{"id":"https://openalex.org/W2160864684","doi":"https://doi.org/10.1093/bioinformatics/btl617","title":"In silicoidentification of putative metal binding motifs","display_name":"In silicoidentification of putative metal binding motifs","publication_year":2006,"publication_date":"2006-11-05","ids":{"openalex":"https://openalex.org/W2160864684","doi":"https://doi.org/10.1093/bioinformatics/btl617","mag":"2160864684","pmid":"https://pubmed.ncbi.nlm.nih.gov/17148509"},"language":"en","primary_location":{"is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btl617","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/23/3/267/49829195/bioinformatics_23_3_267.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_indexed_in_scopus":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311647","https://openalex.org/P4310311648"],"host_organization_lineage_names":["University of Oxford","Oxford University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true},"type":"article","type_crossref":"journal-article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/23/3/267/49829195/bioinformatics_23_3_267.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052163729","display_name":"Richard Thilakaraj","orcid":null},"institutions":[{"id":"https://openalex.org/I33585257","display_name":"Anna University, Chennai","ror":"https://ror.org/01qhf1r47","country_code":"IN","type":"funder","lineage":["https://openalex.org/I33585257"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Richard Thilakaraj","raw_affiliation_strings":["Centre for Biotechnology, Anna University \u00a0 Chennai, 600 025, India"],"affiliations":[{"raw_affiliation_string":"Centre for Biotechnology, Anna University \u00a0 Chennai, 600 025, India","institution_ids":["https://openalex.org/I33585257"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015517782","display_name":"Krishnan Raghunathan","orcid":"https://orcid.org/0000-0003-2228-6313"},"institutions":[{"id":"https://openalex.org/I33585257","display_name":"Anna University, Chennai","ror":"https://ror.org/01qhf1r47","country_code":"IN","type":"funder","lineage":["https://openalex.org/I33585257"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Krishnan Raghunathan","raw_affiliation_strings":["Centre for Biotechnology, Anna University \u00a0 Chennai, 600 025, India"],"affiliations":[{"raw_affiliation_string":"Centre for Biotechnology, Anna University \u00a0 Chennai, 600 025, India","institution_ids":["https://openalex.org/I33585257"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055777341","display_name":"Sharmila Anishetty","orcid":"https://orcid.org/0000-0003-1311-2709"},"institutions":[{"id":"https://openalex.org/I33585257","display_name":"Anna University, Chennai","ror":"https://ror.org/01qhf1r47","country_code":"IN","type":"funder","lineage":["https://openalex.org/I33585257"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Sharmila Anishetty","raw_affiliation_strings":["Centre for Biotechnology, Anna University \u00a0 Chennai, 600 025, India"],"affiliations":[{"raw_affiliation_string":"Centre for Biotechnology, Anna University \u00a0 Chennai, 600 025, India","institution_ids":["https://openalex.org/I33585257"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041046630","display_name":"Gautam Pennathur","orcid":"https://orcid.org/0000-0003-3140-3796"},"institutions":[{"id":"https://openalex.org/I33585257","display_name":"Anna University, Chennai","ror":"https://ror.org/01qhf1r47","country_code":"IN","type":"funder","lineage":["https://openalex.org/I33585257"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Gautam Pennathur","raw_affiliation_strings":["Centre for Biotechnology, Anna University \u00a0 Chennai, 600 025, India"],"affiliations":[{"raw_affiliation_string":"Centre for Biotechnology, Anna University \u00a0 Chennai, 600 025, India","institution_ids":["https://openalex.org/I33585257"]}]}],"institution_assertions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5055777341","https://openalex.org/A5041046630"],"corresponding_institution_ids":["https://openalex.org/I33585257","https://openalex.org/I33585257"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":0.251,"has_fulltext":true,"fulltext_origin":"ngrams","cited_by_count":26,"citation_normalized_percentile":{"value":0.781228,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":89},"biblio":{"volume":"23","issue":"3","first_page":"267","last_page":"271"},"is_retracted":false,"is_paratext":false,"primary_topic":{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.9946,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.9946,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11626","display_name":"Metalloenzymes and iron-sulfur proteins","score":0.9797,"subfield":{"id":"https://openalex.org/subfields/2105","display_name":"Renewable Energy, Sustainability and the Environment"},"field":{"id":"https://openalex.org/fields/21","display_name":"Energy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.978,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/identification","display_name":"Identification","score":0.67766565}],"concepts":[{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.8709825},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.68421805},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.67766565},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.42382944},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3674631},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.33503163},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30264527},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16137058},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008667","descriptor_name":"Metalloproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008670","descriptor_name":"Metals","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008667","descriptor_name":"Metalloproteins","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008670","descriptor_name":"Metals","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":"","qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btl617","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/23/3/267/49829195/bioinformatics_23_3_267.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_indexed_in_scopus":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311647","https://openalex.org/P4310311648"],"host_organization_lineage_names":["University of Oxford","Oxford University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17148509","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_indexed_in_scopus":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":["National Institutes of Health"],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false}],"best_oa_location":{"is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btl617","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/23/3/267/49829195/bioinformatics_23_3_267.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_indexed_in_scopus":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311647","https://openalex.org/P4310311648"],"host_organization_lineage_names":["University of Oxford","Oxford University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true},"sustainable_development_goals":[],"grants":[],"datasets":[],"versions":[],"referenced_works_count":53,"referenced_works":["https://openalex.org/W1503466211","https://openalex.org/W1529325755","https://openalex.org/W1562772426","https://openalex.org/W1580356236","https://openalex.org/W1602652285","https://openalex.org/W1811709262","https://openalex.org/W1964040326","https://openalex.org/W1964917040","https://openalex.org/W1965932921","https://openalex.org/W1968039127","https://openalex.org/W1975648862","https://openalex.org/W1985792227","https://openalex.org/W1990040289","https://openalex.org/W1990601671","https://openalex.org/W1995357525","https://openalex.org/W1995981903","https://openalex.org/W1996160340","https://openalex.org/W1997118025","https://openalex.org/W2009339389","https://openalex.org/W2012302404","https://openalex.org/W2026849306","https://openalex.org/W2029696125","https://openalex.org/W2042375473","https://openalex.org/W2045646349","https://openalex.org/W2048011909","https://openalex.org/W2060647701","https://openalex.org/W2061636126","https://openalex.org/W2063982943","https://openalex.org/W2066006292","https://openalex.org/W2067254817","https://openalex.org/W2071921751","https://openalex.org/W2076210046","https://openalex.org/W2080604158","https://openalex.org/W2081663028","https://openalex.org/W2087985880","https://openalex.org/W2090016283","https://openalex.org/W2095093199","https://openalex.org/W2097382368","https://openalex.org/W2104056430","https://openalex.org/W2111683404","https://openalex.org/W2113755389","https://openalex.org/W2117019496","https://openalex.org/W2120218267","https://openalex.org/W2120808613","https://openalex.org/W2130479394","https://openalex.org/W2133067229","https://openalex.org/W2134115525","https://openalex.org/W2143173841","https://openalex.org/W2160769697","https://openalex.org/W2161062388","https://openalex.org/W2163352757","https://openalex.org/W4388245583","https://openalex.org/W64749174"],"related_works":["https://openalex.org/W4313128508","https://openalex.org/W4237480606","https://openalex.org/W2936968863","https://openalex.org/W2513589746","https://openalex.org/W2213189664","https://openalex.org/W2153919606","https://openalex.org/W2084707189","https://openalex.org/W2062254828","https://openalex.org/W2003194288","https://openalex.org/W1971792277"],"abstract_inverted_index":{"Abstract":[0],"Metal":[1],"ion":[2],"binding":[3,30,37],"domains":[4],"are":[5],"found":[6],"in":[7,25,65],"proteins":[8,31],"that":[9],"mediate":[10],"transport,":[11],"buffering":[12],"or":[13],"detoxification":[14],"of":[15,28,42,71],"metal":[16,29,36],"ions.":[17],"In":[18],"this":[19],"study,":[20],"we":[21],"have":[22,33],"performed":[23],"an":[24],"silico":[26],"analysis":[27],"and":[32,51,59,81],"identified":[34],"putative":[35],"motifs":[38],"for":[39],"the":[40,57,69,72],"ions":[41],"cadmium,":[43],"cobalt,":[44],"zinc,":[45],"arsenic,":[46],"mercury,":[47],"magnesium,":[48],"manganese,":[49],"molybdenum":[50],"nickel.":[52],"A":[53],"pattern":[54],"search":[55],"against":[56,78],"UniProtKB/Swiss-Prot":[58],"UniProtKB/TrEMBL":[60],"databases":[61],"yielded":[62],"true":[63],"positives":[64],"each":[66],"case":[67],"showing":[68],"high-specificity":[70],"motifs.":[73],"Motifs":[74],"were":[75],"also":[76],"validated":[77],"PDB":[79],"structures":[80],"site":[82],"directed":[83],"mutagenesis":[84],"studies.":[85],"Contact:":[86],"pgautam@annauniv.edu;":[87],"s_anishetty@yahoo.co.uk":[88]},"abstract_inverted_index_v3":null,"cited_by_api_url":"https://api.openalex.org/works?filter=cites:W2160864684","counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":1}],"updated_date":"2025-05-01T07:44:03.336855","created_date":"2016-06-24"}