{"id":"https://openalex.org/W2142544064","doi":"https://doi.org/10.1371/journal.pcbi.1002179","title":"Computational Modeling of Allosteric Communication Reveals Organizing Principles of Mutation-Induced Signaling in ABL and EGFR Kinases","display_name":"Computational Modeling of Allosteric Communication Reveals Organizing Principles of Mutation-Induced Signaling in ABL and EGFR Kinases","publication_year":2011,"publication_date":"2011-10-06","ids":{"openalex":"https://openalex.org/W2142544064","doi":"https://doi.org/10.1371/journal.pcbi.1002179","mag":"2142544064","pmid":"https://pubmed.ncbi.nlm.nih.gov/21998569","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3188506"},"language":"en","primary_location":{"is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002179","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002179&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_indexed_in_scopus":true,"is_core":true,"host_organization":"https://openalex.org/P4310316756","host_organization_name":"International Society for Computational Biology","host_organization_lineage":["https://openalex.org/P4310316756"],"host_organization_lineage_names":["International Society for Computational Biology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true},"type":"article","type_crossref":"journal-article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002179&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009132569","display_name":"Anshuman Dixit","orcid":"https://orcid.org/0000-0001-8063-7893"},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"funder","lineage":["https://openalex.org/I146416000"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anshuman Dixit","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, School of Pharmacy, The University of Kansas, Lawrence, Kansas, United States of America."],"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, School of Pharmacy, The University of Kansas, Lawrence, Kansas, United States of America.","institution_ids":["https://openalex.org/I146416000"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031922505","display_name":"Gennady M. Verkhivker","orcid":"https://orcid.org/0000-0002-4507-4471"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"funder","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"funder","lineage":["https://openalex.org/I146416000"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gennady M. Verkhivker","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, School of Pharmacy, The University of Kansas, Lawrence, Kansas, United States of America","Department of Pharmacology, University of California San Diego, La Jolla, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of California San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, School of Pharmacy, The University of Kansas, Lawrence, Kansas, United States of America","institution_ids":["https://openalex.org/I146416000"]}]}],"institution_assertions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":10.11,"has_fulltext":true,"fulltext_origin":"pdf","cited_by_count":78,"citation_normalized_percentile":{"value":0.888486,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"7","issue":"10","first_page":"e1002179","last_page":"e1002179"},"is_retracted":false,"is_paratext":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9966,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9966,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9941,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9912,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/allosteric-enzyme","display_name":"Allosteric enzyme","score":0.61724114},{"id":"https://openalex.org/keywords/cooperativity","display_name":"Cooperativity","score":0.56171024}],"concepts":[{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.97896785},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.617782},{"id":"https://openalex.org/C109964505","wikidata":"https://www.wikidata.org/wiki/Q3321436","display_name":"Allosteric enzyme","level":4,"score":0.61724114},{"id":"https://openalex.org/C166014724","wikidata":"https://www.wikidata.org/wiki/Q337217","display_name":"Cooperativity","level":2,"score":0.56171024},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44399992},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4438735},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.43856233},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37996307},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34063148},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3252327},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.18897808}],"mesh":[{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":"","qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016315","descriptor_name":"Proto-Oncogene Proteins c-abl","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016315","descriptor_name":"Proto-Oncogene Proteins c-abl","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000494","descriptor_name":"Allosteric Regulation","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054730","descriptor_name":"Protein Interaction Domains and Motifs","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020836","descriptor_name":"Protein Structure, Quaternary","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016315","descriptor_name":"Proto-Oncogene Proteins c-abl","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016315","descriptor_name":"Proto-Oncogene Proteins c-abl","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"","qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002179","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002179&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_indexed_in_scopus":true,"is_core":true,"host_organization":"https://openalex.org/P4310316756","host_organization_name":"International Society for Computational Biology","host_organization_lineage":["https://openalex.org/P4310316756"],"host_organization_lineage_names":["International Society for Computational Biology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":true,"landing_page_url":"https://europepmc.org/articles/pmc3188506","pdf_url":"https://europepmc.org/articles/pmc3188506?pdf=render","source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_indexed_in_scopus":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":["European Bioinformatics Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":true,"landing_page_url":"http://hdl.handle.net/1808/13229","pdf_url":"https://kuscholarworks.ku.edu/bitstream/1808/13229/1/Dixit2011a.pdf","source":{"id":"https://openalex.org/S4377196285","display_name":"KU ScholarWorks (University of Kansas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_indexed_in_scopus":false,"is_core":false,"host_organization":"https://openalex.org/I146416000","host_organization_name":"University of Kansas","host_organization_lineage":["https://openalex.org/I146416000"],"host_organization_lineage_names":["University of Kansas"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188506","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_indexed_in_scopus":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":["National Institutes of Health"],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21998569","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_indexed_in_scopus":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":["National Institutes of Health"],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false}],"best_oa_location":{"is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002179","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002179&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_indexed_in_scopus":true,"is_core":true,"host_organization":"https://openalex.org/P4310316756","host_organization_name":"International Society for Computational Biology","host_organization_lineage":["https://openalex.org/P4310316756"],"host_organization_lineage_names":["International Society for Computational Biology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true},"sustainable_development_goals":[],"grants":[],"datasets":[],"versions":[],"referenced_works_count":184,"referenced_works":["https://openalex.org/W1965076207","https://openalex.org/W1966960114","https://openalex.org/W1967095911","https://openalex.org/W1968091681","https://openalex.org/W1969345506","https://openalex.org/W1969939692","https://openalex.org/W1970174659","https://openalex.org/W1971248653","https://openalex.org/W1972964958","https://openalex.org/W1974906797","https://openalex.org/W1975024278","https://openalex.org/W1976051941","https://openalex.org/W1976164436","https://openalex.org/W1976248779","https://openalex.org/W1976499671","https://openalex.org/W1978343870","https://openalex.org/W1978943385","https://openalex.org/W1979948766","https://openalex.org/W1980590401","https://openalex.org/W1981602821","https://openalex.org/W1981946467","https://openalex.org/W1982874561","https://openalex.org/W1983834639","https://openalex.org/W1986139301","https://openalex.org/W1988271243","https://openalex.org/W1988688258","https://openalex.org/W1988837867","https://openalex.org/W1991335138","https://openalex.org/W1991764480","https://openalex.org/W1992784105","https://openalex.org/W1995085157","https://openalex.org/W1998093640","https://openalex.org/W1998171084","https://openalex.org/W2000390423","https://openalex.org/W2002767842","https://openalex.org/W2003229373","https://openalex.org/W2003984225","https://openalex.org/W2005080874","https://openalex.org/W2005392755","https://openalex.org/W2005474992","https://openalex.org/W2005515343","https://openalex.org/W2007832743","https://openalex.org/W2007832948","https://openalex.org/W2009123297","https://openalex.org/W2012490272","https://openalex.org/W2014582878","https://openalex.org/W2015616444","https://openalex.org/W2017428798","https://openalex.org/W2017792882","https://openalex.org/W2018981978","https://openalex.org/W2020094759","https://openalex.org/W2020164940","https://openalex.org/W2021312892","https://openalex.org/W2024133961","https://openalex.org/W2026542427","https://openalex.org/W2026724593","https://openalex.org/W2027408247","https://openalex.org/W2028015151","https://openalex.org/W2028415754","https://openalex.org/W2028876207","https://openalex.org/W2029118067","https://openalex.org/W2031094493","https://openalex.org/W2035024352","https://openalex.org/W2038793346","https://openalex.org/W2040232982","https://openalex.org/W2043789128","https://openalex.org/W2046151919","https://openalex.org/W2046536764","https://openalex.org/W2048258225","https://openalex.org/W2048411595","https://openalex.org/W2050046701","https://openalex.org/W2050422354","https://openalex.org/W2051341715","https://openalex.org/W2052420692","https://openalex.org/W2054272768","https://openalex.org/W2054752913","https://openalex.org/W2055823413","https://openalex.org/W2057594534","https://openalex.org/W2058640773","https://openalex.org/W2059541720","https://openalex.org/W2059736253","https://openalex.org/W2060818930","https://openalex.org/W2061579713","https://openalex.org/W2062568746","https://openalex.org/W2063391304","https://openalex.org/W2063597617","https://openalex.org/W2065717473","https://openalex.org/W2067083902","https://openalex.org/W2073495809","https://openalex.org/W2074129172","https://openalex.org/W2074511635","https://openalex.org/W2077804275","https://openalex.org/W2079398727","https://openalex.org/W2079620307","https://openalex.org/W2080590432","https://openalex.org/W2083975423","https://openalex.org/W2087278189","https://openalex.org/W2092006899","https://openalex.org/W2092606584","https://openalex.org/W2095145098","https://openalex.org/W2095420958","https://openalex.org/W2095745765","https://openalex.org/W2096286606","https://openalex.org/W2097164795","https://openalex.org/W2097946794","https://openalex.org/W2098968010","https://openalex.org/W2099203391","https://openalex.org/W2100358815","https://openalex.org/W2100772783","https://openalex.org/W2100794900","https://openalex.org/W2101635775","https://openalex.org/W2102503844","https://openalex.org/W2103388411","https://openalex.org/W2103484524","https://openalex.org/W2105041993","https://openalex.org/W2106186049","https://openalex.org/W2110648386","https://openalex.org/W2110841878","https://openalex.org/W2111109297","https://openalex.org/W2112033855","https://openalex.org/W2114520383","https://openalex.org/W2115152262","https://openalex.org/W2115298892","https://openalex.org/W2115928493","https://openalex.org/W2116110141","https://openalex.org/W2116265057","https://openalex.org/W2117022661","https://openalex.org/W2118474642","https://openalex.org/W2118733486","https://openalex.org/W2119847916","https://openalex.org/W2123505177","https://openalex.org/W2123853229","https://openalex.org/W2124078205","https://openalex.org/W2124196948","https://openalex.org/W2125580319","https://openalex.org/W2126004255","https://openalex.org/W2128307445","https://openalex.org/W2128393152","https://openalex.org/W2129472062","https://openalex.org/W2130479394","https://openalex.org/W2131174104","https://openalex.org/W2132108032","https://openalex.org/W2132334410","https://openalex.org/W2132589721","https://openalex.org/W2132886170","https://openalex.org/W2136065656","https://openalex.org/W2136298126","https://openalex.org/W2136931941","https://openalex.org/W2137601120","https://openalex.org/W2138645972","https://openalex.org/W2139799027","https://openalex.org/W2141519313","https://openalex.org/W2143185848","https://openalex.org/W2146110873","https://openalex.org/W2146299329","https://openalex.org/W2146928870","https://openalex.org/W2147398227","https://openalex.org/W2147588393","https://openalex.org/W2148745348","https://openalex.org/W2149055390","https://openalex.org/W2150703483","https://openalex.org/W2150981663","https://openalex.org/W2151430724","https://openalex.org/W2153953580","https://openalex.org/W2154279541","https://openalex.org/W2154437955","https://openalex.org/W2155971896","https://openalex.org/W2156647409","https://openalex.org/W2156825507","https://openalex.org/W2159013299","https://openalex.org/W2159291387","https://openalex.org/W2160329145","https://openalex.org/W2161835431","https://openalex.org/W2161893314","https://openalex.org/W2164242115","https://openalex.org/W2164243919","https://openalex.org/W2164831247","https://openalex.org/W2167114132","https://openalex.org/W2168747115","https://openalex.org/W2168841596","https://openalex.org/W2170702897","https://openalex.org/W2177206102","https://openalex.org/W2594475116","https://openalex.org/W2601797347"],"related_works":["https://openalex.org/W4319874929","https://openalex.org/W4244005486","https://openalex.org/W4238923394","https://openalex.org/W2752794680","https://openalex.org/W2747094833","https://openalex.org/W2572355597","https://openalex.org/W2117032992","https://openalex.org/W2108651323","https://openalex.org/W1982170406","https://openalex.org/W1971229210"],"abstract_inverted_index":{"The":[0,158,195,217],"emerging":[1],"structural":[2,138],"information":[3],"about":[4],"allosteric":[5,13,26,81,93,107,156,206,229],"kinase":[6,33,176,193,230],"complexes":[7,60,90,119],"and":[8,22,28,48,61,86,91,116,131,135,155,188,208,232],"the":[9,53,84,96,114,128,151,169,180,191,244],"growing":[10],"number":[11],"of":[12,25,43,55,58,64,80,95,106,123,144,160,168,175,190,197,205,228,237],"inhibitors":[14],"call":[15],"for":[16],"a":[17,121,124,141,165,221,234],"systematic":[18],"strategy":[19],"to":[20,75,179],"delineate":[21],"classify":[23],"mechanisms":[24,105,239],"regulation":[27],"long-range":[29,44,152,182,209],"communication":[30,183],"that":[31,104,148],"control":[32,150],"activity.":[34],"In":[35],"this":[36,161,198],"work,":[37],"we":[38],"have":[39,71,101,110,163],"investigated":[40],"mechanistic":[41,226],"aspects":[42,227],"communications":[45],"in":[46,67,83,113,214,240],"ABL":[47,85,115],"EGFR":[49,87,117],"kinases":[50,242],"based":[51],"on":[52],"results":[54,159,196],"multiscale":[56],"simulations":[57],"regulatory":[59,89,118],"computational":[62],"modeling":[63],"signal":[65],"propagation":[66],"proteins.":[68],"These":[69,137],"approaches":[70],"been":[72],"systematically":[73],"employed":[74],"elucidate":[76],"organizing":[77,129],"molecular":[78,223],"principles":[79],"signaling":[82,231],"multi-domain":[88],"analyze":[92],"signatures":[94],"gate-keeper":[97,170],"cancer":[98,171],"mutations.":[99],"We":[100],"presented":[102,218],"evidence":[103],"activation":[108,238],"may":[109,149],"universally":[111],"evolved":[112],"as":[120,173],"product":[122],"functional":[125],"cross-talk":[126],"between":[127,211],"\u03b1F-helix":[130],"conformationally":[132],"adaptive":[133],"\u03b1I-helix":[134],"\u03b1C-helix.":[136],"elements":[139],"form":[140],"dynamic":[142],"network":[143],"efficiently":[145],"communicated":[146],"clusters":[147],"interdomain":[153],"coupling":[154],"activation.":[157],"study":[162,199,219],"unveiled":[164],"unifying":[166],"effect":[167],"mutations":[172],"catalysts":[174],"activation,":[177],"leading":[178],"enhanced":[181],"among":[184],"allosterically":[185],"coupled":[186],"segments":[187],"stabilization":[189],"active":[192],"form.":[194],"can":[200],"reconcile":[201],"recent":[202],"experimental":[203],"studies":[204],"inhibition":[207],"cooperativity":[210],"binding":[212],"sites":[213],"protein":[215,241],"kinases.":[216],"offers":[220],"novel":[222],"insight":[224],"into":[225],"provides":[233],"quantitative":[235],"picture":[236],"at":[243],"atomic":[245],"level.":[246]},"abstract_inverted_index_v3":null,"cited_by_api_url":"https://api.openalex.org/works?filter=cites:W2142544064","counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":16},{"year":2012,"cited_by_count":7}],"updated_date":"2025-04-16T18:32:35.616023","created_date":"2016-06-24"}