{"id":"https://openalex.org/W2108530422","doi":"https://doi.org/10.1093/bioinformatics/btu140","title":"Assessing multivariate gene-metabolome associations with rare variants using Bayesian reduced rank regression","display_name":"Assessing multivariate gene-metabolome associations with rare variants using Bayesian reduced rank regression","publication_year":2014,"publication_date":"2014-03-24","ids":{"openalex":"https://openalex.org/W2108530422","doi":"https://doi.org/10.1093/bioinformatics/btu140","mag":"2108530422","pmid":"https://pubmed.ncbi.nlm.nih.gov/24665129","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4080737"},"language":"en","primary_location":{"is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btu140","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/30/14/2026/48925112/bioinformatics_30_14_2026.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311647","https://openalex.org/P4310311648"],"host_organization_lineage_names":["University of Oxford","Oxford University Press"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true},"type":"article","type_crossref":"journal-article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/30/14/2026/48925112/bioinformatics_30_14_2026.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089920272","display_name":"Pekka Marttinen","orcid":"https://orcid.org/0000-0001-7078-7927"},"institutions":[{"id":"https://openalex.org/I9927081","display_name":"Aalto University","ror":"https://ror.org/020hwjq30","country_code":"FI","type":"education","lineage":["https://openalex.org/I9927081"]},{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]},{"id":"https://openalex.org/I2799272722","display_name":"Oulu University Hospital","ror":"https://ror.org/045ney286","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2799272722"]},{"id":"https://openalex.org/I32943570","display_name":"Helsinki Institute for Information Technology","ror":"https://ror.org/05kph4940","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I32943570","https://openalex.org/I9927081"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I166825849","display_name":"Tampere University","ror":"https://ror.org/033003e23","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849"]},{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]},{"id":"https://openalex.org/I4210126318","display_name":"Tampere University Hospital","ror":"https://ror.org/02hvt5f17","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210126318"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Pekka Marttinen","raw_affiliation_strings":["1 Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere","Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere School of Medicine, Tampere, Finland, 12 Computational Medicine, School of Social and Community Medicine and the Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK, 13 Department of Clinical Physiology and Nuclear Medicine, 14 Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, 15 Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, 16 Unit of Primary Care, Oulu University Hospital, 17 Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland, 18 Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK, 19 Hjelt Institute and 20 Department of Computer Science, Helsinki Institute for Information Technology HIIT, University of Helsinki, Helsinki, Finland"],"affiliations":[{"raw_affiliation_string":"Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere School of Medicine, Tampere, Finland, 12 Computational Medicine, School of Social and Community Medicine and the Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK, 13 Department of Clinical Physiology and Nuclear Medicine, 14 Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, 15 Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, 16 Unit of Primary Care, Oulu University Hospital, 17 Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland, 18 Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK, 19 Hjelt Institute and 20 Department of Computer Science, Helsinki Institute for Information Technology HIIT, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I9927081","https://openalex.org/I133731052","https://openalex.org/I98381234","https://openalex.org/I2799272722","https://openalex.org/I32943570","https://openalex.org/I4210133586","https://openalex.org/I166825849","https://openalex.org/I175532246","https://openalex.org/I166825849"]},{"raw_affiliation_string":"1 Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere","institution_ids":["https://openalex.org/I9927081","https://openalex.org/I133731052","https://openalex.org/I4210126318","https://openalex.org/I98381234","https://openalex.org/I4210133586","https://openalex.org/I2799272722","https://openalex.org/I32943570","https://openalex.org/I166825849","https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064582174","display_name":"Matti Pirinen","orcid":"https://orcid.org/0000-0002-1664-1350"},"institutions":[{"id":"https://openalex.org/I9927081","display_name":"Aalto University","ror":"https://ror.org/020hwjq30","country_code":"FI","type":"education","lineage":["https://openalex.org/I9927081"]},{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]},{"id":"https://openalex.org/I2799272722","display_name":"Oulu University Hospital","ror":"https://ror.org/045ney286","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2799272722"]},{"id":"https://openalex.org/I32943570","display_name":"Helsinki Institute for Information Technology","ror":"https://ror.org/05kph4940","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I32943570","https://openalex.org/I9927081"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I166825849","display_name":"Tampere University","ror":"https://ror.org/033003e23","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849"]},{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Matti Pirinen","raw_affiliation_strings":["Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere School of Medicine, Tampere, Finland, 12 Computational Medicine, School of Social and Community Medicine and the Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK, 13 Department of Clinical Physiology and Nuclear Medicine, 14 Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, 15 Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, 16 Unit of Primary Care, Oulu University Hospital, 17 Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland, 18 Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK, 19 Hjelt Institute and 20 Department of Computer Science, Helsinki Institute for Information Technology HIIT, University of Helsinki, Helsinki, Finland"],"affiliations":[{"raw_affiliation_string":"Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere School of Medicine, Tampere, Finland, 12 Computational Medicine, School of Social and Community Medicine and the Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK, 13 Department of Clinical Physiology and Nuclear Medicine, 14 Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, 15 Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, 16 Unit of Primary Care, Oulu University Hospital, 17 Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland, 18 Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK, 19 Hjelt Institute and 20 Department of Computer Science, Helsinki Institute for Information Technology HIIT, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I9927081","https://openalex.org/I133731052","https://openalex.org/I98381234","https://openalex.org/I2799272722","https://openalex.org/I32943570","https://openalex.org/I4210133586","https://openalex.org/I166825849","https://openalex.org/I175532246","https://openalex.org/I166825849"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038305434","display_name":"Antti\u2010Pekka Sarin","orcid":"https://orcid.org/0000-0002-5753-9782"},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]},{"id":"https://openalex.org/I2799272722","display_name":"Oulu University Hospital","ror":"https://ror.org/045ney286","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2799272722"]},{"id":"https://openalex.org/I32943570","display_name":"Helsinki Institute for Information Technology","ror":"https://ror.org/05kph4940","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I32943570","https://openalex.org/I9927081"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I166825849","display_name":"Tampere University","ror":"https://ror.org/033003e23","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849"]},{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]},{"id":"https://openalex.org/I9927081","display_name":"Aalto University","ror":"https://ror.org/020hwjq30","country_code":"FI","type":"education","lineage":["https://openalex.org/I9927081"]},{"id":"https://openalex.org/I4210126318","display_name":"Tampere University Hospital","ror":"https://ror.org/02hvt5f17","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210126318"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Antti-Pekka Sarin","raw_affiliation_strings":["1 Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere","Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere School of Medicine, Tampere, Finland, 12 Computational Medicine, School of Social and Community Medicine and the Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK, 13 Department of Clinical Physiology and Nuclear Medicine, 14 Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, 15 Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, 16 Unit of Primary Care, Oulu University Hospital, 17 Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland, 18 Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK, 19 Hjelt Institute and 20 Department of Computer Science, Helsinki Institute for Information Technology HIIT, University of Helsinki, Helsinki, Finland"],"affiliations":[{"raw_affiliation_string":"Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere School of Medicine, Tampere, Finland, 12 Computational Medicine, School of Social and Community Medicine and the Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK, 13 Department of Clinical Physiology and Nuclear Medicine, 14 Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, 15 Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, 16 Unit of Primary Care, Oulu University Hospital, 17 Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland, 18 Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK, 19 Hjelt Institute and 20 Department of Computer Science, Helsinki Institute for Information Technology HIIT, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I98381234","https://openalex.org/I2799272722","https://openalex.org/I32943570","https://openalex.org/I4210133586","https://openalex.org/I166825849","https://openalex.org/I175532246","https://openalex.org/I166825849","https://openalex.org/I9927081"]},{"raw_affiliation_string":"1 Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere","institution_ids":["https://openalex.org/I9927081","https://openalex.org/I133731052","https://openalex.org/I4210126318","https://openalex.org/I98381234","https://openalex.org/I4210133586","https://openalex.org/I2799272722","https://openalex.org/I32943570","https://openalex.org/I166825849","https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090034452","display_name":"Jussi Gillberg","orcid":null},"institutions":[{"id":"https://openalex.org/I9927081","display_name":"Aalto University","ror":"https://ror.org/020hwjq30","country_code":"FI","type":"education","lineage":["https://openalex.org/I9927081"]},{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]},{"id":"https://openalex.org/I2799272722","display_name":"Oulu University Hospital","ror":"https://ror.org/045ney286","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2799272722"]},{"id":"https://openalex.org/I32943570","display_name":"Helsinki Institute for Information Technology","ror":"https://ror.org/05kph4940","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I32943570","https://openalex.org/I9927081"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I166825849","display_name":"Tampere University","ror":"https://ror.org/033003e23","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849"]},{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Jussi Gillberg","raw_affiliation_strings":["Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere School of Medicine, Tampere, Finland, 12 Computational Medicine, School of Social and Community Medicine and the Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK, 13 Department of Clinical Physiology and Nuclear Medicine, 14 Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, 15 Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, 16 Unit of Primary Care, Oulu University Hospital, 17 Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland, 18 Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK, 19 Hjelt Institute and 20 Department of Computer Science, Helsinki Institute for Information Technology HIIT, University of Helsinki, Helsinki, Finland"],"affiliations":[{"raw_affiliation_string":"Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere School of Medicine, Tampere, Finland, 12 Computational Medicine, School of Social and Community Medicine and the Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK, 13 Department of Clinical Physiology and Nuclear Medicine, 14 Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, 15 Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, 16 Unit of Primary Care, Oulu University Hospital, 17 Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland, 18 Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK, 19 Hjelt Institute and 20 Department of Computer Science, Helsinki Institute for Information Technology HIIT, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I9927081","https://openalex.org/I133731052","https://openalex.org/I98381234","https://openalex.org/I2799272722","https://openalex.org/I32943570","https://openalex.org/I4210133586","https://openalex.org/I166825849","https://openalex.org/I175532246","https://openalex.org/I166825849"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022876944","display_name":"Johannes Kettunen","orcid":"https://orcid.org/0000-0002-3345-491X"},"institutions":[{"id":"https://openalex.org/I9927081","display_name":"Aalto University","ror":"https://ror.org/020hwjq30","country_code":"FI","type":"education","lineage":["https://openalex.org/I9927081"]},{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]},{"id":"https://openalex.org/I2799272722","display_name":"Oulu University Hospital","ror":"https://ror.org/045ney286","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2799272722"]},{"id":"https://openalex.org/I32943570","display_name":"Helsinki Institute for Information Technology","ror":"https://ror.org/05kph4940","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I32943570","https://openalex.org/I9927081"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I166825849","display_name":"Tampere University","ror":"https://ror.org/033003e23","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849"]},{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]},{"id":"https://openalex.org/I4210126318","display_name":"Tampere University Hospital","ror":"https://ror.org/02hvt5f17","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210126318"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Johannes Kettunen","raw_affiliation_strings":["1 Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere","Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere School of Medicine, Tampere, Finland, 12 Computational Medicine, School of Social and Community Medicine and the Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK, 13 Department of Clinical Physiology and Nuclear Medicine, 14 Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, 15 Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, 16 Unit of Primary Care, Oulu University Hospital, 17 Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland, 18 Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK, 19 Hjelt Institute and 20 Department of Computer Science, Helsinki Institute for Information Technology HIIT, University of Helsinki, Helsinki, Finland"],"affiliations":[{"raw_affiliation_string":"Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere School of Medicine, Tampere, Finland, 12 Computational Medicine, School of Social and Community Medicine and the Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK, 13 Department of Clinical Physiology and Nuclear Medicine, 14 Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, 15 Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, 16 Unit of Primary Care, Oulu University Hospital, 17 Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland, 18 Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK, 19 Hjelt Institute and 20 Department of Computer Science, Helsinki Institute for Information Technology HIIT, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I9927081","https://openalex.org/I133731052","https://openalex.org/I98381234","https://openalex.org/I2799272722","https://openalex.org/I32943570","https://openalex.org/I4210133586","https://openalex.org/I166825849","https://openalex.org/I175532246","https://openalex.org/I166825849"]},{"raw_affiliation_string":"1 Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere","institution_ids":["https://openalex.org/I9927081","https://openalex.org/I133731052","https://openalex.org/I4210126318","https://openalex.org/I98381234","https://openalex.org/I4210133586","https://openalex.org/I2799272722","https://openalex.org/I32943570","https://openalex.org/I166825849","https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024138963","display_name":"Ida Surakka","orcid":"https://orcid.org/0000-0002-6669-5541"},"institutions":[{"id":"https://openalex.org/I9927081","display_name":"Aalto University","ror":"https://ror.org/020hwjq30","country_code":"FI","type":"education","lineage":["https://openalex.org/I9927081"]},{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]},{"id":"https://openalex.org/I2799272722","display_name":"Oulu University Hospital","ror":"https://ror.org/045ney286","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2799272722"]},{"id":"https://openalex.org/I32943570","display_name":"Helsinki Institute for Information Technology","ror":"https://ror.org/05kph4940","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I32943570","https://openalex.org/I9927081"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I166825849","display_name":"Tampere University","ror":"https://ror.org/033003e23","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849"]},{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]},{"id":"https://openalex.org/I4210126318","display_name":"Tampere University Hospital","ror":"https://ror.org/02hvt5f17","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210126318"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Ida Surakka","raw_affiliation_strings":["1 Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere","Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere School of Medicine, Tampere, Finland, 12 Computational Medicine, School of Social and Community Medicine and the Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK, 13 Department of Clinical Physiology and Nuclear Medicine, 14 Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, 15 Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, 16 Unit of Primary Care, Oulu University Hospital, 17 Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland, 18 Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK, 19 Hjelt Institute and 20 Department of Computer Science, Helsinki Institute for Information Technology HIIT, University of Helsinki, Helsinki, Finland"],"affiliations":[{"raw_affiliation_string":"Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere School of Medicine, Tampere, Finland, 12 Computational Medicine, School of Social and Community Medicine and the Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK, 13 Department of Clinical Physiology and Nuclear Medicine, 14 Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, 15 Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, 16 Unit of Primary Care, Oulu University Hospital, 17 Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland, 18 Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK, 19 Hjelt Institute and 20 Department of Computer Science, Helsinki Institute for Information Technology HIIT, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I9927081","https://openalex.org/I133731052","https://openalex.org/I98381234","https://openalex.org/I2799272722","https://openalex.org/I32943570","https://openalex.org/I4210133586","https://openalex.org/I166825849","https://openalex.org/I175532246","https://openalex.org/I166825849"]},{"raw_affiliation_string":"1 Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere","institution_ids":["https://openalex.org/I9927081","https://openalex.org/I133731052","https://openalex.org/I4210126318","https://openalex.org/I98381234","https://openalex.org/I4210133586","https://openalex.org/I2799272722","https://openalex.org/I32943570","https://openalex.org/I166825849","https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082784196","display_name":"Antti J. Kangas","orcid":"https://orcid.org/0000-0001-7492-1732"},"institutions":[{"id":"https://openalex.org/I166825849","display_name":"Tampere University","ror":"https://ror.org/033003e23","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849"]},{"id":"https://openalex.org/I9927081","display_name":"Aalto University","ror":"https://ror.org/020hwjq30","country_code":"FI","type":"education","lineage":["https://openalex.org/I9927081"]},{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]},{"id":"https://openalex.org/I2799272722","display_name":"Oulu University Hospital","ror":"https://ror.org/045ney286","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2799272722"]},{"id":"https://openalex.org/I32943570","display_name":"Helsinki Institute for Information Technology","ror":"https://ror.org/05kph4940","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I32943570","https://openalex.org/I9927081"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Antti J. Kangas","raw_affiliation_strings":["Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere School of Medicine, Tampere, Finland, 12 Computational Medicine, School of Social and Community Medicine and the Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK, 13 Department of Clinical Physiology and Nuclear Medicine, 14 Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, 15 Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, 16 Unit of Primary Care, Oulu University Hospital, 17 Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland, 18 Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK, 19 Hjelt Institute and 20 Department of Computer Science, Helsinki Institute for Information Technology HIIT, University of Helsinki, Helsinki, Finland"],"affiliations":[{"raw_affiliation_string":"Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere School of Medicine, Tampere, Finland, 12 Computational Medicine, School of Social and Community Medicine and the Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK, 13 Department of Clinical Physiology and Nuclear Medicine, 14 Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, 15 Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, 16 Unit of Primary Care, Oulu University Hospital, 17 Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland, 18 Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK, 19 Hjelt Institute and 20 Department of Computer Science, Helsinki Institute for Information Technology HIIT, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I166825849","https://openalex.org/I9927081","https://openalex.org/I133731052","https://openalex.org/I98381234","https://openalex.org/I2799272722","https://openalex.org/I32943570","https://openalex.org/I4210133586","https://openalex.org/I166825849","https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019754063","display_name":"Pasi Soininen","orcid":null},"institutions":[{"id":"https://openalex.org/I9927081","display_name":"Aalto University","ror":"https://ror.org/020hwjq30","country_code":"FI","type":"education","lineage":["https://openalex.org/I9927081"]},{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]},{"id":"https://openalex.org/I2799272722","display_name":"Oulu University Hospital","ror":"https://ror.org/045ney286","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2799272722"]},{"id":"https://openalex.org/I32943570","display_name":"Helsinki Institute for Information Technology","ror":"https://ror.org/05kph4940","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I32943570","https://openalex.org/I9927081"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I166825849","display_name":"Tampere University","ror":"https://ror.org/033003e23","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849"]},{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]},{"id":"https://openalex.org/I4210126318","display_name":"Tampere University Hospital","ror":"https://ror.org/02hvt5f17","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210126318"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Pasi Soininen","raw_affiliation_strings":["1 Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere","Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere School of Medicine, Tampere, Finland, 12 Computational Medicine, School of Social and Community Medicine and the Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK, 13 Department of Clinical Physiology and Nuclear Medicine, 14 Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, 15 Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, 16 Unit of Primary Care, Oulu University Hospital, 17 Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland, 18 Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK, 19 Hjelt Institute and 20 Department of Computer Science, Helsinki Institute for Information Technology HIIT, University of Helsinki, Helsinki, Finland"],"affiliations":[{"raw_affiliation_string":"Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere School of Medicine, Tampere, Finland, 12 Computational Medicine, School of Social and Community Medicine and the Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK, 13 Department of Clinical Physiology and Nuclear Medicine, 14 Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, 15 Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, 16 Unit of Primary Care, Oulu University Hospital, 17 Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland, 18 Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK, 19 Hjelt Institute and 20 Department of Computer Science, Helsinki Institute for Information Technology HIIT, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I9927081","https://openalex.org/I133731052","https://openalex.org/I98381234","https://openalex.org/I2799272722","https://openalex.org/I32943570","https://openalex.org/I4210133586","https://openalex.org/I166825849","https://openalex.org/I175532246","https://openalex.org/I166825849"]},{"raw_affiliation_string":"1 Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere","institution_ids":["https://openalex.org/I9927081","https://openalex.org/I133731052","https://openalex.org/I4210126318","https://openalex.org/I98381234","https://openalex.org/I4210133586","https://openalex.org/I2799272722","https://openalex.org/I32943570","https://openalex.org/I166825849","https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022427519","display_name":"Paul F. O\u2019Reilly","orcid":"https://orcid.org/0000-0001-7515-0845"},"institutions":[{"id":"https://openalex.org/I9927081","display_name":"Aalto University","ror":"https://ror.org/020hwjq30","country_code":"FI","type":"education","lineage":["https://openalex.org/I9927081"]},{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]},{"id":"https://openalex.org/I2799272722","display_name":"Oulu University Hospital","ror":"https://ror.org/045ney286","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2799272722"]},{"id":"https://openalex.org/I32943570","display_name":"Helsinki Institute for Information Technology","ror":"https://ror.org/05kph4940","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I32943570","https://openalex.org/I9927081"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I166825849","display_name":"Tampere University","ror":"https://ror.org/033003e23","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849"]},{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Paul O\u2019Reilly","raw_affiliation_strings":["Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere School of Medicine, Tampere, Finland, 12 Computational Medicine, School of Social and Community Medicine and the Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK, 13 Department of Clinical Physiology and Nuclear Medicine, 14 Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, 15 Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, 16 Unit of Primary Care, Oulu University Hospital, 17 Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland, 18 Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK, 19 Hjelt Institute and 20 Department of Computer Science, Helsinki Institute for Information Technology HIIT, University of Helsinki, Helsinki, Finland"],"affiliations":[{"raw_affiliation_string":"Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere School of Medicine, Tampere, Finland, 12 Computational Medicine, School of Social and Community Medicine and the Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK, 13 Department of Clinical Physiology and Nuclear Medicine, 14 Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, 15 Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, 16 Unit of Primary Care, Oulu University Hospital, 17 Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland, 18 Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK, 19 Hjelt Institute and 20 Department of Computer Science, Helsinki Institute for Information Technology HIIT, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I9927081","https://openalex.org/I133731052","https://openalex.org/I98381234","https://openalex.org/I2799272722","https://openalex.org/I32943570","https://openalex.org/I4210133586","https://openalex.org/I166825849","https://openalex.org/I175532246","https://openalex.org/I166825849"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065042677","display_name":"Marika Kaakinen","orcid":"https://orcid.org/0000-0002-9228-0462"},"institutions":[{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]},{"id":"https://openalex.org/I9927081","display_name":"Aalto University","ror":"https://ror.org/020hwjq30","country_code":"FI","type":"education","lineage":["https://openalex.org/I9927081"]},{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2799272722","display_name":"Oulu University Hospital","ror":"https://ror.org/045ney286","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2799272722"]},{"id":"https://openalex.org/I32943570","display_name":"Helsinki Institute for Information Technology","ror":"https://ror.org/05kph4940","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I32943570","https://openalex.org/I9927081"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I166825849","display_name":"Tampere University","ror":"https://ror.org/033003e23","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849"]},{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]},{"id":"https://openalex.org/I4210126318","display_name":"Tampere University Hospital","ror":"https://ror.org/02hvt5f17","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210126318"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Marika Kaakinen","raw_affiliation_strings":["1 Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere","Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere School of Medicine, Tampere, Finland, 12 Computational Medicine, School of Social and Community Medicine and the Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK, 13 Department of Clinical Physiology and Nuclear Medicine, 14 Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, 15 Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, 16 Unit of Primary Care, Oulu University Hospital, 17 Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland, 18 Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK, 19 Hjelt Institute and 20 Department of Computer Science, Helsinki Institute for Information Technology HIIT, University of Helsinki, Helsinki, Finland"],"affiliations":[{"raw_affiliation_string":"Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere School of Medicine, Tampere, Finland, 12 Computational Medicine, School of Social and Community Medicine and the Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK, 13 Department of Clinical Physiology and Nuclear Medicine, 14 Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, 15 Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, 16 Unit of Primary Care, Oulu University Hospital, 17 Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland, 18 Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK, 19 Hjelt Institute and 20 Department of Computer Science, Helsinki Institute for Information Technology HIIT, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I98381234","https://openalex.org/I9927081","https://openalex.org/I133731052","https://openalex.org/I2799272722","https://openalex.org/I32943570","https://openalex.org/I4210133586","https://openalex.org/I166825849","https://openalex.org/I175532246","https://openalex.org/I166825849"]},{"raw_affiliation_string":"1 Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere","institution_ids":["https://openalex.org/I9927081","https://openalex.org/I133731052","https://openalex.org/I4210126318","https://openalex.org/I98381234","https://openalex.org/I4210133586","https://openalex.org/I2799272722","https://openalex.org/I32943570","https://openalex.org/I166825849","https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045767788","display_name":"Mika K\u00e4h\u00f6nen","orcid":"https://orcid.org/0000-0002-4510-7341"},"institutions":[{"id":"https://openalex.org/I9927081","display_name":"Aalto University","ror":"https://ror.org/020hwjq30","country_code":"FI","type":"education","lineage":["https://openalex.org/I9927081"]},{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]},{"id":"https://openalex.org/I2799272722","display_name":"Oulu University Hospital","ror":"https://ror.org/045ney286","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2799272722"]},{"id":"https://openalex.org/I32943570","display_name":"Helsinki Institute for Information Technology","ror":"https://ror.org/05kph4940","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I32943570","https://openalex.org/I9927081"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I166825849","display_name":"Tampere University","ror":"https://ror.org/033003e23","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849"]},{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Mika K\u00e4h\u00f6nen","raw_affiliation_strings":["Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere School of Medicine, Tampere, Finland, 12 Computational Medicine, School of Social and Community Medicine and the Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK, 13 Department of Clinical Physiology and Nuclear Medicine, 14 Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, 15 Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, 16 Unit of Primary Care, Oulu University Hospital, 17 Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland, 18 Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK, 19 Hjelt Institute and 20 Department of Computer Science, Helsinki Institute for Information Technology HIIT, University of Helsinki, Helsinki, Finland"],"affiliations":[{"raw_affiliation_string":"Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere School of Medicine, Tampere, Finland, 12 Computational Medicine, School of Social and Community Medicine and the Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK, 13 Department of Clinical Physiology and Nuclear Medicine, 14 Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, 15 Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, 16 Unit of Primary Care, Oulu University Hospital, 17 Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland, 18 Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK, 19 Hjelt Institute and 20 Department of Computer Science, Helsinki Institute for Information Technology HIIT, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I9927081","https://openalex.org/I133731052","https://openalex.org/I98381234","https://openalex.org/I2799272722","https://openalex.org/I32943570","https://openalex.org/I4210133586","https://openalex.org/I166825849","https://openalex.org/I175532246","https://openalex.org/I166825849"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081986241","display_name":"Terho Lehtim\u00e4ki","orcid":"https://orcid.org/0000-0002-2555-4427"},"institutions":[{"id":"https://openalex.org/I9927081","display_name":"Aalto University","ror":"https://ror.org/020hwjq30","country_code":"FI","type":"education","lineage":["https://openalex.org/I9927081"]},{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]},{"id":"https://openalex.org/I2799272722","display_name":"Oulu University Hospital","ror":"https://ror.org/045ney286","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2799272722"]},{"id":"https://openalex.org/I32943570","display_name":"Helsinki Institute for Information Technology","ror":"https://ror.org/05kph4940","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I32943570","https://openalex.org/I9927081"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I166825849","display_name":"Tampere University","ror":"https://ror.org/033003e23","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849"]},{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Terho Lehtim\u00e4ki","raw_affiliation_strings":["Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere School of Medicine, Tampere, Finland, 12 Computational Medicine, School of Social and Community Medicine and the Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK, 13 Department of Clinical Physiology and Nuclear Medicine, 14 Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, 15 Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, 16 Unit of Primary Care, Oulu University Hospital, 17 Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland, 18 Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK, 19 Hjelt Institute and 20 Department of Computer Science, Helsinki Institute for Information Technology HIIT, University of Helsinki, Helsinki, Finland"],"affiliations":[{"raw_affiliation_string":"Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere School of Medicine, Tampere, Finland, 12 Computational Medicine, School of Social and Community Medicine and the Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK, 13 Department of Clinical Physiology and Nuclear Medicine, 14 Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, 15 Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, 16 Unit of Primary Care, Oulu University Hospital, 17 Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland, 18 Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK, 19 Hjelt Institute and 20 Department of Computer Science, Helsinki Institute for Information Technology HIIT, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I9927081","https://openalex.org/I133731052","https://openalex.org/I98381234","https://openalex.org/I2799272722","https://openalex.org/I32943570","https://openalex.org/I4210133586","https://openalex.org/I166825849","https://openalex.org/I175532246","https://openalex.org/I166825849"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078073418","display_name":"Mika Ala\u2010Korpela","orcid":"https://orcid.org/0000-0001-5905-1206"},"institutions":[{"id":"https://openalex.org/I9927081","display_name":"Aalto University","ror":"https://ror.org/020hwjq30","country_code":"FI","type":"education","lineage":["https://openalex.org/I9927081"]},{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]},{"id":"https://openalex.org/I2799272722","display_name":"Oulu University Hospital","ror":"https://ror.org/045ney286","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2799272722"]},{"id":"https://openalex.org/I32943570","display_name":"Helsinki Institute for Information Technology","ror":"https://ror.org/05kph4940","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I32943570","https://openalex.org/I9927081"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I166825849","display_name":"Tampere University","ror":"https://ror.org/033003e23","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849"]},{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]},{"id":"https://openalex.org/I4210126318","display_name":"Tampere University Hospital","ror":"https://ror.org/02hvt5f17","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210126318"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Mika Ala-Korpela","raw_affiliation_strings":["1 Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere","Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere School of Medicine, Tampere, Finland, 12 Computational Medicine, School of Social and Community Medicine and the Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK, 13 Department of Clinical Physiology and Nuclear Medicine, 14 Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, 15 Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, 16 Unit of Primary Care, Oulu University Hospital, 17 Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland, 18 Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK, 19 Hjelt Institute and 20 Department of Computer Science, Helsinki Institute for Information Technology HIIT, University of Helsinki, Helsinki, Finland"],"affiliations":[{"raw_affiliation_string":"Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere School of Medicine, Tampere, Finland, 12 Computational Medicine, School of Social and Community Medicine and the Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK, 13 Department of Clinical Physiology and Nuclear Medicine, 14 Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, 15 Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, 16 Unit of Primary Care, Oulu University Hospital, 17 Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland, 18 Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK, 19 Hjelt Institute and 20 Department of Computer Science, Helsinki Institute for Information Technology HIIT, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I9927081","https://openalex.org/I133731052","https://openalex.org/I98381234","https://openalex.org/I2799272722","https://openalex.org/I32943570","https://openalex.org/I4210133586","https://openalex.org/I166825849","https://openalex.org/I175532246","https://openalex.org/I166825849"]},{"raw_affiliation_string":"1 Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere","institution_ids":["https://openalex.org/I9927081","https://openalex.org/I133731052","https://openalex.org/I4210126318","https://openalex.org/I98381234","https://openalex.org/I4210133586","https://openalex.org/I2799272722","https://openalex.org/I32943570","https://openalex.org/I166825849","https://openalex.org/I175532246","https://openalex.org/I9927081","https://openalex.org/I133731052","https://openalex.org/I4210126318","https://openalex.org/I98381234","https://openalex.org/I4210133586","https://openalex.org/I2799272722","https://openalex.org/I32943570","https://openalex.org/I166825849","https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060131080","display_name":"Olli T. Raitakari","orcid":"https://orcid.org/0000-0001-9365-3702"},"institutions":[{"id":"https://openalex.org/I9927081","display_name":"Aalto University","ror":"https://ror.org/020hwjq30","country_code":"FI","type":"education","lineage":["https://openalex.org/I9927081"]},{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]},{"id":"https://openalex.org/I2799272722","display_name":"Oulu University Hospital","ror":"https://ror.org/045ney286","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2799272722"]},{"id":"https://openalex.org/I32943570","display_name":"Helsinki Institute for Information Technology","ror":"https://ror.org/05kph4940","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I32943570","https://openalex.org/I9927081"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I166825849","display_name":"Tampere University","ror":"https://ror.org/033003e23","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849"]},{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]},{"id":"https://openalex.org/I4210126318","display_name":"Tampere University Hospital","ror":"https://ror.org/02hvt5f17","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210126318"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Olli T. Raitakari","raw_affiliation_strings":["1 Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere","Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere School of Medicine, Tampere, Finland, 12 Computational Medicine, School of Social and Community Medicine and the Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK, 13 Department of Clinical Physiology and Nuclear Medicine, 14 Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, 15 Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, 16 Unit of Primary Care, Oulu University Hospital, 17 Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland, 18 Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK, 19 Hjelt Institute and 20 Department of Computer Science, Helsinki Institute for Information Technology HIIT, University of Helsinki, Helsinki, Finland"],"affiliations":[{"raw_affiliation_string":"Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere School of Medicine, Tampere, Finland, 12 Computational Medicine, School of Social and Community Medicine and the Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK, 13 Department of Clinical Physiology and Nuclear Medicine, 14 Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, 15 Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, 16 Unit of Primary Care, Oulu University Hospital, 17 Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland, 18 Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK, 19 Hjelt Institute and 20 Department of Computer Science, Helsinki Institute for Information Technology HIIT, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I9927081","https://openalex.org/I133731052","https://openalex.org/I98381234","https://openalex.org/I2799272722","https://openalex.org/I32943570","https://openalex.org/I4210133586","https://openalex.org/I166825849","https://openalex.org/I175532246","https://openalex.org/I166825849"]},{"raw_affiliation_string":"1 Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere","institution_ids":["https://openalex.org/I9927081","https://openalex.org/I133731052","https://openalex.org/I4210126318","https://openalex.org/I98381234","https://openalex.org/I4210133586","https://openalex.org/I2799272722","https://openalex.org/I32943570","https://openalex.org/I166825849","https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066237154","display_name":"Veikko Salomaa","orcid":"https://orcid.org/0000-0001-7563-5324"},"institutions":[{"id":"https://openalex.org/I9927081","display_name":"Aalto University","ror":"https://ror.org/020hwjq30","country_code":"FI","type":"education","lineage":["https://openalex.org/I9927081"]},{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]},{"id":"https://openalex.org/I2799272722","display_name":"Oulu University Hospital","ror":"https://ror.org/045ney286","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2799272722"]},{"id":"https://openalex.org/I32943570","display_name":"Helsinki Institute for Information Technology","ror":"https://ror.org/05kph4940","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I32943570","https://openalex.org/I9927081"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I166825849","display_name":"Tampere University","ror":"https://ror.org/033003e23","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849"]},{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Veikko Salomaa","raw_affiliation_strings":["Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere School of Medicine, Tampere, Finland, 12 Computational Medicine, School of Social and Community Medicine and the Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK, 13 Department of Clinical Physiology and Nuclear Medicine, 14 Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, 15 Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, 16 Unit of Primary Care, Oulu University Hospital, 17 Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland, 18 Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK, 19 Hjelt Institute and 20 Department of Computer Science, Helsinki Institute for Information Technology HIIT, University of Helsinki, Helsinki, Finland"],"affiliations":[{"raw_affiliation_string":"Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere School of Medicine, Tampere, Finland, 12 Computational Medicine, School of Social and Community Medicine and the Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK, 13 Department of Clinical Physiology and Nuclear Medicine, 14 Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, 15 Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, 16 Unit of Primary Care, Oulu University Hospital, 17 Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland, 18 Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK, 19 Hjelt Institute and 20 Department of Computer Science, Helsinki Institute for Information Technology HIIT, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I9927081","https://openalex.org/I133731052","https://openalex.org/I98381234","https://openalex.org/I2799272722","https://openalex.org/I32943570","https://openalex.org/I4210133586","https://openalex.org/I166825849","https://openalex.org/I175532246","https://openalex.org/I166825849"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068508022","display_name":"Marjo\u2010Riitta J\u00e4rvelin","orcid":"https://orcid.org/0000-0002-2149-0630"},"institutions":[{"id":"https://openalex.org/I9927081","display_name":"Aalto University","ror":"https://ror.org/020hwjq30","country_code":"FI","type":"education","lineage":["https://openalex.org/I9927081"]},{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]},{"id":"https://openalex.org/I2799272722","display_name":"Oulu University Hospital","ror":"https://ror.org/045ney286","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2799272722"]},{"id":"https://openalex.org/I32943570","display_name":"Helsinki Institute for Information Technology","ror":"https://ror.org/05kph4940","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I32943570","https://openalex.org/I9927081"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I166825849","display_name":"Tampere University","ror":"https://ror.org/033003e23","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849"]},{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]},{"id":"https://openalex.org/I4210126318","display_name":"Tampere University Hospital","ror":"https://ror.org/02hvt5f17","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210126318"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Marjo-Riitta J\u00e4rvelin","raw_affiliation_strings":["1 Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere","Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere School of Medicine, Tampere, Finland, 12 Computational Medicine, School of Social and Community Medicine and the Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK, 13 Department of Clinical Physiology and Nuclear Medicine, 14 Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, 15 Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, 16 Unit of Primary Care, Oulu University Hospital, 17 Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland, 18 Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK, 19 Hjelt Institute and 20 Department of Computer Science, Helsinki Institute for Information Technology HIIT, University of Helsinki, Helsinki, Finland"],"affiliations":[{"raw_affiliation_string":"Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere School of Medicine, Tampere, Finland, 12 Computational Medicine, School of Social and Community Medicine and the Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK, 13 Department of Clinical Physiology and Nuclear Medicine, 14 Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, 15 Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, 16 Unit of Primary Care, Oulu University Hospital, 17 Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland, 18 Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK, 19 Hjelt Institute and 20 Department of Computer Science, Helsinki Institute for Information Technology HIIT, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I9927081","https://openalex.org/I133731052","https://openalex.org/I98381234","https://openalex.org/I2799272722","https://openalex.org/I32943570","https://openalex.org/I4210133586","https://openalex.org/I166825849","https://openalex.org/I175532246","https://openalex.org/I166825849"]},{"raw_affiliation_string":"1 Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere","institution_ids":["https://openalex.org/I9927081","https://openalex.org/I133731052","https://openalex.org/I4210126318","https://openalex.org/I98381234","https://openalex.org/I4210133586","https://openalex.org/I2799272722","https://openalex.org/I32943570","https://openalex.org/I166825849","https://openalex.org/I175532246","https://openalex.org/I9927081","https://openalex.org/I133731052","https://openalex.org/I4210126318","https://openalex.org/I98381234","https://openalex.org/I4210133586","https://openalex.org/I2799272722","https://openalex.org/I32943570","https://openalex.org/I166825849","https://openalex.org/I175532246","https://openalex.org/I9927081","https://openalex.org/I133731052","https://openalex.org/I4210126318","https://openalex.org/I98381234","https://openalex.org/I4210133586","https://openalex.org/I2799272722","https://openalex.org/I32943570","https://openalex.org/I166825849","https://openalex.org/I175532246","https://openalex.org/I9927081","https://openalex.org/I133731052","https://openalex.org/I4210126318","https://openalex.org/I98381234","https://openalex.org/I4210133586","https://openalex.org/I2799272722","https://openalex.org/I32943570","https://openalex.org/I166825849","https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058300698","display_name":"Samuli Ripatti","orcid":"https://orcid.org/0000-0002-0504-1202"},"institutions":[{"id":"https://openalex.org/I9927081","display_name":"Aalto University","ror":"https://ror.org/020hwjq30","country_code":"FI","type":"education","lineage":["https://openalex.org/I9927081"]},{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]},{"id":"https://openalex.org/I2799272722","display_name":"Oulu University Hospital","ror":"https://ror.org/045ney286","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2799272722"]},{"id":"https://openalex.org/I32943570","display_name":"Helsinki Institute for Information Technology","ror":"https://ror.org/05kph4940","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I32943570","https://openalex.org/I9927081"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I166825849","display_name":"Tampere University","ror":"https://ror.org/033003e23","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849"]},{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]},{"id":"https://openalex.org/I4210126318","display_name":"Tampere University Hospital","ror":"https://ror.org/02hvt5f17","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210126318"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Samuli Ripatti","raw_affiliation_strings":["1 Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere","Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere School of Medicine, Tampere, Finland, 12 Computational Medicine, School of Social and Community Medicine and the Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK, 13 Department of Clinical Physiology and Nuclear Medicine, 14 Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, 15 Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, 16 Unit of Primary Care, Oulu University Hospital, 17 Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland, 18 Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK, 19 Hjelt Institute and 20 Department of Computer Science, Helsinki Institute for Information Technology HIIT, University of Helsinki, Helsinki, Finland"],"affiliations":[{"raw_affiliation_string":"Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere School of Medicine, Tampere, Finland, 12 Computational Medicine, School of Social and Community Medicine and the Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK, 13 Department of Clinical Physiology and Nuclear Medicine, 14 Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, 15 Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, 16 Unit of Primary Care, Oulu University Hospital, 17 Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland, 18 Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK, 19 Hjelt Institute and 20 Department of Computer Science, Helsinki Institute for Information Technology HIIT, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I9927081","https://openalex.org/I133731052","https://openalex.org/I98381234","https://openalex.org/I2799272722","https://openalex.org/I32943570","https://openalex.org/I4210133586","https://openalex.org/I166825849","https://openalex.org/I175532246","https://openalex.org/I166825849"]},{"raw_affiliation_string":"1 Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere","institution_ids":["https://openalex.org/I9927081","https://openalex.org/I133731052","https://openalex.org/I4210126318","https://openalex.org/I98381234","https://openalex.org/I4210133586","https://openalex.org/I2799272722","https://openalex.org/I32943570","https://openalex.org/I166825849","https://openalex.org/I175532246","https://openalex.org/I9927081","https://openalex.org/I133731052","https://openalex.org/I4210126318","https://openalex.org/I98381234","https://openalex.org/I4210133586","https://openalex.org/I2799272722","https://openalex.org/I32943570","https://openalex.org/I166825849","https://openalex.org/I175532246","https://openalex.org/I9927081","https://openalex.org/I133731052","https://openalex.org/I4210126318","https://openalex.org/I98381234","https://openalex.org/I4210133586","https://openalex.org/I2799272722","https://openalex.org/I32943570","https://openalex.org/I166825849","https://openalex.org/I175532246"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018305257","display_name":"Samuel Kaski","orcid":"https://orcid.org/0000-0003-1925-9154"},"institutions":[{"id":"https://openalex.org/I9927081","display_name":"Aalto University","ror":"https://ror.org/020hwjq30","country_code":"FI","type":"education","lineage":["https://openalex.org/I9927081"]},{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]},{"id":"https://openalex.org/I2799272722","display_name":"Oulu University Hospital","ror":"https://ror.org/045ney286","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2799272722"]},{"id":"https://openalex.org/I32943570","display_name":"Helsinki Institute for Information Technology","ror":"https://ror.org/05kph4940","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I32943570","https://openalex.org/I9927081"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I166825849","display_name":"Tampere University","ror":"https://ror.org/033003e23","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849"]},{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]},{"id":"https://openalex.org/I4210126318","display_name":"Tampere University Hospital","ror":"https://ror.org/02hvt5f17","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210126318"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Samuel Kaski","raw_affiliation_strings":["1 Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere","Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere School of Medicine, Tampere, Finland, 12 Computational Medicine, School of Social and Community Medicine and the Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK, 13 Department of Clinical Physiology and Nuclear Medicine, 14 Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, 15 Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, 16 Unit of Primary Care, Oulu University Hospital, 17 Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland, 18 Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK, 19 Hjelt Institute and 20 Department of Computer Science, Helsinki Institute for Information Technology HIIT, University of Helsinki, Helsinki, Finland"],"affiliations":[{"raw_affiliation_string":"Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere School of Medicine, Tampere, Finland, 12 Computational Medicine, School of Social and Community Medicine and the Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK, 13 Department of Clinical Physiology and Nuclear Medicine, 14 Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, 15 Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, 16 Unit of Primary Care, Oulu University Hospital, 17 Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland, 18 Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK, 19 Hjelt Institute and 20 Department of Computer Science, Helsinki Institute for Information Technology HIIT, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I9927081","https://openalex.org/I133731052","https://openalex.org/I98381234","https://openalex.org/I2799272722","https://openalex.org/I32943570","https://openalex.org/I4210133586","https://openalex.org/I166825849","https://openalex.org/I175532246","https://openalex.org/I166825849"]},{"raw_affiliation_string":"1 Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Esbo, Finland, 2 Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, MA, USA 3 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 4 Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, 5 Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, 6 NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 7 Department of Epidemiology and Biostatistics, MRC Health Protection, Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK, 8 Institute of Health Sciences, 9 Biocenter Oulu, University of Oulu, Oulu, 10 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, 11 Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere","institution_ids":["https://openalex.org/I9927081","https://openalex.org/I133731052","https://openalex.org/I4210126318","https://openalex.org/I98381234","https://openalex.org/I4210133586","https://openalex.org/I2799272722","https://openalex.org/I32943570","https://openalex.org/I166825849","https://openalex.org/I175532246"]}]}],"institution_assertions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3618,"currency":"USD","value_usd":3618,"provenance":"doaj"},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618,"provenance":"doaj"},"fwci":2.754,"has_fulltext":true,"fulltext_origin":"pdf","cited_by_count":35,"citation_normalized_percentile":{"value":0.917783,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":95},"biblio":{"volume":"30","issue":"14","first_page":"2026","last_page":"2034"},"is_retracted":false,"is_paratext":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9998,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9998,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.993,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9895,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/univariate","display_name":"Univariate","score":0.74683815},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide Association Study","score":0.5836704},{"id":"https://openalex.org/keywords/multiple-comparisons-problem","display_name":"Multiple comparisons problem","score":0.5043572},{"id":"https://openalex.org/keywords/snp","display_name":"SNP","score":0.5037605},{"id":"https://openalex.org/keywords/minor-allele-frequency","display_name":"Minor allele frequency","score":0.48099053},{"id":"https://openalex.org/keywords/genetic-association","display_name":"Genetic Association","score":0.44120672}],"concepts":[{"id":"https://openalex.org/C199163554","wikidata":"https://www.wikidata.org/wiki/Q1681619","display_name":"Univariate","level":3,"score":0.74683815},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.6581669},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.5836704},{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.5735457},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5635999},{"id":"https://openalex.org/C183905921","wikidata":"https://www.wikidata.org/wiki/Q1038757","display_name":"Multiple comparisons problem","level":2,"score":0.5043572},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.5037605},{"id":"https://openalex.org/C157410074","wikidata":"https://www.wikidata.org/wiki/Q6869145","display_name":"Minor allele frequency","level":5,"score":0.48099053},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.48019087},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4583487},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.44120672},{"id":"https://openalex.org/C83546350","wikidata":"https://www.wikidata.org/wiki/Q1139051","display_name":"Regression","level":2,"score":0.4216581},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.30619407},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.30291},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.27034494},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.097596794}],"mesh":[{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"","qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008074","descriptor_name":"Lipoproteins","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008074","descriptor_name":"Lipoproteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":"","qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btu140","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/30/14/2026/48925112/bioinformatics_30_14_2026.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311647","https://openalex.org/P4310311648"],"host_organization_lineage_names":["University of Oxford","Oxford University Press"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":true,"landing_page_url":"https://europepmc.org/articles/pmc4080737","pdf_url":"https://europepmc.org/articles/pmc4080737?pdf=render","source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":["European Bioinformatics Institute"],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":true,"landing_page_url":"https://trepo.tuni.fi/handle/10024/99803","pdf_url":"https://trepo.tuni.fi/bitstream/10024/99803/1/assessing_multivariate_gene-metabolome_2014.pdf","source":{"id":"https://openalex.org/S4306401860","display_name":"Tampere University Institutional Repository (Tampere University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I150589677","host_organization_name":"Tampere University of Applied Sciences","host_organization_lineage":["https://openalex.org/I150589677"],"host_organization_lineage_names":["Tampere University of Applied Sciences"],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080737","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":["National Institutes of Health"],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24665129","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":["National Institutes of Health"],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false}],"best_oa_location":{"is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btu140","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/30/14/2026/48925112/bioinformatics_30_14_2026.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311647","https://openalex.org/P4310311648"],"host_organization_lineage_names":["University of Oxford","Oxford University Press"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true},"sustainable_development_goals":[],"grants":[],"datasets":[],"versions":[],"referenced_works_count":44,"referenced_works":["https://openalex.org/W1601795611","https://openalex.org/W1663973292","https://openalex.org/W1964895626","https://openalex.org/W1967827763","https://openalex.org/W1971102564","https://openalex.org/W1982636457","https://openalex.org/W1992436001","https://openalex.org/W1997494129","https://openalex.org/W2007733142","https://openalex.org/W2008929650","https://openalex.org/W2023447826","https://openalex.org/W2025341678","https://openalex.org/W2026884584","https://openalex.org/W2027837618","https://openalex.org/W2029721016","https://openalex.org/W2036010272","https://openalex.org/W2036070913","https://openalex.org/W2044745456","https://openalex.org/W2045656233","https://openalex.org/W2048612325","https://openalex.org/W2071759640","https://openalex.org/W2078737216","https://openalex.org/W2096791516","https://openalex.org/W2099086736","https://openalex.org/W2102732029","https://openalex.org/W2110065044","https://openalex.org/W2115801316","https://openalex.org/W2123921851","https://openalex.org/W2128335879","https://openalex.org/W2143499400","https://openalex.org/W2143707047","https://openalex.org/W2146519949","https://openalex.org/W2149027279","https://openalex.org/W2153118028","https://openalex.org/W2153899794","https://openalex.org/W2157752701","https://openalex.org/W2163328685","https://openalex.org/W2163953557","https://openalex.org/W2166711199","https://openalex.org/W2169320928","https://openalex.org/W2169718193","https://openalex.org/W2171254004","https://openalex.org/W4232383088","https://openalex.org/W5609562"],"related_works":["https://openalex.org/W4296794555","https://openalex.org/W4214900737","https://openalex.org/W3201929063","https://openalex.org/W3198464064","https://openalex.org/W3132297604","https://openalex.org/W2331649876","https://openalex.org/W2157424635","https://openalex.org/W2148808569","https://openalex.org/W1601337698","https://openalex.org/W1587862541"],"abstract_inverted_index":{"A":[0,40],"typical":[1],"genome-wide":[2,192],"association":[3],"study":[4,234],"searches":[5],"for":[6,32,63,163,190,244],"associations":[7,25,165],"between":[8,26,49],"single":[9],"nucleotide":[10],"polymorphisms":[11],"(SNPs)":[12],"and":[13,29,53,157,176,209,235],"a":[14,20,46,57,119,125,143,218],"univariate":[15,47],"phenotype.":[16,145],"However,":[17,70],"there":[18],"is":[19,43,88,115,160],"growing":[21],"interest":[22],"to":[23,44,55,61,76,107,135,151],"investigate":[24],"genomics":[27],"data":[28,194],"multivariate":[30],"phenotypes,":[31,158],"example,":[33],"in":[34,84,117,217,231],"gene":[35],"expression":[36],"or":[37],"metabolomics":[38],"studies.":[39],"common":[41],"approach":[42,72,128],"perform":[45],"test":[48],"each":[50],"genotype-phenotype":[51],"pair,":[52],"then":[54],"apply":[56],"stringent":[58],"significance":[59],"cutoff":[60],"account":[62],"the":[64,85,89,92,98,101,112,137,148,171,182,228,239],"large":[65],"number":[66,121],"of":[67,91,94,109,122,139,147,173,221],"tests":[68],"performed.":[69],"this":[71],"has":[73],"limited":[74,120],"ability":[75,150],"uncover":[77],"dependencies":[78],"involving":[79,166],"multiple":[80,140,155],"variables.":[81],"Another":[82],"trend":[83],"current":[86],"genetics":[87],"investigation":[90],"impact":[93,138],"rare":[95,167],"variants":[96],"on":[97,130,142],"phenotype,":[99],"where":[100],"standard":[102],"methods":[103],"often":[104],"fail":[105],"owing":[106],"lack":[108],"power":[110],"when":[111],"minor":[113],"allele":[114],"present":[116],"only":[118],"individuals.We":[123],"propose":[124],"new":[126],"statistical":[127],"based":[129],"Bayesian":[131],"reduced":[132],"rank":[133],"regression":[134],"assess":[136],"SNPs":[141,156],"high-dimensional":[144],"Because":[146],"method's":[149],"combine":[152],"information":[153],"over":[154],"it":[159,178],"particularly":[161],"suitable":[162],"detecting":[164],"variants.":[168],"We":[169,204],"demonstrate":[170],"potential":[172],"our":[174],"method":[175],"compare":[177],"with":[179,187,196],"alternatives":[180],"using":[181],"Northern":[183],"Finland":[184],"Birth":[185],"Cohort":[186],"4702":[188],"individuals,":[189],"whom":[191],"SNP":[193],"along":[195],"lipoprotein":[197],"profiles":[198],"comprising":[199],"74":[200],"traits":[201],"are":[202],"available.":[203],"discovered":[205],"two":[206,222],"genes":[207],"(XRCC4":[208],"MTHFD2L)":[210],"without":[211],"previously":[212],"reported":[213],"associations,":[214],"which":[215],"replicated":[216],"combined":[219],"analysis":[220],"additional":[223],"cohorts:":[224],"2390":[225],"individuals":[226,237],"from":[227,238],"Cardiovascular":[229],"Risk":[230],"Young":[232],"Finns":[233],"3659":[236],"FINRISK":[240],"study.R-code":[241],"freely":[242],"available":[243],"download":[245],"at":[246],"http://users.ics.aalto.fi/pemartti/gene_metabolome/.":[247]},"cited_by_api_url":"https://api.openalex.org/works?filter=cites:W2108530422","counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1}],"updated_date":"2024-12-08T18:59:28.864300","created_date":"2016-06-24"}