{"id":"https://openalex.org/W3130228814","doi":"https://doi.org/10.1093/bib/bbab026","title":"Identification of biomarkers and pathways for the SARS-CoV-2 infections that make complexities in pulmonary arterial hypertension patients","display_name":"Identification of biomarkers and pathways for the SARS-CoV-2 infections that make complexities in pulmonary arterial hypertension patients","publication_year":2021,"publication_date":"2021-01-23","ids":{"openalex":"https://openalex.org/W3130228814","doi":"https://doi.org/10.1093/bib/bbab026","mag":"3130228814","pmid":"https://pubmed.ncbi.nlm.nih.gov/33611340","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7929374"},"language":"en","primary_location":{"is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbab026","pdf_url":"https://academic.oup.com/bib/article-pdf/22/2/1451/36655578/bbab026.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311647","https://openalex.org/P4310311648"],"host_organization_lineage_names":["University of Oxford","Oxford University Press"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true},"type":"article","type_crossref":"journal-article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bib/article-pdf/22/2/1451/36655578/bbab026.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041906527","display_name":"Tasnimul Alam Taz","orcid":"https://orcid.org/0000-0003-3557-8737"},"institutions":[{"id":"https://openalex.org/I200606013","display_name":"Daffodil International University","ror":"https://ror.org/052t4a858","country_code":"BD","type":"education","lineage":["https://openalex.org/I200606013"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Tasnimul Alam Taz","raw_affiliation_strings":["Department of Software Engineering, Daffodil International University, Bangladesh"],"affiliations":[{"raw_affiliation_string":"Department of Software Engineering, Daffodil International University, Bangladesh","institution_ids":["https://openalex.org/I200606013"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020570233","display_name":"Kawsar Ahmed","orcid":"https://orcid.org/0000-0002-4034-9819"},"institutions":[{"id":"https://openalex.org/I41173762","display_name":"Mawlana Bhashani Science and Technology University","ror":"https://ror.org/00gvj4587","country_code":"BD","type":"education","lineage":["https://openalex.org/I41173762"]}],"countries":["BD"],"is_corresponding":true,"raw_author_name":"Kawsar Ahmed","raw_affiliation_strings":["Department of Information and Communication Technology (ICT) at Mawlana Bhashani Science and Technology University, Tangail, Bangladesh"],"affiliations":[{"raw_affiliation_string":"Department of Information and Communication Technology (ICT) at Mawlana Bhashani Science and Technology University, Tangail, Bangladesh","institution_ids":["https://openalex.org/I41173762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100639768","display_name":"Bikash Kumar Paul","orcid":"https://orcid.org/0000-0002-4414-2751"},"institutions":[{"id":"https://openalex.org/I41173762","display_name":"Mawlana Bhashani Science and Technology University","ror":"https://ror.org/00gvj4587","country_code":"BD","type":"education","lineage":["https://openalex.org/I41173762"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Bikash Kumar Paul","raw_affiliation_strings":["Department of ICT at Mawlana Bhashani Science and Technology University, Bangladesh"],"affiliations":[{"raw_affiliation_string":"Department of ICT at Mawlana Bhashani Science and Technology University, Bangladesh","institution_ids":["https://openalex.org/I41173762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101942828","display_name":"Fahad Ahmed Al-Zahrani","orcid":"https://orcid.org/0000-0003-1490-5460"},"institutions":[{"id":"https://openalex.org/I199693650","display_name":"Umm al-Qura University","ror":"https://ror.org/01xjqrm90","country_code":"SA","type":"education","lineage":["https://openalex.org/I199693650"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Fahad Ahmed Al-Zahrani","raw_affiliation_strings":["Computer Engineering Department at Umm Al-Qura University, Saudi Arabia"],"affiliations":[{"raw_affiliation_string":"Computer Engineering Department at Umm Al-Qura University, Saudi Arabia","institution_ids":["https://openalex.org/I199693650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001933676","display_name":"Saifuddin Mahmud","orcid":"https://orcid.org/0000-0002-6828-3559"},"institutions":[{"id":"https://openalex.org/I200606013","display_name":"Daffodil International University","ror":"https://ror.org/052t4a858","country_code":"BD","type":"education","lineage":["https://openalex.org/I200606013"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"S M Hasan Mahmud","raw_affiliation_strings":["Department of Software Engineering, Daffodil International University, Bangladesh"],"affiliations":[{"raw_affiliation_string":"Department of Software Engineering, Daffodil International University, Bangladesh","institution_ids":["https://openalex.org/I200606013"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034828056","display_name":"Mohammad Ali Moni","orcid":"https://orcid.org/0000-0003-0756-1006"},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Mohammad Ali Moni","raw_affiliation_strings":["University of New South Wales (UNSW), Australia"],"affiliations":[{"raw_affiliation_string":"University of New South Wales (UNSW), Australia","institution_ids":["https://openalex.org/I31746571"]}]}],"institution_assertions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5020570233","https://openalex.org/A5034828056"],"corresponding_institution_ids":["https://openalex.org/I41173762","https://openalex.org/I31746571"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011,"provenance":"doaj"},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011,"provenance":"doaj"},"fwci":3.682,"has_fulltext":true,"fulltext_origin":"pdf","cited_by_count":39,"citation_normalized_percentile":{"value":0.999913,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"22","issue":"2","first_page":"1451","last_page":"1465"},"is_retracted":false,"is_paratext":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9969,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9969,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9931,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9878,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/s100a9","display_name":"S100A9","score":0.6280488},{"id":"https://openalex.org/keywords/s100a8","display_name":"S100A8","score":0.47759104}],"concepts":[{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6440946},{"id":"https://openalex.org/C2776307749","wikidata":"https://www.wikidata.org/wiki/Q18031354","display_name":"S100A9","level":3,"score":0.6280488},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.58400637},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5669343},{"id":"https://openalex.org/C2987395477","wikidata":"https://www.wikidata.org/wiki/Q135085","display_name":"Gene ontology","level":4,"score":0.553176},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.5037009},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4779425},{"id":"https://openalex.org/C2778557267","wikidata":"https://www.wikidata.org/wiki/Q20969990","display_name":"S100A8","level":3,"score":0.47759104},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39284465},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.34066105},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23667783}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D063990","descriptor_name":"Gene Ontology","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016247","descriptor_name":"Information Storage and Retrieval","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbab026","pdf_url":"https://academic.oup.com/bib/article-pdf/22/2/1451/36655578/bbab026.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311647","https://openalex.org/P4310311648"],"host_organization_lineage_names":["University of Oxford","Oxford University Press"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7929374","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":["National Institutes of Health"],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33611340","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":["National Institutes of Health"],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false}],"best_oa_location":{"is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbab026","pdf_url":"https://academic.oup.com/bib/article-pdf/22/2/1451/36655578/bbab026.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311647","https://openalex.org/P4310311648"],"host_organization_lineage_names":["University of Oxford","Oxford University Press"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true},"sustainable_development_goals":[{"score":0.87,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"grants":[],"datasets":[],"versions":[],"referenced_works_count":68,"referenced_works":["https://openalex.org/W1533335653","https://openalex.org/W1546952499","https://openalex.org/W1566831845","https://openalex.org/W1845872091","https://openalex.org/W1969842170","https://openalex.org/W1970772422","https://openalex.org/W1989277387","https://openalex.org/W2001230051","https://openalex.org/W2011477996","https://openalex.org/W2020541351","https://openalex.org/W2052685738","https://openalex.org/W2061715434","https://openalex.org/W2070050178","https://openalex.org/W2100239923","https://openalex.org/W2101725042","https://openalex.org/W2103912979","https://openalex.org/W2105805010","https://openalex.org/W2110065044","https://openalex.org/W2122135124","https://openalex.org/W2124967403","https://openalex.org/W2127322768","https://openalex.org/W2132784310","https://openalex.org/W2134582937","https://openalex.org/W2142879323","https://openalex.org/W2159482845","https://openalex.org/W2159675211","https://openalex.org/W2160697532","https://openalex.org/W2166043581","https://openalex.org/W2175370850","https://openalex.org/W2179438025","https://openalex.org/W2275381817","https://openalex.org/W2341128841","https://openalex.org/W2345356016","https://openalex.org/W2767914218","https://openalex.org/W2891237404","https://openalex.org/W2935024989","https://openalex.org/W2950595506","https://openalex.org/W2997000181","https://openalex.org/W3009335299","https://openalex.org/W3009906937","https://openalex.org/W3011045928","https://openalex.org/W3012310159","https://openalex.org/W3013215798","https://openalex.org/W3013395653","https://openalex.org/W3013826036","https://openalex.org/W3014027512","https://openalex.org/W3015769695","https://openalex.org/W3015900407","https://openalex.org/W3016079389","https://openalex.org/W3016489853","https://openalex.org/W3016771699","https://openalex.org/W3023496100","https://openalex.org/W3034133937","https://openalex.org/W3034758467","https://openalex.org/W3035667291","https://openalex.org/W3036529319","https://openalex.org/W3037369303","https://openalex.org/W3042053346","https://openalex.org/W3047971105","https://openalex.org/W3058564909","https://openalex.org/W3081388769","https://openalex.org/W3089311859","https://openalex.org/W3092577522","https://openalex.org/W3105053009","https://openalex.org/W3110939623","https://openalex.org/W3187792636","https://openalex.org/W4233698560","https://openalex.org/W4294216483"],"related_works":["https://openalex.org/W4361290181","https://openalex.org/W4233554345","https://openalex.org/W3143953005","https://openalex.org/W3115826556","https://openalex.org/W3083103331","https://openalex.org/W3030913893","https://openalex.org/W2480145060","https://openalex.org/W2144578507","https://openalex.org/W2141268830","https://openalex.org/W1950981769"],"abstract_inverted_index":{"Abstract":[0],"This":[1],"study":[2],"aimed":[3],"to":[4,32,104],"identify":[5],"significant":[6,97,143,235],"gene":[7,153,203],"expression":[8,94,98],"profiles":[9],"of":[10,77,152,161,183,194,200,204],"the":[11,51,146,181,188,198,239,251],"human":[12,105],"lung":[13,106,229],"epithelial":[14,107],"cells":[15,108],"caused":[16],"by":[17],"severe":[18],"acute":[19],"respiratory":[20],"syndrome":[21],"coronavirus":[22,89],"2":[23],"(SARS-CoV-2)":[24],"infections.":[25,166],"We":[26],"performed":[27,62],"a":[28,75],"comparative":[29],"genomic":[30,34,47,52],"analysis":[31,48],"show":[33],"observations":[35],"between":[36,54],"SARS-CoV":[37,55],"and":[38,56,67,109,118,128,133,138,155,170,227,231],"SARS-CoV-2.":[39,57],"A":[40],"phylogenetic":[41],"tree":[42],"has":[43],"been":[44,61,80],"carried":[45],"for":[46,63,100,130,187],"that":[49,141,173,220],"confirmed":[50],"variance":[53],"Transcriptomic":[58],"analyses":[59,151,215],"have":[60,79,174],"SARS-CoV-2":[64,101,132,165,205,224],"infection":[65,102,225],"responses":[66,103,163,226],"pulmonary":[68],"arterial":[69],"hypertension":[70],"(PAH)":[71],"patients\u2019":[72],"lungs":[73,111],"as":[74,112],"number":[76],"patients":[78],"identified":[81],"who":[82],"faced":[83],"PAH":[84,110,134,228],"after":[85],"being":[86],"diagnosed":[87],"with":[88,190,223],"disease":[90],"2019":[91],"(COVID-19).":[92],"Gene":[93],"profiling":[95],"showed":[96,120,142,234],"levels":[99],"well.":[113],"Differentially":[114],"expressed":[115],"genes":[116,122,140],"identification":[117,158],"integration":[119],"concordant":[121,217],"(SAA2,":[123],"S100A9,":[124],"S100A8,":[125],"SAA1,":[126],"S100A12":[127],"EDN1)":[129],"both":[131],"samples,":[135,230],"including":[136],"S100A9":[137],"S100A8":[139],"interaction":[144],"in":[145,206,247,250],"protein\u2013protein":[147],"interactions":[148],"network.":[149,212],"Extensive":[150],"ontology":[154,171],"signaling":[156,169],"pathways":[157,172],"provided":[159,216],"evidence":[160],"inflammatory":[162],"regarding":[164],"The":[167],"altered":[168],"emerged":[175],"from":[176],"this":[177],"research":[178],"may":[179],"influence":[180],"development":[182,249],"effective":[184],"drugs,":[185],"especially":[186],"people":[189],"preexisting":[191],"conditions.":[192],"Identification":[193],"regulatory":[195],"biomolecules":[196],"revealed":[197],"presence":[199],"active":[201],"promoter":[202],"Transferrin-micro":[207],"Ribonucleic":[208],"acid":[209],"(TF-miRNA)":[210],"co-regulatory":[211],"Predictive":[213],"drug":[214,218],"compounds":[219,233],"are":[221],"associated":[222],"these":[232],"immune":[236],"response":[237],"against":[238],"RNA":[240],"viruses":[241],"like":[242],"SARS-CoV-2,":[243],"which":[244],"is":[245],"beneficial":[246],"therapeutic":[248],"COVID-19":[252],"pandemic.":[253]},"cited_by_api_url":"https://api.openalex.org/works?filter=cites:W3130228814","counts_by_year":[{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":11}],"updated_date":"2025-01-09T08:05:34.533834","created_date":"2021-03-01"}