乐胖代购免代理版

{"id":"https://openalex.org/W4403231300","doi":"https://doi.org/10.1021/acs.jcim.4c01303","title":"qProtein: Exploring Physical Features of Protein Thermostability Based on Structural Proteomics","display_name":"qProtein: Exploring Physical Features of Protein Thermostability Based on Structural Proteomics","publication_year":2024,"publication_date":"2024-10-07","ids":{"openalex":"https://openalex.org/W4403231300","doi":"https://doi.org/10.1021/acs.jcim.4c01303","pmid":"https://pubmed.ncbi.nlm.nih.gov/39375829"},"language":"en","primary_location":{"is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.4c01303","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_indexed_in_scopus":true,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false},"type":"article","type_crossref":"journal-article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028382404","display_name":"Zhixin Dou","orcid":"https://orcid.org/0000-0002-3682-8307"},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"funder","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4391767886","display_name":"State Key Laboratory of Microbial Technology","ror":"https://ror.org/03x08qn04","country_code":null,"type":"facility","lineage":["https://openalex.org/I154099455","https://openalex.org/I4391767886"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhixin Dou","raw_affiliation_strings":["State Key Laboratory of Microbial Technology, Shandong University, No. 72 Binhai Road, Qingdao 266237, P.R. China"],"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Microbial Technology, Shandong University, No. 72 Binhai Road, Qingdao 266237, P.R. China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4391767886"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113182396","display_name":"Jiaxin He","orcid":null},"institutions":[{"id":"https://openalex.org/I186691195","display_name":"Qingdao Binhai University","ror":"https://ror.org/023er3e86","country_code":"CN","type":"education","lineage":["https://openalex.org/I186691195"]},{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"funder","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiaxin He","raw_affiliation_strings":["School of Computer Science and Technology, Shandong University, No. 72 Binhai Road, Qingdao 266237, P.R. China"],"affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Shandong University, No. 72 Binhai Road, Qingdao 266237, P.R. China","institution_ids":["https://openalex.org/I186691195","https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068401442","display_name":"Chao Han","orcid":"https://orcid.org/0000-0002-0823-9329"},"institutions":[{"id":"https://openalex.org/I74485261","display_name":"Shandong Agricultural University","ror":"https://ror.org/02ke8fw32","country_code":"CN","type":"funder","lineage":["https://openalex.org/I74485261"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chao Han","raw_affiliation_strings":["Shandong Key Laboratory of Agricultural Microbiology, Shandong Agricultural University, Tai'an 271018, China"],"affiliations":[{"raw_affiliation_string":"Shandong Key Laboratory of Agricultural Microbiology, Shandong Agricultural University, Tai'an 271018, China","institution_ids":["https://openalex.org/I74485261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008664030","display_name":"Xiuyun Wu","orcid":"https://orcid.org/0000-0002-5287-5218"},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"funder","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4391767886","display_name":"State Key Laboratory of Microbial Technology","ror":"https://ror.org/03x08qn04","country_code":null,"type":"facility","lineage":["https://openalex.org/I154099455","https://openalex.org/I4391767886"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiuyun Wu","raw_affiliation_strings":["State Key Laboratory of Microbial Technology, Shandong University, No. 72 Binhai Road, Qingdao 266237, P.R. China"],"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Microbial Technology, Shandong University, No. 72 Binhai Road, Qingdao 266237, P.R. China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4391767886"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045027872","display_name":"Lin Wan","orcid":"https://orcid.org/0000-0003-2627-8775"},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"funder","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lin Wan","raw_affiliation_strings":["School of Software, Shandong University, Shunhua Road, Jinan 250101, P.R. China"],"affiliations":[{"raw_affiliation_string":"School of Software, Shandong University, Shunhua Road, Jinan 250101, P.R. China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037577175","display_name":"Jian Yang","orcid":"https://orcid.org/0000-0003-4887-3444"},"institutions":[{"id":"https://openalex.org/I186691195","display_name":"Qingdao Binhai University","ror":"https://ror.org/023er3e86","country_code":"CN","type":"education","lineage":["https://openalex.org/I186691195"]},{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"funder","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Yang","raw_affiliation_strings":["School of Computer Science and Technology, Shandong University, No. 72 Binhai Road, Qingdao 266237, P.R. China"],"affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Shandong University, No. 72 Binhai Road, Qingdao 266237, P.R. China","institution_ids":["https://openalex.org/I186691195","https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036270412","display_name":"Yanwei Zheng","orcid":"https://orcid.org/0000-0002-2115-6237"},"institutions":[{"id":"https://openalex.org/I186691195","display_name":"Qingdao Binhai University","ror":"https://ror.org/023er3e86","country_code":"CN","type":"education","lineage":["https://openalex.org/I186691195"]},{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"funder","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanwei Zheng","raw_affiliation_strings":["School of Computer Science and Technology, Shandong University, No. 72 Binhai Road, Qingdao 266237, P.R. China"],"affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Shandong University, No. 72 Binhai Road, Qingdao 266237, P.R. China","institution_ids":["https://openalex.org/I186691195","https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079312541","display_name":"Bin Gong","orcid":"https://orcid.org/0000-0001-9820-4762"},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"funder","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin Gong","raw_affiliation_strings":["School of Software, Shandong University, Shunhua Road, Jinan 250101, P.R. China"],"affiliations":[{"raw_affiliation_string":"School of Software, Shandong University, Shunhua Road, Jinan 250101, P.R. China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108572322","display_name":"Lushan Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I4391767886","display_name":"State Key Laboratory of Microbial Technology","ror":"https://ror.org/03x08qn04","country_code":null,"type":"facility","lineage":["https://openalex.org/I154099455","https://openalex.org/I4391767886"]},{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"funder","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lushan Wang","raw_affiliation_strings":["State Key Laboratory of Microbial Technology, Shandong University, No. 72 Binhai Road, Qingdao 266237, P.R. China"],"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Microbial Technology, Shandong University, No. 72 Binhai Road, Qingdao 266237, P.R. China","institution_ids":["https://openalex.org/I4391767886","https://openalex.org/I154099455"]}]}],"institution_assertions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5108572322"],"corresponding_institution_ids":["https://openalex.org/I4391767886","https://openalex.org/I154099455"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":0,"max":79},"biblio":{"volume":"64","issue":"20","first_page":"7885","last_page":"7894"},"is_retracted":false,"is_paratext":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9998,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9998,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.997,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9944,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thermostability","display_name":"Thermostability","score":0.98676276},{"id":"https://openalex.org/keywords/structural-protein","display_name":"Structural protein","score":0.48986194}],"concepts":[{"id":"https://openalex.org/C2781216036","wikidata":"https://www.wikidata.org/wiki/Q902494","display_name":"Thermostability","level":3,"score":0.98676276},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.5206605},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5182974},{"id":"https://openalex.org/C3018069271","wikidata":"https://www.wikidata.org/wiki/Q8054","display_name":"Structural protein","level":3,"score":0.48986194},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.41231614},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2710018},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2019847},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0906176},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D006026","descriptor_name":"Glycoside Hydrolases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":"","qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jcim.4c01303","pdf_url":null,"source":{"id":"https://openalex.org/S167262187","display_name":"Journal of Chemical Information and Modeling","issn_l":"1549-9596","issn":["1549-9596","1549-960X"],"is_oa":false,"is_in_doaj":false,"is_indexed_in_scopus":true,"is_core":true,"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false},{"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39375829","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_indexed_in_scopus":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":["National Institutes of Health"],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false}],"best_oa_location":null,"sustainable_development_goals":[],"grants":[{"funder":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China","award_id":"32100022"},{"funder":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China","award_id":"2023YFC3403600"}],"datasets":[],"versions":[],"referenced_works_count":66,"referenced_works":["https://openalex.org/W1971251199","https://openalex.org/W1986394739","https://openalex.org/W1992579032","https://openalex.org/W2015001812","https://openalex.org/W2027739998","https://openalex.org/W2041372545","https://openalex.org/W2047399603","https://openalex.org/W2070783701","https://openalex.org/W2073229442","https://openalex.org/W2081893178","https://openalex.org/W2105387956","https://openalex.org/W2148165483","https://openalex.org/W2149031462","https://openalex.org/W2151457629","https://openalex.org/W2151550848","https://openalex.org/W2170471837","https://openalex.org/W2292998093","https://openalex.org/W2330799739","https://openalex.org/W2462393580","https://openalex.org/W2565045120","https://openalex.org/W2673359774","https://openalex.org/W2766460411","https://openalex.org/W2770191769","https://openalex.org/W2785250581","https://openalex.org/W2792520453","https://openalex.org/W2795641220","https://openalex.org/W2888107191","https://openalex.org/W2893348872","https://openalex.org/W2898470143","https://openalex.org/W2906224870","https://openalex.org/W2911475376","https://openalex.org/W2948728900","https://openalex.org/W2955704392","https://openalex.org/W2992752586","https://openalex.org/W3023884143","https://openalex.org/W3048495640","https://openalex.org/W3048804154","https://openalex.org/W3106745904","https://openalex.org/W3125756628","https://openalex.org/W3135682489","https://openalex.org/W3163390259","https://openalex.org/W3177828909","https://openalex.org/W3193976797","https://openalex.org/W3200707343","https://openalex.org/W3210737855","https://openalex.org/W3216076504","https://openalex.org/W3217216416","https://openalex.org/W4213193686","https://openalex.org/W4224988655","https://openalex.org/W4280524269","https://openalex.org/W4283586641","https://openalex.org/W4293475204","https://openalex.org/W4309436804","https://openalex.org/W4313503960","https://openalex.org/W4320038537","https://openalex.org/W4322721797","https://openalex.org/W4327550249","https://openalex.org/W4384820649","https://openalex.org/W4385186106","https://openalex.org/W4386495900","https://openalex.org/W4386604765","https://openalex.org/W4386708656","https://openalex.org/W4386709418","https://openalex.org/W4387934645","https://openalex.org/W4388464011","https://openalex.org/W4389236189"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W4387497383","https://openalex.org/W2948807893","https://openalex.org/W2778153218","https://openalex.org/W2748952813","https://openalex.org/W2362777130","https://openalex.org/W2094336165","https://openalex.org/W2088324202","https://openalex.org/W1568205932","https://openalex.org/W1531601525"],"abstract_inverted_index":{"Thermostability,":[0],"which":[1],"is":[2,10,208,227,258],"essential":[3],"for":[4,78,231,250],"the":[5,30,45,60,79,86,115,121,155,168,178,183,190,194,199,205,214,218,222,233,240,247,255],"functional":[6],"performance":[7],"of":[8,33,47,62,82,88,117,137,163,177,193,204,213,221,236,242],"enzymes,":[9],"largely":[11],"determined":[12],"by":[13,44],"intramolecular":[14],"physical":[15,83],"interactions.":[16],"Although":[17],"many":[18],"tools":[19],"have":[20,26,41,58,158],"been":[21,42],"developed,":[22],"existing":[23],"computational":[24],"methods":[25],"struggled":[27],"to":[28,125,167],"find":[29],"universal":[31],"principles":[32],"protein":[34,63,94,126,139],"thermostability.":[35],"Recent":[36],"advancements":[37],"in":[38,128,145,189,217],"structural":[39,89,101,122,234,243],"proteomics":[40],"driven":[43],"introduction":[46],"deep":[48],"neural":[49],"networks":[50],"such":[51],"as":[52,96],"AlphaFold2":[53],"and":[54,68,98,110,153,254],"ESMFold.":[55],"These":[56],"innovations":[57],"enabled":[59],"characterization":[61],"structures":[64],"with":[65],"unprecedented":[66],"speed":[67],"accuracy.":[69],"Here,":[70],"we":[71,119],"introduce":[72],"qProtein,":[73,118],"a":[74,135,159,228],"Python-implemented":[75],"workflow":[76],"designed":[77],"quantitative":[80],"analysis":[81,176],"interactions":[84],"on":[85],"scale":[87],"proteomics.":[90,244],"This":[91],"platform":[92,230],"accepts":[93],"sequences":[95],"input":[97],"produces":[99],"four":[100],"features,":[102],"including":[103],"hydrophobic":[104,164,184,201],"clusters,":[105],"hydrogen":[106],"bonds,":[107],"electrostatic":[108],"interactions,":[109],"disulfide":[111],"bonds.":[112],"To":[113],"demonstrate":[114],"use":[116],"investigate":[120],"features":[123,235],"related":[124],"thermostability":[127],"six":[129],"glycoside":[130],"hydrolase":[131],"(GH)":[132],"families,":[133],"comprising":[134],"total":[136],"3,811":[138],"structures.":[140],"Our":[141],"results":[142],"indicate":[143],"that":[144,182,212],"five":[146],"enzyme":[147],"families":[148],"(GH11,":[149],"GH12,":[150],"GH5_2,":[151],"GH10,":[152],"GH48),":[154],"thermophilic":[156,206],"enzymes":[157,170,207,216],"larger":[160],"average":[161,200],"area":[162,203],"clusters":[165,185],"compared":[166],"nonthermophilic":[169,215],"within":[171],"each":[172],"family.":[173],"Furthermore,":[174],"our":[175],"local-structure":[179],"regions":[180,192,220],"reveals":[181],"are":[186],"predominantly":[187],"distributed":[188],"distal":[191,219],"GH11":[195,223],"enzymes.":[196,224],"In":[197],"addition,":[198],"cluster":[202],"significantly":[209],"higher":[210],"than":[211],"Therefore,":[225],"qProtein":[226,251],"well-suited":[229],"analyzing":[232],"thermal":[237],"stability":[238],"at":[239,252,260],"level":[241],"We":[245],"provide":[246],"source":[248],"code":[249],"https://github.com/bj600800/qProtein,":[253],"web":[256],"server":[257],"available":[259],"http://qProtein.sdu.edu.cn:8888.":[261]},"abstract_inverted_index_v3":null,"cited_by_api_url":"https://api.openalex.org/works?filter=cites:W4403231300","counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2025-03-29T09:35:14.807904","created_date":"2024-10-09"}