{"id":"https://openalex.org/W3106764684","doi":"https://doi.org/10.1109/dcis51330.2020.9268654","title":"Novel Methodology for Alzheimer's Disease Biomarker Identification in Plasma using Hyperspectral Microscopy","display_name":"Novel Methodology for Alzheimer's Disease Biomarker Identification in Plasma using Hyperspectral Microscopy","publication_year":2020,"publication_date":"2020-11-18","ids":{"openalex":"https://openalex.org/W3106764684","doi":"https://doi.org/10.1109/dcis51330.2020.9268654","mag":"3106764684"},"language":"en","primary_location":{"is_oa":false,"landing_page_url":"https://doi.org/10.1109/dcis51330.2020.9268654","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false},"type":"article","type_crossref":"proceedings-article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045090259","display_name":"Himar Fabelo","orcid":"https://orcid.org/0000-0002-9794-490X"},"institutions":[{"id":"https://openalex.org/I119635470","display_name":"Universidad de Las Palmas de Gran Canaria","ror":"https://ror.org/01teme464","country_code":"ES","type":"education","lineage":["https://openalex.org/I119635470"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Himar Fabelo","raw_affiliation_strings":["Research Institute for Applied Microelectronics (IUMA), Universidad de Las Palmas de Gran Canaria (ULPGC), Las Palmas de Gran Canaria, Spain"],"affiliations":[{"raw_affiliation_string":"Research Institute for Applied Microelectronics (IUMA), Universidad de Las Palmas de Gran Canaria (ULPGC), Las Palmas de Gran Canaria, Spain","institution_ids":["https://openalex.org/I119635470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058895136","display_name":"Raquel Le\u00f3n","orcid":"https://orcid.org/0000-0002-4287-3200"},"institutions":[{"id":"https://openalex.org/I119635470","display_name":"Universidad de Las Palmas de Gran Canaria","ror":"https://ror.org/01teme464","country_code":"ES","type":"education","lineage":["https://openalex.org/I119635470"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Raquel Leon","raw_affiliation_strings":["Research Institute for Applied Microelectronics (IUMA), Universidad de Las Palmas de Gran Canaria (ULPGC), Las Palmas de Gran Canaria, Spain"],"affiliations":[{"raw_affiliation_string":"Research Institute for Applied Microelectronics (IUMA), Universidad de Las Palmas de Gran Canaria (ULPGC), Las Palmas de Gran Canaria, Spain","institution_ids":["https://openalex.org/I119635470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013980644","display_name":"Samuel Ortega","orcid":"https://orcid.org/0000-0002-7519-954X"},"institutions":[{"id":"https://openalex.org/I119635470","display_name":"Universidad de Las Palmas de Gran Canaria","ror":"https://ror.org/01teme464","country_code":"ES","type":"education","lineage":["https://openalex.org/I119635470"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Samuel Ortega","raw_affiliation_strings":["Research Institute for Applied Microelectronics (IUMA), Universidad de Las Palmas de Gran Canaria (ULPGC), Las Palmas de Gran Canaria, Spain"],"affiliations":[{"raw_affiliation_string":"Research Institute for Applied Microelectronics (IUMA), Universidad de Las Palmas de Gran Canaria (ULPGC), Las Palmas de Gran Canaria, Spain","institution_ids":["https://openalex.org/I119635470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055312220","display_name":"Francisco Balea-Fernandez","orcid":"https://orcid.org/0000-0003-2028-0858"},"institutions":[{"id":"https://openalex.org/I119635470","display_name":"Universidad de Las Palmas de Gran Canaria","ror":"https://ror.org/01teme464","country_code":"ES","type":"education","lineage":["https://openalex.org/I119635470"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Francisco Balea-Fernandez","raw_affiliation_strings":["Research Institute for Applied Microelectronics (IUMA), Universidad de Las Palmas de Gran Canaria (ULPGC), Las Palmas de Gran Canaria, Spain"],"affiliations":[{"raw_affiliation_string":"Research Institute for Applied Microelectronics (IUMA), Universidad de Las Palmas de Gran Canaria (ULPGC), Las Palmas de Gran Canaria, Spain","institution_ids":["https://openalex.org/I119635470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068226450","display_name":"Cristina Bilbao","orcid":"https://orcid.org/0000-0002-4796-1445"},"institutions":[{"id":"https://openalex.org/I4210098027","display_name":"Hospital Universitario de Gran Canaria Doctor Negr\u00edn","ror":"https://ror.org/00s4vhs88","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210098027"]},{"id":"https://openalex.org/I119635470","display_name":"Universidad de Las Palmas de Gran Canaria","ror":"https://ror.org/01teme464","country_code":"ES","type":"education","lineage":["https://openalex.org/I119635470"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Cristina Bilbao","raw_affiliation_strings":["Hospital Universitario de Gran Canaria Doctor Negr\u00edn, Universidad de Las Palmas de Gran Canaria (ULPGC), Las Palmas de Gran Canaria, Spain"],"affiliations":[{"raw_affiliation_string":"Hospital Universitario de Gran Canaria Doctor Negr\u00edn, Universidad de Las Palmas de Gran Canaria (ULPGC), Las Palmas de Gran Canaria, Spain","institution_ids":["https://openalex.org/I4210098027","https://openalex.org/I119635470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037084402","display_name":"Gustavo M. Callic\u00f3","orcid":"https://orcid.org/0000-0002-3784-5504"},"institutions":[{"id":"https://openalex.org/I119635470","display_name":"Universidad de Las Palmas de Gran Canaria","ror":"https://ror.org/01teme464","country_code":"ES","type":"education","lineage":["https://openalex.org/I119635470"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Gustavo M. Callico","raw_affiliation_strings":["Research Institute for Applied Microelectronics (IUMA), Universidad de Las Palmas de Gran Canaria (ULPGC), Las Palmas de Gran Canaria, Spain"],"affiliations":[{"raw_affiliation_string":"Research Institute for Applied Microelectronics (IUMA), Universidad de Las Palmas de Gran Canaria (ULPGC), Las Palmas de Gran Canaria, Spain","institution_ids":["https://openalex.org/I119635470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044517309","display_name":"Ana M. W\u00e4gner","orcid":"https://orcid.org/0000-0002-7663-9308"},"institutions":[{"id":"https://openalex.org/I2799299272","display_name":"Hospital Universitario Insular de Gran Canaria","ror":"https://ror.org/04cbm7s05","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2799299272","https://openalex.org/I4210120310"]},{"id":"https://openalex.org/I119635470","display_name":"Universidad de Las Palmas de Gran Canaria","ror":"https://ror.org/01teme464","country_code":"ES","type":"education","lineage":["https://openalex.org/I119635470"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ana Wagner","raw_affiliation_strings":["Complejo Hospitalario Universitario Insular Materno-Infantil. Research Institute of Biomedical and Health Sciences (IUIBS) Universidad de Las Palmas de Gran Canaria (ULPGC), Las Palmas de Gran Canaria, Spain"],"affiliations":[{"raw_affiliation_string":"Complejo Hospitalario Universitario Insular Materno-Infantil. Research Institute of Biomedical and Health Sciences (IUIBS) Universidad de Las Palmas de Gran Canaria (ULPGC), Las Palmas de Gran Canaria, Spain","institution_ids":["https://openalex.org/I2799299272","https://openalex.org/I119635470"]}]}],"institution_assertions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.0,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.995294,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":84,"max":85},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"6"},"is_retracted":false,"is_paratext":false,"primary_topic":{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.9943,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.9943,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10689","display_name":"Remote-Sensing Image Classification","score":0.9915,"subfield":{"id":"https://openalex.org/subfields/2214","display_name":"Media Technology"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.9669,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurocognitive","display_name":"Neurocognitive","score":0.46857285},{"id":"https://openalex.org/keywords/identification","display_name":"Identification","score":0.46594915}],"concepts":[{"id":"https://openalex.org/C159078339","wikidata":"https://www.wikidata.org/wiki/Q959005","display_name":"Hyperspectral imaging","level":2,"score":0.84864163},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.5785642},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.53905714},{"id":"https://openalex.org/C172467417","wikidata":"https://www.wikidata.org/wiki/Q1670397","display_name":"Neurocognitive","level":3,"score":0.46857285},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.46594915},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42520708},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.41322094},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3603233},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.35763592},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3236481},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2003003},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.121486634},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.10922718},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"is_oa":false,"landing_page_url":"https://doi.org/10.1109/dcis51330.2020.9268654","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.56,"display_name":"Good health and well-being"}],"grants":[{"funder":"https://openalex.org/F4320338080","funder_display_name":"European Social Fund","award_id":null}],"datasets":[],"versions":[],"referenced_works_count":25,"referenced_works":["https://openalex.org/W1590007975","https://openalex.org/W1965227180","https://openalex.org/W2024501220","https://openalex.org/W2098098075","https://openalex.org/W2107003353","https://openalex.org/W2117485536","https://openalex.org/W2128323493","https://openalex.org/W2157321686","https://openalex.org/W2163886442","https://openalex.org/W2165755981","https://openalex.org/W2169210068","https://openalex.org/W2271071822","https://openalex.org/W2341006816","https://openalex.org/W2565735643","https://openalex.org/W2615003530","https://openalex.org/W2793272303","https://openalex.org/W2798054687","https://openalex.org/W2907172380","https://openalex.org/W2947976683","https://openalex.org/W2973454555","https://openalex.org/W3011934240","https://openalex.org/W3013080024","https://openalex.org/W3014251530","https://openalex.org/W3021686598","https://openalex.org/W4237234927"],"related_works":["https://openalex.org/W4313014865","https://openalex.org/W4230131218","https://openalex.org/W3209970181","https://openalex.org/W3185423717","https://openalex.org/W3034375524","https://openalex.org/W2560983496","https://openalex.org/W2072166414","https://openalex.org/W2070598848","https://openalex.org/W2060875994","https://openalex.org/W2044184146"],"abstract_inverted_index":{"Alzheimer's":[0,39],"disease":[1],"(AD)":[2],"is":[3,31,56],"a":[4,11,61,121,151],"gradually":[5],"progressive":[6],"neurocognitive":[7],"disorder":[8],"(NCD)":[9],"with":[10,107],"preclinical":[12],"phase":[13],"where":[14],"the":[15,34,69,125,143],"patient":[16],"can":[17],"be":[18],"asymptomatic":[19],"for":[20,47,68],"many":[21],"years.":[22],"The":[23,85,140],"detection":[24],"of":[25,33,71,124,145],"AD":[26],"in":[27,38,73],"its":[28],"earliest":[29],"stages":[30],"one":[32],"most":[35],"active":[36],"areas":[37],"science.":[40],"This":[41,58,116],"early":[42,48,153],"diagnosis":[43,154],"could":[44],"potentially":[45],"allow":[46],"intervention":[49],"and":[50,78,99,114,120,137,147],"improved":[51],"prognosis,":[52],"once":[53],"effective":[54],"treatment":[55],"available.":[57],"paper":[59],"proposes":[60],"novel":[62],"methodology":[63],"based":[64],"on":[65],"spectral":[66],"unmixing":[67],"identification":[70],"biomarkers":[72],"plasma":[74,92,148],"samples":[75,93,149],"using":[76,89],"visual":[77],"near":[79],"infrared":[80],"(VNIR)":[81],"hyperspectral":[82],"microscopy":[83],"(HSM).":[84],"study":[86],"was":[87,118,128],"performed":[88,129],"ten":[90],"drop":[91],"from":[94],"10":[95],"patients":[96],"(5":[97],"control":[98,138],"5":[100],"case":[101,136],"subjects":[102],"affected":[103],"by":[104],"NCD)":[105],"captured":[106],"HSM":[108,146],"at":[109],"two":[110],"different":[111],"magnifications:":[112],"5\u00d7":[113],"20\u00d7.":[115],"data":[117],"processed,":[119],"statistical":[122],"analysis":[123],"abundance":[126],"estimation":[127],"to":[130,134],"identify":[131],"relevant":[132],"endmembers":[133],"differentiate":[135],"groups.":[139],"results":[141],"suggest":[142],"potential":[144],"as":[150],"cost-effective":[152],"tool.":[155]},"cited_by_api_url":"https://api.openalex.org/works?filter=cites:W3106764684","counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2024-12-10T21:41:15.028499","created_date":"2020-12-07"}