{"id":"https://openalex.org/W4220959946","doi":"https://doi.org/10.1117/12.2612675","title":"Convolutional neural network with a hybrid loss function for fully automated segmentation of lymphoma lesions in FDG PET images","display_name":"Convolutional neural network with a hybrid loss function for fully automated segmentation of lymphoma lesions in FDG PET images","publication_year":2022,"publication_date":"2022-03-31","ids":{"openalex":"https://openalex.org/W4220959946","doi":"https://doi.org/10.1117/12.2612675"},"language":"en","primary_location":{"is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2612675","pdf_url":null,"source":{"id":"https://openalex.org/S4363607561","display_name":"Medical Imaging 2022: Image Processing","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false},"type":"article","type_crossref":"proceedings-article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://arxiv.org/pdf/2208.00274","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058744346","display_name":"Fereshteh Yousefirizi","orcid":"https://orcid.org/0000-0001-5261-6163"},"institutions":[],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Fereshteh Yousefirizi","raw_affiliation_strings":["BC Cancer Research Institute (Canada)"],"affiliations":[{"raw_affiliation_string":"BC Cancer Research Institute (Canada)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013315582","display_name":"Natalia Dubljevic","orcid":null},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Natalia Dubljevic","raw_affiliation_strings":["The Univ. of British Columbia (Canada)"],"affiliations":[{"raw_affiliation_string":"The Univ. of British Columbia (Canada)","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044877506","display_name":"Shadab Ahamed","orcid":null},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Shadab Ahamed","raw_affiliation_strings":["BC Cancer Research Institute (Canada)","The Univ. of British Columbia (Canada)"],"affiliations":[{"raw_affiliation_string":"BC Cancer Research Institute (Canada)","institution_ids":[]},{"raw_affiliation_string":"The Univ. of British Columbia (Canada)","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078819407","display_name":"Ingrid Bloise","orcid":null},"institutions":[],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ingrid Bloise","raw_affiliation_strings":["BC Cancer Research Institute (Canada)"],"affiliations":[{"raw_affiliation_string":"BC Cancer Research Institute (Canada)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032700631","display_name":"Claire Gowdy","orcid":"https://orcid.org/0009-0008-8054-0635"},"institutions":[{"id":"https://openalex.org/I4210153200","display_name":"British Columbia Children's Hospital","ror":"https://ror.org/04n901w50","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4210153200"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Claire Gowdy","raw_affiliation_strings":["BC Children's Hospital (Canada)"],"affiliations":[{"raw_affiliation_string":"BC Children's Hospital (Canada)","institution_ids":["https://openalex.org/I4210153200"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085739405","display_name":"Joo Hyun O","orcid":null},"institutions":[{"id":"https://openalex.org/I4210160144","display_name":"Seoul St. Mary's Hospital","ror":"https://ror.org/056cn0e37","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210160144"]},{"id":"https://openalex.org/I87111246","display_name":"Catholic University of Korea","ror":"https://ror.org/01fpnj063","country_code":"KR","type":"education","lineage":["https://openalex.org/I87111246"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Joo Hyun O.","raw_affiliation_strings":["Seoul St. Mary's Hospital, College of Medicine, The Catholic Univ. of Korea (Korea, Republic of)"],"affiliations":[{"raw_affiliation_string":"Seoul St. Mary's Hospital, College of Medicine, The Catholic Univ. of Korea (Korea, Republic of)","institution_ids":["https://openalex.org/I4210160144","https://openalex.org/I87111246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040257052","display_name":"Youssef M.K. Farag","orcid":"https://orcid.org/0000-0003-0106-8456"},"institutions":[],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Youssef Farag","raw_affiliation_strings":["BC Cancer Research Institute (Canada)"],"affiliations":[{"raw_affiliation_string":"BC Cancer Research Institute (Canada)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009567562","display_name":"Rodrigue de Schaetzen","orcid":null},"institutions":[],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Rodrigue de Schaetzen","raw_affiliation_strings":["BC Cancer Research Institute (Canada)"],"affiliations":[{"raw_affiliation_string":"BC Cancer Research Institute (Canada)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056135337","display_name":"Patrick Martineau","orcid":"https://orcid.org/0000-0002-5833-3145"},"institutions":[],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Patrick Martineau","raw_affiliation_strings":["BC Cancer Research Institute (Canada)"],"affiliations":[{"raw_affiliation_string":"BC Cancer Research Institute (Canada)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086508714","display_name":"Don E. Wilson","orcid":"https://orcid.org/0000-0003-4228-5334"},"institutions":[],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Don Wilson","raw_affiliation_strings":["BC Cancer Research Institute (Canada)"],"affiliations":[{"raw_affiliation_string":"BC Cancer Research Institute (Canada)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077969822","display_name":"Carlos Uribe","orcid":null},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Carlos F. Uribe","raw_affiliation_strings":["BC Cancer Research Institute (Canada)","The Univ. of British Columbia (Canada)"],"affiliations":[{"raw_affiliation_string":"The Univ. of British Columbia (Canada)","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"BC Cancer Research Institute (Canada)","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021438906","display_name":"Arman Rahmim","orcid":"https://orcid.org/0000-0002-9980-2403"},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Arman Rahmim","raw_affiliation_strings":["BC Cancer Research Institute (Canada)","The Univ. of British Columbia (Canada)"],"affiliations":[{"raw_affiliation_string":"The Univ. of British Columbia (Canada)","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"BC Cancer Research Institute (Canada)","institution_ids":[]}]}],"institution_assertions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.546,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.785918,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":80,"max":83},"biblio":{"volume":null,"issue":null,"first_page":"33","last_page":"33"},"is_retracted":false,"is_paratext":false,"primary_topic":{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9999,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9999,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.9997,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9968,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.82768},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.7049365},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.67619574},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.57626814},{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.5169774},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.48734435},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.46150947},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.46108598},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.39784843},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.19678867},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13945362},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2612675","pdf_url":null,"source":{"id":"https://openalex.org/S4363607561","display_name":"Medical Imaging 2022: Image Processing","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false},{"is_oa":true,"landing_page_url":"https://arxiv.org/abs/2208.00274","pdf_url":"https://arxiv.org/pdf/2208.00274","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":["Cornell University"],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false}],"best_oa_location":{"is_oa":true,"landing_page_url":"https://arxiv.org/abs/2208.00274","pdf_url":"https://arxiv.org/pdf/2208.00274","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":["Cornell University"],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false},"sustainable_development_goals":[],"grants":[],"datasets":[],"versions":[],"referenced_works_count":27,"referenced_works":["https://openalex.org/W2107638293","https://openalex.org/W2558789525","https://openalex.org/W2592929672","https://openalex.org/W2734349601","https://openalex.org/W2752782242","https://openalex.org/W2773727367","https://openalex.org/W2795587607","https://openalex.org/W2892266666","https://openalex.org/W2962767316","https://openalex.org/W2963043051","https://openalex.org/W2963351448","https://openalex.org/W2964098128","https://openalex.org/W2971779924","https://openalex.org/W2986910815","https://openalex.org/W3093594532","https://openalex.org/W3101310341","https://openalex.org/W3119385269","https://openalex.org/W3131237683","https://openalex.org/W3160412534","https://openalex.org/W3186775438","https://openalex.org/W3191554766","https://openalex.org/W3199152014","https://openalex.org/W3217285723","https://openalex.org/W3217466224","https://openalex.org/W4212991200","https://openalex.org/W4243810992","https://openalex.org/W4250685322"],"related_works":["https://openalex.org/W4399188509","https://openalex.org/W4391266461","https://openalex.org/W4321487865","https://openalex.org/W4313906399","https://openalex.org/W4239306820","https://openalex.org/W2947043951","https://openalex.org/W2811106690","https://openalex.org/W2590798552","https://openalex.org/W2318112981","https://openalex.org/W1522196789"],"abstract_inverted_index":{"Segmentation":[0],"of":[1,30,43,149,159,167,234,248],"lymphoma":[2,34,59],"lesions":[3],"is":[4,88],"challenging":[5],"due":[6],"to":[7,73,126,188],"their":[8],"varied":[9],"sizes":[10],"and":[11,64,103,110,115,135,138,163,202,209,240],"locations":[12],"in":[13,82,223],"whole-body":[14],"PET":[15],"scans.":[16],"In":[17],"this":[18],"work,":[19],"we":[20],"present":[21],"a":[22,27,41,89,96,154,218,224],"fully-automated":[23],"segmentation":[24,86,178],"technique":[25],"using":[26,195],"multi-center":[28,225],"dataset":[29,42],"diffuse":[31],"large":[32,57],"B-cell":[33,58],"(DLBCL)":[35],"with":[36,54,174,179],"heterogeneous":[37],"characteristics.":[38],"We":[39],"utilized":[40,69,119],"[18F]FDG-PET":[44],"scans":[45],"(n=194)":[46],"from":[47],"two":[48],"different":[49,132],"imaging":[50],"centers":[51],"including":[52],"cases":[53],"primary":[55],"mediastinal":[56],"(PMBCL)":[60],"(n=104).":[61],"Automated":[62],"brain":[63],"bladder":[65],"removal":[66],"approaches":[67],"were":[68,118,142],"as":[70,186],"preprocessing":[71],"steps,":[72],"tackle":[74],"false":[75],"positives":[76],"caused":[77],"by":[78],"normal":[79],"hypermetabolic":[80],"uptake":[81],"these":[83,150],"organs.":[84],"Our":[85,170,214],"model":[87,173,215],"convolutional":[90],"neural":[91],"network":[92],"(CNN),":[93],"based":[94],"on":[95,144],"3D":[97,171,190],"U-Net":[98,191],"architecture":[99],"that":[100,120,227],"includes":[101],"squeeze":[102],"excitation":[104],"(SE)":[105],"modules.":[106],"Hybrid":[107],"distribution,":[108],"region,":[109],"boundary-based":[111],"losses":[112],"(Unified":[113,200],"Focal":[114,201],"Mumford-Shah":[116],"(MS))":[117],"showed":[121],"the":[122,189,196,229,246],"best":[123],"performance":[124],"compared":[125,187],"other":[127,241],"combinations":[128],"(p<0.05).":[129],"Cross-validation":[130],"between":[131],"centers,":[133],"DLBCL":[134],"PMBCL":[136],"cases,":[137],"three":[139],"random":[140],"splits":[141],"applied":[143],"train/validation":[145],"data.":[146],"The":[147],"ensemble":[148],"six":[151],"models":[152],"achieved":[153],"Dice":[155],"similarity":[156],"coefficient":[157],"(DSC)":[158],"0.77":[160],"\u00b1":[161,207,212],"0.08":[162],"Hausdorff":[164],"distance":[165],"(HD)":[166],"16.5":[168],"\u00b112.5.":[169],"U-net":[172],"SE":[175,193],"modules":[176],"for":[177,231,245],"hybrid":[180],"loss":[181,198],"performed":[182],"significantly":[183],"better":[184],"(p<0.05)":[185],"(without":[192],"modules)":[194],"same":[197],"function":[199],"MS":[203],"loss)":[204],"(DSC=":[205],"0.64":[206],"0.21":[208],"HD=":[210],"26.3":[211],"18.7).":[213],"can":[216],"facilitate":[217],"fully":[219],"automated":[220],"quantification":[221],"pipeline":[222],"context":[226],"opens":[228],"possibility":[230],"routine":[232],"reporting":[233],"total":[235],"metabolic":[236],"tumor":[237],"volume":[238],"(TMTV)":[239],"metrics":[242],"shown":[243],"useful":[244],"management":[247],"lymphoma.":[249]},"cited_by_api_url":"https://api.openalex.org/works?filter=cites:W4220959946","counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":1}],"updated_date":"2024-12-24T05:04:03.337316","created_date":"2022-04-03"}