{"id":"https://openalex.org/W2095057511","doi":"https://doi.org/10.1371/journal.pcbi.1003766","title":"Allele-Specific Network Reveals Combinatorial Interaction That Transcends Small Effects in Psoriasis GWAS","display_name":"Allele-Specific Network Reveals Combinatorial Interaction That Transcends Small Effects in Psoriasis GWAS","publication_year":2014,"publication_date":"2014-09-18","ids":{"openalex":"https://openalex.org/W2095057511","doi":"https://doi.org/10.1371/journal.pcbi.1003766","mag":"2095057511","pmid":"https://pubmed.ncbi.nlm.nih.gov/25233071","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4168982"},"language":"en","primary_location":{"is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003766","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003766&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310316756","host_organization_name":"International Society for Computational Biology","host_organization_lineage":["https://openalex.org/P4310316756"],"host_organization_lineage_names":["International Society for Computational Biology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true},"type":"article","type_crossref":"journal-article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003766&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019827444","display_name":"Sharlee Climer","orcid":"https://orcid.org/0000-0003-2731-7377"},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sharlee Climer","raw_affiliation_strings":["Department of Computer Science and Engineering, Washington University, St. Louis, Missouri, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, Washington University, St. Louis, Missouri, United States of America","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021333022","display_name":"Alan R. Templeton","orcid":"https://orcid.org/0000-0002-0167-845X"},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I91203450","display_name":"University of Haifa","ror":"https://ror.org/02f009v59","country_code":"IL","type":"education","lineage":["https://openalex.org/I91203450"]}],"countries":["IL","US"],"is_corresponding":true,"raw_author_name":"Alan R. Templeton","raw_affiliation_strings":["Department of Biology, Washington University, St. Louis, Missouri, United States of America","Department of Genetics, Washington University, St. Louis, Missouri, United States of America","Institute of Evolution, and Department of Evolutionary and Environmental Biology, University of Haifa, Haifa, Israel"],"affiliations":[{"raw_affiliation_string":"Department of Biology, Washington University, St. Louis, Missouri, United States of America","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Genetics, Washington University, St. Louis, Missouri, United States of America","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Institute of Evolution, and Department of Evolutionary and Environmental Biology, University of Haifa, Haifa, Israel","institution_ids":["https://openalex.org/I91203450"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068659777","display_name":"Weixiong Zhang","orcid":"https://orcid.org/0000-0002-4998-9791"},"institutions":[{"id":"https://openalex.org/I31590910","display_name":"Jianghan University","ror":"https://ror.org/041c9x778","country_code":"CN","type":"education","lineage":["https://openalex.org/I31590910"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Weixiong Zhang","raw_affiliation_strings":["Department of Computer Science and Engineering, Washington University, St. Louis, Missouri, United States of America","Department of Genetics, Washington University, St. Louis, Missouri, United States of America","Institute for Systems Biology, Jianghan University, Wuhan, Hubei, China"],"affiliations":[{"raw_affiliation_string":"Institute for Systems Biology, Jianghan University, Wuhan, Hubei, China","institution_ids":["https://openalex.org/I31590910"]},{"raw_affiliation_string":"Department of Genetics, Washington University, St. Louis, Missouri, United States of America","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Computer Science and Engineering, Washington University, St. Louis, Missouri, United States of America","institution_ids":["https://openalex.org/I204465549"]}]}],"institution_assertions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5019827444","https://openalex.org/A5021333022","https://openalex.org/A5068659777"],"corresponding_institution_ids":["https://openalex.org/I204465549","https://openalex.org/I204465549","https://openalex.org/I91203450","https://openalex.org/I31590910","https://openalex.org/I204465549"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655,"provenance":"doaj"},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655,"provenance":"doaj"},"fwci":0.652,"has_fulltext":true,"fulltext_origin":"pdf","cited_by_count":23,"citation_normalized_percentile":{"value":0.795654,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":92},"biblio":{"volume":"10","issue":"9","first_page":"e1003766","last_page":"e1003766"},"is_retracted":false,"is_paratext":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9979,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9979,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.9937,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9856,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/missing-heritability-problem","display_name":"Missing heritability problem","score":0.8474965},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide Association Study","score":0.6786084},{"id":"https://openalex.org/keywords/genetic-association","display_name":"Genetic Association","score":0.49112675},{"id":"https://openalex.org/keywords/bonferroni-correction","display_name":"Bonferroni correction","score":0.43574303}],"concepts":[{"id":"https://openalex.org/C144621757","wikidata":"https://www.wikidata.org/wiki/Q3083720","display_name":"Missing heritability problem","level":5,"score":0.8474965},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.6786084},{"id":"https://openalex.org/C161890455","wikidata":"https://www.wikidata.org/wiki/Q1503548","display_name":"Heritability","level":2,"score":0.6178579},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.59370494},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5620624},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5415601},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.49112675},{"id":"https://openalex.org/C127808970","wikidata":"https://www.wikidata.org/wiki/Q385989","display_name":"Bonferroni correction","level":2,"score":0.43574303},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.43305287},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.34808943},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22993281},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.21174502},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.20607716},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.15628451}],"mesh":[{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D011565","descriptor_name":"Psoriasis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011565","descriptor_name":"Psoriasis","qualifier_ui":"","qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003766","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003766&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310316756","host_organization_name":"International Society for Computational Biology","host_organization_lineage":["https://openalex.org/P4310316756"],"host_organization_lineage_names":["International Society for Computational Biology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":true,"landing_page_url":"https://europepmc.org/articles/pmc4168982","pdf_url":"https://europepmc.org/articles/pmc4168982?pdf=render","source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":["European Bioinformatics Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":true,"landing_page_url":"https://digitalcommons.wustl.edu/cgi/viewcontent.cgi?article=4466&context=open_access_pubs","pdf_url":"https://digitalcommons.wustl.edu/cgi/viewcontent.cgi?article=4466&context=open_access_pubs","source":{"id":"https://openalex.org/S4306400764","display_name":"Digital Commons@Becker (Washington University School of Medicine)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I204465549","host_organization_name":"Washington University in St. Louis","host_organization_lineage":["https://openalex.org/I204465549"],"host_organization_lineage_names":["Washington University in St. Louis"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.12613/5586","pdf_url":"https://scholarshare.temple.edu/bitstream/20.500.12613/5586/2/Allele-specific%20network%20reveals%20combinatorial%20interaction%20that%20transcends%20small%20effects%20in%20psoriasis%20GWAS.pdf","source":{"id":"https://openalex.org/S4306402624","display_name":"TUScholarShare (Temple University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I84392919","host_organization_name":"Temple University","host_organization_lineage":["https://openalex.org/I84392919"],"host_organization_lineage_names":["Temple University"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":true,"landing_page_url":"https://irl.umsl.edu/cmpsci-faculty/20","pdf_url":"https://irl.umsl.edu/cgi/viewcontent.cgi?article=1020&context=cmpsci-faculty","source":{"id":"https://openalex.org/S4377196466","display_name":"IRL - University of Missouri, St. Louis (University of Missouri\u2013St. Louis)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I208333798","host_organization_name":"University of Missouri\u2013St. Louis","host_organization_lineage":["https://openalex.org/I208333798"],"host_organization_lineage_names":["University of Missouri\u2013St. Louis"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168982","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":["National Institutes of Health"],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25233071","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":["National Institutes of Health"],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false}],"best_oa_location":{"is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003766","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003766&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310316756","host_organization_name":"International Society for Computational Biology","host_organization_lineage":["https://openalex.org/P4310316756"],"host_organization_lineage_names":["International Society for Computational Biology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true},"sustainable_development_goals":[],"grants":[],"datasets":[],"versions":[],"referenced_works_count":84,"referenced_works":["https://openalex.org/W1507985183","https://openalex.org/W1546962148","https://openalex.org/W1600165106","https://openalex.org/W1882059917","https://openalex.org/W1901627773","https://openalex.org/W1922801175","https://openalex.org/W1964995490","https://openalex.org/W1966360257","https://openalex.org/W1971421925","https://openalex.org/W1978150238","https://openalex.org/W1979963342","https://openalex.org/W1981924240","https://openalex.org/W1982994867","https://openalex.org/W1983226456","https://openalex.org/W1989215915","https://openalex.org/W1989531990","https://openalex.org/W1994592982","https://openalex.org/W1998957301","https://openalex.org/W2005428052","https://openalex.org/W2006950321","https://openalex.org/W2007858625","https://openalex.org/W2017597599","https://openalex.org/W2019630743","https://openalex.org/W2020906240","https://openalex.org/W2030628077","https://openalex.org/W2032442401","https://openalex.org/W2035464895","https://openalex.org/W2037098416","https://openalex.org/W2038309633","https://openalex.org/W2038509324","https://openalex.org/W2044833878","https://openalex.org/W2045113343","https://openalex.org/W2047923046","https://openalex.org/W2049572499","https://openalex.org/W2058112220","https://openalex.org/W2062741735","https://openalex.org/W2065719278","https://openalex.org/W2068281838","https://openalex.org/W2075408374","https://openalex.org/W2075557772","https://openalex.org/W2079098929","https://openalex.org/W2079256218","https://openalex.org/W2081218034","https://openalex.org/W2088400499","https://openalex.org/W2092836731","https://openalex.org/W2102889851","https://openalex.org/W2103017472","https://openalex.org/W2103879666","https://openalex.org/W2105842551","https://openalex.org/W2106292145","https://openalex.org/W2109460336","https://openalex.org/W2109953038","https://openalex.org/W2113952909","https://openalex.org/W2114701953","https://openalex.org/W2121112297","https://openalex.org/W2122276216","https://openalex.org/W2122736167","https://openalex.org/W2123468478","https://openalex.org/W2132243013","https://openalex.org/W2143856741","https://openalex.org/W2152119060","https://openalex.org/W2152224204","https://openalex.org/W2152381343","https://openalex.org/W2155496693","https://openalex.org/W2158217645","https://openalex.org/W2159482845","https://openalex.org/W2161633633","https://openalex.org/W2161998322","https://openalex.org/W2162530578","https://openalex.org/W2167638767","https://openalex.org/W2168521098","https://openalex.org/W2168755415","https://openalex.org/W2170293083","https://openalex.org/W2171377520","https://openalex.org/W2337429169","https://openalex.org/W2466004493","https://openalex.org/W3006032487","https://openalex.org/W3150545588","https://openalex.org/W3214092816","https://openalex.org/W4211099883","https://openalex.org/W4236706032","https://openalex.org/W4294216483","https://openalex.org/W4319308347","https://openalex.org/W656060844"],"related_works":["https://openalex.org/W2924960962","https://openalex.org/W2170506381","https://openalex.org/W2144000849","https://openalex.org/W2136285728","https://openalex.org/W2111896105","https://openalex.org/W2102533238","https://openalex.org/W1987620105","https://openalex.org/W1975304626","https://openalex.org/W1847429134","https://openalex.org/W159064268"],"abstract_inverted_index":{"Hundreds":[0],"of":[1,26,60,66,81,102,122,127,138,146,153],"genetic":[2,40,61,106,166],"markers":[3,181],"have":[4,33],"shown":[5],"associations":[6,65,167],"with":[7,69,118],"various":[8],"complex":[9],"diseases,":[10],"yet":[11],"the":[12,64,70,76,139,154,174],"\"missing":[13],"heritability\"":[14],"remains":[15],"alarmingly":[16],"elusive.":[17],"Combinatorial":[18],"interactions":[19],"may":[20],"account":[21],"for":[22,93,163],"a":[23,45,79,87,99,115],"substantial":[24],"portion":[25],"this":[27],"missing":[28],"heritability,":[29],"but":[30],"their":[31],"discoveries":[32],"been":[34],"impeded":[35],"by":[36,179],"computational":[37],"complexity":[38],"and":[39,73,97,124,149],"heterogeneity.":[41,107],"We":[42,108],"present":[43],"BlocBuster,":[44],"novel":[46],"systems-level":[47],"approach":[48],"that":[49,55,90,104],"efficiently":[50],"constructs":[51],"genome-wide,":[52],"allele-specific":[53],"networks":[54],"accurately":[56],"segregate":[57],"homogenous":[58],"combinations":[59,68],"factors,":[62],"tests":[63],"these":[67,158],"given":[71],"phenotype,":[72],"rigorously":[74],"validates":[75],"results":[77,159],"using":[78],"series":[80],"unbiased":[82],"validation":[83],"methods.":[84],"BlocBuster":[85,110],"employs":[86],"correlation":[88],"measure":[89],"is":[91],"customized":[92],"single":[94],"nucleotide":[95],"polymorphisms":[96],"returns":[98],"multi-faceted":[100],"collection":[101],"values":[103],"captures":[105],"applied":[109],"to":[111,143],"analyze":[112],"psoriasis,":[113,157],"discovering":[114,164],"combinatorial":[116,165],"pattern":[117,130],"an":[119],"odds":[120],"ratio":[121],"3.64":[123],"Bonferroni-corrected":[125],"p-value":[126],"5.01\u00d710\u221216.":[128],"This":[129],"was":[131],"replicated":[132],"in":[133,183],"independent":[134],"data,":[135,171],"reflecting":[136],"robustness":[137],"method.":[140],"In":[141],"addition":[142],"improving":[144],"prediction":[145],"disease":[147],"susceptibility":[148],"broadening":[150],"our":[151],"understanding":[152],"pathogenesis":[155],"underlying":[156],"demonstrate":[160],"BlocBuster's":[161],"potential":[162],"within":[168],"heterogeneous":[169],"genome-wide":[170],"thereby":[172],"transcending":[173],"limiting":[175],"\"small":[176],"effects\"":[177],"produced":[178],"individual":[180],"examined":[182],"isolation.":[184]},"cited_by_api_url":"https://api.openalex.org/works?filter=cites:W2095057511","counts_by_year":[{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2024-12-08T22:49:36.193533","created_date":"2016-06-24"}