{"id":"https://openalex.org/W2519639196","doi":"https://doi.org/10.1145/2967446.2967458","title":"An Autonomous and Adaptive Bacteria-based Drug Delivery System","display_name":"An Autonomous and Adaptive Bacteria-based Drug Delivery System","publication_year":2016,"publication_date":"2016-09-12","ids":{"openalex":"https://openalex.org/W2519639196","doi":"https://doi.org/10.1145/2967446.2967458","mag":"2519639196"},"language":"en","primary_location":{"is_oa":false,"landing_page_url":"https://doi.org/10.1145/2967446.2967458","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false},"type":"article","type_crossref":"proceedings-article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054603014","display_name":"Chieh Lo","orcid":"https://orcid.org/0000-0002-5528-494X"},"institutions":[{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"funder","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chieh Lo","raw_affiliation_strings":["Carnegie Mellon University, Pittsburgh, PA"],"affiliations":[{"raw_affiliation_string":"Carnegie Mellon University, Pittsburgh, PA","institution_ids":["https://openalex.org/I74973139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033612167","display_name":"Kartikeya Bhardwaj","orcid":"https://orcid.org/0000-0002-8115-4276"},"institutions":[{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"funder","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kartikeya Bhardwaj","raw_affiliation_strings":["Carnegie Mellon University, Pittsburgh, PA"],"affiliations":[{"raw_affiliation_string":"Carnegie Mellon University, Pittsburgh, PA","institution_ids":["https://openalex.org/I74973139"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036227385","display_name":"Radu M\u0103rculescu","orcid":"https://orcid.org/0000-0003-1826-7646"},"institutions":[{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"funder","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Radu Marculescu","raw_affiliation_strings":["Carnegie Mellon University, Pittsburgh, PA"],"affiliations":[{"raw_affiliation_string":"Carnegie Mellon University, Pittsburgh, PA","institution_ids":["https://openalex.org/I74973139"]}]}],"institution_assertions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.541,"has_fulltext":true,"fulltext_origin":"ngrams","cited_by_count":6,"citation_normalized_percentile":{"value":0.779959,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":82,"max":83},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"6"},"is_retracted":false,"is_paratext":false,"primary_topic":{"id":"https://openalex.org/T13052","display_name":"Molecular Communication and Nanonetworks","score":0.998,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13052","display_name":"Molecular Communication and Nanonetworks","score":0.998,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Cancer Research and Treatments","score":0.9957,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9905,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.68927294},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.57425},{"id":"https://openalex.org/C118687296","wikidata":"https://www.wikidata.org/wiki/Q905754","display_name":"Quorum sensing","level":4,"score":0.553682},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.49750927},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.29848057},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.23076043},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21676102},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.19737598},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.07545203},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"is_oa":false,"landing_page_url":"https://doi.org/10.1145/2967446.2967458","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.83,"display_name":"Good health and well-being"}],"grants":[],"datasets":[],"versions":[],"referenced_works_count":18,"referenced_works":["https://openalex.org/W1593844282","https://openalex.org/W1966982932","https://openalex.org/W1979507175","https://openalex.org/W1998629953","https://openalex.org/W2025607954","https://openalex.org/W2044151431","https://openalex.org/W2078149628","https://openalex.org/W2082398508","https://openalex.org/W2112010454","https://openalex.org/W2115286109","https://openalex.org/W2116194016","https://openalex.org/W2121490181","https://openalex.org/W2131153966","https://openalex.org/W2139667048","https://openalex.org/W2146762168","https://openalex.org/W2158365762","https://openalex.org/W2165836181","https://openalex.org/W2166657167"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2748952813","https://openalex.org/W2389505468","https://openalex.org/W2378205681","https://openalex.org/W2201786346","https://openalex.org/W2169415577","https://openalex.org/W2059010035","https://openalex.org/W2007182598","https://openalex.org/W1980352067","https://openalex.org/W1822942219"],"abstract_inverted_index":{"Traditional":[0],"drug":[1,61,139],"delivery":[2,46,62],"systems":[3],"are":[4],"often":[5,23],"inefficient":[6,45],"and":[7,27,58,68,75,99,123,141],"imprecise":[8],"as":[9],"they":[10],"mainly":[11],"rely":[12],"on":[13,120],"diffusion":[14],"processes.":[15],"For":[16],"example,":[17],"the":[18,31,35,90,101,108,114],"blood":[19],"circulation":[20],"system":[21,63,109,130],"is":[22],"used":[24,133],"to":[25,34,71,88],"transport":[26],"deliver":[28,72],"drugs":[29,73,103,117],"throughout":[30],"body;":[32],"due":[33],"randomness":[36],"involved":[37],"in":[38,104],"molecular":[39],"diffusion,":[40],"this":[41,52],"approach":[42],"may":[43],"cause":[44],"of":[47,97,116],"drugs.":[48],"To":[49],"deal":[50],"with":[51],"problem,":[53],"we":[54,79],"propose":[55],"an":[56],"autonomous":[57],"adaptive":[59],"bacteria-based":[60],"that":[64,85,127],"integrates":[65],"bacterial":[66],"chemotaxis":[67],"quorum":[69],"sensing":[70],"efficiently":[74],"precisely.":[76],"More":[77],"specifically,":[78],"design":[80],"a":[81,94,105,129],"synthetic":[82],"AND":[83],"gate":[84],"enables":[86],"bacteria":[87],"detect":[89],"molecules":[91],"produced":[92],"by":[93],"particular":[95],"type":[96],"tumor":[98,121],"release":[100],"appropriate":[102],"coordinated":[106],"manner;":[107],"can":[110,131],"also":[111],"dynamically":[112],"adjust":[113],"amount":[115],"released":[118],"based":[119],"size":[122],"activity.":[124],"We":[125],"envision":[126],"such":[128],"be":[132],"for":[134],"cell-based":[135],"therapeutics":[136],"while":[137],"preventing":[138],"overuse":[140],"multidrug":[142],"resistance.":[143]},"abstract_inverted_index_v3":null,"cited_by_api_url":"https://api.openalex.org/works?filter=cites:W2519639196","counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2}],"updated_date":"2025-03-20T20:46:44.763845","created_date":"2016-09-23"}