{"id":"https://openalex.org/W2074581987","doi":"https://doi.org/10.1016/s1672-0229(06)60019-3","title":"Characterization of Binding Sites of Eukaryotic Transcription Factors","display_name":"Characterization of Binding Sites of Eukaryotic Transcription Factors","publication_year":2006,"publication_date":"2006-06-01","ids":{"openalex":"https://openalex.org/W2074581987","doi":"https://doi.org/10.1016/s1672-0229(06)60019-3","mag":"2074581987","pmid":"https://pubmed.ncbi.nlm.nih.gov/16970547","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5054036"},"language":"en","primary_location":{"is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1672-0229(06)60019-3","pdf_url":null,"source":{"id":"https://openalex.org/S155547894","display_name":"Genomics Proteomics & Bioinformatics","issn_l":"1672-0229","issn":["1672-0229","2210-3244"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true},"type":"article","type_crossref":"journal-article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/s1672-0229(06)60019-3","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100610506","display_name":"Jiang Qian","orcid":"https://orcid.org/0000-0002-0476-3596"},"institutions":[{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiang Qian","raw_affiliation_strings":["The Wilmer Institute, Johns Hopkins University School of Medicine , Baltimore, MD, 21287 , USA"],"affiliations":[{"raw_affiliation_string":"The Wilmer Institute, Johns Hopkins University School of Medicine , Baltimore, MD, 21287 , USA","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112213111","display_name":"Jimmy Lin","orcid":null},"institutions":[{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jimmy Lin","raw_affiliation_strings":["The Wilmer Institute, Johns Hopkins University School of Medicine , Baltimore, MD, 21287 , USA"],"affiliations":[{"raw_affiliation_string":"The Wilmer Institute, Johns Hopkins University School of Medicine , Baltimore, MD, 21287 , USA","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040841311","display_name":"Donald J. Zack","orcid":"https://orcid.org/0000-0002-7966-1973"},"institutions":[{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald J. Zack","raw_affiliation_strings":["Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine , Baltimore, MD, 21287 , USA","Department of Neuroscience, Johns Hopkins University School of Medicine , Baltimore, MD, 21287 , USA","McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine , Baltimore, MD, 21287 , USA","The Wilmer Institute, Johns Hopkins University School of Medicine , Baltimore, MD, 21287 , USA"],"affiliations":[{"raw_affiliation_string":"The Wilmer Institute, Johns Hopkins University School of Medicine , Baltimore, MD, 21287 , USA","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine , Baltimore, MD, 21287 , USA","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Neuroscience, Johns Hopkins University School of Medicine , Baltimore, MD, 21287 , USA","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I145311948"]},{"raw_affiliation_string":"McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine , Baltimore, MD, 21287 , USA","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I145311948"]}]}],"institution_assertions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500,"provenance":"doaj"},"apc_paid":{"value":3500,"currency":"USD","value_usd":3500,"provenance":"doaj"},"fwci":0.0,"has_fulltext":true,"fulltext_origin":"pdf","cited_by_count":3,"citation_normalized_percentile":{"value":0.475987,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":72,"max":74},"biblio":{"volume":"4","issue":"2","first_page":"67","last_page":"79"},"is_retracted":false,"is_paratext":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9997,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9997,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9957,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9952,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sequence-motif","display_name":"Sequence motif","score":0.65512276},{"id":"https://openalex.org/keywords/palindromic-sequence","display_name":"Palindromic sequence","score":0.6075181},{"id":"https://openalex.org/keywords/dna-binding-site","display_name":"DNA binding site","score":0.5116325},{"id":"https://openalex.org/keywords/intergenic-region","display_name":"Intergenic region","score":0.5096245},{"id":"https://openalex.org/keywords/motif","display_name":"Motif (music)","score":0.5093738},{"id":"https://openalex.org/keywords/structural-motif","display_name":"Structural motif","score":0.47878444},{"id":"https://openalex.org/keywords/eukaryotic-transcription","display_name":"Eukaryotic transcription","score":0.43732312},{"id":"https://openalex.org/keywords/transcription","display_name":"Transcription","score":0.41875634}],"concepts":[{"id":"https://openalex.org/C44667518","wikidata":"https://www.wikidata.org/wiki/Q12321","display_name":"Palindrome","level":4,"score":0.7967534},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6825975},{"id":"https://openalex.org/C117745874","wikidata":"https://www.wikidata.org/wiki/Q901612","display_name":"Sequence motif","level":3,"score":0.65512276},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.619411},{"id":"https://openalex.org/C76557","wikidata":"https://www.wikidata.org/wiki/Q369801","display_name":"Palindromic sequence","level":5,"score":0.6075181},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5602019},{"id":"https://openalex.org/C21592294","wikidata":"https://www.wikidata.org/wiki/Q3238407","display_name":"Regulatory sequence","level":4,"score":0.5123111},{"id":"https://openalex.org/C3662595","wikidata":"https://www.wikidata.org/wiki/Q5205743","display_name":"DNA binding site","level":5,"score":0.5116325},{"id":"https://openalex.org/C195139083","wikidata":"https://www.wikidata.org/wiki/Q3463539","display_name":"Intergenic region","level":4,"score":0.5096245},{"id":"https://openalex.org/C32276052","wikidata":"https://www.wikidata.org/wiki/Q908349","display_name":"Motif (music)","level":2,"score":0.5093738},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.50669795},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.49870038},{"id":"https://openalex.org/C132677234","wikidata":"https://www.wikidata.org/wiki/Q3273544","display_name":"Structural motif","level":2,"score":0.47878444},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.46319953},{"id":"https://openalex.org/C54985914","wikidata":"https://www.wikidata.org/wiki/Q1295754","display_name":"Consensus sequence","level":4,"score":0.4444687},{"id":"https://openalex.org/C100733574","wikidata":"https://www.wikidata.org/wiki/Q5408694","display_name":"Eukaryotic transcription","level":5,"score":0.43732312},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.42035234},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.41875634},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.38616693},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.31593072},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.30479372},{"id":"https://openalex.org/C3017666073","wikidata":"https://www.wikidata.org/wiki/Q1764062","display_name":"Base sequence","level":3,"score":0.1372475},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1321089},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.082221836},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004271","descriptor_name":"DNA, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020218","descriptor_name":"Response Elements","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"","qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001482","descriptor_name":"Base Composition","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001482","descriptor_name":"Base Composition","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004271","descriptor_name":"DNA, Fungal","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004271","descriptor_name":"DNA, Fungal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D030561","descriptor_name":"Databases, Nucleic Acid","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020218","descriptor_name":"Response Elements","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016335","descriptor_name":"Zinc Fingers","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016335","descriptor_name":"Zinc Fingers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":4,"locations":[{"is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1672-0229(06)60019-3","pdf_url":null,"source":{"id":"https://openalex.org/S155547894","display_name":"Genomics Proteomics & Bioinformatics","issn_l":"1672-0229","issn":["1672-0229","2210-3244"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":true,"landing_page_url":"https://europepmc.org/articles/pmc5054036","pdf_url":"https://europepmc.org/articles/pmc5054036?pdf=render","source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":["European Bioinformatics Institute"],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054036","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":["National Institutes of Health"],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16970547","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":["National Institutes of Health"],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false}],"best_oa_location":{"is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1672-0229(06)60019-3","pdf_url":null,"source":{"id":"https://openalex.org/S155547894","display_name":"Genomics Proteomics & Bioinformatics","issn_l":"1672-0229","issn":["1672-0229","2210-3244"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true},"sustainable_development_goals":[{"score":0.7,"display_name":"Life on land","id":"https://metadata.un.org/sdg/15"}],"grants":[{"funder":"https://openalex.org/F4320306340","funder_display_name":"Foundation Fighting Blindness","award_id":null},{"funder":"https://openalex.org/F4320306811","funder_display_name":"Research to Prevent Blindness","award_id":null},{"funder":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute","award_id":null}],"datasets":[],"versions":[],"referenced_works_count":32,"referenced_works":["https://openalex.org/W1592870802","https://openalex.org/W1966645907","https://openalex.org/W1987498682","https://openalex.org/W1994352206","https://openalex.org/W1999510229","https://openalex.org/W2003967338","https://openalex.org/W2008900336","https://openalex.org/W2026979173","https://openalex.org/W2027408624","https://openalex.org/W2047033234","https://openalex.org/W2054624670","https://openalex.org/W2058682865","https://openalex.org/W2084620487","https://openalex.org/W2084908610","https://openalex.org/W2087887622","https://openalex.org/W2099189600","https://openalex.org/W2121356022","https://openalex.org/W2126602684","https://openalex.org/W2128016314","https://openalex.org/W2135000328","https://openalex.org/W2140115103","https://openalex.org/W2141060672","https://openalex.org/W2141408320","https://openalex.org/W2147789429","https://openalex.org/W2148711195","https://openalex.org/W2151464048","https://openalex.org/W2152350018","https://openalex.org/W2162891889","https://openalex.org/W2168157737","https://openalex.org/W2756110755","https://openalex.org/W297918892","https://openalex.org/W4238300309"],"related_works":["https://openalex.org/W4384664566","https://openalex.org/W2412607611","https://openalex.org/W2162181074","https://openalex.org/W2094943798","https://openalex.org/W2094586524","https://openalex.org/W2055277464","https://openalex.org/W2037433390","https://openalex.org/W2005909367","https://openalex.org/W2005563268","https://openalex.org/W1986616196"],"abstract_inverted_index":{"Abstract":[0],"To":[1],"explore":[2],"the":[3,43,48,91,101,110,116,123,128,162,181],"nature":[4],"of":[5,42,100,174,183],"eukaryotic":[6],"transcription":[7],"factor":[8],"(TF)":[9],"binding":[10,28],"sites":[11],"and":[12,36,105,177],"determine":[13],"how":[14],"they":[15,96,133],"differ":[16],"from":[17,47],"surrounding":[18],"DNA":[19,27],"sequences,":[20],"we":[21,141],"examined":[22],"four":[23,60],"features":[24,61,86],"associated":[25],"with":[26],"sites:":[29],"G+C":[30,148],"content,":[31],"pattern":[32],"complexity,":[33],"palindromic":[34,77],"structure,":[35],"Markov":[37],"sequence":[38],"ordering.":[39],"Our":[40],"analysis":[41,167],"regulatory":[44,92,117,184],"motifs":[45,118,185],"obtained":[46],"TRANSFAC":[49],"database,":[50],"using":[51],"yeast":[52],"intergenic":[53],"sequences":[54,71,103,125],"as":[55,147,156],"background,":[56],"revealed":[57],"that":[58,95,143],"these":[59,85],"show":[62],"variable":[63],"enrichment":[64],"in":[65,114],"motif":[66,70,102,124],"sequences.":[67,82],"For":[68],"example,":[69],"were":[72,80,87,138,151,159],"more":[73,135],"likely":[74],"to":[75,90,127,131],"have":[76],"structure":[78],"than":[79],"background":[81],"In":[83],"addition,":[84],"tightly":[88],"localized":[89],"motifs,":[93],"indicating":[94],"are":[97,106],"a":[98],"property":[99],"themselves":[104],"not":[107],"shared":[108],"by":[109],"general":[111],"promoter":[112],"\u201cenvironment\u201d":[113],"which":[115,132],"reside.":[119],"By":[120],"breaking":[121],"down":[122],"according":[126],"TF":[129],"classes":[130],"bind,":[134],"specific":[136],"associations":[137],"identified.":[139],"Finally,":[140],"found":[142],"some":[144],"correlations,":[145],"such":[146,155],"content":[149],"enrichment,":[150,158],"species-specific,":[152],"while":[153],"others,":[154],"complexity":[157],"universal":[160],"across":[161],"species":[163],"examined.":[164],"The":[165],"quantitative":[166],"provided":[168],"here":[169],"should":[170],"increase":[171],"our":[172],"understanding":[173],"protein-DNA":[175],"interactions":[176],"also":[178],"help":[179],"facilitate":[180],"discovery":[182],"through":[186],"bioinformatics.":[187]},"cited_by_api_url":"https://api.openalex.org/works?filter=cites:W2074581987","counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2025-01-06T11:17:18.657453","created_date":"2016-06-24"}