{"id":"https://openalex.org/W2172236534","doi":"https://doi.org/10.1021/ci970004w","title":"PARM: A Genetic Evolved Algorithm To Predict Bioactivity","display_name":"PARM: A Genetic Evolved Algorithm To Predict Bioactivity","publication_year":1998,"publication_date":"1998-03-23","ids":{"openalex":"https://openalex.org/W2172236534","doi":"https://doi.org/10.1021/ci970004w","mag":"2172236534"},"language":"en","primary_location":{"is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci970004w","pdf_url":null,"source":{"id":"https://openalex.org/S171559003","display_name":"Journal of Chemical Information and Computer Sciences","issn_l":"0095-2338","issn":["0095-2338","1520-5142"],"is_oa":false,"is_in_doaj":false,"is_indexed_in_scopus":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false},"type":"article","type_crossref":"journal-article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100729955","display_name":"Hongming Chen","orcid":"https://orcid.org/0000-0002-4470-876X"},"institutions":[{"id":"https://openalex.org/I4210133325","display_name":"Institute of Process Engineering","ror":"https://ror.org/03j4x9j18","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210133325"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongming Chen","raw_affiliation_strings":["Laboratory of Computer Chemistry, Institute of Chemical Metallurgy, Chinese Academy of Sciences, P.O. Box 353, Beijing 100080, P. R. China"],"affiliations":[{"raw_affiliation_string":"Laboratory of Computer Chemistry, Institute of Chemical Metallurgy, Chinese Academy of Sciences, P.O. Box 353, Beijing 100080, P. R. China","institution_ids":["https://openalex.org/I4210133325","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102165877","display_name":"Jiaju Zhou","orcid":null},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210133325","display_name":"Institute of Process Engineering","ror":"https://ror.org/03j4x9j18","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210133325"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiaju Zhou","raw_affiliation_strings":["Laboratory of Computer Chemistry, Institute of Chemical Metallurgy, Chinese Academy of Sciences, P.O. Box 353, Beijing 100080, P. R. China"],"affiliations":[{"raw_affiliation_string":"Laboratory of Computer Chemistry, Institute of Chemical Metallurgy, Chinese Academy of Sciences, P.O. Box 353, Beijing 100080, P. R. China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210133325"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100901210","display_name":"Guirong Xie","orcid":null},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210133325","display_name":"Institute of Process Engineering","ror":"https://ror.org/03j4x9j18","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210133325"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guirong Xie","raw_affiliation_strings":["Laboratory of Computer Chemistry, Institute of Chemical Metallurgy, Chinese Academy of Sciences, P.O. Box 353, Beijing 100080, P. R. China"],"affiliations":[{"raw_affiliation_string":"Laboratory of Computer Chemistry, Institute of Chemical Metallurgy, Chinese Academy of Sciences, P.O. Box 353, Beijing 100080, P. R. China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210133325"]}]}],"institution_assertions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.059,"has_fulltext":true,"fulltext_origin":"ngrams","cited_by_count":39,"citation_normalized_percentile":{"value":0.853525,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":91},"biblio":{"volume":"38","issue":"2","first_page":"243","last_page":"250"},"is_retracted":false,"is_paratext":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9999,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9999,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13013","display_name":"Free Radicals and Antioxidants","score":0.9904,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11882","display_name":"Plant biochemistry and biosynthesis","score":0.9856,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C8880873","wikidata":"https://www.wikidata.org/wiki/Q187787","display_name":"Genetic algorithm","level":2,"score":0.69566846},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.62024224},{"id":"https://openalex.org/C166950319","wikidata":"https://www.wikidata.org/wiki/Q245031","display_name":"Intermolecular force","level":3,"score":0.5339799},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.5217279},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.48968318},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.46587938},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.44233724},{"id":"https://openalex.org/C186370098","wikidata":"https://www.wikidata.org/wiki/Q442787","display_name":"Energy (signal processing)","level":2,"score":0.4114256},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.29730338},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.26261282},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.22626665},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.19939113},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16993743},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.084430665},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"is_oa":false,"landing_page_url":"https://doi.org/10.1021/ci970004w","pdf_url":null,"source":{"id":"https://openalex.org/S171559003","display_name":"Journal of Chemical Information and Computer Sciences","issn_l":"0095-2338","issn":["0095-2338","1520-5142"],"is_oa":false,"is_in_doaj":false,"is_indexed_in_scopus":false,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/7","score":0.66,"display_name":"Affordable and clean energy"}],"grants":[],"datasets":[],"versions":[],"referenced_works_count":6,"referenced_works":["https://openalex.org/W1509196567","https://openalex.org/W1963827402","https://openalex.org/W1971344406","https://openalex.org/W2015870870","https://openalex.org/W2052226480","https://openalex.org/W2063060349"],"related_works":["https://openalex.org/W781020412","https://openalex.org/W2967128405","https://openalex.org/W2889857666","https://openalex.org/W2806312579","https://openalex.org/W2782331705","https://openalex.org/W2068727497","https://openalex.org/W2050400197","https://openalex.org/W2037504287","https://openalex.org/W2002091057","https://openalex.org/W1497930170"],"abstract_inverted_index":{"Based":[0],"on":[1,39,57],"Walters'":[2],"GERM":[3],"(Genetic":[4],"Evolved":[5],"Receptor":[6,15],"Model)":[7,16],"algorithm,":[8],"an":[9,34,50,89],"improved":[10],"algorithm":[11,27,103],"PARM":[12,20],"(Pseudo":[13],"Atomic":[14],"was":[17,64,104],"put":[18],"forward.":[19],"uses":[21],"a":[22,25,29,40,58,75],"combination":[23],"of":[24,42,61,88,98],"genetic":[26,48],"and":[28,81,83,109],"cross-validation":[30],"technique":[31],"to":[32,66,106],"produce":[33],"atomic-level":[35],"pseudoreceptor":[36],"model,":[37],"based":[38,56],"set":[41],"known":[43],"structure\u2212activity":[44,100],"relationships.":[45],"During":[46],"the":[47,68,86,95,99],"process,":[49],"artificial":[51],"interfering":[52],"method,":[53],"which":[54],"is":[55],"complementary":[59],"principle":[60],"ligand\u2212receptor":[62],"interaction,":[63],"used":[65],"accelerate":[67],"search":[69],"speed.":[70],"The":[71],"evolved":[72],"models":[73],"show":[74],"high":[76],"correlation":[77],"between":[78],"intermolecular":[79],"energy":[80],"bioactivity":[82,87],"can":[84],"predict":[85],"unknown":[90],"molecule":[91],"by":[92],"interpolating":[93],"in":[94],"regression":[96],"equation":[97],"relationship.":[101],"This":[102],"applied":[105],"two":[107],"systems":[108],"produced":[110],"reasonable":[111],"results.":[112]},"abstract_inverted_index_v3":null,"cited_by_api_url":"https://api.openalex.org/works?filter=cites:W2172236534","counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2025-03-23T14:45:35.456335","created_date":"2016-06-24"}