乐胖代购免代理版

{"id":"https://openalex.org/W2993280872","doi":"https://doi.org/10.1021/acs.jcim.9b00814","title":"Combined Experimental and Molecular Simulation Study of Insulin\u2013Chitosan Complexation Driven by Electrostatic Interactions","display_name":"Combined Experimental and Molecular Simulation Study of Insulin\u2013Chitosan Complexation Driven by Electrostatic Interactions","publication_year":2019,"publication_date":"2019-12-02","ids":{"openalex":"https://openalex.org/W2993280872","doi":"https://doi.org/10.1021/acs.jcim.9b00814","mag":"2993280872","pmid":"https://pubmed.ncbi.nlm.nih.gov/31790240"},"language":"en","primary_location":{"is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.9b00814","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_indexed_in_scopus":true,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false},"type":"article","type_crossref":"journal-article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ri.conicet.gov.ar/bitstream/11336/121455/2/CONICET_Digital_Nro.f9ffb433-9774-46c7-86ad-4ab1c9099ca7_A.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048269143","display_name":"Cecilia Prudkin-Silva","orcid":"https://orcid.org/0000-0001-8593-845X"},"institutions":[{"id":"https://openalex.org/I53241121","display_name":"Fundaci\u00f3n Ciencias Exactas y Naturales","ror":"https://ror.org/05rxmkq09","country_code":"AR","type":"nonprofit","lineage":["https://openalex.org/I53241121"]},{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I24354313","display_name":"University of Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"funder","lineage":["https://openalex.org/I24354313"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Cecilia Prudkin-Silva","raw_affiliation_strings":["Departamento de Qu\u00edmica Biol\u00f3gica, Facultad de Ciencias Exactas y Naturales, Instituto de Qu\u00edmica Biol\u00f3gica de la Facultad de Ciencias Exactas y Naturales, IQUIBICEN-CONICET, Universidad de Buenos Aires, Buenos Aires, Intendente G\u00fciraldes, s/n, Ciudad Universitaria, Pabell\u00f3n 2, Buenos Aires CP 1428, Argentina"],"affiliations":[{"raw_affiliation_string":"Departamento de Qu\u00edmica Biol\u00f3gica, Facultad de Ciencias Exactas y Naturales, Instituto de Qu\u00edmica Biol\u00f3gica de la Facultad de Ciencias Exactas y Naturales, IQUIBICEN-CONICET, Universidad de Buenos Aires, Buenos Aires, Intendente G\u00fciraldes, s/n, Ciudad Universitaria, Pabell\u00f3n 2, Buenos Aires CP 1428, Argentina","institution_ids":["https://openalex.org/I53241121","https://openalex.org/I151201029","https://openalex.org/I24354313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057488067","display_name":"Oscar E. P\u00e9rez","orcid":"https://orcid.org/0000-0002-8223-1077"},"institutions":[{"id":"https://openalex.org/I24354313","display_name":"University of Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"funder","lineage":["https://openalex.org/I24354313"]},{"id":"https://openalex.org/I53241121","display_name":"Fundaci\u00f3n Ciencias Exactas y Naturales","ror":"https://ror.org/05rxmkq09","country_code":"AR","type":"nonprofit","lineage":["https://openalex.org/I53241121"]},{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Oscar E. P\u00e9rez","raw_affiliation_strings":["Departamento de Qu\u00edmica Biol\u00f3gica, Facultad de Ciencias Exactas y Naturales, Instituto de Qu\u00edmica Biol\u00f3gica de la Facultad de Ciencias Exactas y Naturales, IQUIBICEN-CONICET, Universidad de Buenos Aires, Buenos Aires, Intendente G\u00fciraldes, s/n, Ciudad Universitaria, Pabell\u00f3n 2, Buenos Aires CP 1428, Argentina"],"affiliations":[{"raw_affiliation_string":"Departamento de Qu\u00edmica Biol\u00f3gica, Facultad de Ciencias Exactas y Naturales, Instituto de Qu\u00edmica Biol\u00f3gica de la Facultad de Ciencias Exactas y Naturales, IQUIBICEN-CONICET, Universidad de Buenos Aires, Buenos Aires, Intendente G\u00fciraldes, s/n, Ciudad Universitaria, Pabell\u00f3n 2, Buenos Aires CP 1428, Argentina","institution_ids":["https://openalex.org/I24354313","https://openalex.org/I53241121","https://openalex.org/I151201029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050972095","display_name":"Karina D. Mart\u00ednez","orcid":"https://orcid.org/0000-0002-5208-6067"},"institutions":[{"id":"https://openalex.org/I53241121","display_name":"Fundaci\u00f3n Ciencias Exactas y Naturales","ror":"https://ror.org/05rxmkq09","country_code":"AR","type":"nonprofit","lineage":["https://openalex.org/I53241121"]},{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I24354313","display_name":"University of Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"funder","lineage":["https://openalex.org/I24354313"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Karina D. Mart\u00ednez","raw_affiliation_strings":["Departamento de Industrias, Facultad de Ciencias Exactas y Naturales, Consejo Nacional de Investigaci\u00f3n Cient\u00edfica y T\u00e9cnicas de la Rep\u00fablica Argentina, ITAPROQ-CONICET, Universidad de Buenos Aires, Intendente G\u00fciraldes, s/n, Ciudad Universitaria, Buenos Aires CP 1428, Argentina"],"affiliations":[{"raw_affiliation_string":"Departamento de Industrias, Facultad de Ciencias Exactas y Naturales, Consejo Nacional de Investigaci\u00f3n Cient\u00edfica y T\u00e9cnicas de la Rep\u00fablica Argentina, ITAPROQ-CONICET, Universidad de Buenos Aires, Intendente G\u00fciraldes, s/n, Ciudad Universitaria, Buenos Aires CP 1428, Argentina","institution_ids":["https://openalex.org/I53241121","https://openalex.org/I151201029","https://openalex.org/I24354313"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017475982","display_name":"Fernando Lu\u00eds Barroso da Silva","orcid":"https://orcid.org/0000-0003-2526-2085"},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"funder","lineage":["https://openalex.org/I137902535"]},{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"funder","lineage":["https://openalex.org/I17974374"]}],"countries":["BR","US"],"is_corresponding":true,"raw_author_name":"Fernando L. Barroso da Silva","raw_affiliation_strings":["Departamento de Ci\u00eancias Biomoleculares, Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, Ribeir\u00e3o Preto, S\u00e3o Paulo, 14040-903 Brazil","Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina 27695, United States"],"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina 27695, United States","institution_ids":["https://openalex.org/I137902535"]},{"raw_affiliation_string":"Departamento de Ci\u00eancias Biomoleculares, Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, Ribeir\u00e3o Preto, S\u00e3o Paulo, 14040-903 Brazil","institution_ids":["https://openalex.org/I17974374"]}]}],"institution_assertions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5017475982"],"corresponding_institution_ids":["https://openalex.org/I137902535","https://openalex.org/I17974374"],"apc_list":null,"apc_paid":null,"fwci":2.068,"has_fulltext":true,"fulltext_origin":"pdf","cited_by_count":15,"citation_normalized_percentile":{"value":0.999955,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":89},"biblio":{"volume":"60","issue":"2","first_page":"854","last_page":"865"},"is_retracted":false,"is_paratext":false,"primary_topic":{"id":"https://openalex.org/T10411","display_name":"Proteins in Food Systems","score":0.9999,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10411","display_name":"Proteins in Food Systems","score":0.9999,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10488","display_name":"Nanocomposite Films for Food Packaging","score":0.9998,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10859","display_name":"Polymer Surface Interaction Studies","score":0.9987,"subfield":{"id":"https://openalex.org/subfields/2508","display_name":"Surfaces, Coatings and Films"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amide","display_name":"Amide","score":0.6731623},{"id":"https://openalex.org/keywords/cationic-polymerization","display_name":"Cationic polymerization","score":0.61473036},{"id":"https://openalex.org/keywords/electrostatics","display_name":"Electrostatics","score":0.53820324},{"id":"https://openalex.org/keywords/electrostatic-interaction","display_name":"Electrostatic interaction","score":0.4864771},{"id":"https://openalex.org/keywords/static-electricity","display_name":"Static electricity","score":0.4560336}],"concepts":[{"id":"https://openalex.org/C153356533","wikidata":"https://www.wikidata.org/wiki/Q901016","display_name":"Polyelectrolyte","level":3,"score":0.77560145},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.77235615},{"id":"https://openalex.org/C166940927","wikidata":"https://www.wikidata.org/wiki/Q178827","display_name":"Monomer","level":3,"score":0.69081396},{"id":"https://openalex.org/C2778439535","wikidata":"https://www.wikidata.org/wiki/Q188777","display_name":"Amide","level":2,"score":0.6731623},{"id":"https://openalex.org/C183882617","wikidata":"https://www.wikidata.org/wiki/Q3046749","display_name":"Cationic polymerization","level":2,"score":0.61473036},{"id":"https://openalex.org/C2779732960","wikidata":"https://www.wikidata.org/wiki/Q408510","display_name":"Chitosan","level":2,"score":0.60926807},{"id":"https://openalex.org/C117626034","wikidata":"https://www.wikidata.org/wiki/Q26336","display_name":"Electrostatics","level":2,"score":0.53820324},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.5373226},{"id":"https://openalex.org/C2982804355","wikidata":"https://www.wikidata.org/wiki/Q26336","display_name":"Electrostatic interaction","level":2,"score":0.4864771},{"id":"https://openalex.org/C87716614","wikidata":"https://www.wikidata.org/wiki/Q845744","display_name":"Static electricity","level":2,"score":0.4560336},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.40919176},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.3262136},{"id":"https://openalex.org/C159467904","wikidata":"https://www.wikidata.org/wiki/Q2001702","display_name":"Chemical physics","level":1,"score":0.2702934},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.23791125},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.21683618},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.18097141},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D048271","descriptor_name":"Chitosan","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":"","qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055672","descriptor_name":"Static Electricity","qualifier_ui":"","qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002236","descriptor_name":"Carbohydrate Conformation","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048271","descriptor_name":"Chitosan","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048271","descriptor_name":"Chitosan","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":"","qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.9b00814","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_indexed_in_scopus":true,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false},{"is_oa":true,"landing_page_url":"https://hdl.handle.net/11336/121455","pdf_url":"https://ri.conicet.gov.ar/bitstream/11336/121455/2/CONICET_Digital_Nro.f9ffb433-9774-46c7-86ad-4ab1c9099ca7_A.pdf","source":{"id":"https://openalex.org/S4306402455","display_name":"CONICET Digital (CONICET)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_indexed_in_scopus":false,"is_core":false,"host_organization":"https://openalex.org/I4210148385","host_organization_name":"Biomedicine Research Institute of Buenos Aires - CONICET - Partner Institute of the Max Planck Society","host_organization_lineage":["https://openalex.org/I4210148385"],"host_organization_lineage_names":["Biomedicine Research Institute of Buenos Aires - CONICET - Partner Institute of the Max Planck Society"],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31790240","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_indexed_in_scopus":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":["National Institutes of Health"],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false}],"best_oa_location":{"is_oa":true,"landing_page_url":"https://hdl.handle.net/11336/121455","pdf_url":"https://ri.conicet.gov.ar/bitstream/11336/121455/2/CONICET_Digital_Nro.f9ffb433-9774-46c7-86ad-4ab1c9099ca7_A.pdf","source":{"id":"https://openalex.org/S4306402455","display_name":"CONICET Digital (CONICET)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_indexed_in_scopus":false,"is_core":false,"host_organization":"https://openalex.org/I4210148385","host_organization_name":"Biomedicine Research Institute of Buenos Aires - CONICET - Partner Institute of the Max Planck Society","host_organization_lineage":["https://openalex.org/I4210148385"],"host_organization_lineage_names":["Biomedicine Research Institute of Buenos Aires - CONICET - Partner Institute of the Max Planck Society"],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true},"sustainable_development_goals":[],"grants":[{"funder":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","award_id":"2015/16116-3"},{"funder":"https://openalex.org/F4320321594","funder_display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","award_id":null},{"funder":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","award_id":"310791/2017-0"},{"funder":"https://openalex.org/F4320323257","funder_display_name":"Universidad de Buenos Aires","award_id":"20020150100079BA"},{"funder":"https://openalex.org/F4320323339","funder_display_name":"Universidade de S\u00e3o Paulo","award_id":null},{"funder":"https://openalex.org/F4320337954","funder_display_name":"Fondo para la Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","award_id":"PICT 2015-3866"},{"funder":"https://openalex.org/F4320337954","funder_display_name":"Fondo para la Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","award_id":"PICT2017-1683"}],"datasets":[],"versions":[],"referenced_works_count":71,"referenced_works":["https://openalex.org/W1238203966","https://openalex.org/W1558317780","https://openalex.org/W1641978920","https://openalex.org/W1964123359","https://openalex.org/W1969812174","https://openalex.org/W1973782845","https://openalex.org/W1975233757","https://openalex.org/W1975353473","https://openalex.org/W1978145906","https://openalex.org/W1980439325","https://openalex.org/W1990932004","https://openalex.org/W2007852088","https://openalex.org/W2028308911","https://openalex.org/W2038062561","https://openalex.org/W2038255984","https://openalex.org/W2039192332","https://openalex.org/W2040824780","https://openalex.org/W2041815073","https://openalex.org/W2041860421","https://openalex.org/W2046088544","https://openalex.org/W204702100","https://openalex.org/W2050294803","https://openalex.org/W2050376077","https://openalex.org/W2051287565","https://openalex.org/W2057917344","https://openalex.org/W2059046402","https://openalex.org/W2066105837","https://openalex.org/W2073020659","https://openalex.org/W2091742793","https://openalex.org/W2093834422","https://openalex.org/W2101790210","https://openalex.org/W2105531392","https://openalex.org/W2105867620","https://openalex.org/W2114884378","https://openalex.org/W2118702829","https://openalex.org/W2120763229","https://openalex.org/W2126152059","https://openalex.org/W2141775785","https://openalex.org/W2143010345","https://openalex.org/W2146034144","https://openalex.org/W2172103188","https://openalex.org/W2216043012","https://openalex.org/W2312184864","https://openalex.org/W2316778497","https://openalex.org/W2336504073","https://openalex.org/W2345491040","https://openalex.org/W2484698331","https://openalex.org/W2515486545","https://openalex.org/W2522706925","https://openalex.org/W2552739997","https://openalex.org/W2599741499","https://openalex.org/W2605158478","https://openalex.org/W2734772774","https://openalex.org/W2753309749","https://openalex.org/W2753349025","https://openalex.org/W2756160777","https://openalex.org/W2757538131","https://openalex.org/W2766306234","https://openalex.org/W2768502235","https://openalex.org/W2776380140","https://openalex.org/W2799371175","https://openalex.org/W2799603405","https://openalex.org/W2799978369","https://openalex.org/W2806538368","https://openalex.org/W2885543262","https://openalex.org/W2890756228","https://openalex.org/W2906759355","https://openalex.org/W3179346294","https://openalex.org/W4212841973","https://openalex.org/W4247395273","https://openalex.org/W4253503853"],"related_works":["https://openalex.org/W4220825681","https://openalex.org/W4211242772","https://openalex.org/W2754954066","https://openalex.org/W2536299144","https://openalex.org/W2367179472","https://openalex.org/W2072782342","https://openalex.org/W2043030458","https://openalex.org/W2032758046","https://openalex.org/W1987726601","https://openalex.org/W1983384780"],"abstract_inverted_index":{"Protein\u2013polysaccharide":[0],"complexes":[1,82],"constructed":[2],"via":[3,36],"self-assembly":[4],"methods":[5],"are":[6],"often":[7],"used":[8],"to":[9,30,34,72,86,103,140,154],"develop":[10],"novel":[11],"biomaterials":[12],"for":[13,80,131],"a":[14,87,194,215,227],"wide":[15],"range":[16,151],"of":[17,26,89,115,166,226],"applications":[18],"in":[19,126,170,193],"biomedicine,":[20],"food,":[21],"and":[22,33,48,67,95,109,134],"biotechnology.":[23],"The":[24,76,99,149,207],"objective":[25],"this":[27],"work":[28],"was":[29,152],"investigate":[31],"theoretically":[32],"demonstrate":[35],"constant-pH":[37],"Monte":[38],"Carlo":[39],"simulations":[40],"that":[41],"the":[42,49,74,81,104,107,110,113,164,171,174,179,203],"complexation":[43,119,138,150,180,219],"phenomenon":[44],"between":[45,106],"insulin":[46],"(INS)":[47],"cationic":[50],"polyelectrolyte":[51],"chitosan":[52],"(CS)":[53],"is":[54,125],"mainly":[55],"driven":[56],"by":[57,202,223],"an":[58],"electrostatic":[59],"mechanism.":[60],"Experimental":[61],"results":[62],"obtained":[63],"from":[64,91],"FTIR":[65],"spectra":[66],"\u03b6-potential":[68],"determinations":[69],"allowed":[70],"us":[71],"complement":[73],"conclusions.":[75],"characteristic":[77],"absorption":[78],"bands":[79],"could":[83],"be":[84,155,212],"assigned":[85],"combination":[88],"signals":[90],"CS":[92],"amide":[93,97,116],"I":[94],"INS":[96,124,167,199],"II.":[98,117],"second":[100],"peak":[101],"corresponds":[102],"interaction":[105],"polymer":[108],"protein":[111],"at":[112,146,177],"level":[114],"INS\u2013CS":[118],"processes":[120],"not":[121],"expected":[122],"when":[123,163],"its":[127],"monomeric":[128],"form,":[129],"but":[130],"both":[132],"tetrameric":[133],"hexameric":[135],"forms,":[136],"incipient":[137],"due":[139],"charge":[141,208],"regulation":[142,209],"mechanism":[143,210],"took":[144],"place":[145],"pH":[147,158,176,196],"5.":[148],"observed":[153],"5.5":[156],"<":[157,159],"6.5.":[160],"In":[161],"general,":[162],"number":[165],"units":[168],"increases":[169],"simulation":[172],"process,":[173],"solution":[175],"which":[178],"can":[181,211],"occur":[182],"shifts":[183],"toward":[184,218],"acidic":[185],"conditions.":[186],"CS's":[187],"chain":[188],"interacts":[189],"more":[190],"efficiently,":[191],"i.e.":[192],"wider":[195],"range,":[197],"with":[198],"aggregates":[200],"formed":[201],"highest":[204],"monomer":[205],"number.":[206],"considered":[213],"as":[214],"previous":[216],"phase":[217],"(incipient":[220],"complexation)":[221],"caused":[222],"weak":[224],"interactions":[225],"Coulombic":[228],"nature.":[229]},"abstract_inverted_index_v3":null,"cited_by_api_url":"https://api.openalex.org/works?filter=cites:W2993280872","counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1}],"updated_date":"2025-04-26T04:59:33.437456","created_date":"2019-12-13"}