{"id":"https://openalex.org/W2786254065","doi":"https://doi.org/10.1145/3175587.3175602","title":"Interrogation of the Solution Dynamics of Eukaryotic Initiation Factor 5A by Coupling Simulation Dynamics with NMR Observables","display_name":"Interrogation of the Solution Dynamics of Eukaryotic Initiation Factor 5A by Coupling Simulation Dynamics with NMR Observables","publication_year":2017,"publication_date":"2017-12-08","ids":{"openalex":"https://openalex.org/W2786254065","doi":"https://doi.org/10.1145/3175587.3175602","mag":"2786254065"},"language":"en","primary_location":{"is_oa":false,"landing_page_url":"https://doi.org/10.1145/3175587.3175602","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false},"type":"article","type_crossref":"proceedings-article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061863935","display_name":"Lester Takunda Sigauke","orcid":"https://orcid.org/0000-0002-6026-1304"},"institutions":[{"id":"https://openalex.org/I203238179","display_name":"Rhodes University","ror":"https://ror.org/016sewp10","country_code":"ZA","type":"funder","lineage":["https://openalex.org/I203238179"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Lester T. Sigauke","raw_affiliation_strings":["Rhodes University, South Afica"],"affiliations":[{"raw_affiliation_string":"Rhodes University, South Afica","institution_ids":["https://openalex.org/I203238179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061152247","display_name":"Rosemary A. Dorrington Kevin","orcid":null},"institutions":[{"id":"https://openalex.org/I203238179","display_name":"Rhodes University","ror":"https://ror.org/016sewp10","country_code":"ZA","type":"funder","lineage":["https://openalex.org/I203238179"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Rosemary A. Dorrington Kevin","raw_affiliation_strings":["Rhodes University, South Afica"],"affiliations":[{"raw_affiliation_string":"Rhodes University, South Afica","institution_ids":["https://openalex.org/I203238179"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077488283","display_name":"Adele Lobb","orcid":null},"institutions":[{"id":"https://openalex.org/I203238179","display_name":"Rhodes University","ror":"https://ror.org/016sewp10","country_code":"ZA","type":"funder","lineage":["https://openalex.org/I203238179"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"A. Lobb","raw_affiliation_strings":["Rhodes University, South Afica"],"affiliations":[{"raw_affiliation_string":"Rhodes University, South Afica","institution_ids":["https://openalex.org/I203238179"]}]}],"institution_assertions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"fulltext_origin":"ngrams","cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":0,"max":63},"biblio":{"volume":null,"issue":null,"first_page":"20","last_page":"26"},"is_retracted":false,"is_paratext":false,"primary_topic":{"id":"https://openalex.org/T11924","display_name":"Polyamine Metabolism and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11924","display_name":"Polyamine Metabolism and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":0.9532,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.9289,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/eukaryotic-translation","display_name":"Eukaryotic translation","score":0.6880835},{"id":"https://openalex.org/keywords/initiation-factor","display_name":"Initiation factor","score":0.5722926},{"id":"https://openalex.org/keywords/eukaryotic-initiation-factor","display_name":"Eukaryotic initiation factor","score":0.55167913},{"id":"https://openalex.org/keywords/eif4a1","display_name":"EIF4A1","score":0.48472047},{"id":"https://openalex.org/keywords/folding","display_name":"Folding (DSP implementation)","score":0.44515216}],"concepts":[{"id":"https://openalex.org/C77430603","wikidata":"https://www.wikidata.org/wiki/Q166992","display_name":"Internal ribosome entry site","level":5,"score":0.7433201},{"id":"https://openalex.org/C4718897","wikidata":"https://www.wikidata.org/wiki/Q5408698","display_name":"Eukaryotic translation","level":5,"score":0.6880835},{"id":"https://openalex.org/C33277056","wikidata":"https://www.wikidata.org/wiki/Q17916089","display_name":"Eukaryotic translation initiation factor 4 gamma","level":5,"score":0.6405573},{"id":"https://openalex.org/C62493599","wikidata":"https://www.wikidata.org/wiki/Q424137","display_name":"Initiation factor","level":5,"score":0.5722926},{"id":"https://openalex.org/C97154109","wikidata":"https://www.wikidata.org/wiki/Q906570","display_name":"Eukaryotic initiation factor","level":5,"score":0.55167913},{"id":"https://openalex.org/C142587794","wikidata":"https://www.wikidata.org/wiki/Q17916083","display_name":"EIF4A1","level":5,"score":0.48472047},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46517062},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4527909},{"id":"https://openalex.org/C2776545253","wikidata":"https://www.wikidata.org/wiki/Q5464292","display_name":"Folding (DSP implementation)","level":2,"score":0.44515216},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43452105},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.42885488},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.42576963},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.38011202},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.34651497},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33024168},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30950716},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12256947},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"is_oa":false,"landing_page_url":"https://doi.org/10.1145/3175587.3175602","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.83,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"grants":[],"datasets":[],"versions":[],"referenced_works_count":39,"referenced_works":["https://openalex.org/W1502942890","https://openalex.org/W1504811083","https://openalex.org/W1542603018","https://openalex.org/W1544068656","https://openalex.org/W1971017211","https://openalex.org/W1975705094","https://openalex.org/W1975993749","https://openalex.org/W1977247543","https://openalex.org/W1977373765","https://openalex.org/W1995225108","https://openalex.org/W2008850469","https://openalex.org/W2012072946","https://openalex.org/W2014489014","https://openalex.org/W2022881642","https://openalex.org/W2028156270","https://openalex.org/W2030729948","https://openalex.org/W2038344003","https://openalex.org/W2057475458","https://openalex.org/W2070743165","https://openalex.org/W2089819918","https://openalex.org/W2094700934","https://openalex.org/W2103699686","https://openalex.org/W2109939279","https://openalex.org/W2119274812","https://openalex.org/W2132417094","https://openalex.org/W2133312664","https://openalex.org/W2137015675","https://openalex.org/W2137441527","https://openalex.org/W2157772242","https://openalex.org/W2159646590","https://openalex.org/W2160544821","https://openalex.org/W2169821755","https://openalex.org/W2223861440","https://openalex.org/W2271736303","https://openalex.org/W2395051652","https://openalex.org/W2465933865","https://openalex.org/W3169629205","https://openalex.org/W4285719527","https://openalex.org/W69754666"],"related_works":["https://openalex.org/W4288077806","https://openalex.org/W2999058473","https://openalex.org/W2115804977","https://openalex.org/W2089313831","https://openalex.org/W2064821101","https://openalex.org/W1920555941","https://openalex.org/W1558701845","https://openalex.org/W1483945746","https://openalex.org/W144266797","https://openalex.org/W132148142"],"abstract_inverted_index":{"Eukaryotic":[0],"initiation":[1,17],"factor":[2],"5A,":[3],"eIF5A,":[4],"isa":[5],"ubiquitous":[6],"eukaryotic":[7],"protein":[8,28,143],"that":[9,76,109],"has":[10,50],"been":[11,51],"shown":[12,52],"to":[13,30,53,107],"influence":[14,54],"the":[15,26,64,84,94,101],"translation":[16,55,137],"of":[18,22,56,66,72,86,96,100,111,147],"a":[19,34,114],"specific":[20],"subset":[21],"mRNAs.":[23],"It":[24],"is":[25],"only":[27,120],"known":[29],"undergo":[31],"hypusinylation":[32,122],"in":[33,70,88,134],"two-step":[35],"post":[36],"translational":[37],"modification":[38],"process":[39],"involving":[40],"deoxyhypusine":[41],"synthase":[42],"(DHS)":[43],"and":[44,58,90,123,149],"deoxyhypusin":[45],"hydroxylase":[46],"(DOHH)":[47],"enzymes.":[48],"Hypusinylation":[49],"HIV-1":[57],"HTLV-1":[59],"nuclear":[60],"export":[61],"signals,":[62],"while":[63],"involvement":[65],"active":[67],"hypusinylated":[68],"eIF5A":[69,87,132],"induction":[71],"IRES":[73,135],"mediated":[74],"processes":[75,79],"initiate":[77],"pro-apoptotic":[78],"have":[80],"inspired":[81],"studies":[82,146],"into":[83,113],"manipulation":[85],"anti-cancer":[89],"anti-diabetic":[91],"therapies.":[92],"Through":[93],"extraction":[95],"solution":[97],"NMR":[98],"resonances":[99],"purified":[102],"protein,":[103],"we":[104],"were":[105],"able":[106],"show":[108],"introduction":[110],"rigidity":[112],"critical":[115,130],"loop":[116],"region":[117],"did":[118],"not":[119],"prevent":[121],"oligomerisation":[124],"but":[125],"prevented":[126],"appropriate":[127],"structural":[128],"organisation":[129],"for":[131],"function":[133],"dependant":[136],"initiation.":[138],"This":[139],"data":[140],"corroborated":[141],"with":[142],"folding":[144],"simulation":[145],"native":[148],"mutant":[150],"proteins.":[151]},"abstract_inverted_index_v3":null,"cited_by_api_url":"https://api.openalex.org/works?filter=cites:W2786254065","counts_by_year":[],"updated_date":"2025-01-27T21:07:49.558627","created_date":"2018-02-23"}