{"id":"https://openalex.org/W2611747160","doi":"https://doi.org/10.1109/tcbb.2017.2701379","title":"Integrating Multiple Heterogeneous Networks for Novel LncRNA-Disease Association Inference","display_name":"Integrating Multiple Heterogeneous Networks for Novel LncRNA-Disease Association Inference","publication_year":2017,"publication_date":"2017-05-04","ids":{"openalex":"https://openalex.org/W2611747160","doi":"https://doi.org/10.1109/tcbb.2017.2701379","mag":"2611747160","pmid":"https://pubmed.ncbi.nlm.nih.gov/28489543"},"language":"en","primary_location":{"is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2017.2701379","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_indexed_in_scopus":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false},"type":"article","type_crossref":"journal-article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012966716","display_name":"Jingpu Zhang","orcid":"https://orcid.org/0000-0002-8006-747X"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"funder","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingpu Zhang","raw_affiliation_strings":["School of Information Science and Engineering, Central South University, Changsha, China"],"affiliations":[{"raw_affiliation_string":"School of Information Science and Engineering, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064823007","display_name":"Zuping Zhang","orcid":"https://orcid.org/0000-0002-2528-7808"},"institutions":[{"id":"https://openalex.org/I151878197","display_name":"Pingdingshan University","ror":"https://ror.org/026c29h90","country_code":"CN","type":"funder","lineage":["https://openalex.org/I151878197"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zuping Zhang","raw_affiliation_strings":["School of Computer (Software), Ping Ding Shan University, Pingdingshan 467000, China"],"affiliations":[{"raw_affiliation_string":"School of Computer (Software), Ping Ding Shan University, Pingdingshan 467000, China","institution_ids":["https://openalex.org/I151878197"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100332258","display_name":"Zhigang Chen","orcid":"https://orcid.org/0000-0002-4437-4077"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"funder","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhigang Chen","raw_affiliation_strings":["School of Information Science and Engineering, Central South University, Changsha, China"],"affiliations":[{"raw_affiliation_string":"School of Information Science and Engineering, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085608332","display_name":"Lei Deng","orcid":"https://orcid.org/0000-0003-2869-1619"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"funder","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Deng","raw_affiliation_strings":["School of Software, Central South University, Changsha, China"],"affiliations":[{"raw_affiliation_string":"School of Software, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479"]}]}],"institution_assertions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.069,"has_fulltext":true,"fulltext_origin":"ngrams","cited_by_count":115,"citation_normalized_percentile":{"value":0.839497,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"16","issue":"2","first_page":"396","last_page":"406"},"is_retracted":false,"is_paratext":false,"primary_topic":{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9576,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.933,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/similarity","display_name":"Similarity (geometry)","score":0.46867117},{"id":"https://openalex.org/keywords/representation","display_name":"Representation","score":0.4365322}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6729816},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.598787},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.54416084},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.5288623},{"id":"https://openalex.org/C103278499","wikidata":"https://www.wikidata.org/wiki/Q254465","display_name":"Similarity (geometry)","level":3,"score":0.46867117},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4466927},{"id":"https://openalex.org/C2776359362","wikidata":"https://www.wikidata.org/wiki/Q2145286","display_name":"Representation (politics)","level":3,"score":0.4365322},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3625325},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.26038784},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25545666},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12402928},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C94625758","wikidata":"https://www.wikidata.org/wiki/Q7163","display_name":"Politics","level":2,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":"","qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcbb.2017.2701379","pdf_url":null,"source":{"id":"https://openalex.org/S36029991","display_name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","issn_l":"1545-5963","issn":["1545-5963","1557-9964","2374-0043"],"is_oa":false,"is_in_doaj":false,"is_indexed_in_scopus":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false},{"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28489543","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_indexed_in_scopus":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":["National Institutes of Health"],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Partnerships for the goals","id":"https://metadata.un.org/sdg/17","score":0.44}],"grants":[{"funder":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China","award_id":"60970095"},{"funder":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China","award_id":"61672541"},{"funder":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China","award_id":"61379057"},{"funder":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China","award_id":"61309010"},{"funder":"https://openalex.org/F4320321543","funder_display_name":"China Postdoctoral Science Foundation","award_id":"2015T80886"},{"funder":"https://openalex.org/F4320332588","funder_display_name":"Shanghai Key Laboratory of Intelligent Information Processing","award_id":"IIPL-2014-002"},{"funder":"https://openalex.org/F4320336024","funder_display_name":"Specialized Research Fund for the Doctoral Program of Higher Education of China","award_id":"20130162120073"}],"datasets":[],"versions":[],"referenced_works_count":61,"referenced_works":["https://openalex.org/W1500090790","https://openalex.org/W1576461546","https://openalex.org/W1978967539","https://openalex.org/W1987093629","https://openalex.org/W1999008082","https://openalex.org/W1999746344","https://openalex.org/W2002185065","https://openalex.org/W2008491586","https://openalex.org/W2014162182","https://openalex.org/W2021936091","https://openalex.org/W2023410485","https://openalex.org/W2024715297","https://openalex.org/W2030047242","https://openalex.org/W2031954078","https://openalex.org/W2035918394","https://openalex.org/W2036044314","https://openalex.org/W2038122249","https://openalex.org/W2039816251","https://openalex.org/W2046851700","https://openalex.org/W2047929507","https://openalex.org/W2049621625","https://openalex.org/W2052938279","https://openalex.org/W2053758959","https://openalex.org/W2062502437","https://openalex.org/W2063692638","https://openalex.org/W2064835029","https://openalex.org/W2069139855","https://openalex.org/W2086968193","https://openalex.org/W2087377443","https://openalex.org/W2090968329","https://openalex.org/W2091161969","https://openalex.org/W2095544161","https://openalex.org/W2100982253","https://openalex.org/W2108051165","https://openalex.org/W2109100311","https://openalex.org/W2110684048","https://openalex.org/W2112632190","https://openalex.org/W2115954319","https://openalex.org/W2124050695","https://openalex.org/W2126543222","https://openalex.org/W2128983843","https://openalex.org/W2134672568","https://openalex.org/W2152970345","https://openalex.org/W2154654747","https://openalex.org/W2155295585","https://openalex.org/W2162151166","https://openalex.org/W2165423269","https://openalex.org/W2167714537","https://openalex.org/W2174891444","https://openalex.org/W2201374517","https://openalex.org/W2226947704","https://openalex.org/W2236856444","https://openalex.org/W2265970986","https://openalex.org/W2312558633","https://openalex.org/W2334019504","https://openalex.org/W2408796111","https://openalex.org/W2409062259","https://openalex.org/W2479195013","https://openalex.org/W2537993442","https://openalex.org/W611910056","https://openalex.org/W622497121"],"related_works":["https://openalex.org/W4321636575","https://openalex.org/W2741131631","https://openalex.org/W2379232404","https://openalex.org/W2375480909","https://openalex.org/W2357796999","https://openalex.org/W2353314428","https://openalex.org/W2062195135","https://openalex.org/W2055243143","https://openalex.org/W2012019886","https://openalex.org/W1986418932"],"abstract_inverted_index":{"Accumulating":[0],"experimental":[1],"evidence":[2],"has":[3],"indicated":[4],"that":[5,145],"long":[6],"non-coding":[7],"RNAs":[8],"(lncRNAs)":[9],"are":[10,66,184],"critical":[11],"for":[12,175],"the":[13,92,135,151,160,163,167,172,190,197],"regulation":[14],"of":[15,71,89,124,162],"cellular":[16],"biological":[17,125,198],"processes":[18],"implicated":[19],"in":[20,94,155,189],"many":[21],"human":[22],"diseases.":[23,62],"However,":[24],"only":[25],"relatively":[26],"few":[27],"experimentally":[28],"supported":[29],"lncRNA-disease":[30,41,141],"associations":[31,42,58,136],"have":[32,193],"been":[33,194],"reported.":[34],"Developing":[35],"effective":[36],"computational":[37,96],"methods":[38,65],"to":[39,55,81,106,116,139,170],"infer":[40,140],"is":[43],"becoming":[44],"increasingly":[45],"important.":[46],"Current":[47],"network-based":[48,103],"algorithms":[49],"typically":[50],"use":[51,166],"a":[52,100,112,122],"network":[53],"representation":[54],"identify":[56,171],"novel":[57],"between":[59,137],"lncRNAs":[60,174,188],"and":[61,74,76,134,179],"But":[63],"these":[64],"concentrated":[67],"on":[68,121],"specific":[69],"entities":[70],"interest":[72],"(lncRNAs":[73],"diseases)":[75],"they":[77],"do":[78],"not":[79],"allow":[80],"consider":[82],"networks":[83,119],"with":[84],"more":[85],"than":[86,150],"two":[87],"types":[88],"entities.":[90],"Considering":[91],"limitations":[93],"previous":[95],"methods,":[97],"we":[98,165],"develop":[99],"new":[101],"global":[102],"framework,":[104],"LncRDNetFlow,":[105],"prioritize":[107],"disease-related":[108],"lncRNAs.":[109],"LncRDNetFlow":[110,146],"utilizes":[111],"flow":[113],"propagation":[114],"algorithm":[115],"integrate":[117],"multiple":[118],"based":[120],"variety":[123],"information":[126],"including":[127],"lncRNA":[128],"similarity,":[129,133],"protein-protein":[130],"interactions,":[131],"disease":[132],"them":[138],"associations.":[142],"We":[143],"show":[144],"performs":[147],"significantly":[148],"better":[149],"existing":[152],"state-of-the-art":[153],"approaches":[154],"cross-validation.":[156],"To":[157],"further":[158],"validate":[159],"reproducibility":[161],"performance,":[164],"proposed":[168],"method":[169],"related":[173],"ovarian":[176],"cancer,":[177],"glioma,":[178],"cervical":[180],"cancer.":[181],"The":[182],"results":[183],"encouraging.":[185],"Many":[186],"predicted":[187],"top":[191],"list":[192],"verified":[195],"by":[196],"studies.":[199]},"abstract_inverted_index_v3":null,"cited_by_api_url":"https://api.openalex.org/works?filter=cites:W2611747160","counts_by_year":[{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":23},{"year":2019,"cited_by_count":28},{"year":2018,"cited_by_count":21},{"year":2017,"cited_by_count":6}],"updated_date":"2025-04-04T00:47:56.621525","created_date":"2017-05-12"}