{"id":"https://openalex.org/W2905691307","doi":"https://doi.org/10.1109/access.2018.2889809","title":"Transcriptome Comparisons of Multi-Species Identify Differential Genome Activation of Mammals Embryogenesis","display_name":"Transcriptome Comparisons of Multi-Species Identify Differential Genome Activation of Mammals Embryogenesis","publication_year":2018,"publication_date":"2018-12-25","ids":{"openalex":"https://openalex.org/W2905691307","doi":"https://doi.org/10.1109/access.2018.2889809","mag":"2905691307"},"language":"en","primary_location":{"is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2018.2889809","pdf_url":"https://ieeexplore.ieee.org/ielx7/6287639/8600701/08588329.pdf","source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_indexed_in_scopus":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true},"type":"article","type_crossref":"journal-article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://ieeexplore.ieee.org/ielx7/6287639/8600701/08588329.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012243501","display_name":"Chunshen Long","orcid":"https://orcid.org/0000-0002-1942-5936"},"institutions":[{"id":"https://openalex.org/I2722730","display_name":"Inner Mongolia University","ror":"https://ror.org/0106qb496","country_code":"CN","type":"funder","lineage":["https://openalex.org/I2722730"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunshen Long","raw_affiliation_strings":["The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot, China"],"affiliations":[{"raw_affiliation_string":"The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot, China","institution_ids":["https://openalex.org/I2722730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100359703","display_name":"Li Wei","orcid":"https://orcid.org/0000-0001-6885-8888"},"institutions":[{"id":"https://openalex.org/I2722730","display_name":"Inner Mongolia University","ror":"https://ror.org/0106qb496","country_code":"CN","type":"funder","lineage":["https://openalex.org/I2722730"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Li","raw_affiliation_strings":["The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot, China"],"affiliations":[{"raw_affiliation_string":"The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot, China","institution_ids":["https://openalex.org/I2722730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101856804","display_name":"Pengfei Liang","orcid":"https://orcid.org/0000-0001-9541-9485"},"institutions":[{"id":"https://openalex.org/I2722730","display_name":"Inner Mongolia University","ror":"https://ror.org/0106qb496","country_code":"CN","type":"funder","lineage":["https://openalex.org/I2722730"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pengfei Liang","raw_affiliation_strings":["The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot, China"],"affiliations":[{"raw_affiliation_string":"The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot, China","institution_ids":["https://openalex.org/I2722730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090788114","display_name":"Shuai Liu","orcid":"https://orcid.org/0000-0001-9909-0664"},"institutions":[{"id":"https://openalex.org/I2722730","display_name":"Inner Mongolia University","ror":"https://ror.org/0106qb496","country_code":"CN","type":"funder","lineage":["https://openalex.org/I2722730"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuai Liu","raw_affiliation_strings":["College of Computer Science, Inner Mongolia University, Hohhot, China"],"affiliations":[{"raw_affiliation_string":"College of Computer Science, Inner Mongolia University, Hohhot, China","institution_ids":["https://openalex.org/I2722730"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001300435","display_name":"Yongchun Zuo","orcid":"https://orcid.org/0000-0002-6065-7835"},"institutions":[{"id":"https://openalex.org/I2722730","display_name":"Inner Mongolia University","ror":"https://ror.org/0106qb496","country_code":"CN","type":"funder","lineage":["https://openalex.org/I2722730"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongchun Zuo","raw_affiliation_strings":["The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot, China"],"affiliations":[{"raw_affiliation_string":"The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot, China","institution_ids":["https://openalex.org/I2722730"]}]}],"institution_assertions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":{"value":1850,"currency":"USD","value_usd":1850},"fwci":4.636,"has_fulltext":true,"fulltext_origin":"pdf","cited_by_count":37,"citation_normalized_percentile":{"value":0.801641,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":95},"biblio":{"volume":"7","issue":null,"first_page":"7794","last_page":"7802"},"is_retracted":false,"is_paratext":false,"primary_topic":{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.9977,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.9977,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9948,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.9937,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inner-cell-mass","display_name":"Inner cell mass","score":0.49727467}],"concepts":[{"id":"https://openalex.org/C17341445","wikidata":"https://www.wikidata.org/wiki/Q6786633","display_name":"Maternal to zygotic transition","level":5,"score":0.81562257},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.78953385},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7846995},{"id":"https://openalex.org/C2778177303","wikidata":"https://www.wikidata.org/wiki/Q227717","display_name":"Blastocyst","level":4,"score":0.71437204},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.6717118},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.6571298},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.545491},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.50985044},{"id":"https://openalex.org/C159399396","wikidata":"https://www.wikidata.org/wiki/Q1335221","display_name":"Inner cell mass","level":5,"score":0.49727467},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.49532905},{"id":"https://openalex.org/C28748434","wikidata":"https://www.wikidata.org/wiki/Q170145","display_name":"Zygote","level":4,"score":0.47212157},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46890843},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.43448168},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3662594}],"mesh":[],"locations_count":2,"locations":[{"is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2018.2889809","pdf_url":"https://ieeexplore.ieee.org/ielx7/6287639/8600701/08588329.pdf","source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_indexed_in_scopus":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":false,"landing_page_url":"https://doaj.org/article/889939127d314633ad15483d5072fdfa","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_indexed_in_scopus":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false}],"best_oa_location":{"is_oa":true,"landing_page_url":"https://doi.org/10.1109/access.2018.2889809","pdf_url":"https://ieeexplore.ieee.org/ielx7/6287639/8600701/08588329.pdf","source":{"id":"https://openalex.org/S2485537415","display_name":"IEEE Access","issn_l":"2169-3536","issn":["2169-3536"],"is_oa":true,"is_in_doaj":true,"is_indexed_in_scopus":true,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true},"sustainable_development_goals":[{"display_name":"Life on land","score":0.68,"id":"https://metadata.un.org/sdg/15"}],"grants":[{"funder":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China","award_id":"61561036"},{"funder":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China","award_id":"61702290"},{"funder":"https://openalex.org/F4320321494","funder_display_name":"Government of Inner Mongolia Autonomous Region","award_id":"NJYT-18-B01"},{"funder":"https://openalex.org/F4320322216","funder_display_name":"Inner Mongolia University","award_id":"201614247"}],"datasets":[],"versions":[],"referenced_works_count":51,"referenced_works":["https://openalex.org/W1556608323","https://openalex.org/W1978006592","https://openalex.org/W1979431956","https://openalex.org/W1990498979","https://openalex.org/W1996166586","https://openalex.org/W2004102023","https://openalex.org/W2015217968","https://openalex.org/W2018531315","https://openalex.org/W2041255962","https://openalex.org/W2041611151","https://openalex.org/W2044039536","https://openalex.org/W2045409489","https://openalex.org/W2049017883","https://openalex.org/W2049868101","https://openalex.org/W2051993973","https://openalex.org/W2052904493","https://openalex.org/W2056397474","https://openalex.org/W2059354543","https://openalex.org/W2059449165","https://openalex.org/W2063337177","https://openalex.org/W2078035928","https://openalex.org/W2084651803","https://openalex.org/W2086277161","https://openalex.org/W2106886154","https://openalex.org/W2111323820","https://openalex.org/W2112737916","https://openalex.org/W2116422259","https://openalex.org/W2121817763","https://openalex.org/W2130652821","https://openalex.org/W2133769516","https://openalex.org/W2136597956","https://openalex.org/W2144142672","https://openalex.org/W2146512944","https://openalex.org/W2146984594","https://openalex.org/W2150049391","https://openalex.org/W2158217645","https://openalex.org/W2165828372","https://openalex.org/W2168664853","https://openalex.org/W2171199014","https://openalex.org/W2287766201","https://openalex.org/W2316095770","https://openalex.org/W2526866696","https://openalex.org/W2571241168","https://openalex.org/W2571829893","https://openalex.org/W2589553348","https://openalex.org/W2737942054","https://openalex.org/W2747899047","https://openalex.org/W2771133880","https://openalex.org/W2790732445","https://openalex.org/W2800603474","https://openalex.org/W2810876096"],"related_works":["https://openalex.org/W4283163228","https://openalex.org/W4250377422","https://openalex.org/W4235844543","https://openalex.org/W2944440052","https://openalex.org/W2900356592","https://openalex.org/W2508470117","https://openalex.org/W2299890764","https://openalex.org/W2155957092","https://openalex.org/W2151872057","https://openalex.org/W1990243394"],"abstract_inverted_index":{"The":[0,40,57,131,157],"identification":[1],"of":[2,11,21,33,42,47,109,172],"underlying":[3],"differences":[4,32],"is":[5],"crucial":[6],"for":[7],"understanding":[8],"the":[9,29,45,64,88,92,96,100,107,129,178],"embryogenesis":[10,34],"species":[12],"specificity.":[13],"In":[14],"this":[15],"paper,":[16],"a":[17,70,77,167],"comparative":[18],"transcriptome":[19],"analysis":[20],"multi-species":[22],"(CTAMS)":[23],"was":[24,175],"first":[25],"developed":[26],"to":[27,52,80],"detect":[28],"genome":[30,74,174],"activation":[31,75],"among":[35],"human,":[36],"mouse,":[37],"and":[38,44,60,66,111,122,133,151],"bovine.":[39],"annotation":[41],"intra-species":[43],"detection":[46],"inter-species":[48],"difference":[49],"were":[50,137],"separately":[51],"avoid":[53],"potential":[54],"batch":[55],"effects.":[56],"profile":[58],"clusters":[59],"Pearson":[61],"correlation":[62],"showed":[63],"human":[65,121,144],"bovine":[67,123,149],"embryos":[68,90,150],"displayed":[69,162],"high":[71,93],"similarity":[72],"in":[73,120,128,143,148,154],"with":[76,177],"dramatic":[78],"maternal":[79],"zygotic":[81],"transition":[82],"between":[83],"4\u20138":[84],"cell":[85,113],"stages.":[86],"But":[87],"mouse":[89,155],"maintained":[91],"activity":[94],"during":[95],"whole":[97],"embryogenesis.":[98],"Moreover,":[99],"stage-specific":[101],"differentially":[102],"expressed":[103],"genes":[104],"(DEGs)":[105],"exhibited":[106],"specification":[108],"trophectoderm":[110],"inner":[112],"mass":[114],"may":[115],"occur":[116],"at":[117,125,140],"blastocyst":[118],"stage":[119,127,142,147,153],"embryos,":[124,145],"morula":[126,141],"mouse.":[130],"transcription":[132],"translation":[134],"associated":[135],"pathways":[136,160],"widely":[138],"activated":[139,170],"8-cell":[146],"2-cell":[152],"embryos.":[156],"signal":[158],"transduction":[159],"also":[161],"species-specific":[163],"expression":[164],"patterns.":[165],"Finally,":[166],"probable":[168],"pathway":[169],"landscape":[171],"embryonic":[173],"given":[176],"development":[179],"axis.":[180]},"abstract_inverted_index_v3":null,"cited_by_api_url":"https://api.openalex.org/works?filter=cites:W2905691307","counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":16}],"updated_date":"2025-05-04T06:26:02.261353","created_date":"2019-01-01"}