乐胖代购免代理版

{"id":"https://openalex.org/W2507598713","doi":"https://doi.org/10.1109/cbms.2016.10","title":"Mutations and Drugs Portal (MDP): A Database Linking Drug Response Data and Genomic Information","display_name":"Mutations and Drugs Portal (MDP): A Database Linking Drug Response Data and Genomic Information","publication_year":2016,"publication_date":"2016-06-01","ids":{"openalex":"https://openalex.org/W2507598713","doi":"https://doi.org/10.1109/cbms.2016.10","mag":"2507598713"},"language":"en","primary_location":{"is_oa":false,"landing_page_url":"https://doi.org/10.1109/cbms.2016.10","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false},"type":"article","type_crossref":"proceedings-article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016519067","display_name":"Jimmy Caroli","orcid":"https://orcid.org/0000-0002-4362-2972"},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"funder","lineage":["https://openalex.org/I122346577"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Jimmy Caroli","raw_affiliation_strings":["Dept. of Life Sciences, Center for Genome Research, University of Modena and Reggio Emilia, Modena, Italy"],"affiliations":[{"raw_affiliation_string":"Dept. of Life Sciences, Center for Genome Research, University of Modena and Reggio Emilia, Modena, Italy","institution_ids":["https://openalex.org/I122346577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033146912","display_name":"Cristian Taccioli","orcid":"https://orcid.org/0000-0003-2995-5612"},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"funder","lineage":["https://openalex.org/I122346577"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cristian Taccioli","raw_affiliation_strings":["Dept. of Life Sciences, Center for Genome Research, University of Modena and Reggio Emilia, Modena, Italy"],"affiliations":[{"raw_affiliation_string":"Dept. of Life Sciences, Center for Genome Research, University of Modena and Reggio Emilia, Modena, Italy","institution_ids":["https://openalex.org/I122346577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069062060","display_name":"Giovanni Sorrentino","orcid":"https://orcid.org/0000-0001-8628-8778"},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"funder","lineage":["https://openalex.org/I122346577"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni Sorrentino","raw_affiliation_strings":["Dept. of Life Sciences, Center for Genome Research, University of Modena and Reggio Emilia, Modena, Italy"],"affiliations":[{"raw_affiliation_string":"Dept. of Life Sciences, Center for Genome Research, University of Modena and Reggio Emilia, Modena, Italy","institution_ids":["https://openalex.org/I122346577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058620782","display_name":"Giannino Del Sal","orcid":"https://orcid.org/0000-0003-2185-6003"},"institutions":[{"id":"https://openalex.org/I142444530","display_name":"University of Trieste","ror":"https://ror.org/02n742c10","country_code":"IT","type":"funder","lineage":["https://openalex.org/I142444530"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giannino Del Sal","raw_affiliation_strings":["Dept. of Life Sciences, CIB National Laboratory, University of Trieste, Trieste, Friuli-Venezia Giulia, IT"],"affiliations":[{"raw_affiliation_string":"Dept. of Life Sciences, CIB National Laboratory, University of Trieste, Trieste, Friuli-Venezia Giulia, IT","institution_ids":["https://openalex.org/I142444530"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062054067","display_name":"Silvio Bicciato","orcid":"https://orcid.org/0000-0002-1944-7078"},"institutions":[{"id":"https://openalex.org/I142444530","display_name":"University of Trieste","ror":"https://ror.org/02n742c10","country_code":"IT","type":"funder","lineage":["https://openalex.org/I142444530"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Silvio Bicciato","raw_affiliation_strings":["Dept. of Life Sciences, CIB National Laboratory, University of Trieste, Trieste, Italy"],"affiliations":[{"raw_affiliation_string":"Dept. of Life Sciences, CIB National Laboratory, University of Trieste, Trieste, Italy","institution_ids":["https://openalex.org/I142444530"]}]}],"institution_assertions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"fulltext_origin":"ngrams","cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":0,"max":66},"biblio":{"volume":"6","issue":null,"first_page":"24","last_page":"29"},"is_retracted":false,"is_paratext":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9993,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9993,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9965,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9954,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cancer-cell-lines","display_name":"Cancer cell lines","score":0.49200293},{"id":"https://openalex.org/keywords/drug-response","display_name":"Drug response","score":0.44980043}],"concepts":[{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5540876},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.53844124},{"id":"https://openalex.org/C2994372470","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell lines","level":4,"score":0.49200293},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4879093},{"id":"https://openalex.org/C2994119904","wikidata":"https://www.wikidata.org/wiki/Q1251001","display_name":"Drug response","level":3,"score":0.44980043},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.42553157},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36024284},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.34175733},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.33879137},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3294503},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.2781019},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24571371},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22177407},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.1768305},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.1076366}],"mesh":[],"locations_count":1,"locations":[{"is_oa":false,"landing_page_url":"https://doi.org/10.1109/cbms.2016.10","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false}],"best_oa_location":null,"sustainable_development_goals":[],"grants":[],"datasets":[],"versions":[],"referenced_works_count":22,"referenced_works":["https://openalex.org/W1989654707","https://openalex.org/W1991785121","https://openalex.org/W1992014004","https://openalex.org/W2038595016","https://openalex.org/W2043398720","https://openalex.org/W2050377304","https://openalex.org/W2061946780","https://openalex.org/W2070012858","https://openalex.org/W2080783895","https://openalex.org/W2084422836","https://openalex.org/W2087312216","https://openalex.org/W2098426299","https://openalex.org/W2103174054","https://openalex.org/W2108068107","https://openalex.org/W2125321800","https://openalex.org/W2149642154","https://openalex.org/W2150562727","https://openalex.org/W2152883907","https://openalex.org/W2154254307","https://openalex.org/W2168711434","https://openalex.org/W2168841715","https://openalex.org/W2173710913"],"related_works":["https://openalex.org/W4239572564","https://openalex.org/W3129816939","https://openalex.org/W3117207241","https://openalex.org/W2985427592","https://openalex.org/W2912862995","https://openalex.org/W2786081287","https://openalex.org/W2400569965","https://openalex.org/W2197241765","https://openalex.org/W2101501829","https://openalex.org/W2003194288"],"abstract_inverted_index":{"The":[0,32],"integration":[1],"of":[2,19,23,27,177,179,185],"large-scale":[3],"genomic":[4,52,88,103,188],"and":[5,26,34,61,110,133,139,162,181,190],"pharmacological":[6,49],"data":[7,53,71,98,161],"from":[8,55],"cancer":[9,83,121,131],"cell":[10,84,94,122],"lines":[11,123],"promises":[12],"to":[13,79,91,143,147,159,172],"be":[14,115],"effective":[15],"in":[16,120,129],"the":[17,46,56,62,183],"discovery":[18,184],"new":[20],"genetic":[21,138],"markers":[22],"drug":[24,69,92,96,191],"sensitivity":[25,70,97,144],"clinically":[28],"relevant":[29],"anticancer":[30],"compounds.":[31],"Mutations":[33],"Drugs":[35],"Portal":[36],"(MDP,":[37],"http://mdp.unimore.it)":[38],"is":[39],"a":[40,148,168],"web":[41,170],"accessible":[42],"database":[43],"that":[44],"combines":[45],"cell-based":[47],"NCI60":[48,63],"screening":[50],"with":[51,101,157],"extracted":[54],"Cancer":[57],"Cell":[58],"Line":[59],"Encyclopedia":[60],"DTP":[64],"projects.":[65],"MDP":[66,113,166],"currently":[67],"contains":[68],"for":[72,117,137],"more":[73],"than":[74],"50,800":[75],"compounds,":[76],"describing":[77],"response":[78],"drugs":[80,118],"across":[81],"115":[82],"lines.":[85],"To":[86],"identify":[87],"features":[89],"associated":[90,142],"response,":[93],"line":[95],"are":[99,152,163],"integrated":[100],"large":[102],"datasets,":[104],"including":[105],"information":[106],"on":[107],"somatic":[108],"mutations":[109,125],"transcriptional":[111,127,140],"data.":[112],"can":[114],"queried":[116],"active":[119],"carrying":[124],"or":[126,136,145],"alterations":[128],"specific":[130],"genes":[132],"signaling":[134],"pathways":[135],"profiles":[141],"resistance":[146],"given":[149],"compound.":[150],"Results":[151],"presented":[153],"through":[154],"graphical":[155],"representations":[156],"links":[158],"related":[160],"fully":[164],"downloadable.":[165],"provides":[167],"user-friendly":[169],"resource":[171],"perform":[173],"in-silico":[174],"high-throughput":[175],"screenings":[176],"thousand":[178],"compounds":[180],"facilitate":[182],"associations":[186],"between":[187],"portraits":[189],"responses.":[192]},"abstract_inverted_index_v3":null,"cited_by_api_url":"https://api.openalex.org/works?filter=cites:W2507598713","counts_by_year":[],"updated_date":"2025-02-03T11:10:29.804698","created_date":"2016-09-16"}