乐胖代购免代理版

{"id":"https://openalex.org/W4225504409","doi":"https://doi.org/10.1093/bib/bbac115","title":"Fast heritability estimation based on MINQUE and batch training","display_name":"Fast heritability estimation based on MINQUE and batch training","publication_year":2022,"publication_date":"2022-04-05","ids":{"openalex":"https://openalex.org/W4225504409","doi":"https://doi.org/10.1093/bib/bbac115","pmid":"https://pubmed.ncbi.nlm.nih.gov/35383355"},"language":"en","primary_location":{"is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbac115","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311647","https://openalex.org/P4310311648"],"host_organization_lineage_names":["University of Oxford","Oxford University Press"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false},"type":"article","type_crossref":"journal-article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045910129","display_name":"Mingsheng Tang","orcid":null},"institutions":[{"id":"https://openalex.org/I17721919","display_name":"Shanxi Medical University","ror":"https://ror.org/0265d1010","country_code":"CN","type":"education","lineage":["https://openalex.org/I17721919"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingsheng Tang","raw_affiliation_strings":["Division of Health Statistics, School of Public Health, Shanxi Medical University, No.56 Xin jian South Road, 030001 Shanxi, China"],"affiliations":[{"raw_affiliation_string":"Division of Health Statistics, School of Public Health, Shanxi Medical University, No.56 Xin jian South Road, 030001 Shanxi, China","institution_ids":["https://openalex.org/I17721919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102814297","display_name":"Tingting Hou","orcid":"https://orcid.org/0000-0003-2614-8145"},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tingting Hou","raw_affiliation_strings":["Department of Biostatistics, University of Florida, 2004 Mowry Road, 32611 FL, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University of Florida, 2004 Mowry Road, 32611 FL, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041755127","display_name":"Xiaoran Tong","orcid":"https://orcid.org/0000-0002-4648-3330"},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoran Tong","raw_affiliation_strings":["Department of Biostatistics, University of Florida, 2004 Mowry Road, 32611 FL, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University of Florida, 2004 Mowry Road, 32611 FL, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100624448","display_name":"Xiaoxi Shen","orcid":"https://orcid.org/0000-0001-6424-1426"},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoxi Shen","raw_affiliation_strings":["Department of Biostatistics, University of Florida, 2004 Mowry Road, 32611 FL, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University of Florida, 2004 Mowry Road, 32611 FL, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102909473","display_name":"Zhang Xue-fen","orcid":"https://orcid.org/0000-0001-9163-5586"},"institutions":[{"id":"https://openalex.org/I17721919","display_name":"Shanxi Medical University","ror":"https://ror.org/0265d1010","country_code":"CN","type":"education","lineage":["https://openalex.org/I17721919"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuefen Zhang","raw_affiliation_strings":["Social Medicine, School of Public Health, Shanxi Medical University,No.56 Xin jian South Road, 030001 Shanxi, China"],"affiliations":[{"raw_affiliation_string":"Social Medicine, School of Public Health, Shanxi Medical University,No.56 Xin jian South Road, 030001 Shanxi, China","institution_ids":["https://openalex.org/I17721919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100451016","display_name":"Tong Wang","orcid":"https://orcid.org/0000-0002-9403-7167"},"institutions":[{"id":"https://openalex.org/I17721919","display_name":"Shanxi Medical University","ror":"https://ror.org/0265d1010","country_code":"CN","type":"education","lineage":["https://openalex.org/I17721919"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Tong Wang","raw_affiliation_strings":["Division of Health Statistics, School of Public Health, Shanxi Medical University, No.56 Xin jian South Road, 030001 Shanxi, China"],"affiliations":[{"raw_affiliation_string":"Division of Health Statistics, School of Public Health, Shanxi Medical University, No.56 Xin jian South Road, 030001 Shanxi, China","institution_ids":["https://openalex.org/I17721919"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085071632","display_name":"Qing Lu","orcid":"https://orcid.org/0000-0002-7943-966X"},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Qing Lu","raw_affiliation_strings":["Department of Biostatistics, University of Florida, 2004 Mowry Road, 32611 FL, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University of Florida, 2004 Mowry Road, 32611 FL, USA","institution_ids":["https://openalex.org/I33213144"]}]}],"institution_assertions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100451016","https://openalex.org/A5085071632"],"corresponding_institution_ids":["https://openalex.org/I17721919","https://openalex.org/I33213144"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011,"provenance":"doaj"},"apc_paid":null,"fwci":0.191,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.390874,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":70,"max":76},"biblio":{"volume":"23","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"primary_topic":{"id":"https://openalex.org/T11201","display_name":"Metallurgy and Material Forming","score":0.8806,"subfield":{"id":"https://openalex.org/subfields/2211","display_name":"Mechanics of Materials"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11201","display_name":"Metallurgy and Material Forming","score":0.8806,"subfield":{"id":"https://openalex.org/subfields/2211","display_name":"Mechanics of Materials"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13717","display_name":"Advanced Algorithms and Applications","score":0.8455,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10057","display_name":"Face and Expression Recognition","score":0.8365,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/training-set","display_name":"Training set","score":0.46968108}],"concepts":[{"id":"https://openalex.org/C96250715","wikidata":"https://www.wikidata.org/wiki/Q965330","display_name":"Estimation","level":2,"score":0.5310177},{"id":"https://openalex.org/C161890455","wikidata":"https://www.wikidata.org/wiki/Q1503548","display_name":"Heritability","level":2,"score":0.5246135},{"id":"https://openalex.org/C51632099","wikidata":"https://www.wikidata.org/wiki/Q3985153","display_name":"Training set","level":2,"score":0.46968108},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.42271432},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35617197},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.33827928},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1311444},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.07720435},{"id":"https://openalex.org/C201995342","wikidata":"https://www.wikidata.org/wiki/Q682496","display_name":"Systems engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"","qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":"","qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"","qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbac115","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311647","https://openalex.org/P4310311648"],"host_organization_lineage_names":["University of Oxford","Oxford University Press"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false},{"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35383355","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":["National Institutes of Health"],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/17","score":0.44,"display_name":"Partnerships for the goals"}],"grants":[],"datasets":[],"versions":[],"referenced_works_count":34,"referenced_works":["https://openalex.org/W1966775465","https://openalex.org/W1966932096","https://openalex.org/W1980991473","https://openalex.org/W1982387893","https://openalex.org/W1983539381","https://openalex.org/W1993849755","https://openalex.org/W1997887791","https://openalex.org/W2000084758","https://openalex.org/W2000486953","https://openalex.org/W2013274313","https://openalex.org/W2033151532","https://openalex.org/W2040924786","https://openalex.org/W2044964157","https://openalex.org/W2079927753","https://openalex.org/W2082704080","https://openalex.org/W2086799994","https://openalex.org/W2099085143","https://openalex.org/W2110808585","https://openalex.org/W2155496693","https://openalex.org/W2157752701","https://openalex.org/W2163953557","https://openalex.org/W2167638767","https://openalex.org/W2168354474","https://openalex.org/W2170917431","https://openalex.org/W2188707104","https://openalex.org/W2559028527","https://openalex.org/W2591693479","https://openalex.org/W2617742891","https://openalex.org/W2725988230","https://openalex.org/W2737435306","https://openalex.org/W2773459529","https://openalex.org/W2895486342","https://openalex.org/W2909346791","https://openalex.org/W2949626150"],"related_works":["https://openalex.org/W3152090159","https://openalex.org/W2788277189","https://openalex.org/W2281560785","https://openalex.org/W2130076355","https://openalex.org/W2119695867","https://openalex.org/W2082860237","https://openalex.org/W2046158694","https://openalex.org/W2013243191","https://openalex.org/W1993764875","https://openalex.org/W1990804418"],"abstract_inverted_index":{"Abstract":[0],"Heritability,":[1],"the":[2,22,35,88,118,147],"proportion":[3],"of":[4,21,38,91],"phenotypic":[5],"variance":[6,54,111],"explained":[7],"by":[8,60,122],"genome-wide":[9],"single":[10],"nucleotide":[11],"polymorphisms":[12],"(SNPs)":[13],"in":[14,33,143],"unrelated":[15],"individuals,":[16],"is":[17,69,75,163],"an":[18,70],"important":[19],"measure":[20],"genetic":[23,36,93,151],"contribution":[24],"to":[25,80,109,145],"human":[26,39],"diseases":[27],"and":[28,132,155,171],"plays":[29],"a":[30,62,97,126],"critical":[31],"role":[32],"studying":[34],"architecture":[37],"diseases.":[40],"Linear":[41],"mixed":[42],"model":[43],"(LMM)":[44],"has":[45,125,133,139],"been":[46,141],"widely":[47],"used":[48],"for":[49,129,149],"SNP":[50],"heritability":[51,89],"estimation,":[52],"where":[53],"component":[55],"parameters":[56,119],"are":[57,120],"commonly":[58],"estimated":[59,121],"using":[61],"restricted":[63],"maximum":[64],"likelihood":[65],"(REML)":[66],"method.":[67],"REML":[68],"iterative":[71],"optimization":[72],"algorithm,":[73],"which":[74,124],"computationally":[76],"intensive":[77],"when":[78],"applied":[79],"large-scale":[81,92,150],"datasets":[82],"(e.g.":[83],"UK":[84],"Biobank).":[85],"To":[86],"facilitate":[87],"analysis":[90],"datasets,":[94],"we":[95,159],"develop":[96],"fast":[98,130],"approach,":[99],"minimum":[100],"norm":[101],"quadratic":[102],"unbiased":[103],"estimator":[104],"(MINQUE)":[105],"with":[106],"batch":[107],"training,":[108],"estimate":[110],"components":[112],"from":[113],"LMM":[114],"(LMM.MNQ.BCH).":[115],"In":[116],"LMM.MNQ.BCH,":[117],"MINQUE,":[123],"closed-form":[127],"solution":[128],"computation":[131,148],"no":[134],"convergence":[135],"issue.":[136],"Batch":[137],"training":[138],"also":[140],"adopted":[142],"LMM.MNQ.BCH":[144,162],"accelerate":[146],"datasets.":[152],"Through":[153],"simulations":[154],"real":[156],"data":[157],"analysis,":[158],"demonstrate":[160],"that":[161],"much":[164],"faster":[165],"than":[166],"two":[167],"existing":[168],"approaches,":[169],"GCTA":[170],"BOLT-REML.":[172]},"cited_by_api_url":"https://api.openalex.org/works?filter=cites:W4225504409","counts_by_year":[{"year":2024,"cited_by_count":2}],"updated_date":"2025-01-07T01:12:31.867245","created_date":"2022-05-05"}