{"id":"https://openalex.org/W2967657981","doi":"https://doi.org/10.1371/journal.pcbi.1007230","title":"FAMoS: A Flexible and dynamic Algorithm for Model Selection to analyse complex systems dynamics","display_name":"FAMoS: A Flexible and dynamic Algorithm for Model Selection to analyse complex systems dynamics","publication_year":2019,"publication_date":"2019-08-16","ids":{"openalex":"https://openalex.org/W2967657981","doi":"https://doi.org/10.1371/journal.pcbi.1007230","mag":"2967657981","pmid":"https://pubmed.ncbi.nlm.nih.gov/31419221","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6697322"},"language":"en","primary_location":{"is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007230","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007230&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310316756","host_organization_name":"International Society for Computational Biology","host_organization_lineage":["https://openalex.org/P4310316756"],"host_organization_lineage_names":["International Society for Computational Biology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true},"type":"article","type_crossref":"journal-article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007230&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017374939","display_name":"Michael Gabel","orcid":null},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Michael Gabel","raw_affiliation_strings":["Center for Modelling and Simulation in the Biosciences, BioQuant-Center, Heidelberg University, Heidelberg, Germany"],"affiliations":[{"raw_affiliation_string":"Center for Modelling and Simulation in the Biosciences, BioQuant-Center, Heidelberg University, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082207862","display_name":"Tobias Hohl","orcid":"https://orcid.org/0000-0002-2229-4391"},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Tobias Hohl","raw_affiliation_strings":["Center for Modelling and Simulation in the Biosciences, BioQuant-Center, Heidelberg University, Heidelberg, Germany"],"affiliations":[{"raw_affiliation_string":"Center for Modelling and Simulation in the Biosciences, BioQuant-Center, Heidelberg University, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045409518","display_name":"Andrea Imle","orcid":"https://orcid.org/0000-0002-8740-1477"},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Andrea Imle","raw_affiliation_strings":["Department of Infectious Diseases, Centre for Integrative Infectious Disease Research (CIID), Integrative Virology, University Hospital Heidelberg, Heidelberg, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Centre for Integrative Infectious Disease Research (CIID), Integrative Virology, University Hospital Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966","https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011493742","display_name":"O. Fackler","orcid":"https://orcid.org/0000-0003-2982-4209"},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Oliver T. Fackler","raw_affiliation_strings":["Department of Infectious Diseases, Centre for Integrative Infectious Disease Research (CIID), Integrative Virology, University Hospital Heidelberg, Heidelberg, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Centre for Integrative Infectious Disease Research (CIID), Integrative Virology, University Hospital Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966","https://openalex.org/I223822909"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058044076","display_name":"Frederik Graw","orcid":"https://orcid.org/0000-0002-1198-6632"},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Frederik Graw","raw_affiliation_strings":["Center for Modelling and Simulation in the Biosciences, BioQuant-Center, Heidelberg University, Heidelberg, Germany"],"affiliations":[{"raw_affiliation_string":"Center for Modelling and Simulation in the Biosciences, BioQuant-Center, Heidelberg University, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]}],"institution_assertions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5017374939","https://openalex.org/A5082207862","https://openalex.org/A5045409518","https://openalex.org/A5011493742","https://openalex.org/A5058044076"],"corresponding_institution_ids":["https://openalex.org/I223822909","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I223822909","https://openalex.org/I223822909"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655,"provenance":"doaj"},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655,"provenance":"doaj"},"fwci":0.575,"has_fulltext":true,"fulltext_origin":"pdf","cited_by_count":8,"citation_normalized_percentile":{"value":0.446378,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":83,"max":84},"biblio":{"volume":"15","issue":"8","first_page":"e1007230","last_page":"e1007230"},"is_retracted":false,"is_paratext":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9994,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9994,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9954,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9892,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/maxima-and-minima","display_name":"Maxima and minima","score":0.6321633},{"id":"https://openalex.org/keywords/complex-system","display_name":"Complex system","score":0.4156774}],"concepts":[{"id":"https://openalex.org/C2780598303","wikidata":"https://www.wikidata.org/wiki/Q65921492","display_name":"Flexibility (engineering)","level":2,"score":0.7272093},{"id":"https://openalex.org/C186633575","wikidata":"https://www.wikidata.org/wiki/Q845060","display_name":"Maxima and minima","level":2,"score":0.6321633},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6318991},{"id":"https://openalex.org/C93959086","wikidata":"https://www.wikidata.org/wiki/Q6888345","display_name":"Model selection","level":2,"score":0.529013},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.49225846},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.48871827},{"id":"https://openalex.org/C79379906","wikidata":"https://www.wikidata.org/wiki/Q3174497","display_name":"Dynamical systems theory","level":2,"score":0.44258428},{"id":"https://openalex.org/C47822265","wikidata":"https://www.wikidata.org/wiki/Q854457","display_name":"Complex system","level":2,"score":0.4156774},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.37608415},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.32421932},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.30792677},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.21157396},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":"","qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":"","qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"","qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007230","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007230&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310316756","host_organization_name":"International Society for Computational Biology","host_organization_lineage":["https://openalex.org/P4310316756"],"host_organization_lineage_names":["International Society for Computational Biology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":false,"landing_page_url":"https://doaj.org/article/41885b331a164df1aadd08ea1291c0b4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false},{"is_oa":true,"landing_page_url":"https://europepmc.org/articles/pmc6697322","pdf_url":"https://europepmc.org/articles/pmc6697322?pdf=render","source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":["European Bioinformatics Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697322","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":["National Institutes of Health"],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/FAMoS_A_Flexible_and_dynamic_Algorithm_for_Model_Selection_to_analyse_complex_systems_dynamics/9639386","pdf_url":"https://figshare.com/ndownloader/files/17293016","source":{"id":"https://openalex.org/S4306400572","display_name":"OPAL (Open@LaTrobe) (La Trobe University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I196829312","host_organization_name":"La Trobe University","host_organization_lineage":["https://openalex.org/I196829312"],"host_organization_lineage_names":["La Trobe University"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false},{"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31419221","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":["National Institutes of Health"],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false}],"best_oa_location":{"is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007230","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007230&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310316756","host_organization_name":"International Society for Computational Biology","host_organization_lineage":["https://openalex.org/P4310316756"],"host_organization_lineage_names":["International Society for Computational Biology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true},"sustainable_development_goals":[],"grants":[{"funder":"https://openalex.org/F4320324609","funder_display_name":"Center for Modelling and Simulation in the Biosciences","award_id":null}],"datasets":[],"versions":[],"referenced_works_count":47,"referenced_works":["https://openalex.org/W1513618424","https://openalex.org/W1525111052","https://openalex.org/W1969423031","https://openalex.org/W1971931476","https://openalex.org/W1987464952","https://openalex.org/W1994500716","https://openalex.org/W1996676269","https://openalex.org/W2019048224","https://openalex.org/W2032196578","https://openalex.org/W2035681961","https://openalex.org/W2038163209","https://openalex.org/W2057271096","https://openalex.org/W2058815839","https://openalex.org/W2071413187","https://openalex.org/W2085149748","https://openalex.org/W2086221877","https://openalex.org/W2107467541","https://openalex.org/W2115558707","https://openalex.org/W2123901775","https://openalex.org/W2126351705","https://openalex.org/W2128011175","https://openalex.org/W2130902307","https://openalex.org/W2142635246","https://openalex.org/W2144407007","https://openalex.org/W2149537945","https://openalex.org/W2160837236","https://openalex.org/W2167334954","https://openalex.org/W2168175751","https://openalex.org/W2168648059","https://openalex.org/W2230272026","https://openalex.org/W2239232218","https://openalex.org/W2328425223","https://openalex.org/W2330399463","https://openalex.org/W2478738321","https://openalex.org/W2586633795","https://openalex.org/W2588239017","https://openalex.org/W2590514560","https://openalex.org/W2800317020","https://openalex.org/W2945993058","https://openalex.org/W2953380254","https://openalex.org/W3100641539","https://openalex.org/W3188875553","https://openalex.org/W4211177544","https://openalex.org/W4252310231","https://openalex.org/W4285719527","https://openalex.org/W4297515751","https://openalex.org/W4300819821"],"related_works":["https://openalex.org/W4320035781","https://openalex.org/W4246278799","https://openalex.org/W3188646203","https://openalex.org/W2909957174","https://openalex.org/W2375684291","https://openalex.org/W2354676191","https://openalex.org/W2105527480","https://openalex.org/W2052387497","https://openalex.org/W2050203848","https://openalex.org/W136674370"],"abstract_inverted_index":{"Most":[0],"biological":[1,34,265],"systems":[2,35,137],"are":[3,92],"difficult":[4],"to":[5,8,39,75,131,202,244,247,259],"analyse":[6,203],"due":[7],"a":[9,29,63,72,98,144,260,269],"multitude":[10,64],"of":[11,18,32,53,62,65,86,101,108,121,168,211,232,263,276],"interacting":[12],"components":[13],"and":[14,36,44,138,151,180,188,213,267],"the":[15,21,50,60,84,109,119,160,169,182,200,207,229,248,255,273],"concomitant":[16],"lack":[17],"information":[19],"about":[20],"essential":[22],"dynamics.":[23],"Finding":[24],"appropriate":[25,77],"models":[26,67,102],"that":[27,37,58,128,157,217,234],"provide":[28,71],"systematic":[30],"description":[31],"such":[33],"help":[38],"identify":[40,76],"their":[41],"relevant":[42],"factors":[43],"processes":[45],"can":[46,158],"be":[47,115],"challenging":[48],"given":[49],"sheer":[51],"number":[52,100,120],"possibilities.":[54,122],"Model":[55],"selection":[56,134],"algorithms":[57,82],"evaluate":[59],"performance":[61],"different":[66,194,221,264],"against":[68],"experimental":[69,204],"data":[70,187,205],"useful":[73,270],"tool":[74,271],"model":[78,111,133,141,170,195,253,278],"structures.":[79,196],"However,":[80],"many":[81],"addressing":[83],"analysis":[85],"complex":[87,136,277],"dynamical":[88,145,226],"systems,":[89],"as":[90],"they":[91],"often":[93],"used":[94,199],"in":[95,143,165,250],"biology,":[96],"compare":[97],"preselected":[99],"or":[103],"rely":[104],"on":[105,118,135,185,206],"exhaustive":[106],"searches":[107,139],"total":[110],"space":[112,171],"which":[113],"might":[114],"unfeasible":[116],"dependent":[117],"Therefore,":[123],"we":[124],"developed":[125,153],"an":[126],"algorithm":[127,148,161,183,201,256],"is":[129,257],"able":[130],"perform":[132],"large":[140,261],"spaces":[142],"way.":[146],"Our":[147,223],"includes":[149],"local":[150,166],"newly":[152],"non-local":[154],"search":[155],"methods":[156],"prevent":[159],"from":[162],"ending":[163],"up":[164],"minima":[167],"by":[172],"accounting":[173],"for":[174,192,272],"structurally":[175],"similar":[176],"processes.":[177],"We":[178,197],"tested":[179],"validated":[181],"based":[184],"simulated":[186],"showed":[189],"its":[190],"flexibility":[191,249],"handling":[193,251],"also":[198],"cell":[208],"proliferation":[209,230],"dynamics":[210],"CD4+":[212],"CD8+":[214],"T":[215],"cells":[216,233],"were":[218],"cultured":[219],"under":[220],"conditions.":[222],"analyses":[224],"indicated":[225],"changes":[227],"within":[228,237],"potential":[231],"was":[235],"reduced":[236],"tissue-like":[238],"3D":[239],"ex":[240],"vivo":[241],"cultures":[242],"compared":[243],"suspension.":[245],"Due":[246],"various":[252],"structures,":[254],"applicable":[258],"variety":[262],"problems":[266],"represents":[268],"data-oriented":[274],"evaluation":[275],"spaces.":[279]},"cited_by_api_url":"https://api.openalex.org/works?filter=cites:W2967657981","counts_by_year":[{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":1}],"updated_date":"2025-01-18T10:38:11.175935","created_date":"2019-08-22"}