{"id":"https://openalex.org/W4401499954","doi":"https://doi.org/10.1093/bib/bbae393","title":"Synthesis of geometrically realistic and watertight neuronal ultrastructure manifolds for in silico modeling","display_name":"Synthesis of geometrically realistic and watertight neuronal ultrastructure manifolds for in silico modeling","publication_year":2024,"publication_date":"2024-07-25","ids":{"openalex":"https://openalex.org/W4401499954","doi":"https://doi.org/10.1093/bib/bbae393","pmid":"https://pubmed.ncbi.nlm.nih.gov/39129363"},"language":"en","primary_location":{"is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae393","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311647","https://openalex.org/P4310311648"],"host_organization_lineage_names":["University of Oxford","Oxford University Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true},"type":"article","type_crossref":"journal-article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1093/bib/bbae393","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011611586","display_name":"Marwan Abdellah","orcid":"https://orcid.org/0000-0003-0751-2300"},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Marwan Abdellah","raw_affiliation_strings":["Blue Brain Project , \u00c9cole Polytecnique F\u00e9d\u00e9rale de Lausanne (EPFL), Campus Biotech, Chemin des Mines 9, Gen\u00e8ve 1202, Switzerland"],"affiliations":[{"raw_affiliation_string":"Blue Brain Project , \u00c9cole Polytecnique F\u00e9d\u00e9rale de Lausanne (EPFL), Campus Biotech, Chemin des Mines 9, Gen\u00e8ve 1202, Switzerland","institution_ids":["https://openalex.org/I5124864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014288688","display_name":"Alessandro Foni","orcid":null},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Alessandro Foni","raw_affiliation_strings":["Blue Brain Project , \u00c9cole Polytecnique F\u00e9d\u00e9rale de Lausanne (EPFL), Campus Biotech, Chemin des Mines 9, Gen\u00e8ve 1202, Switzerland"],"affiliations":[{"raw_affiliation_string":"Blue Brain Project , \u00c9cole Polytecnique F\u00e9d\u00e9rale de Lausanne (EPFL), Campus Biotech, Chemin des Mines 9, Gen\u00e8ve 1202, Switzerland","institution_ids":["https://openalex.org/I5124864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073776466","display_name":"Juan Jos\u00e9 Garc\u00eda Cantero","orcid":null},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Juan Jos\u00e9 Garc\u00eda Cantero","raw_affiliation_strings":["Blue Brain Project , \u00c9cole Polytecnique F\u00e9d\u00e9rale de Lausanne (EPFL), Campus Biotech, Chemin des Mines 9, Gen\u00e8ve 1202, Switzerland"],"affiliations":[{"raw_affiliation_string":"Blue Brain Project , \u00c9cole Polytecnique F\u00e9d\u00e9rale de Lausanne (EPFL), Campus Biotech, Chemin des Mines 9, Gen\u00e8ve 1202, Switzerland","institution_ids":["https://openalex.org/I5124864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033440393","display_name":"Nadir Rom\u00e1n Guerrero","orcid":"https://orcid.org/0000-0001-7528-2549"},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Nadir Rom\u00e1n Guerrero","raw_affiliation_strings":["Blue Brain Project , \u00c9cole Polytecnique F\u00e9d\u00e9rale de Lausanne (EPFL), Campus Biotech, Chemin des Mines 9, Gen\u00e8ve 1202, Switzerland"],"affiliations":[{"raw_affiliation_string":"Blue Brain Project , \u00c9cole Polytecnique F\u00e9d\u00e9rale de Lausanne (EPFL), Campus Biotech, Chemin des Mines 9, Gen\u00e8ve 1202, Switzerland","institution_ids":["https://openalex.org/I5124864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091973366","display_name":"Elvis Boci","orcid":"https://orcid.org/0009-0002-5871-4164"},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Elvis Boci","raw_affiliation_strings":["Blue Brain Project , \u00c9cole Polytecnique F\u00e9d\u00e9rale de Lausanne (EPFL), Campus Biotech, Chemin des Mines 9, Gen\u00e8ve 1202, Switzerland"],"affiliations":[{"raw_affiliation_string":"Blue Brain Project , \u00c9cole Polytecnique F\u00e9d\u00e9rale de Lausanne (EPFL), Campus Biotech, Chemin des Mines 9, Gen\u00e8ve 1202, Switzerland","institution_ids":["https://openalex.org/I5124864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084061510","display_name":"Adrien Christian Fleury","orcid":null},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Adrien Fleury","raw_affiliation_strings":["Blue Brain Project , \u00c9cole Polytecnique F\u00e9d\u00e9rale de Lausanne (EPFL), Campus Biotech, Chemin des Mines 9, Gen\u00e8ve 1202, Switzerland"],"affiliations":[{"raw_affiliation_string":"Blue Brain Project , \u00c9cole Polytecnique F\u00e9d\u00e9rale de Lausanne (EPFL), Campus Biotech, Chemin des Mines 9, Gen\u00e8ve 1202, Switzerland","institution_ids":["https://openalex.org/I5124864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026765183","display_name":"Jay S. Coggan","orcid":"https://orcid.org/0000-0002-2270-1989"},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Jay S Coggan","raw_affiliation_strings":["Blue Brain Project , \u00c9cole Polytecnique F\u00e9d\u00e9rale de Lausanne (EPFL), Campus Biotech, Chemin des Mines 9, Gen\u00e8ve 1202, Switzerland"],"affiliations":[{"raw_affiliation_string":"Blue Brain Project , \u00c9cole Polytecnique F\u00e9d\u00e9rale de Lausanne (EPFL), Campus Biotech, Chemin des Mines 9, Gen\u00e8ve 1202, Switzerland","institution_ids":["https://openalex.org/I5124864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064154590","display_name":"Daniel Keller","orcid":"https://orcid.org/0000-0003-3280-6255"},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Daniel Keller","raw_affiliation_strings":["Blue Brain Project , \u00c9cole Polytecnique F\u00e9d\u00e9rale de Lausanne (EPFL), Campus Biotech, Chemin des Mines 9, Gen\u00e8ve 1202, Switzerland"],"affiliations":[{"raw_affiliation_string":"Blue Brain Project , \u00c9cole Polytecnique F\u00e9d\u00e9rale de Lausanne (EPFL), Campus Biotech, Chemin des Mines 9, Gen\u00e8ve 1202, Switzerland","institution_ids":["https://openalex.org/I5124864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066561858","display_name":"Judit Planas","orcid":"https://orcid.org/0000-0002-8221-7988"},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Judit Planas","raw_affiliation_strings":["Blue Brain Project , \u00c9cole Polytecnique F\u00e9d\u00e9rale de Lausanne (EPFL), Campus Biotech, Chemin des Mines 9, Gen\u00e8ve 1202, Switzerland"],"affiliations":[{"raw_affiliation_string":"Blue Brain Project , \u00c9cole Polytecnique F\u00e9d\u00e9rale de Lausanne (EPFL), Campus Biotech, Chemin des Mines 9, Gen\u00e8ve 1202, Switzerland","institution_ids":["https://openalex.org/I5124864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056584440","display_name":"Jean-Denis Courcol","orcid":"https://orcid.org/0000-0002-9351-1461"},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Jean-Denis Courcol","raw_affiliation_strings":["Blue Brain Project , \u00c9cole Polytecnique F\u00e9d\u00e9rale de Lausanne (EPFL), Campus Biotech, Chemin des Mines 9, Gen\u00e8ve 1202, Switzerland"],"affiliations":[{"raw_affiliation_string":"Blue Brain Project , \u00c9cole Polytecnique F\u00e9d\u00e9rale de Lausanne (EPFL), Campus Biotech, Chemin des Mines 9, Gen\u00e8ve 1202, Switzerland","institution_ids":["https://openalex.org/I5124864"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003912229","display_name":"Georges Khazen","orcid":"https://orcid.org/0000-0002-9244-2978"},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Georges Khazen","raw_affiliation_strings":["Blue Brain Project , \u00c9cole Polytecnique F\u00e9d\u00e9rale de Lausanne (EPFL), Campus Biotech, Chemin des Mines 9, Gen\u00e8ve 1202, Switzerland"],"affiliations":[{"raw_affiliation_string":"Blue Brain Project , \u00c9cole Polytecnique F\u00e9d\u00e9rale de Lausanne (EPFL), Campus Biotech, Chemin des Mines 9, Gen\u00e8ve 1202, Switzerland","institution_ids":["https://openalex.org/I5124864"]}]}],"institution_assertions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4011,"currency":"USD","value_usd":4011,"provenance":"doaj"},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011,"provenance":"doaj"},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":0,"max":84},"biblio":{"volume":"25","issue":"5","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9999,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9999,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9951,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9829,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness","score":0.710634}],"concepts":[{"id":"https://openalex.org/C31487907","wikidata":"https://www.wikidata.org/wiki/Q1154597","display_name":"Polygon mesh","level":2,"score":0.88153857},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7158636},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.710634},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5715443},{"id":"https://openalex.org/C48044578","wikidata":"https://www.wikidata.org/wiki/Q727490","display_name":"Scalability","level":2,"score":0.5680049},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.45570454},{"id":"https://openalex.org/C459310","wikidata":"https://www.wikidata.org/wiki/Q117801","display_name":"Computational science","level":1,"score":0.43160877},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.3394856},{"id":"https://openalex.org/C121684516","wikidata":"https://www.wikidata.org/wiki/Q7600677","display_name":"Computer graphics (images)","level":1,"score":0.22202617},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14936942},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.13615265},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false}],"locations_count":3,"locations":[{"is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae393","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311647","https://openalex.org/P4310311648"],"host_organization_lineage_names":["University of Oxford","Oxford University Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11317524","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":["National Institutes of Health"],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39129363","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":["National Institutes of Health"],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false}],"best_oa_location":{"is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae393","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311647","https://openalex.org/P4310311648"],"host_organization_lineage_names":["University of Oxford","Oxford University Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/14","score":0.8,"display_name":"Life below water"}],"grants":[{"funder":"https://openalex.org/F4320322320","funder_display_name":"King Abdullah University of Science and Technology","award_id":"OSR-2017-CRG6-3438"}],"datasets":[],"versions":[],"referenced_works_count":39,"referenced_works":["https://openalex.org/W1584095431","https://openalex.org/W1592074189","https://openalex.org/W1921182138","https://openalex.org/W1981504555","https://openalex.org/W1982365464","https://openalex.org/W1986482900","https://openalex.org/W1987927468","https://openalex.org/W1993556615","https://openalex.org/W2002386777","https://openalex.org/W2004430398","https://openalex.org/W2010575732","https://openalex.org/W2018986990","https://openalex.org/W2061186544","https://openalex.org/W2061628168","https://openalex.org/W2077346271","https://openalex.org/W2107373448","https://openalex.org/W2109991971","https://openalex.org/W2114240651","https://openalex.org/W2117120818","https://openalex.org/W2119848151","https://openalex.org/W2139815948","https://openalex.org/W2143816834","https://openalex.org/W2193304014","https://openalex.org/W2508450936","https://openalex.org/W2570603060","https://openalex.org/W2608086886","https://openalex.org/W2681183998","https://openalex.org/W2734512521","https://openalex.org/W2809944305","https://openalex.org/W2810701990","https://openalex.org/W2892622821","https://openalex.org/W2911934184","https://openalex.org/W2971430069","https://openalex.org/W3025050472","https://openalex.org/W3092291918","https://openalex.org/W3178088103","https://openalex.org/W3192633652","https://openalex.org/W4288046563","https://openalex.org/W4307553486"],"related_works":["https://openalex.org/W4388257798","https://openalex.org/W3183639206","https://openalex.org/W3129816939","https://openalex.org/W2985427592","https://openalex.org/W2912862995","https://openalex.org/W2366350639","https://openalex.org/W2365659824","https://openalex.org/W2087496541","https://openalex.org/W2044628889","https://openalex.org/W1557607869"],"abstract_inverted_index":{"Understanding":[0],"the":[1],"intracellular":[2],"dynamics":[3],"of":[4,29,80,88,98,108,115],"brain":[5],"cells":[6],"entails":[7],"performing":[8],"three-dimensional":[9],"molecular":[10],"simulations":[11,154],"incorporating":[12],"ultrastructural":[13],"models":[14],"that":[15,129],"can":[16],"capture":[17],"cellular":[18,157],"membrane":[19],"geometries":[20],"at":[21],"nanometer":[22],"scales.":[23],"While":[24],"there":[25],"is":[26,51,101,120,165],"an":[27,73],"abundance":[28],"neuronal":[30,54],"morphologies":[31,128],"available":[32],"online,":[33],"e.g.":[34],"from":[35,92],"NeuroMorpho.Org,":[36],"converting":[37],"those":[38],"fairly":[39],"abstract":[40],"point-and-diameter":[41],"representations":[42],"into":[43],"geometrically":[44,82],"realistic":[45,83],"and":[46,75,84,123,161],"simulation-ready,":[47],"i.e.":[48],"watertight,":[49],"manifolds":[50,87],"challenging.":[52],"Many":[53],"mesh":[55],"reconstruction":[56],"methods":[57],"have":[58],"been":[59],"proposed;":[60],"however,":[61],"their":[62,93],"resulting":[63],"meshes":[64,137,144],"are":[65,130,138],"either":[66],"biologically":[67],"unplausible":[68],"or":[69],"non-watertight.":[70],"We":[71],"present":[72],"effective":[74],"unconditionally":[76],"robust":[77],"method":[78,100,164],"capable":[79],"generating":[81],"watertight":[85],"surface":[86],"spiny":[89],"cortical":[90,109],"neurons":[91,110],"morphological":[94,116],"descriptions.":[95],"The":[96,118],"robustness":[97],"our":[99],"assessed":[102],"based":[103],"on":[104],"a":[105,112,169],"mixed":[106],"dataset":[107],"with":[111,145],"wide":[113],"variety":[114],"classes.":[117],"implementation":[119],"seamlessly":[121],"extended":[122],"applied":[124],"to":[125,141,148],"synthetic":[126],"astrocytic":[127],"also":[131],"plausibly":[132],"biological":[133],"in":[134,151,167],"detail.":[135],"Resulting":[136],"ultimately":[139],"used":[140],"create":[142],"volumetric":[143],"tetrahedral":[146],"domains":[147],"perform":[149],"scalable":[150],"silico":[152],"reaction-diffusion":[153],"for":[155,179],"revealing":[156],"structure-function":[158],"relationships.":[159],"Availability":[160],"implementation:":[162],"Our":[163],"implemented":[166],"NeuroMorphoVis,":[168],"neuroscience-specific":[170],"open":[171],"source":[172],"Blender":[173],"add-on,":[174],"making":[175],"it":[176],"freely":[177],"accessible":[178],"neuroscience":[180],"researchers.":[181]},"cited_by_api_url":"https://api.openalex.org/works?filter=cites:W4401499954","counts_by_year":[],"updated_date":"2024-12-16T23:27:22.400120","created_date":"2024-08-12"}