{"id":"https://openalex.org/W2530324122","doi":"https://doi.org/10.1287/inte.2016.0862","title":"Machine Learning for Predicting Vaccine Immunogenicity","display_name":"Machine Learning for Predicting Vaccine Immunogenicity","publication_year":2016,"publication_date":"2016-10-01","ids":{"openalex":"https://openalex.org/W2530324122","doi":"https://doi.org/10.1287/inte.2016.0862","mag":"2530324122"},"language":"en","primary_location":{"is_oa":false,"landing_page_url":"https://doi.org/10.1287/inte.2016.0862","pdf_url":null,"source":{"id":"https://openalex.org/S140455145","display_name":"INFORMS Journal on Applied Analytics","issn_l":"0092-2102","issn":["0092-2102","1526-551X"],"is_oa":false,"is_in_doaj":false,"is_indexed_in_scopus":false,"is_core":true,"host_organization":"https://openalex.org/P4310315699","host_organization_name":"Institute for Operations Research and the Management Sciences","host_organization_lineage":["https://openalex.org/P4310315699"],"host_organization_lineage_names":["Institute for Operations Research and the Management Sciences"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false},"type":"article","type_crossref":"journal-article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050619335","display_name":"Eva K. Lee","orcid":"https://orcid.org/0000-0003-0415-4640"},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"funder","lineage":["https://openalex.org/I130701444"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eva K. Lee","raw_affiliation_strings":["NSF-Whitaker Center for Operations Research in Medicine and HealthCare, Atlanta, Georgia 30332; and NSF I/UCRC Center for Health Organization Transformation, Atlanta, Georgia 30332; and Industrial and Systems Engineering and Computer Science, Georgia Institute of Technology, Atlanta, Georgia 30332"],"affiliations":[{"raw_affiliation_string":"NSF-Whitaker Center for Operations Research in Medicine and HealthCare, Atlanta, Georgia 30332; and NSF I/UCRC Center for Health Organization Transformation, Atlanta, Georgia 30332; and Industrial and Systems Engineering and Computer Science, Georgia Institute of Technology, Atlanta, Georgia 30332","institution_ids":["https://openalex.org/I130701444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022539185","display_name":"Helder I. Nakaya","orcid":"https://orcid.org/0000-0001-5297-9108"},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"funder","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"funder","lineage":["https://openalex.org/I17974374"]}],"countries":["BR","US"],"is_corresponding":false,"raw_author_name":"Helder I. Nakaya","raw_affiliation_strings":["School of Pharmaceutical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil; and Department of Pathology, School of Medicine, Emory University, Atlanta, Georgia 30329"],"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil; and Department of Pathology, School of Medicine, Emory University, Atlanta, Georgia 30329","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033255876","display_name":"Fan Yuan","orcid":null},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"funder","lineage":["https://openalex.org/I130701444"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fan Yuan","raw_affiliation_strings":["NSF-Whitaker Center for Operations Research in Medicine and HealthCare, Atlanta, Georgia 30332; and NSF I/UCRC Center for Health Organization Transformation, Atlanta, Georgia 30332; and Industrial and Systems Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332"],"affiliations":[{"raw_affiliation_string":"NSF-Whitaker Center for Operations Research in Medicine and HealthCare, Atlanta, Georgia 30332; and NSF I/UCRC Center for Health Organization Transformation, Atlanta, Georgia 30332; and Industrial and Systems Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332","institution_ids":["https://openalex.org/I130701444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023700352","display_name":"Troy D. Querec","orcid":"https://orcid.org/0000-0002-3787-6271"},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Troy D. Querec","raw_affiliation_strings":["Chronic Viral Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 30322"],"affiliations":[{"raw_affiliation_string":"Chronic Viral Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 30322","institution_ids":["https://openalex.org/I1289490764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006729340","display_name":"Greg Burel","orcid":null},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Greg Burel","raw_affiliation_strings":["Strategic National Stockpile, Centers for Disease Control and Prevention, Atlanta, Georgia 30322"],"affiliations":[{"raw_affiliation_string":"Strategic National Stockpile, Centers for Disease Control and Prevention, Atlanta, Georgia 30322","institution_ids":["https://openalex.org/I1289490764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059718360","display_name":"Ferdinand Pietz","orcid":null},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ferdinand H. Pietz","raw_affiliation_strings":["Strategic National Stockpile, Centers for Disease Control and Prevention, Atlanta, Georgia 30322"],"affiliations":[{"raw_affiliation_string":"Strategic National Stockpile, Centers for Disease Control and Prevention, Atlanta, Georgia 30322","institution_ids":["https://openalex.org/I1289490764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080152075","display_name":"Bernard Benecke","orcid":null},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bernard A. Benecke","raw_affiliation_strings":["Global Disease Detection and Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia 30322"],"affiliations":[{"raw_affiliation_string":"Global Disease Detection and Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia 30322","institution_ids":["https://openalex.org/I1289490764"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038753777","display_name":"Bali Pulendran","orcid":"https://orcid.org/0000-0001-6517-4333"},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"funder","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bali Pulendran","raw_affiliation_strings":["Department of Microbiology and Immunology, Emory University School of Medicine; and Department of Pathology, School of Medicine, Emory University, Atlanta, Georgia 30329"],"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Emory University School of Medicine; and Department of Pathology, School of Medicine, Emory University, Atlanta, Georgia 30329","institution_ids":["https://openalex.org/I150468666"]}]}],"institution_assertions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.238,"has_fulltext":true,"fulltext_origin":"ngrams","cited_by_count":21,"citation_normalized_percentile":{"value":0.624788,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":92},"biblio":{"volume":"46","issue":"5","first_page":"368","last_page":"390"},"is_retracted":false,"is_paratext":false,"primary_topic":{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9998,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9998,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9983,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9974,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.7139007},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.58338463},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5061688},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4269692},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.422466},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.40304726},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39228863},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.33154315}],"mesh":[],"locations_count":1,"locations":[{"is_oa":false,"landing_page_url":"https://doi.org/10.1287/inte.2016.0862","pdf_url":null,"source":{"id":"https://openalex.org/S140455145","display_name":"INFORMS Journal on Applied Analytics","issn_l":"0092-2102","issn":["0092-2102","1526-551X"],"is_oa":false,"is_in_doaj":false,"is_indexed_in_scopus":false,"is_core":true,"host_organization":"https://openalex.org/P4310315699","host_organization_name":"Institute for Operations Research and the Management Sciences","host_organization_lineage":["https://openalex.org/P4310315699"],"host_organization_lineage_names":["Institute for Operations Research and the Management Sciences"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"grants":[],"datasets":[],"versions":[],"referenced_works_count":53,"referenced_works":["https://openalex.org/W1593677984","https://openalex.org/W1597759080","https://openalex.org/W1638275756","https://openalex.org/W1671034959","https://openalex.org/W1826120111","https://openalex.org/W1974670739","https://openalex.org/W1978153508","https://openalex.org/W1981070227","https://openalex.org/W1986805971","https://openalex.org/W1990429464","https://openalex.org/W2000918486","https://openalex.org/W2005496259","https://openalex.org/W2012125315","https://openalex.org/W2026806899","https://openalex.org/W2027664158","https://openalex.org/W2030811514","https://openalex.org/W2032901444","https://openalex.org/W2036535631","https://openalex.org/W2052686497","https://openalex.org/W2057566115","https://openalex.org/W2058706999","https://openalex.org/W2059980695","https://openalex.org/W2070847551","https://openalex.org/W2072621593","https://openalex.org/W2075351740","https://openalex.org/W2091994574","https://openalex.org/W2095522046","https://openalex.org/W2102942531","https://openalex.org/W2108488764","https://openalex.org/W2109445534","https://openalex.org/W2114754216","https://openalex.org/W2116887336","https://openalex.org/W2122964757","https://openalex.org/W2125138683","https://openalex.org/W2126263355","https://openalex.org/W2144902263","https://openalex.org/W2144927023","https://openalex.org/W2146904405","https://openalex.org/W2152195021","https://openalex.org/W2152711966","https://openalex.org/W2156194752","https://openalex.org/W2157419914","https://openalex.org/W2157795344","https://openalex.org/W2161573253","https://openalex.org/W2169415889","https://openalex.org/W2215687226","https://openalex.org/W2298455863","https://openalex.org/W2543580944","https://openalex.org/W4231585158","https://openalex.org/W4239148553","https://openalex.org/W4242033688","https://openalex.org/W4294107304","https://openalex.org/W631417898"],"related_works":["https://openalex.org/W3042894437","https://openalex.org/W2470318958","https://openalex.org/W2428121789","https://openalex.org/W2403806215","https://openalex.org/W2079675939","https://openalex.org/W1606819293","https://openalex.org/W1585253481","https://openalex.org/W1556199149","https://openalex.org/W1552738310","https://openalex.org/W1548104248"],"abstract_inverted_index":{"The":[0],"ability":[1,122],"to":[2,9,12,42,84,123,162,176,191,204],"predict":[3,60],"how":[4],"different":[5],"individuals":[6,17,40],"will":[7],"respond":[8],"vaccination":[10],"and":[11,31,35,38,63,90,99,165,182,186,208],"understand":[13],"what":[14],"best":[15],"protects":[16],"from":[18],"infection":[19],"greatly":[20],"facilitates":[21,26],"developing":[22],"next-generation":[23],"vaccines.":[24,167],"It":[25],"both":[27,163],"the":[28,86,102,117,198,215,226],"rapid":[29,199],"design":[30,190],"evaluation":[32],"of":[33,88,105,133,153,201],"new":[34],"emerging":[36,206],"vaccines":[37,203],"identifies":[39],"unlikely":[41],"be":[43,128],"protected":[44],"by":[45,146],"vaccine.":[46],"We":[47],"describe":[48],"a":[49,67,80,92,120,125,150,170],"general-purpose":[50],"machine-learning":[51],"framework,":[52],"DAMIP,":[53,108,147],"for":[54,111,116,156,211],"discovering":[55],"gene":[56,144],"signatures":[57],"that":[58,71,95],"can":[59],"vaccine":[61,158],"immunity":[62],"efficacy.":[64],"DAMIP":[65],"is":[66],"multiple-group,":[68],"concurrent":[69],"classifier":[70],"offers":[72],"unique":[73],"features":[74],"not":[75],"present":[76],"in":[77,169,214],"other":[78],"models:":[79],"nonlinear":[81],"data":[82],"transformation":[83],"manage":[85],"curse":[87],"dimensionality":[89],"noise;":[91],"reserved-judgment":[93],"region":[94],"handles":[96],"fuzzy":[97],"entities;":[98],"constraints":[100],"on":[101],"allowed":[103],"percentage":[104],"misclassifications.":[106],"Using":[107],"implemented":[109],"results":[110],"yellow":[112],"fever":[113],"demonstrated":[114,159],"that,":[115],"first":[118],"time,":[119],"vaccine\u2019s":[121],"immunize":[124],"patient":[126],"could":[127],"successfully":[129],"predicted":[130],"(with":[131],"accuracy":[132],"greater":[134],"than":[135],"90":[136],"percent)":[137],"within":[138],"one":[139],"week":[140],"after":[141],"vaccination.":[142,154],"A":[143],"identified":[145],"EIF2AK4,":[148],"decrypted":[149],"seven-decade-old":[151],"mystery":[152],"Results":[155,168],"flu":[157],"DAMIP\u2019s":[160],"applicability":[161],"live-attenuated":[164],"inactivated":[166],"malaria":[171],"study":[172],"enabled":[173],"targeted":[174],"delivery":[175],"individual":[177],"patients.":[178],"Our":[179],"project\u2019s":[180,227],"methods":[181],"findings":[183],"permit":[184],"highlighting":[185],"probabilistically":[187],"prioritizing":[188],"hypothesis":[189],"enhance":[192],"biological":[193],"discovery.":[194],"Moreover,":[195],"they":[196],"guide":[197],"development":[200],"better":[202],"fight":[205],"infections,":[207],"improve":[209],"monitoring":[210],"poor":[212],"responses":[213],"elderly,":[216],"infants,":[217],"or":[218],"others":[219],"with":[220,231],"weakened":[221],"immune":[222],"systems.":[223],"In":[224],"addition,":[225],"work":[228],"should":[229],"help":[230],"universal":[232],"flu-vaccine":[233],"design.":[234]},"abstract_inverted_index_v3":null,"cited_by_api_url":"https://api.openalex.org/works?filter=cites:W2530324122","counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":2}],"updated_date":"2025-03-30T09:12:54.481468","created_date":"2016-10-21"}