{"id":"https://openalex.org/W2918698221","doi":"https://doi.org/10.1142/s0129065719500102","title":"Scaled Subprofile Modeling and Convolutional Neural Networks for the Identification of Parkinson\u2019s Disease in 3D Nuclear Imaging Data","display_name":"Scaled Subprofile Modeling and Convolutional Neural Networks for the Identification of Parkinson\u2019s Disease in 3D Nuclear Imaging Data","publication_year":2019,"publication_date":"2019-03-04","ids":{"openalex":"https://openalex.org/W2918698221","doi":"https://doi.org/10.1142/s0129065719500102","mag":"2918698221","pmid":"https://pubmed.ncbi.nlm.nih.gov/31046514"},"language":"en","primary_location":{"is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0129065719500102","pdf_url":null,"source":{"id":"https://openalex.org/S197665576","display_name":"International Journal of Neural Systems","issn_l":"0129-0657","issn":["0129-0657","1793-6462"],"is_oa":false,"is_in_doaj":false,"is_indexed_in_scopus":true,"is_core":true,"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false},"type":"article","type_crossref":"journal-article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088972656","display_name":"Octavio Martinez Manzanera","orcid":"https://orcid.org/0000-0001-6869-3024"},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"funder","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Octavio Martinez Manzanera","raw_affiliation_strings":["Department of Neurology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands"],"affiliations":[{"raw_affiliation_string":"Department of Neurology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032684903","display_name":"Sanne K. Meles","orcid":"https://orcid.org/0000-0002-5505-3527"},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"funder","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Sanne K. Meles","raw_affiliation_strings":["Department of Neurology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands"],"affiliations":[{"raw_affiliation_string":"Department of Neurology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076606508","display_name":"Klaus L. Leenders","orcid":"https://orcid.org/0000-0002-9406-5512"},"institutions":[{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"funder","lineage":["https://openalex.org/I169381384"]},{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Klaus L. Leenders","raw_affiliation_strings":["Department of Neurology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands"],"affiliations":[{"raw_affiliation_string":"Department of Neurology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands","institution_ids":["https://openalex.org/I169381384","https://openalex.org/I1334415907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011471000","display_name":"Remco J. Renken","orcid":"https://orcid.org/0000-0002-7777-9484"},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"funder","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Remco J. Renken","raw_affiliation_strings":["Faculty of Medical Sciences, University Medical Center Groningen, University of Groningen, A. Deusinglaan 1, Groningen, The Netherlands"],"affiliations":[{"raw_affiliation_string":"Faculty of Medical Sciences, University Medical Center Groningen, University of Groningen, A. Deusinglaan 1, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101809433","display_name":"M. Pagani","orcid":"https://orcid.org/0000-0001-9697-8959"},"institutions":[{"id":"https://openalex.org/I4210166865","display_name":"Institute of Cognitive Sciences and Technologies","ror":"https://ror.org/05w9g2j85","country_code":"IT","type":"funder","lineage":["https://openalex.org/I4210155236","https://openalex.org/I4210166865"]},{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"funder","lineage":["https://openalex.org/I169381384"]}],"countries":["IT","NL","SE"],"is_corresponding":false,"raw_author_name":"Marco Pagani","raw_affiliation_strings":["Department of Nuclear Medicine, Karolinska University Hospital, Huddinge, SE-141 86, Stockholm, Sweden","Department of Nuclear Medicine, University Medical Center Groningen, University of Groningen, Hanzeplein 1,9713 GZ Groningen, The Netherlands","Institute of Cognitive Sciences and Technologies, Consiglio Nazionale delle Ricerche, via S. Martino della Battaglia, 44-00185 Rome, Italy"],"affiliations":[{"raw_affiliation_string":"Institute of Cognitive Sciences and Technologies, Consiglio Nazionale delle Ricerche, via S. Martino della Battaglia, 44-00185 Rome, Italy","institution_ids":["https://openalex.org/I4210166865"]},{"raw_affiliation_string":"Department of Nuclear Medicine, Karolinska University Hospital, Huddinge, SE-141 86, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835"]},{"raw_affiliation_string":"Department of Nuclear Medicine, University Medical Center Groningen, University of Groningen, Hanzeplein 1,9713 GZ Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083708156","display_name":"Dario Arnaldi","orcid":"https://orcid.org/0000-0001-6823-6069"},"institutions":[{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"funder","lineage":["https://openalex.org/I83816512"]},{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Dario Arnaldi","raw_affiliation_strings":["Department of Neuroscience, Rehabilitation, Opthalmology, Genetics and Maternal and Child Science (DINOGMI), University of Genoa Largo Paolo Daneo 3, 16132 Genoa, Italy","IRCCS AOU San Martino \u2014 IST, Largo R. Benzi 10, 16132 Genoa, Italy"],"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Rehabilitation, Opthalmology, Genetics and Maternal and Child Science (DINOGMI), University of Genoa Largo Paolo Daneo 3, 16132 Genoa, Italy","institution_ids":["https://openalex.org/I83816512"]},{"raw_affiliation_string":"IRCCS AOU San Martino \u2014 IST, Largo R. Benzi 10, 16132 Genoa, Italy","institution_ids":["https://openalex.org/I4210146472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072151058","display_name":"Flavio Nobili","orcid":"https://orcid.org/0000-0001-9811-0897"},"institutions":[{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"funder","lineage":["https://openalex.org/I83816512"]},{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Flavio Nobili","raw_affiliation_strings":["Department of Neuroscience, Rehabilitation, Opthalmology, Genetics and Maternal and Child Science (DINOGMI), University of Genoa Largo Paolo Daneo 3, 16132 Genoa, Italy","IRCCS AOU San Martino \u2014 IST, Largo R. Benzi 10, 16132 Genoa, Italy"],"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Rehabilitation, Opthalmology, Genetics and Maternal and Child Science (DINOGMI), University of Genoa Largo Paolo Daneo 3, 16132 Genoa, Italy","institution_ids":["https://openalex.org/I83816512"]},{"raw_affiliation_string":"IRCCS AOU San Martino \u2014 IST, Largo R. Benzi 10, 16132 Genoa, Italy","institution_ids":["https://openalex.org/I4210146472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062838955","display_name":"Jos\u00e9 \u00c1. Obeso","orcid":"https://orcid.org/0000-0002-6996-8613"},"institutions":[{"id":"https://openalex.org/I4210122888","display_name":"University Hospital HM Puerta del Sur","ror":"https://ror.org/03rk6g530","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210122888"]},{"id":"https://openalex.org/I118091203","display_name":"Universidad San Pablo CEU","ror":"https://ror.org/00tvate34","country_code":"ES","type":"education","lineage":["https://openalex.org/I118091203","https://openalex.org/I2801318690"]},{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210086696","display_name":"Biomedical Research Networking Center on Neurodegenerative Diseases","ror":"https://ror.org/00zca7903","country_code":"ES","type":"funder","lineage":["https://openalex.org/I4210086696"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jose Obeso","raw_affiliation_strings":["CEU Universidad San Pablo, C/Juli\u00e1n Romea 18, 28003 Madrid, Spain","CIBERNED, Instituto Carlos III, C/Valderrebollo 5, 28031 Madrid, Spain","CINAC, HM Puerta del Sur, Avda. de Carlos V 70, 28938 M\u00f3stoles (Madrid), Spain"],"affiliations":[{"raw_affiliation_string":"CINAC, HM Puerta del Sur, Avda. de Carlos V 70, 28938 M\u00f3stoles (Madrid), Spain","institution_ids":["https://openalex.org/I4210122888"]},{"raw_affiliation_string":"CEU Universidad San Pablo, C/Juli\u00e1n Romea 18, 28003 Madrid, Spain","institution_ids":["https://openalex.org/I118091203"]},{"raw_affiliation_string":"CIBERNED, Instituto Carlos III, C/Valderrebollo 5, 28031 Madrid, Spain","institution_ids":["https://openalex.org/I2801357902","https://openalex.org/I4210086696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041436608","display_name":"Mar\u00eda Rodr\u00edguez\u2010Oroz","orcid":"https://orcid.org/0000-0001-5962-772X"},"institutions":[{"id":"https://openalex.org/I4210100188","display_name":"Biogipuzkoa Health Research Institute","ror":"https://ror.org/01a2wsa50","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210100188"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Maria Rodriguez Oroz","raw_affiliation_strings":["Department of Neurosciences, Biodonostia Health Research Institute, Begiristain Doktorea Pasealekua, 20014 Donostia-San Sebasti\u00e1n, Guip\u00fazcoa, Spain"],"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, Biodonostia Health Research Institute, Begiristain Doktorea Pasealekua, 20014 Donostia-San Sebasti\u00e1n, Guip\u00fazcoa, Spain","institution_ids":["https://openalex.org/I4210100188"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084333635","display_name":"Silvia Morbelli","orcid":"https://orcid.org/0000-0002-7833-6095"},"institutions":[{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"funder","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Silvia Morbelli","raw_affiliation_strings":["IRCCS AOU San Martino \u2014 IST, Largo R. Benzi 10, 16132 Genoa, Italy","Nuclear Medicine Unit, Department of Health Sciences (DISSAL), University of Genoa via A. Pastore 1, 16132 Genoa, Italy"],"affiliations":[{"raw_affiliation_string":"IRCCS AOU San Martino \u2014 IST, Largo R. Benzi 10, 16132 Genoa, Italy","institution_ids":["https://openalex.org/I4210146472"]},{"raw_affiliation_string":"Nuclear Medicine Unit, Department of Health Sciences (DISSAL), University of Genoa via A. Pastore 1, 16132 Genoa, Italy","institution_ids":["https://openalex.org/I83816512"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065911879","display_name":"Natasha M. Maurits","orcid":"https://orcid.org/0000-0001-6231-7044"},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"funder","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Natasha M. Maurits","raw_affiliation_strings":["Department of Neurology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands"],"affiliations":[{"raw_affiliation_string":"Department of Neurology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]}],"institution_assertions":[],"countries_distinct_count":4,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5065911879"],"corresponding_institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"],"apc_list":null,"apc_paid":null,"fwci":7.952,"has_fulltext":true,"fulltext_origin":"ngrams","cited_by_count":56,"citation_normalized_percentile":{"value":0.999919,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"29","issue":"09","first_page":"1950010","last_page":"1950010"},"is_retracted":false,"is_paratext":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9881,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9881,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10863","display_name":"Voice and Speech Disorders","score":0.9876,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.9753,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/partial-volume","display_name":"Partial volume","score":0.43462908}],"concepts":[{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.77156323},{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.6700133},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6365265},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.6238087},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.62258035},{"id":"https://openalex.org/C54170458","wikidata":"https://www.wikidata.org/wiki/Q663554","display_name":"Voxel","level":2,"score":0.6047999},{"id":"https://openalex.org/C2776477761","wikidata":"https://www.wikidata.org/wiki/Q945930","display_name":"Progressive supranuclear palsy","level":3,"score":0.5326991},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5011437},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.4457279},{"id":"https://openalex.org/C82233179","wikidata":"https://www.wikidata.org/wiki/Q2054500","display_name":"Partial volume","level":2,"score":0.43462908},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.26672423},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26301426},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.17045313},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.16303849}],"mesh":[{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":"","qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019788","descriptor_name":"Fluorodeoxyglucose F18","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019788","descriptor_name":"Fluorodeoxyglucose F18","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059907","descriptor_name":"Functional Neuroimaging","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":"","qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0129065719500102","pdf_url":null,"source":{"id":"https://openalex.org/S197665576","display_name":"International Journal of Neural Systems","issn_l":"0129-0657","issn":["0129-0657","1793-6462"],"is_oa":false,"is_in_doaj":false,"is_indexed_in_scopus":true,"is_core":true,"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false},{"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31046514","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_indexed_in_scopus":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":["National Institutes of Health"],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/10","score":0.76,"display_name":"Reduced inequalities"}],"grants":[],"datasets":[],"versions":[],"referenced_works_count":59,"referenced_works":["https://openalex.org/W1516595210","https://openalex.org/W1530490147","https://openalex.org/W1677182931","https://openalex.org/W1764076319","https://openalex.org/W1827708574","https://openalex.org/W1962229341","https://openalex.org/W1964163952","https://openalex.org/W1965123421","https://openalex.org/W1981014938","https://openalex.org/W1994605917","https://openalex.org/W1999694937","https://openalex.org/W2007856779","https://openalex.org/W2008560062","https://openalex.org/W2008591007","https://openalex.org/W2024696865","https://openalex.org/W2029316659","https://openalex.org/W2044266196","https://openalex.org/W2048207814","https://openalex.org/W2057374433","https://openalex.org/W2058415227","https://openalex.org/W2091536386","https://openalex.org/W2093977564","https://openalex.org/W2095705004","https://openalex.org/W2097117768","https://openalex.org/W2097998348","https://openalex.org/W2107979498","https://openalex.org/W2115192827","https://openalex.org/W2121275558","https://openalex.org/W2140880028","https://openalex.org/W2147730137","https://openalex.org/W2216351247","https://openalex.org/W2226581991","https://openalex.org/W2238131783","https://openalex.org/W2336829316","https://openalex.org/W2345463153","https://openalex.org/W2408919776","https://openalex.org/W2409901013","https://openalex.org/W2502390809","https://openalex.org/W2557098028","https://openalex.org/W2557738935","https://openalex.org/W2559968629","https://openalex.org/W2581082771","https://openalex.org/W2593323195","https://openalex.org/W2604272474","https://openalex.org/W2605106061","https://openalex.org/W2626992457","https://openalex.org/W2640197071","https://openalex.org/W2736807184","https://openalex.org/W2755418381","https://openalex.org/W2759483166","https://openalex.org/W2789220454","https://openalex.org/W2792232945","https://openalex.org/W2800428573","https://openalex.org/W2947931368","https://openalex.org/W2952331513","https://openalex.org/W3099395032","https://openalex.org/W4231109964","https://openalex.org/W70150863","https://openalex.org/W71094016"],"related_works":["https://openalex.org/W2420770795","https://openalex.org/W2169101840","https://openalex.org/W2160056785","https://openalex.org/W2089168353","https://openalex.org/W2054948569","https://openalex.org/W2021722477","https://openalex.org/W2004884856","https://openalex.org/W1977815680","https://openalex.org/W1970457826","https://openalex.org/W1605096437"],"abstract_inverted_index":{"Over":[0],"the":[1,64,97,107,111,127,131,147,155,189],"last":[2],"years":[3],"convolutional":[4],"neural":[5],"networks":[6,132],"(CNNs)":[7],"have":[8],"shown":[9],"remarkable":[10],"results":[11],"in":[12,59,114],"different":[13],"image":[14],"classification":[15,128],"tasks,":[16,187],"including":[17],"medical":[18],"imaging.":[19],"One":[20],"area":[21,145],"that":[22,101,139,177],"has":[23],"been":[24],"less":[25],"explored":[26],"with":[27,63,70,161,195],"CNNs":[28,58],"is":[29,39],"Positron":[30,35],"Emission":[31,36],"Tomography":[32,37],"(PET).":[33],"Fluorodeoxyglucose":[34],"(FDG-PET)":[38],"a":[40,46,86],"PET":[41],"technique":[42,179],"employed":[43,56,77],"to":[44,89,125,183],"obtain":[45],"representation":[47],"of":[48,66,99,130,192],"brain":[49,61,93],"metabolic":[50],"function.":[51],"In":[52],"this":[53,178],"study":[54],"we":[55,140],"3D":[57],"FDG-PET":[60,173],"images":[62],"purpose":[65],"discriminating":[67],"patients":[68,165],"diagnosed":[69],"Parkinson's":[71],"disease":[72],"(PD)":[73],"from":[74,170],"controls.":[75],"We":[76,117,158],"Scaled":[78],"Subprofile":[79],"Modeling":[80],"using":[81],"Principal":[82],"Component":[83],"Analysis":[84],"as":[85,104,199],"preprocessing":[87],"step":[88],"focus":[90],"on":[91,121,133,154],"specific":[92],"regions":[94],"and":[95,144,176,205],"limit":[96],"number":[98],"voxels":[100],"are":[102],"used":[103],"input":[105],"for":[106],"CNNs,":[108],"thereby":[109],"increasing":[110],"signal-to-noise":[112],"ratio":[113],"our":[115],"data.":[116,135],"performed":[118],"hyperparameter":[119],"optimization":[120],"three":[122],"CNN":[123],"architectures":[124],"estimate":[126],"accuracy":[129],"new":[134],"The":[136],"best":[137],"performance":[138],"obtained":[141],"was":[142],"accuracy=0.86":[143],"under":[146],"receiver":[148],"operating":[149],"characteristic":[150],"curve":[151],"(AUC":[152],"ROC)=0.94":[153],"test":[156],"set.":[157],"believe":[159],"that,":[160],"larger":[162],"datasets,":[163],"PD":[164],"could":[166,180],"be":[167,181],"reliably":[168],"distinguished":[169],"controls":[171],"by":[172],"scans":[174],"alone":[175],"applied":[182],"more":[184],"clinically":[185],"challenging":[186],"like":[188],"differential":[190],"diagnosis":[191],"neurological":[193],"disorders":[194],"similar":[196],"symptoms,":[197],"such":[198],"PD,":[200],"Progressive":[201],"Supranuclear":[202],"Palsy":[203],"(PSP)":[204],"Multiple":[206],"System":[207],"Atrophy":[208],"(MSA).":[209]},"abstract_inverted_index_v3":null,"cited_by_api_url":"https://api.openalex.org/works?filter=cites:W2918698221","counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":20},{"year":2019,"cited_by_count":1}],"updated_date":"2025-04-19T02:08:40.983501","created_date":"2019-03-11"}