},{"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32101536","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_indexed_in_scopus":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":["National Institutes of Health"],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false}],"best_oa_location":{"is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007701","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007701&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_indexed_in_scopus":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.68,"id":"https://metadata.un.org/sdg/3"}],"grants":[{"funder":"https://openalex.org/F4320306080","funder_display_name":"Foundation for the National Institutes of Health","award_id":"HHSN261200800001E"},{"funder":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China","award_id":"61873080"}],"datasets":[],"versions":[],"referenced_works_count":73,"referenced_works":["https://openalex.org/W1798664598","https://openalex.org/W1814635547","https://openalex.org/W1855299742","https://openalex.org/W1855992024","https://openalex.org/W1895317372","https://openalex.org/W1939472951","https://openalex.org/W1950829641","https://openalex.org/W1978918363","https://openalex.org/W1983829317","https://openalex.org/W1989773675","https://openalex.org/W2030057907","https://openalex.org/W2042227848","https://openalex.org/W2044433401","https://openalex.org/W2044702943","https://openalex.org/W2045953361","https://openalex.org/W2053391598","https://openalex.org/W2059069581","https://openalex.org/W2067821218","https://openalex.org/W2071221524","https://openalex.org/W2078429149","https://openalex.org/W2086924064","https://openalex.org/W2088145034","https://openalex.org/W2093549003","https://openalex.org/W2095463689","https://openalex.org/W2096283457","https://openalex.org/W2102140136","https://openalex.org/W2109518208","https://openalex.org/W2110065044","https://openalex.org/W2121906867","https://openalex.org/W2126605118","https://openalex.org/W2143852804","https://openalex.org/W2144940507","https://openalex.org/W2147051792","https://openalex.org/W2151839642","https://openalex.org/W2161566038","https://openalex.org/W2168303063","https://openalex.org/W2169589032","https://openalex.org/W2204695746","https://openalex.org/W2217722934","https://openalex.org/W2260312731","https://openalex.org/W2280597385","https://openalex.org/W2281997013","https://openalex.org/W2295843667","https://openalex.org/W2315404161","https://openalex.org/W2318276819","https://openalex.org/W2323738288","https://openalex.org/W2411238967","https://openalex.org/W2432855159","https://openalex.org/W2461427403","https://openalex.org/W2489126592","https://openalex.org/W2522417827","https://openalex.org/W2534288116","https://openalex.org/W2560367415","https://openalex.org/W2568822576","https://openalex.org/W2580189873","https://openalex.org/W2584033231","https://openalex.org/W2601016637","https://openalex.org/W2618439945","https://openalex.org/W2704159227","https://openalex.org/W2735132087","https://openalex.org/W2758817823","https://openalex.org/W2776352834","https://openalex.org/W2795993993","https://openalex.org/W2796366554","https://openalex.org/W2796408191","https://openalex.org/W2802429942","https://openalex.org/W2899600207","https://openalex.org/W2905375440","https://openalex.org/W2916911849","https://openalex.org/W2936686072","https://openalex.org/W2963382551","https://openalex.org/W2965506096","https://openalex.org/W2998119497"],"related_works":["https://openalex.org/W4282960865","https://openalex.org/W4214810602","https://openalex.org/W3146811394","https://openalex.org/W2983649157","https://openalex.org/W2741306635","https://openalex.org/W2556855892","https://openalex.org/W2523769397","https://openalex.org/W2151009083","https://openalex.org/W2097289205","https://openalex.org/W2000687555"],"abstract_inverted_index":{"Tumor-specific":[0],"genomic":[1],"alterations":[2],"allow":[3],"systematic":[4],"identification":[5,230],"of":[6,20,138,159,231,241,247],"genetic":[7,62,107,123,150,216],"interactions":[8,124,151,217],"that":[9,100,146,166,235],"promote":[10],"tumorigenesis":[11],"and":[12,77,119,180,192,196,239],"tumor":[13,45,220,237],"vulnerabilities,":[14],"offering":[15],"novel":[16],"strategies":[17],"for":[18,23,229,245],"development":[19,246],"targeted":[21],"therapies":[22],"individual":[24],"patients.":[25],"We":[26,98,163],"develop":[27],"an":[28],"Individualized":[29],"Network-based":[30],"Co-Mutation":[31],"(INCM)":[32],"methodology":[33,228],"by":[34,90,110,218],"inspecting":[35],"over":[36],"2.5":[37],"million":[38],"nonsynonymous":[39],"somatic":[40],"mutations":[41],"derived":[42],"from":[43,51,135],"6,789":[44],"exomes":[46],"across":[47],"14":[48],"cancer":[49,72,95,105,117,249],"types":[50],"The":[52],"Cancer":[53,142],"Genome":[54],"Atlas.":[55],"Our":[56],"INCM":[57,111],"analysis":[58,211],"reveals":[59,212],"a":[60,225],"higher":[61],"interaction":[63],"burden":[64],"on":[65,93,173],"the":[66,104,120,136,147,169],"significantly":[67,113,155],"mutated":[68],"genes,":[69,73,81],"experimentally":[70,164],"validated":[71,165],"chromosome":[74],"regulatory":[75],"factors,":[76],"DNA":[78],"damage":[79],"repair":[80],"as":[82],"compared":[83,183],"to":[84,184],"human":[85],"pan-cancer":[86],"essential":[87],"genes":[88,101],"identified":[89,109],"CRISPR-Cas9":[91],"screenings":[92],"324":[94],"cell":[96],"lines.":[97],"find":[99],"involved":[102],"in":[103,115,141],"type-specific":[106],"subnetworks":[108],"are":[112,125,154],"enriched":[114],"established":[116],"pathways,":[118],"INCM-inferred":[121],"putative":[122,149],"correlated":[126,156],"with":[127,157],"patient":[128],"survival.":[129],"By":[130],"analyzing":[131],"drug":[132],"pharmacogenomics":[133,243],"profiles":[134],"Genomics":[137],"Drug":[139],"Sensitivity":[140],"database,":[143],"we":[144],"show":[145],"network-predicted":[148],"(e.g.,":[152],"BRCA2-TP53)":[153],"sensitivity/resistance":[158],"multiple":[160],"therapeutic":[161,233],"agents.":[162],"afatinib":[167],"has":[168],"strongest":[170],"cytotoxic":[171],"activity":[172],"BT474":[174],"(IC50":[175,186,198],"=":[176,187,199],"55.5":[177],"nM,":[178],"BRCA2":[179,191,202],"TP53":[181,193,206],"co-mutant)":[182],"MCF7":[185],"7.7":[188],"\u03bcM,":[189,201],"both":[190],"wild":[194,203],"type)":[195],"MDA-MB-231":[197],"7.9":[200],"type":[204],"but":[205],"mutant).":[207],"Finally,":[208],"drug-target":[209],"network":[210],"several":[213],"potential":[214,242],"druggable":[215],"targeting":[219],"vulnerabilities.":[221],"This":[222],"study":[223],"offers":[224],"powerful":[226],"network-based":[227],"candidate":[232],"pathways":[234],"target":[236],"vulnerabilities":[238],"prioritization":[240],"biomarkers":[244],"personalized":[248],"medicine.":[250]},"abstract_inverted_index_v3":null,"cited_by_api_url":"https://api.openalex.org/works?filter=cites:W3007090700","counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":6}],"updated_date":"2025-04-23T02:24:34.452165","created_date":"2020-03-06"}