{"id":"https://openalex.org/W1974075712","doi":"https://doi.org/10.1016/s0166-218x(98)00066-3","title":"On the complexity and approximation of syntenic distance","display_name":"On the complexity and approximation of syntenic distance","publication_year":1998,"publication_date":"1998-11-01","ids":{"openalex":"https://openalex.org/W1974075712","doi":"https://doi.org/10.1016/s0166-218x(98)00066-3","mag":"1974075712"},"language":"en","primary_location":{"is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0166-218x(98)00066-3","pdf_url":null,"source":{"id":"https://openalex.org/S171741597","display_name":"Discrete Applied Mathematics","issn_l":"0166-218X","issn":["0166-218X","1872-6771"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true},"type":"article","type_crossref":"journal-article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0166-218x(98)00066-3","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063144451","display_name":"Bhaskar Dasgupta","orcid":"https://orcid.org/0000-0003-0630-4593"},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bhaskar Dasgupta","raw_affiliation_strings":["Department of Computer Science, Rutgers University, Camden, NJ 08102, USA"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Rutgers University, Camden, NJ 08102, USA","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101911266","display_name":"Tao Jiang","orcid":"https://orcid.org/0000-0003-3833-4498"},"institutions":[{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Tao Jiang","raw_affiliation_strings":["Department of Computer Science, McMaster University, Hamilton, Ont., Canada L8S 4K1"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, McMaster University, Hamilton, Ont., Canada L8S 4K1","institution_ids":["https://openalex.org/I98251732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103555404","display_name":"Sampath Kannan","orcid":null},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sampath Kannan","raw_affiliation_strings":["Department of Computer and Information Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA#TAB#"],"affiliations":[{"raw_affiliation_string":"Department of Computer and Information Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA#TAB#","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100351398","display_name":"Ming Li","orcid":"https://orcid.org/0000-0002-2157-2775"},"institutions":[{"id":"https://openalex.org/I151746483","display_name":"University of Waterloo","ror":"https://ror.org/01aff2v68","country_code":"CA","type":"education","lineage":["https://openalex.org/I151746483"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ming Li","raw_affiliation_strings":["Department of Computer Science, University of Waterloo, Waterloo, Ont. Canada N2L 3G1"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Waterloo, Waterloo, Ont. Canada N2L 3G1","institution_ids":["https://openalex.org/I151746483"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014577367","display_name":"Elizabeth Sweedyk","orcid":null},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth Sweedyk","raw_affiliation_strings":["Department of Computer and Information Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA#TAB#"],"affiliations":[{"raw_affiliation_string":"Department of Computer and Information Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA#TAB#","institution_ids":["https://openalex.org/I79576946"]}]}],"institution_assertions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2750,"currency":"USD","value_usd":2750,"provenance":"doaj"},"apc_paid":{"value":2750,"currency":"USD","value_usd":2750,"provenance":"doaj"},"fwci":1.436,"has_fulltext":true,"fulltext_origin":"ngrams","cited_by_count":35,"citation_normalized_percentile":{"value":0.774387,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":90},"biblio":{"volume":"88","issue":"1-3","first_page":"59","last_page":"82"},"is_retracted":false,"is_paratext":false,"primary_topic":{"id":"https://openalex.org/T13664","display_name":"Genome Rearrangement Algorithms","score":0.9999,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13664","display_name":"Genome Rearrangement Algorithms","score":0.9999,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11269","display_name":"Algorithms and Data Compression","score":0.9834,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.9742,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/synteny","display_name":"Synteny","score":0.87484705}],"concepts":[{"id":"https://openalex.org/C53702515","wikidata":"https://www.wikidata.org/wiki/Q971246","display_name":"Synteny","level":4,"score":0.87484705},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.60979855},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.5843891},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.58062863},{"id":"https://openalex.org/C311688","wikidata":"https://www.wikidata.org/wiki/Q2393193","display_name":"Time complexity","level":2,"score":0.5275378},{"id":"https://openalex.org/C148764684","wikidata":"https://www.wikidata.org/wiki/Q621751","display_name":"Approximation algorithm","level":2,"score":0.49879622},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.45654842},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.44576845},{"id":"https://openalex.org/C179799912","wikidata":"https://www.wikidata.org/wiki/Q205084","display_name":"Computational complexity theory","level":2,"score":0.4180736},{"id":"https://openalex.org/C118615104","wikidata":"https://www.wikidata.org/wiki/Q121416","display_name":"Discrete mathematics","level":1,"score":0.32868117},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.29581723},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.25320458},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17210606},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1496256},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.124731004},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0166-218x(98)00066-3","pdf_url":null,"source":{"id":"https://openalex.org/S171741597","display_name":"Discrete Applied Mathematics","issn_l":"0166-218X","issn":["0166-218X","1872-6771"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true}],"best_oa_location":{"is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0166-218x(98)00066-3","pdf_url":null,"source":{"id":"https://openalex.org/S171741597","display_name":"Discrete Applied Mathematics","issn_l":"0166-218X","issn":["0166-218X","1872-6771"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true},"sustainable_development_goals":[],"grants":[],"datasets":[],"versions":[],"referenced_works_count":11,"referenced_works":["https://openalex.org/W1895774903","https://openalex.org/W2011039300","https://openalex.org/W2023749136","https://openalex.org/W2053913299","https://openalex.org/W2054600183","https://openalex.org/W2069323107","https://openalex.org/W2102813451","https://openalex.org/W2131912646","https://openalex.org/W2161959030","https://openalex.org/W2752885492","https://openalex.org/W2912936566"],"related_works":["https://openalex.org/W961142965","https://openalex.org/W4299801389","https://openalex.org/W2962917430","https://openalex.org/W2775068415","https://openalex.org/W2574604093","https://openalex.org/W2571897395","https://openalex.org/W2028468530","https://openalex.org/W1969010119","https://openalex.org/W1903284337","https://openalex.org/W1589381382"],"abstract_inverted_index":{"The":[0,42,209],"paper":[1],"studies":[2],"the":[3,51,65,71,87,95,120,125,134,162,168,176,184,194,199,205,214,220,226],"computational":[4],"complexity":[5],"and":[6,22,34,57,76,117,203,230],"approximation":[7,80,179,235],"algorithms":[8],"for":[9,138,243],"a":[10,25,30,35,38,78,140,149,191,232,238],"new":[11],"evolutionary":[12],"distance":[13,44,73,97,197],"between":[14,45],"multi-chromosomal":[15],"genomes":[16,47,202],"introduced":[17],"recently":[18],"by":[19,167],"Ferretti,":[20],"Nadeau":[21],"Sankoff.":[23],"Here,":[24],"chromosome":[26],"is":[27,37,48,74,98,142,161,228],"represented":[28],"as":[29,50],"set":[31,135],"of":[32,40,54,122,136,164,178,216,241],"genes":[33],"genome":[36,63,141,192],"collections":[39],"chromosomes.":[41],"syntenic":[43,72,96,105,196,221],"two":[46,126],"defined":[49],"minimum":[52],"number":[53,121,163],"translocations,":[55],"fusions":[56],"fissions":[58],"required":[59],"to":[60,198],"transform":[61],"one":[62],"into":[64],"other.":[66],"We":[67,223],"prove":[68,224],"that":[69,102,132,151,225],"computing":[70],"NP-hard":[75,229],"give":[77],"simple":[79],"algorithm":[81,236],"with":[82,237],"performance":[83,239],"ratio":[84,240],"2.":[85],"For":[86],"case":[88],"when":[89],"an":[90,103],"upper":[91],"bound":[92],"d":[93,160],"on":[94,219],"known,":[99],"we":[100,130,145,182],"show":[101,131],"optimal":[104],"sequence":[106],"can":[107,146],"be":[108],"found":[109],"in":[110,124,175,213],"O(nk":[111],"+":[112],"2o(d2))":[113],"time,":[114],"where":[115,159],"n":[116],"k":[118],"are":[119],"chromosomes":[123],"given":[127,201],"genomes.":[128],"Next,":[129],"if":[133],"operations":[137],"transforming":[139],"significantly":[143],"restricted,":[144],"nevertheless":[147],"find":[148],"solution":[150],"performs":[152],"at":[153],"most":[154],"O(log":[155],"d)":[156],"additional":[157],"moves,":[158],"moves":[165],"performed":[166],"unrestricted":[169],"optimum.":[170],"This":[171],"result":[172],"should":[173],"help":[174],"design":[177,231],"algorithms.":[180],"Finally,":[181],"investigate":[183],"median":[185,207],"problem:":[186],"Given":[187],"three":[188,200],"genomes,":[189],"construct":[190],"minimizing":[193],"total":[195],"compute":[204],"corresponding":[206],"distance.":[208,222],"problem":[210,227],"has":[211],"application":[212],"inference":[215],"phytogenies":[217],"based":[218],"polynomial":[233],"time":[234],"4+\u03b5":[242],"any":[244],"constant":[245],"\u03b5":[246],">":[247],"0.":[248]},"cited_by_api_url":"https://api.openalex.org/works?filter=cites:W1974075712","counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2025-01-05T05:47:46.984226","created_date":"2016-06-24"}