{"id":"https://openalex.org/W2081443357","doi":"https://doi.org/10.1117/12.845554","title":"A structural-functional MRI-based disease atlas: application to computer-aided-diagnosis of prostate cancer","display_name":"A structural-functional MRI-based disease atlas: application to computer-aided-diagnosis of prostate cancer","publication_year":2010,"publication_date":"2010-03-04","ids":{"openalex":"https://openalex.org/W2081443357","doi":"https://doi.org/10.1117/12.845554","mag":"2081443357"},"language":"en","primary_location":{"is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.845554","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false},"type":"article","type_crossref":"proceedings-article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109854539","display_name":"Gaoyu Xiao","orcid":null},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. Xiao","raw_affiliation_strings":["Rutgers, The State University of New Jersey [New Brunswick]"],"affiliations":[{"raw_affiliation_string":"Rutgers, The State University of New Jersey [New Brunswick]","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059325659","display_name":"B Bloch","orcid":"https://orcid.org/0000-0001-8040-159X"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B. Bloch","raw_affiliation_strings":["Boston University"],"affiliations":[{"raw_affiliation_string":"Boston University","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039249902","display_name":"Jonathan Chappelow","orcid":null},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Chappelow","raw_affiliation_strings":["Rutgers, The State University of New Jersey [New Brunswick]"],"affiliations":[{"raw_affiliation_string":"Rutgers, The State University of New Jersey [New Brunswick]","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060918423","display_name":"Elizabeth M. Genega","orcid":"https://orcid.org/0000-0002-7333-3709"},"institutions":[{"id":"https://openalex.org/I2801851002","display_name":"Harvard University Press","ror":"https://ror.org/006v7bf86","country_code":"US","type":"other","lineage":["https://openalex.org/I136199984","https://openalex.org/I2801851002"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Genega","raw_affiliation_strings":["Harvard University"],"affiliations":[{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I2801851002"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018711422","display_name":"Neil M. Rofsky","orcid":"https://orcid.org/0000-0002-1207-3704"},"institutions":[{"id":"https://openalex.org/I2801851002","display_name":"Harvard University Press","ror":"https://ror.org/006v7bf86","country_code":"US","type":"other","lineage":["https://openalex.org/I136199984","https://openalex.org/I2801851002"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. Rofsky","raw_affiliation_strings":["Harvard University"],"affiliations":[{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I2801851002"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086139759","display_name":"Robert E. Lenkinski","orcid":"https://orcid.org/0000-0001-7371-5048"},"institutions":[{"id":"https://openalex.org/I2801851002","display_name":"Harvard University Press","ror":"https://ror.org/006v7bf86","country_code":"US","type":"other","lineage":["https://openalex.org/I136199984","https://openalex.org/I2801851002"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Lenkinski","raw_affiliation_strings":["Harvard University"],"affiliations":[{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I2801851002"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027642699","display_name":"Anant Madabhushi","orcid":"https://orcid.org/0000-0002-5741-0399"},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Madabhushi","raw_affiliation_strings":["Rutgers, The State University of New Jersey [New Brunswick]"],"affiliations":[{"raw_affiliation_string":"Rutgers, The State University of New Jersey [New Brunswick]","institution_ids":["https://openalex.org/I102322142"]}]}],"institution_assertions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.262,"has_fulltext":true,"fulltext_origin":"ngrams","cited_by_count":8,"citation_normalized_percentile":{"value":0.795163,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":83,"max":84},"biblio":{"volume":"7623","issue":null,"first_page":"762303","last_page":"762303"},"is_retracted":false,"is_paratext":false,"primary_topic":{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.9995,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.9995,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9973,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.991,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6574551},{"id":"https://openalex.org/C2776673561","wikidata":"https://www.wikidata.org/wiki/Q655357","display_name":"Atlas (anatomy)","level":2,"score":0.61239046},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5336609},{"id":"https://openalex.org/C31601959","wikidata":"https://www.wikidata.org/wiki/Q931309","display_name":"Medical imaging","level":2,"score":0.4791814},{"id":"https://openalex.org/C2780385302","wikidata":"https://www.wikidata.org/wiki/Q367158","display_name":"Protocol (science)","level":3,"score":0.42073905},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4141036},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33071053},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.32597992},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3233651},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2797286},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.845554","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.61,"id":"https://metadata.un.org/sdg/3"}],"grants":[],"datasets":[],"versions":[],"referenced_works_count":29,"referenced_works":["https://openalex.org/W1578557524","https://openalex.org/W1870126640","https://openalex.org/W1966296929","https://openalex.org/W1971318487","https://openalex.org/W2004537679","https://openalex.org/W2007934749","https://openalex.org/W2012039837","https://openalex.org/W2021189280","https://openalex.org/W2034432063","https://openalex.org/W2039342983","https://openalex.org/W2058687871","https://openalex.org/W2084384373","https://openalex.org/W2092946690","https://openalex.org/W2093693898","https://openalex.org/W2101054201","https://openalex.org/W2105456967","https://openalex.org/W2113576511","https://openalex.org/W2123090765","https://openalex.org/W2125878029","https://openalex.org/W2131202198","https://openalex.org/W2144952095","https://openalex.org/W2148176788","https://openalex.org/W2150410007","https://openalex.org/W2152620868","https://openalex.org/W2154702468","https://openalex.org/W2156875677","https://openalex.org/W2158466399","https://openalex.org/W2171349848","https://openalex.org/W2899740253"],"related_works":["https://openalex.org/W638747717","https://openalex.org/W606911313","https://openalex.org/W4393084406","https://openalex.org/W4284509","https://openalex.org/W4229506690","https://openalex.org/W2803101231","https://openalex.org/W2373521488","https://openalex.org/W2324878645","https://openalex.org/W2314146950","https://openalex.org/W2011187995"],"abstract_inverted_index":{"Different":[0],"imaging":[1,271,319,414],"modalities":[2],"or":[3,143,148],"protocols":[4],"of":[5,13,39,82,117,130,179,197,205,253,267,279,289,300],"a":[6,16,75,83,124,169,191,198,268,309,340,370,377,407],"single":[7],"patient":[8,213,357],"may":[9],"convey":[10],"different":[11,32,105],"types":[12],"information":[14],"regarding":[15],"disease":[17,41,50,98,110,170,180,202,216,254,320,388],"for":[18,127,167,194,262,312,410],"the":[19,24,40,80,89,97,128,132,155,195,258,276,280,287,290,349,363,387,392],"same":[20],"anatomical":[21,118],"organ/tissue.":[22],"On":[23],"other":[25],"hand,":[26],"multi-modal/multi-protocol":[27,93],"medical":[28,69],"images":[29,70],"from":[30,71,141,210,354,390],"several":[31],"patients":[33,73,176],"can":[34,46,183,336,366],"also":[35,87],"provide":[36],"spatial":[37,99,133,255,272,304,331,360,393],"statistics":[38],"occurrence,":[42],"which":[43,274],"in":[44,49,54,101,230,333,362,384],"turn":[45,374],"greatly":[47],"aid":[48,53],"diagnosis":[51],"and":[52,58,96,108,207,223,282,286,303,317,379,394],"improved,":[55],"accurate":[56],"biopsy":[57],"targeted":[59],"treatment.":[60],"It":[61],"is":[62,152,159],"therefore":[63],"important":[64],"to":[65,103,314,324],"not":[66,160,165],"only":[67],"integrate":[68],"multiple":[72,212,356],"into":[74],"common":[76],"coordinate":[77],"frame":[78],"(in":[79,373],"form":[81],"population-based":[84,125],"atlas),":[85],"but":[86],"find":[88],"correlation":[90],"between":[91,175],"these":[92,136],"data":[94,209,301,395],"features":[95],"distribution":[100,372],"order":[102],"identify":[104],"quantitative":[106,344,401],"structural":[107,221,316],"functional":[109,224,318],"signatures.":[111,415],"Most":[112],"previous":[113],"work":[114],"on":[115,122,177,257],"construction":[116,196,245,266,288],"atlases":[119,305,397],"has":[120],"focused":[121],"deriving":[123,131],"atlas":[126,203,217,244,273,335,365,402],"purpose":[129],"statistics.":[134],"Moreover,":[135],"models":[137],"are":[138,164,352],"typically":[139],"derived":[140],"normal":[142],"healthy":[144],"subjects,":[145],"either":[146],"explicitly":[147],"implicitly,":[149],"where":[150,172],"it":[151],"assumed":[153],"that":[154,399],"inter-patient":[156],"pathological":[157],"variation":[158],"large.":[161],"These":[162],"methods":[163],"suitable":[166],"constructing":[168],"atlas,":[171],"significant":[173],"differences":[174],"account":[178],"related":[181],"variations":[182],"be":[184,337,367],"expected.":[185],"In":[186],"this":[187,334],"paper,":[188],"we":[189],"present":[190],"novel":[192],"framework":[193,246,403],"multi-parametric":[199],"MRI-based":[200],"data-driven":[201,291,364],"consisting":[204],"multi-modal":[206],"multi-protocol":[208,259,269,292],"across":[211,355,391],"studies.":[214],"Our":[215,243],"contains":[218],"3":[219,248],"Tesla":[220],"(T2)":[222],"(dynamic":[225],"contrast":[226],"enhanced":[227],"(DCE))":[228],"prostate":[229,295,412],"vivo":[231],"MRI":[232,293],"with":[233,339],"corresponding":[234],"whole":[235],"mount":[236],"histology":[237],"specimens":[238],"obtained":[239],"via":[240],"radical":[241],"prostatectomy.":[242],"comprises":[247],"distinct":[249],"modules:":[250],"(a)":[251],"determination":[252],"extent":[256],"MR":[260,270],"imagery":[261],"each":[263,359],"patient,":[264],"(b)":[265],"captures":[275],"geographical":[277],"proclivity":[278],"disease,":[281],"(c)":[283],"feature":[284,345,350,371],"extraction":[285],"based":[294],"cancer":[296,413],"atlas.":[297],"The":[298],"marriage":[299],"driven":[302,396],"could":[306,404],"serve":[307],"as":[308,323,406],"useful":[310],"tool":[311,409],"clinicians":[313],"identifying":[315],"signatures":[321,389],"so":[322],"make":[325],"better,":[326],"more":[327],"informed":[328],"diagnoses.":[329],"Each":[330],"location":[332,361],"associated":[338],"high":[341],"dimensional":[342],"multi-attribute":[343],"vector.":[346],"Additionally,":[347],"since":[348],"vectors":[351],"extracted":[353],"studies,":[358],"characterized":[368,375],"by":[369,376],"mean":[378],"standard":[380],"deviation).":[381],"Preliminary":[382],"investigation":[383],"quantitatively":[385],"correlating":[386],"suggests":[398],"our":[400],"emerge":[405],"powerful":[408],"discovering":[411]},"cited_by_api_url":"https://api.openalex.org/works?filter=cites:W2081443357","counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2024-12-12T15:39:53.226485","created_date":"2016-06-24"}