{"id":"https://openalex.org/W3020691036","doi":"https://doi.org/10.1137/19m1271245","title":"Interaction Between Switching Diffusivities and Cellular Microstructure","display_name":"Interaction Between Switching Diffusivities and Cellular Microstructure","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W3020691036","doi":"https://doi.org/10.1137/19m1271245","mag":"3020691036"},"language":"en","primary_location":{"is_oa":false,"landing_page_url":"https://doi.org/10.1137/19m1271245","pdf_url":null,"source":{"id":"https://openalex.org/S4357572","display_name":"Multiscale Modeling and Simulation","issn_l":"1540-3459","issn":["1540-3459","1540-3467"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320508","host_organization_name":"Society for Industrial and Applied Mathematics","host_organization_lineage":["https://openalex.org/P4310320508"],"host_organization_lineage_names":["Society for Industrial and Applied Mathematics"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false},"type":"article","type_crossref":"journal-article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006226257","display_name":"Patrick Murphy","orcid":"https://orcid.org/0000-0003-1321-8749"},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick Murphy","raw_affiliation_strings":["Department of Mathematics, University of Utah, Salt Lake City, UT 84112"],"affiliations":[{"raw_affiliation_string":"Department of Mathematics, University of Utah, Salt Lake City, UT 84112","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013056878","display_name":"Paul C. Bressloff","orcid":"https://orcid.org/0000-0002-7714-9853"},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul C. Bressloff","raw_affiliation_strings":["Department of Mathematics, University of Utah, Salt Lake City, UT 84112"],"affiliations":[{"raw_affiliation_string":"Department of Mathematics, University of Utah, Salt Lake City, UT 84112","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001461789","display_name":"Sean D. Lawley","orcid":"https://orcid.org/0000-0003-2208-026X"},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sean D. Lawley","raw_affiliation_strings":["Department of Mathematics, University of Utah, Salt Lake City, UT 84112"],"affiliations":[{"raw_affiliation_string":"Department of Mathematics, University of Utah, Salt Lake City, UT 84112","institution_ids":["https://openalex.org/I223532165"]}]}],"institution_assertions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"fulltext_origin":"pdf","cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":0,"max":60},"biblio":{"volume":"18","issue":"2","first_page":"572","last_page":"588"},"is_retracted":false,"is_paratext":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9947,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9947,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11520","display_name":"Advanced Thermodynamics and Statistical Mechanics","score":0.9029,"subfield":{"id":"https://openalex.org/subfields/3109","display_name":"Statistical and Nonlinear Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C87976508","wikidata":"https://www.wikidata.org/wiki/Q1498213","display_name":"Microstructure","level":2,"score":0.6668053},{"id":"https://openalex.org/C69357855","wikidata":"https://www.wikidata.org/wiki/Q163214","display_name":"Diffusion","level":2,"score":0.5567232},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.5472058},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.42884412},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.4180221},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.32061416},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.30574045},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.15921333},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12028384},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.10063723}],"mesh":[],"locations_count":1,"locations":[{"is_oa":false,"landing_page_url":"https://doi.org/10.1137/19m1271245","pdf_url":null,"source":{"id":"https://openalex.org/S4357572","display_name":"Multiscale Modeling and Simulation","issn_l":"1540-3459","issn":["1540-3459","1540-3467"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320508","host_organization_name":"Society for Industrial and Applied Mathematics","host_organization_lineage":["https://openalex.org/P4310320508"],"host_organization_lineage_names":["Society for Industrial and Applied Mathematics"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false}],"best_oa_location":null,"sustainable_development_goals":[],"grants":[{"funder":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation","award_id":"DMS-1613048"},{"funder":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation","award_id":"IOS-1755431"}],"datasets":[],"versions":[],"referenced_works_count":15,"referenced_works":["https://openalex.org/W1962855533","https://openalex.org/W2001221216","https://openalex.org/W2037870039","https://openalex.org/W2147688960","https://openalex.org/W2164565944","https://openalex.org/W2167892316","https://openalex.org/W2207388150","https://openalex.org/W2574626594","https://openalex.org/W2585592087","https://openalex.org/W2601953622","https://openalex.org/W2621893682","https://openalex.org/W2734967491","https://openalex.org/W2883763125","https://openalex.org/W2922018584","https://openalex.org/W3102321461"],"related_works":["https://openalex.org/W54078636","https://openalex.org/W3148032049","https://openalex.org/W3105167352","https://openalex.org/W3084825885","https://openalex.org/W2954470139","https://openalex.org/W2935759653","https://openalex.org/W2902782467","https://openalex.org/W2298861036","https://openalex.org/W2271181815","https://openalex.org/W1501425562"],"abstract_inverted_index":{"Single-particle":[0],"tracking":[1],"experiments":[2],"have":[3],"recently":[4],"found":[5],"that":[6,33,92],"C.":[7],"elegans":[8],"zygotes":[9],"rely":[10],"on":[11,31,97,105,150],"space-dependent":[12],"switching":[13,71],"diffusivities":[14],"to":[15,141],"form":[16],"intracellular":[17],"gradients":[18],"during":[19],"cell":[20],"polarization.":[21],"The":[22],"relevant":[23],"proteins":[24],"switch":[25],"between":[26,116],"fast-diffusing":[27],"and":[28,111],"slow-diffusing":[29],"states":[30,73],"timescales":[32],"are":[34],"much":[35],"shorter":[36],"than":[37],"the":[38,58,82,106,117,145,148,151],"timescale":[39],"of":[40,57,69,108,124,147],"diffusion":[41],"or":[42],"gradient":[43,59],"formation.":[44,60],"This":[45],"manifests":[46],"in":[47,81],"models":[48],"as":[49],"a":[50,76,86,131,138],"small":[51,88,99],"parameter,":[52],"allowing":[53],"an":[54,93,113],"asymptotic":[55,94],"analysis":[56,95,125],"In":[61],"this":[62,67],"paper":[63],"we":[64],"consider":[65],"how":[66],"mechanism":[68],"rapidly":[70],"diffusive":[72],"interacts":[74],"with":[75],"locally":[77],"varying":[78],"periodic":[79],"microstructure":[80,149],"cell,":[83],"incorporated":[84],"through":[85],"second":[87],"parameter.":[89],"We":[90,128],"show":[91],"based":[96,104],"both":[98],"parameters":[100,119],"yields":[101],"different":[102],"results":[103],"order":[107],"limits":[109],"taken":[110],"suggest":[112],"explicit":[114],"relation":[115],"two":[118],"for":[120,137],"when":[121],"each":[122],"type":[123],"is":[126],"appropriate.":[127],"further":[129],"investigate":[130],"mean":[132],"first":[133],"passage":[134],"time":[135],"problem":[136],"diffusing":[139],"protein":[140],"gain":[142],"insight":[143],"into":[144],"effects":[146],"global":[152],"environment.":[153]},"cited_by_api_url":"https://api.openalex.org/works?filter=cites:W3020691036","counts_by_year":[],"updated_date":"2025-01-02T07:18:20.487290","created_date":"2020-05-01"}