{"id":"https://openalex.org/W2576908058","doi":"https://doi.org/10.1109/bibm.2016.7822797","title":"A disease module detection algorithm for lung adenocarcinoma tumor network with significance of connections and network controllability methodology","display_name":"A disease module detection algorithm for lung adenocarcinoma tumor network with significance of connections and network controllability methodology","publication_year":2016,"publication_date":"2016-12-01","ids":{"openalex":"https://openalex.org/W2576908058","doi":"https://doi.org/10.1109/bibm.2016.7822797","mag":"2576908058"},"language":"en","primary_location":{"is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2016.7822797","pdf_url":null,"source":{"id":"https://openalex.org/S4363607735","display_name":"2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false},"type":"article","type_crossref":"proceedings-article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086370741","display_name":"Guimin Qin","orcid":"https://orcid.org/0000-0001-8272-9599"},"institutions":[{"id":"https://openalex.org/I149594827","display_name":"Xidian University","ror":"https://ror.org/05s92vm98","country_code":"CN","type":"education","lineage":["https://openalex.org/I149594827"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gui-Min Qin","raw_affiliation_strings":["School of Software, Xidian University, Xi'an, China"],"affiliations":[{"raw_affiliation_string":"School of Software, Xidian University, Xi'an, China","institution_ids":["https://openalex.org/I149594827"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100555205","display_name":"Yi-Bo Hou","orcid":null},"institutions":[{"id":"https://openalex.org/I149594827","display_name":"Xidian University","ror":"https://ror.org/05s92vm98","country_code":"CN","type":"education","lineage":["https://openalex.org/I149594827"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi-Bo Hou","raw_affiliation_strings":["School of Computer Science and Technology, Xidian University, Xi'an, China"],"affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Xidian University, Xi'an, China","institution_ids":["https://openalex.org/I149594827"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032888897","display_name":"Baoguo Yu","orcid":"https://orcid.org/0000-0002-3006-7519"},"institutions":[{"id":"https://openalex.org/I2800372957","display_name":"China Electronics Technology Group Corporation","ror":"https://ror.org/0098hst83","country_code":"CN","type":"company","lineage":["https://openalex.org/I2800372957"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"None Bao-Guo Yu","raw_affiliation_strings":["State Key Laboratory of Satellite Navigation System and Equipment Technology, The 54th Research Institute of China Electronics Technology Group Corporation, Shi Jia Zhuang, China"],"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Satellite Navigation System and Equipment Technology, The 54th Research Institute of China Electronics Technology Group Corporation, Shi Jia Zhuang, China","institution_ids":["https://openalex.org/I2800372957"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026770080","display_name":"Xi-Yang Liu","orcid":"https://orcid.org/0000-0001-7898-9224"},"institutions":[{"id":"https://openalex.org/I149594827","display_name":"Xidian University","ror":"https://ror.org/05s92vm98","country_code":"CN","type":"education","lineage":["https://openalex.org/I149594827"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"None Xi-Yang Liu","raw_affiliation_strings":["School of Software, Xidian University, Xi'an, China"],"affiliations":[{"raw_affiliation_string":"School of Software, Xidian University, Xi'an, China","institution_ids":["https://openalex.org/I149594827"]}]}],"institution_assertions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"fulltext_origin":"ngrams","cited_by_count":1,"citation_normalized_percentile":{"value":0.431413,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":66,"max":73},"biblio":{"volume":null,"issue":null,"first_page":"1834","last_page":"1840"},"is_retracted":false,"is_paratext":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9999,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9999,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9985,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9972,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C184898388","wikidata":"https://www.wikidata.org/wiki/Q1435712","display_name":"Pairwise comparison","level":2,"score":0.585774},{"id":"https://openalex.org/C48209547","wikidata":"https://www.wikidata.org/wiki/Q1331104","display_name":"Controllability","level":2,"score":0.5326808},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5219026},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5142452},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.4696623},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.45644882},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4472},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.43273023},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.43014103},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36478573},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.35247383},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32521093},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.30499986},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.23680776},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.22191119},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20143774},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13179019},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.115569115},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07340893},{"id":"https://openalex.org/C28826006","wikidata":"https://www.wikidata.org/wiki/Q33521","display_name":"Applied mathematics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2016.7822797","pdf_url":null,"source":{"id":"https://openalex.org/S4363607735","display_name":"2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Reduced inequalities","score":0.69,"id":"https://metadata.un.org/sdg/10"}],"grants":[],"datasets":[],"versions":[],"referenced_works_count":44,"referenced_works":["https://openalex.org/W1582734106","https://openalex.org/W1940319397","https://openalex.org/W1976873804","https://openalex.org/W1982564236","https://openalex.org/W1984675437","https://openalex.org/W1991865867","https://openalex.org/W2011637659","https://openalex.org/W2019163875","https://openalex.org/W2029784998","https://openalex.org/W2031028006","https://openalex.org/W2031984119","https://openalex.org/W2042736191","https://openalex.org/W2046024621","https://openalex.org/W2060942394","https://openalex.org/W2071480068","https://openalex.org/W2101420429","https://openalex.org/W2105192488","https://openalex.org/W2107889651","https://openalex.org/W2107953475","https://openalex.org/W2110503722","https://openalex.org/W2110553827","https://openalex.org/W2118151336","https://openalex.org/W2119412782","https://openalex.org/W2120627772","https://openalex.org/W2122863289","https://openalex.org/W2126052291","https://openalex.org/W2129137060","https://openalex.org/W2138669911","https://openalex.org/W2141808484","https://openalex.org/W2151006472","https://openalex.org/W2152482858","https://openalex.org/W2153635508","https://openalex.org/W2155521690","https://openalex.org/W2157658519","https://openalex.org/W2158217645","https://openalex.org/W2158485828","https://openalex.org/W2159482845","https://openalex.org/W2161062388","https://openalex.org/W2162172965","https://openalex.org/W2163798887","https://openalex.org/W2417536924","https://openalex.org/W2949122516","https://openalex.org/W3120421331","https://openalex.org/W4240237951"],"related_works":["https://openalex.org/W4239246781","https://openalex.org/W4205698120","https://openalex.org/W3201620972","https://openalex.org/W2738802168","https://openalex.org/W2561315646","https://openalex.org/W2542825942","https://openalex.org/W2332386680","https://openalex.org/W2248621902","https://openalex.org/W2036697162","https://openalex.org/W2003779889"],"abstract_inverted_index":{"The":[0],"protein":[1,7],"phosphorylation":[2,18,33],"modifications":[3,19],"are":[4,20,54,73],"important":[5,143],"to":[6,22,48,68],"activities":[8],"and":[9,36,109,166],"functions.":[10],"It":[11],"has":[12],"been":[13,46,149],"widely":[14],"recognized":[15],"that":[16,129],"dysfunctional":[17],"related":[21],"cancer.":[23],"Specifically,":[24],"some":[25],"single":[26],"amino":[27],"acid":[28],"variations":[29],"could":[30,133],"disrupt":[31],"existing":[32],"kinase-substrate":[34,39,99],"relationships":[35],"create":[37],"novel":[38],"relationships.":[40],"Besides,":[41],"numerous":[42],"network-based":[43],"methods":[44],"have":[45,148],"proposed":[47,62],"identify":[49,168],"meaningful":[50],"disease":[51,70,125,131,163],"modules,":[52,71],"which":[53,72],"locally":[55],"dense":[56],"subnetworks.":[57],"In":[58],"this":[59],"work,":[60],"we":[61,89],"a":[63,91,117],"new":[64],"network":[65,94],"clustering":[66],"method":[67,122],"uncover":[69],"correlated":[74],"with":[75,98],"the":[76,162,175],"specific":[77],"disease,":[78],"based":[79],"on":[80],"significance":[81],"of":[82,85,95,154,172,177],"connections":[83],"instead":[84],"local":[86],"density.":[87],"Specially,":[88],"build":[90],"weighted":[92],"tumor":[93,136],"lung":[96],"adenocarcinoma":[97],"relationships,":[100],"tissue-specific":[101],"gene":[102,106],"regulatory":[103],"network,":[104],"pairwise":[105],"expression":[107],"data":[108],"mutation":[110],"data.":[111],"With":[112],"appropriate":[113],"parameters":[114],"decided":[115],"by":[116],"machine":[118],"learning":[119],"method,":[120],"our":[121],"identified":[123,150],"9":[124],"modules.":[126],"We":[127],"found":[128],"these":[130,146],"modules":[132,147],"effectively":[134],"discriminate":[135],"samples":[137],"from":[138],"normal":[139],"samples.":[140],"Some":[141],"significantly":[142],"genes":[144,153,171],"in":[145,174],"as":[151],"target":[152,170],"drugs":[155,173],"recently.":[156],"Our":[157],"results":[158],"provide":[159],"insights":[160],"into":[161],"mechanism":[164],"underlying,":[165],"help":[167],"more":[169],"era":[176],"precision":[178],"medicine.":[179]},"cited_by_api_url":"https://api.openalex.org/works?filter=cites:W2576908058","counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2025-01-16T18:32:24.760312","created_date":"2017-01-26"}