乐胖代购免代理版

{"id":"https://openalex.org/W2166124280","doi":"https://doi.org/10.1109/icsmc.2008.4811538","title":"Support vector machine application in drug discovery of aldose reductase inhibitors","display_name":"Support vector machine application in drug discovery of aldose reductase inhibitors","publication_year":2008,"publication_date":"2008-10-01","ids":{"openalex":"https://openalex.org/W2166124280","doi":"https://doi.org/10.1109/icsmc.2008.4811538","mag":"2166124280"},"language":"en","primary_location":{"is_oa":false,"landing_page_url":"https://doi.org/10.1109/icsmc.2008.4811538","pdf_url":null,"source":{"id":"https://openalex.org/S4210195764","display_name":"Conference proceedings/Conference proceedings - IEEE International Conference on Systems, Man, and Cybernetics","issn_l":"1062-922X","issn":["1062-922X","2577-1655"],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"conference"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false},"type":"article","type_crossref":"proceedings-article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049913930","display_name":"Jagdish C. Patra","orcid":"https://orcid.org/0000-0002-6257-0469"},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"J. C. Patra","raw_affiliation_strings":["School of Computer Engineering, Nanyang Technological University, Singapore, Singapore"],"affiliations":[{"raw_affiliation_string":"School of Computer Engineering, Nanyang Technological University, Singapore, Singapore","institution_ids":["https://openalex.org/I172675005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100412922","display_name":"Lin Li","orcid":"https://orcid.org/0000-0002-9840-8367"},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"L. Li","raw_affiliation_strings":["School of Computer Engineering, Nanyang Technological University, Singapore, Singapore"],"affiliations":[{"raw_affiliation_string":"School of Computer Engineering, Nanyang Technological University, Singapore, Singapore","institution_ids":["https://openalex.org/I172675005"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025809855","display_name":"Pramod Kumar Meher","orcid":"https://orcid.org/0000-0003-0992-1159"},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"P. K. Meher","raw_affiliation_strings":["School of Computer Engineering, Nanyang Technological University, Singapore, Singapore"],"affiliations":[{"raw_affiliation_string":"School of Computer Engineering, Nanyang Technological University, Singapore, Singapore","institution_ids":["https://openalex.org/I172675005"]}]}],"institution_assertions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.314,"has_fulltext":true,"fulltext_origin":"ngrams","cited_by_count":1,"citation_normalized_percentile":{"value":0.252027,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":63,"max":70},"biblio":{"volume":null,"issue":null,"first_page":"1731","last_page":"1736"},"is_retracted":false,"is_paratext":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9985,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9985,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11025","display_name":"Nonlinear Optical Materials Research","score":0.9952,"subfield":{"id":"https://openalex.org/subfields/2504","display_name":"Electronic, Optical and Magnetic Materials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12748","display_name":"Molecular spectroscopy and chirality","score":0.9805,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/perceptron","display_name":"Perceptron","score":0.49989367},{"id":"https://openalex.org/keywords/electronegativity","display_name":"Electronegativity","score":0.42374375}],"concepts":[{"id":"https://openalex.org/C2776439734","wikidata":"https://www.wikidata.org/wiki/Q414213","display_name":"Aldose reductase","level":3,"score":0.9224593},{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.84272623},{"id":"https://openalex.org/C164126121","wikidata":"https://www.wikidata.org/wiki/Q766383","display_name":"Quantitative structure\u2013activity relationship","level":2,"score":0.6226449},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5204109},{"id":"https://openalex.org/C60908668","wikidata":"https://www.wikidata.org/wiki/Q690207","display_name":"Perceptron","level":3,"score":0.49989367},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.48772058},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.45031807},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.4249824},{"id":"https://openalex.org/C177293861","wikidata":"https://www.wikidata.org/wiki/Q78974","display_name":"Electronegativity","level":2,"score":0.42374375},{"id":"https://openalex.org/C56173144","wikidata":"https://www.wikidata.org/wiki/Q1539893","display_name":"Pharmacophore","level":2,"score":0.42316073},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38454193},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3715855},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.22183615},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.20640719},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17855617},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.12171805},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.07927388}],"mesh":[],"locations_count":1,"locations":[{"is_oa":false,"landing_page_url":"https://doi.org/10.1109/icsmc.2008.4811538","pdf_url":null,"source":{"id":"https://openalex.org/S4210195764","display_name":"Conference proceedings/Conference proceedings - IEEE International Conference on Systems, Man, and Cybernetics","issn_l":"1062-922X","issn":["1062-922X","2577-1655"],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"conference"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"grants":[],"datasets":[],"versions":[],"referenced_works_count":25,"referenced_works":["https://openalex.org/W1496317909","https://openalex.org/W1501283731","https://openalex.org/W1565866145","https://openalex.org/W1974166884","https://openalex.org/W1981177794","https://openalex.org/W1986490585","https://openalex.org/W2002551521","https://openalex.org/W2024191422","https://openalex.org/W2037181055","https://openalex.org/W2037695191","https://openalex.org/W2038133793","https://openalex.org/W2048448698","https://openalex.org/W2055394288","https://openalex.org/W2074179213","https://openalex.org/W2079225934","https://openalex.org/W2123737232","https://openalex.org/W2127767552","https://openalex.org/W2158994553","https://openalex.org/W2159749487","https://openalex.org/W2603246093","https://openalex.org/W3148720599","https://openalex.org/W4239022737","https://openalex.org/W4285719527","https://openalex.org/W4301501800","https://openalex.org/W592520988"],"related_works":["https://openalex.org/W3183948672","https://openalex.org/W3173606202","https://openalex.org/W2333220762","https://openalex.org/W2314430254","https://openalex.org/W2225633491","https://openalex.org/W2059558045","https://openalex.org/W2021051369","https://openalex.org/W2002578321","https://openalex.org/W2001552790","https://openalex.org/W1531601525"],"abstract_inverted_index":{"Using":[0],"support":[1],"vector":[2],"machine":[3],"(SVM)":[4],"function":[5],"approximation,":[6],"in":[7],"this":[8],"paper,":[9],"we":[10],"present":[11],"the":[12,18,32,35],"quantitative":[13],"structure-activity":[14],"relationship":[15],"(QSAR)":[16],"among":[17],"known":[19],"aldose":[20],"reductase":[21],"inhibitors":[22],"(ARIs).":[23],"The":[24],"two":[25],"physical":[26],"descriptors":[27],"of":[28],"a":[29],"molecule,":[30],"namely":[31],"electronegativity":[33],"and":[34],"molar":[36],"volume":[37],"are":[38],"evaluated":[39],"by":[40],"SVM.":[41],"SVM":[42],"is":[43],"found":[44],"to":[45],"work":[46],"better":[47],"than":[48],"multi-layer":[49],"perceptron":[50],"(MLP).":[51]},"cited_by_api_url":"https://api.openalex.org/works?filter=cites:W2166124280","counts_by_year":[],"updated_date":"2024-12-07T23:25:04.744889","created_date":"2016-06-24"}