{"id":"https://openalex.org/W4405489322","doi":"https://doi.org/10.1109/embc53108.2024.10782071","title":"Reduced Synaptic Heterogeneity in a Tetanus Toxin Model of Epilepsy: Insights from Computational Modeling","display_name":"Reduced Synaptic Heterogeneity in a Tetanus Toxin Model of Epilepsy: Insights from Computational Modeling","publication_year":2024,"publication_date":"2024-07-15","ids":{"openalex":"https://openalex.org/W4405489322","doi":"https://doi.org/10.1109/embc53108.2024.10782071","pmid":"https://pubmed.ncbi.nlm.nih.gov/40040052"},"language":"en","primary_location":{"is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc53108.2024.10782071","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false},"type":"article","type_crossref":"proceedings-article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004267935","display_name":"Parvin Zarei Eskikand","orcid":"https://orcid.org/0000-0002-1424-6445"},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"funder","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Parvin Zarei Eskikand","raw_affiliation_strings":["The University of Melbourne,Department of Biomedical Engineering,Victoria,Australia,3010"],"affiliations":[{"raw_affiliation_string":"The University of Melbourne,Department of Biomedical Engineering,Victoria,Australia,3010","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052643152","display_name":"Mark Cook","orcid":"https://orcid.org/0000-0002-8875-4135"},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"funder","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Mark J. Cook","raw_affiliation_strings":["The University of Melbourne,Department of Biomedical Engineering,Victoria,Australia,3010"],"affiliations":[{"raw_affiliation_string":"The University of Melbourne,Department of Biomedical Engineering,Victoria,Australia,3010","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002748431","display_name":"Anthony N. Burkitt","orcid":"https://orcid.org/0000-0001-5672-2772"},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"funder","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Anthony N. Burkitt","raw_affiliation_strings":["The University of Melbourne,Department of Biomedical Engineering,Victoria,Australia,3010"],"affiliations":[{"raw_affiliation_string":"The University of Melbourne,Department of Biomedical Engineering,Victoria,Australia,3010","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014100961","display_name":"David B. Grayden","orcid":"https://orcid.org/0000-0002-5497-7234"},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"funder","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"David B. Grayden","raw_affiliation_strings":["The University of Melbourne,Department of Biomedical Engineering,Victoria,Australia,3010"],"affiliations":[{"raw_affiliation_string":"The University of Melbourne,Department of Biomedical Engineering,Victoria,Australia,3010","institution_ids":["https://openalex.org/I165779595"]}]}],"institution_assertions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":0,"max":77},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9995,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9995,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9983,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.998,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2779841045","wikidata":"https://www.wikidata.org/wiki/Q47790","display_name":"Tetanus","level":3,"score":0.66605186},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.61206555},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5329866},{"id":"https://openalex.org/C2777367657","wikidata":"https://www.wikidata.org/wiki/Q184651","display_name":"Toxin","level":2,"score":0.47490752},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.38457692},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.24903324},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20381013},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10523674},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.06353706},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013744","descriptor_name":"Tetanus Toxin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":2,"locations":[{"is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc53108.2024.10782071","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false},{"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40040052","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_indexed_in_scopus":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":["National Institutes of Health"],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2","score":0.51}],"grants":[{"funder":"https://openalex.org/F4320315885","funder_display_name":"Australian Government","award_id":null},{"funder":"https://openalex.org/F4320334704","funder_display_name":"Australian Research Council","award_id":null}],"datasets":[],"versions":[],"referenced_works_count":13,"referenced_works":["https://openalex.org/W1512746852","https://openalex.org/W2030773781","https://openalex.org/W2055930493","https://openalex.org/W2059668389","https://openalex.org/W2097965856","https://openalex.org/W2109596721","https://openalex.org/W2950958538","https://openalex.org/W2952921509","https://openalex.org/W3009954736","https://openalex.org/W3018136038","https://openalex.org/W4281388304","https://openalex.org/W4384764819","https://openalex.org/W4402734275"],"related_works":["https://openalex.org/W86077716","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2423854683","https://openalex.org/W2414579877","https://openalex.org/W2409602088","https://openalex.org/W2381538932","https://openalex.org/W2328094839","https://openalex.org/W2038198109","https://openalex.org/W1605877026"],"abstract_inverted_index":{"A":[0,59],"neural":[1],"mass":[2],"model":[3,16,27,123],"was":[4],"used":[5],"to":[6,17,111],"assess":[7],"connectivity":[8],"strength":[9,91],"across":[10,93],"diverse":[11],"populations":[12],"by":[13],"fitting":[14],"the":[15,37,50,56,83,131],"background":[18],"EEG":[19,44],"data":[20,45],"obtained":[21],"from":[22,47],"a":[23,33,77,104,125],"Tetanus":[24,51,86],"Toxin":[25,52,87],"rat":[26],"of":[28,39,62,80,85,130,133],"epilepsy.":[29,119],"Our":[30],"findings":[31],"reveal":[32],"notable":[34],"decline":[35],"in":[36,49,65,106,114],"variability":[38,92],"estimated":[40,66],"parameters":[41,67],"when":[42],"using":[43],"recorded":[46],"rats":[48],"group":[53],"compared":[54],"with":[55,76,118],"control":[57],"group.":[58],"detailed":[60],"comparison":[61],"standard":[63],"deviations":[64],"between":[68],"day":[69,72],"1":[70],"and":[71],"20":[73],"recordings,":[74],"coinciding":[75],"heightened":[78],"number":[79],"seizures,":[81],"underscores":[82],"impact":[84],"on":[88],"diminishing":[89],"synaptic":[90],"recordings.":[94],"This":[95],"study":[96],"supports":[97],"electrophysiological":[98],"studies":[99],"suggesting":[100],"that":[101],"epileptogenesis":[102],"induces":[103],"reduction":[105],"biophysical":[107],"heterogeneity,":[108],"potentially":[109],"leading":[110],"an":[112],"increase":[113],"network":[115],"synchrony":[116],"associated":[117],"Furthermore,":[120],"our":[121],"computational":[122],"establishes":[124],"foundation":[126],"for":[127],"future":[128],"explorations":[129],"implications":[132],"this":[134],"diminished":[135],"variability.":[136]},"abstract_inverted_index_v3":null,"cited_by_api_url":"https://api.openalex.org/works?filter=cites:W4405489322","counts_by_year":[],"updated_date":"2025-04-18T11:29:40.477451","created_date":"2024-12-18"}