{"id":"https://openalex.org/W2302979210","doi":"https://doi.org/10.1093/bioinformatics/btw052","title":"metaCCA: summary statistics-based multivariate meta-analysis of genome-wide association studies using canonical correlation analysis","display_name":"metaCCA: summary statistics-based multivariate meta-analysis of genome-wide association studies using canonical correlation analysis","publication_year":2016,"publication_date":"2016-02-19","ids":{"openalex":"https://openalex.org/W2302979210","doi":"https://doi.org/10.1093/bioinformatics/btw052","mag":"2302979210","pmid":"https://pubmed.ncbi.nlm.nih.gov/27153689","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4920109"},"language":"en","primary_location":{"is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btw052","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/32/13/1981/16920004/btw052.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311647","https://openalex.org/P4310311648"],"host_organization_lineage_names":["University of Oxford","Oxford University Press"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true},"type":"review","type_crossref":"journal-article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/32/13/1981/16920004/btw052.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017141939","display_name":"Anna Cicho\u0144ska","orcid":"https://orcid.org/0000-0003-1072-8858"},"institutions":[{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I32943570","display_name":"Helsinki Institute for Information Technology","ror":"https://ror.org/05kph4940","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I32943570","https://openalex.org/I9927081"]},{"id":"https://openalex.org/I9927081","display_name":"Aalto University","ror":"https://ror.org/020hwjq30","country_code":"FI","type":"education","lineage":["https://openalex.org/I9927081"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Anna Cichonska","raw_affiliation_strings":["1 Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland,","2 Helsinki Institute for Information Technology HIIT, Department of Computer Science, Aalto University, Espoo, Finland,"],"affiliations":[{"raw_affiliation_string":"1 Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland,","institution_ids":["https://openalex.org/I4210133586","https://openalex.org/I133731052"]},{"raw_affiliation_string":"2 Helsinki Institute for Information Technology HIIT, Department of Computer Science, Aalto University, Espoo, Finland,","institution_ids":["https://openalex.org/I32943570","https://openalex.org/I9927081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091883185","display_name":"Juho Rousu","orcid":"https://orcid.org/0000-0002-0705-4314"},"institutions":[{"id":"https://openalex.org/I32943570","display_name":"Helsinki Institute for Information Technology","ror":"https://ror.org/05kph4940","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I32943570","https://openalex.org/I9927081"]},{"id":"https://openalex.org/I9927081","display_name":"Aalto University","ror":"https://ror.org/020hwjq30","country_code":"FI","type":"education","lineage":["https://openalex.org/I9927081"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Juho Rousu","raw_affiliation_strings":["2 Helsinki Institute for Information Technology HIIT, Department of Computer Science, Aalto University, Espoo, Finland,"],"affiliations":[{"raw_affiliation_string":"2 Helsinki Institute for Information Technology HIIT, Department of Computer Science, Aalto University, Espoo, Finland,","institution_ids":["https://openalex.org/I32943570","https://openalex.org/I9927081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089920272","display_name":"Pekka Marttinen","orcid":"https://orcid.org/0000-0001-7078-7927"},"institutions":[{"id":"https://openalex.org/I32943570","display_name":"Helsinki Institute for Information Technology","ror":"https://ror.org/05kph4940","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I32943570","https://openalex.org/I9927081"]},{"id":"https://openalex.org/I9927081","display_name":"Aalto University","ror":"https://ror.org/020hwjq30","country_code":"FI","type":"education","lineage":["https://openalex.org/I9927081"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Pekka Marttinen","raw_affiliation_strings":["2 Helsinki Institute for Information Technology HIIT, Department of Computer Science, Aalto University, Espoo, Finland,"],"affiliations":[{"raw_affiliation_string":"2 Helsinki Institute for Information Technology HIIT, Department of Computer Science, Aalto University, Espoo, Finland,","institution_ids":["https://openalex.org/I32943570","https://openalex.org/I9927081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082784196","display_name":"Antti J. Kangas","orcid":"https://orcid.org/0000-0001-7492-1732"},"institutions":[{"id":"https://openalex.org/I2799272722","display_name":"Oulu University Hospital","ror":"https://ror.org/045ney286","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2799272722"]},{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Antti J. Kangas","raw_affiliation_strings":["3 Computational Medicine, University of Oulu, Oulu University Hospital and Biocenter Oulu, Oulu, Finland,"],"affiliations":[{"raw_affiliation_string":"3 Computational Medicine, University of Oulu, Oulu University Hospital and Biocenter Oulu, Oulu, Finland,","institution_ids":["https://openalex.org/I2799272722","https://openalex.org/I98381234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019754063","display_name":"Pasi Soininen","orcid":null},"institutions":[{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]},{"id":"https://openalex.org/I2799272722","display_name":"Oulu University Hospital","ror":"https://ror.org/045ney286","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2799272722"]},{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Pasi Soininen","raw_affiliation_strings":["3 Computational Medicine, University of Oulu, Oulu University Hospital and Biocenter Oulu, Oulu, Finland,","4 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland,"],"affiliations":[{"raw_affiliation_string":"3 Computational Medicine, University of Oulu, Oulu University Hospital and Biocenter Oulu, Oulu, Finland,","institution_ids":["https://openalex.org/I98381234","https://openalex.org/I2799272722"]},{"raw_affiliation_string":"4 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland,","institution_ids":["https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081986241","display_name":"Terho Lehtim\u00e4ki","orcid":"https://orcid.org/0000-0002-2555-4427"},"institutions":[{"id":"https://openalex.org/I166825849","display_name":"Tampere University","ror":"https://ror.org/033003e23","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849"]},{"id":"https://openalex.org/I4210133601","display_name":"Fimlab (Finland)","ror":"https://ror.org/031y6w871","country_code":"FI","type":"company","lineage":["https://openalex.org/I4210133601"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Terho Lehtim\u00e4ki","raw_affiliation_strings":["5 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere School of Medicine, Tampere, Finland,"],"affiliations":[{"raw_affiliation_string":"5 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere School of Medicine, Tampere, Finland,","institution_ids":["https://openalex.org/I166825849","https://openalex.org/I4210133601","https://openalex.org/I166825849"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060131080","display_name":"Olli T. Raitakari","orcid":"https://orcid.org/0000-0001-9365-3702"},"institutions":[{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]},{"id":"https://openalex.org/I2801970007","display_name":"Turku University Hospital","ror":"https://ror.org/05dbzj528","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2801970007","https://openalex.org/I4210127022"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Olli T. Raitakari","raw_affiliation_strings":["7 Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland,","Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland,"],"affiliations":[{"raw_affiliation_string":"7 Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland,","institution_ids":["https://openalex.org/I155660961","https://openalex.org/I2801970007"]},{"raw_affiliation_string":"Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland,","institution_ids":["https://openalex.org/I2801970007","https://openalex.org/I155660961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068508022","display_name":"Marjo\u2010Riitta J\u00e4rvelin","orcid":"https://orcid.org/0000-0002-2149-0630"},"institutions":[{"id":"https://openalex.org/I2799272722","display_name":"Oulu University Hospital","ror":"https://ror.org/045ney286","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2799272722"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]},{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]}],"countries":["FI","GB"],"is_corresponding":false,"raw_author_name":"Marjo-Riitta J\u00e4rvelin","raw_affiliation_strings":["10 Biocenter Oulu, University of Oulu, Oulu, Finland,","11 Unit of Primary Care, Oulu University Hospital, Oulu, Finland,","8 Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment & Health, School of Public Health, Imperial College London, London, UK,","9 Centre for Life Course Epidemiology, Faculty of Medicine, University of Oulu, Oulu, Finland,"],"affiliations":[{"raw_affiliation_string":"11 Unit of Primary Care, Oulu University Hospital, Oulu, Finland,","institution_ids":["https://openalex.org/I2799272722"]},{"raw_affiliation_string":"8 Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment & Health, School of Public Health, Imperial College London, London, UK,","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"9 Centre for Life Course Epidemiology, Faculty of Medicine, University of Oulu, Oulu, Finland,","institution_ids":["https://openalex.org/I98381234"]},{"raw_affiliation_string":"10 Biocenter Oulu, University of Oulu, Oulu, Finland,","institution_ids":["https://openalex.org/I98381234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066237154","display_name":"Veikko Salomaa","orcid":"https://orcid.org/0000-0001-7563-5324"},"institutions":[{"id":"https://openalex.org/I39624965","display_name":"Finnish Institute for Health and Welfare","ror":"https://ror.org/03tf0c761","country_code":"FI","type":"government","lineage":["https://openalex.org/I39624965"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Veikko Salomaa","raw_affiliation_strings":["12 National Institute for Health and Welfare, Helsinki, Finland,"],"affiliations":[{"raw_affiliation_string":"12 National Institute for Health and Welfare, Helsinki, Finland,","institution_ids":["https://openalex.org/I39624965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078073418","display_name":"Mika Ala\u2010Korpela","orcid":"https://orcid.org/0000-0001-5905-1206"},"institutions":[{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]},{"id":"https://openalex.org/I2799272722","display_name":"Oulu University Hospital","ror":"https://ror.org/045ney286","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2799272722"]},{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]},{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI","GB"],"is_corresponding":false,"raw_author_name":"Mika Ala-Korpela","raw_affiliation_strings":["13 Computational Medicine, School of Social and Community Medicine and the Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK,","3 Computational Medicine, University of Oulu, Oulu University Hospital and Biocenter Oulu, Oulu, Finland,","4 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland,"],"affiliations":[{"raw_affiliation_string":"13 Computational Medicine, School of Social and Community Medicine and the Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK,","institution_ids":["https://openalex.org/I90344618","https://openalex.org/I36234482"]},{"raw_affiliation_string":"3 Computational Medicine, University of Oulu, Oulu University Hospital and Biocenter Oulu, Oulu, Finland,","institution_ids":["https://openalex.org/I2799272722","https://openalex.org/I98381234"]},{"raw_affiliation_string":"4 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland,","institution_ids":["https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058300698","display_name":"Samuli Ripatti","orcid":"https://orcid.org/0000-0002-0504-1202"},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]}],"countries":["FI","GB"],"is_corresponding":false,"raw_author_name":"Samuli Ripatti","raw_affiliation_strings":["1 Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland,","14 Public Health, University of Helsinki, Helsinki, Finland and","15 Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK"],"affiliations":[{"raw_affiliation_string":"1 Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland,","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"raw_affiliation_string":"14 Public Health, University of Helsinki, Helsinki, Finland and","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"15 Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK","institution_ids":["https://openalex.org/I2802476451"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064582174","display_name":"Matti Pirinen","orcid":"https://orcid.org/0000-0002-1664-1350"},"institutions":[{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Matti Pirinen","raw_affiliation_strings":["1 Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland,"],"affiliations":[{"raw_affiliation_string":"1 Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland,","institution_ids":["https://openalex.org/I4210133586","https://openalex.org/I133731052"]}]}],"institution_assertions":[],"countries_distinct_count":2,"institutions_distinct_count":16,"corresponding_author_ids":["https://openalex.org/A5017141939","https://openalex.org/A5064582174"],"corresponding_institution_ids":["https://openalex.org/I4210133586","https://openalex.org/I133731052","https://openalex.org/I32943570","https://openalex.org/I9927081","https://openalex.org/I4210133586","https://openalex.org/I133731052"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618,"provenance":"doaj"},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618,"provenance":"doaj"},"fwci":2.817,"has_fulltext":true,"fulltext_origin":"ngrams","cited_by_count":134,"citation_normalized_percentile":{"value":0.999114,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"32","issue":"13","first_page":"1981","last_page":"1989"},"is_retracted":false,"is_paratext":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9978,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9978,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9975,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9932,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/univariate","display_name":"Univariate","score":0.881163},{"id":"https://openalex.org/keywords/canonical-correlation","display_name":"Canonical correlation","score":0.69693375},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide Association Study","score":0.4455107}],"concepts":[{"id":"https://openalex.org/C199163554","wikidata":"https://www.wikidata.org/wiki/Q1681619","display_name":"Univariate","level":3,"score":0.881163},{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.8436115},{"id":"https://openalex.org/C153874254","wikidata":"https://www.wikidata.org/wiki/Q115542","display_name":"Canonical correlation","level":2,"score":0.69693375},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.6795059},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.5555014},{"id":"https://openalex.org/C192424360","wikidata":"https://www.wikidata.org/wiki/Q929408","display_name":"Multivariate analysis of variance","level":2,"score":0.49646884},{"id":"https://openalex.org/C129848803","wikidata":"https://www.wikidata.org/wiki/Q2564360","display_name":"Sample size determination","level":2,"score":0.48928282},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.47052065},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.4455107},{"id":"https://openalex.org/C178650346","wikidata":"https://www.wikidata.org/wiki/Q201984","display_name":"Covariance","level":2,"score":0.42213914},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3733942},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.36252964},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27186108},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.26445335},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.2051433},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.19875914},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15337846},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"","qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":"","qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"","qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btw052","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/32/13/1981/16920004/btw052.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311647","https://openalex.org/P4310311648"],"host_organization_lineage_names":["University of Oxford","Oxford University Press"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":true,"landing_page_url":"https://europepmc.org/articles/pmc4920109","pdf_url":"https://europepmc.org/articles/pmc4920109?pdf=render","source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":["European Bioinformatics Institute"],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":true,"landing_page_url":"https://trepo.tuni.fi/handle/10024/100384","pdf_url":"https://trepo.tuni.fi/bitstream/10024/100384/1/metacca_summary_statistics-based_2016.pdf","source":{"id":"https://openalex.org/S4306401860","display_name":"Tampere University Institutional Repository (Tampere University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I150589677","host_organization_name":"Tampere University of Applied Sciences","host_organization_lineage":["https://openalex.org/I150589677"],"host_organization_lineage_names":["Tampere University of Applied Sciences"],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920109","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":["National Institutes of Health"],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":true,"landing_page_url":"https://doi.org/10.1101/022665","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory"],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false},{"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27153689","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":["National Institutes of Health"],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false}],"best_oa_location":{"is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btw052","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/32/13/1981/16920004/btw052.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311647","https://openalex.org/P4310311648"],"host_organization_lineage_names":["University of Oxford","Oxford University Press"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true},"sustainable_development_goals":[{"score":0.45,"id":"https://metadata.un.org/sdg/17","display_name":"Partnerships for the goals"}],"grants":[],"datasets":[],"versions":[],"referenced_works_count":37,"referenced_works":["https://openalex.org/W1533942137","https://openalex.org/W1968886567","https://openalex.org/W1969851044","https://openalex.org/W1977391294","https://openalex.org/W1989568128","https://openalex.org/W1992436001","https://openalex.org/W2025341678","https://openalex.org/W2036070913","https://openalex.org/W2050730569","https://openalex.org/W2056165766","https://openalex.org/W2063655230","https://openalex.org/W2065397672","https://openalex.org/W2068509302","https://openalex.org/W2069716529","https://openalex.org/W2071949631","https://openalex.org/W2087036932","https://openalex.org/W2096791516","https://openalex.org/W2097572487","https://openalex.org/W2099086736","https://openalex.org/W2101357408","https://openalex.org/W2102732029","https://openalex.org/W2108530422","https://openalex.org/W2122492792","https://openalex.org/W2123921851","https://openalex.org/W2128335879","https://openalex.org/W2145506835","https://openalex.org/W2146519949","https://openalex.org/W2148749248","https://openalex.org/W2152603994","https://openalex.org/W2152885121","https://openalex.org/W2153118028","https://openalex.org/W2163328685","https://openalex.org/W2165408259","https://openalex.org/W2166124982","https://openalex.org/W2169718193","https://openalex.org/W2259938310","https://openalex.org/W5609562"],"related_works":["https://openalex.org/W4206502560","https://openalex.org/W2899206237","https://openalex.org/W2371153315","https://openalex.org/W2299583982","https://openalex.org/W2263152475","https://openalex.org/W2138153301","https://openalex.org/W2073029688","https://openalex.org/W2053542176","https://openalex.org/W2047547195","https://openalex.org/W1828158523"],"abstract_inverted_index":{"A":[0],"dominant":[1],"approach":[2],"to":[3,8,90,106,163],"genetic":[4],"association":[5,155],"studies":[6,71,113],"is":[7,176],"perform":[9],"univariate":[10,123],"tests":[11],"between":[12],"genotype-phenotype":[13,48],"pairs.":[14],"However,":[15],"analyzing":[16],"related":[17],"traits":[18],"together":[19],"increases":[20],"statistical":[21,84],"power,":[22],"and":[23,43,79,100],"certain":[24],"complex":[25],"associations":[26],"become":[27],"detectable":[28],"only":[29],"when":[30],"several":[31],"variants":[32],"are":[33,97,183],"tested":[34],"jointly.":[35],"Currently,":[36],"modest":[37],"sample":[38],"sizes":[39],"of":[40,46,66,76,86,110,114,138],"individual":[41],"cohorts,":[42],"restricted":[44],"availability":[45],"individual-level":[47,95,136],"data":[49,182],"across":[50],"the":[51,83,91,126,134,147],"cohorts":[52],"limit":[53],"conducting":[54],"multivariate":[55,74,144,154],"tests.We":[56],"introduce":[57],"metaCCA,":[58,120],"a":[59,67,102,160],"computational":[60],"framework":[61],"for":[62],"summary":[63,170],"statistics-based":[64],"analysis":[65,89,137],"single":[68],"or":[69,180],"multiple":[70],"that":[72,153],"allows":[73],"representation":[75],"both":[77],"genotype":[78],"phenotype.":[80],"It":[81],"extends":[82],"technique":[85],"canonical":[87],"correlation":[88],"setting":[92],"where":[93],"original":[94,139],"records":[96],"not":[98],"available,":[99],"employs":[101],"covariance":[103],"shrinkage":[104],"algorithm":[105],"achieve":[107],"robustness.Multivariate":[108],"meta-analysis":[109],"two":[111],"Finnish":[112],"nuclear":[115],"magnetic":[116],"resonance":[117],"metabolomics":[118],"by":[119,142],"using":[121,157],"standard":[122],"output":[124],"from":[125,167,172],"program":[127],"SNPTEST,":[128],"shows":[129],"an":[130],"excellent":[131],"agreement":[132],"with":[133],"pooled":[135],"data.":[140],"Motivated":[141],"strong":[143],"signals":[145],"in":[146],"lipid":[148],"genes":[149],"tested,":[150],"we":[151],"envision":[152],"testing":[156],"metaCCA":[158],"has":[159],"great":[161],"potential":[162],"provide":[164],"novel":[165],"insights":[166],"already":[168],"published":[169],"statistics":[171],"high-throughput":[173],"phenotyping":[174],"technologies.Code":[175],"available":[177,184],"at":[178,185],"https://github.com/aalto-ics-kepacoanna.cichonska@helsinki.fi":[179],"matti.pirinen@helsinki.fiSupplementary":[181],"Bioinformatics":[186],"online.":[187]},"cited_by_api_url":"https://api.openalex.org/works?filter=cites:W2302979210","counts_by_year":[{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":20},{"year":2020,"cited_by_count":19},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":19},{"year":2017,"cited_by_count":17},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2}],"updated_date":"2024-12-28T12:12:51.901218","created_date":"2016-06-24"}