{"id":"https://openalex.org/W2409206425","doi":"https://doi.org/10.1016/j.neuroimage.2016.06.010","title":"The BOLD cerebrovascular reactivity response to progressive hypercapnia in young and elderly","display_name":"The BOLD cerebrovascular reactivity response to progressive hypercapnia in young and elderly","publication_year":2016,"publication_date":"2016-06-11","ids":{"openalex":"https://openalex.org/W2409206425","doi":"https://doi.org/10.1016/j.neuroimage.2016.06.010","mag":"2409206425","pmid":"https://pubmed.ncbi.nlm.nih.gov/27291492"},"language":"en","primary_location":{"is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2016.06.010","pdf_url":null,"source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":true,"is_in_doaj":true,"is_indexed_in_scopus":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false},"type":"article","type_crossref":"journal-article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049199298","display_name":"Alex A. Bhogal","orcid":"https://orcid.org/0000-0003-3211-1760"},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Alex A. Bhogal","raw_affiliation_strings":["Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands"],"affiliations":[{"raw_affiliation_string":"Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003522229","display_name":"Jill B. De Vis","orcid":null},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jill B. De Vis","raw_affiliation_strings":["Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands"],"affiliations":[{"raw_affiliation_string":"Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001626119","display_name":"Jeroen C.W. Siero","orcid":"https://orcid.org/0000-0001-5079-2868"},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jeroen C.W. Siero","raw_affiliation_strings":["Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands"],"affiliations":[{"raw_affiliation_string":"Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067524733","display_name":"Esben Thade Petersen","orcid":"https://orcid.org/0000-0001-7529-3432"},"institutions":[{"id":"https://openalex.org/I2801942218","display_name":"Hvidovre Hospital","ror":"https://ror.org/00edrn755","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801942218","https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Esben T. Petersen","raw_affiliation_strings":["Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital, Hvidovre, Denmark"],"affiliations":[{"raw_affiliation_string":"Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital, Hvidovre, Denmark","institution_ids":["https://openalex.org/I2801942218","https://openalex.org/I2802567020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006677921","display_name":"Peter R. Luijten","orcid":"https://orcid.org/0000-0002-8040-8449"},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Peter R. Luijten","raw_affiliation_strings":["Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands"],"affiliations":[{"raw_affiliation_string":"Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080311936","display_name":"Jeroen Hendrikse","orcid":"https://orcid.org/0000-0001-6384-6140"},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jeroen Hendrikse","raw_affiliation_strings":["Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands"],"affiliations":[{"raw_affiliation_string":"Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043918952","display_name":"M.E.P. Philippens","orcid":"https://orcid.org/0000-0003-0205-3459"},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Marielle E.P. Philippens","raw_affiliation_strings":["Department of Radiotherapy, University Medical Center Utrecht, Utrecht, The Netherlands"],"affiliations":[{"raw_affiliation_string":"Department of Radiotherapy, University Medical Center Utrecht, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069665156","display_name":"Hans Hoogduin","orcid":"https://orcid.org/0000-0001-7707-0750"},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Hans Hoogduin","raw_affiliation_strings":["Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands"],"affiliations":[{"raw_affiliation_string":"Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]}],"institution_assertions":[{"id":"https://openalex.org/I96673099","display_name":"Technical University of Denmark","ror":"https://ror.org/04qtj9h94","country_code":"DK","type":"education","lineage":["https://openalex.org/I96673099"]}],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5049199298"],"corresponding_institution_ids":["https://openalex.org/I3018483916"],"apc_list":{"value":3450,"currency":"USD","value_usd":3450,"provenance":"doaj"},"apc_paid":null,"fwci":2.225,"has_fulltext":true,"fulltext_origin":"ngrams","cited_by_count":40,"citation_normalized_percentile":{"value":0.855027,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"139","issue":null,"first_page":"94","last_page":"102"},"is_retracted":false,"is_paratext":false,"primary_topic":{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9999,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9999,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.9991,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10816","display_name":"Cerebrovascular and Carotid Artery Diseases","score":0.999,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/grey-matter","display_name":"Grey matter","score":0.6893201}],"concepts":[{"id":"https://openalex.org/C2777037550","wikidata":"https://www.wikidata.org/wiki/Q615759","display_name":"Hypercapnia","level":3,"score":0.90132254},{"id":"https://openalex.org/C2778013878","wikidata":"https://www.wikidata.org/wiki/Q646150","display_name":"Grey matter","level":4,"score":0.6893201},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.6506424},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5601617},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4758282},{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.4691875},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4657866},{"id":"https://openalex.org/C157767197","wikidata":"https://www.wikidata.org/wiki/Q886843","display_name":"Cerebral blood flow","level":2,"score":0.4271827},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4187148},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.38480085},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.28179246},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.098728},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.08921179}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":"","qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006935","descriptor_name":"Hypercapnia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D018810","descriptor_name":"Magnetic Resonance Angiography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D010092","descriptor_name":"Oximetry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001783","descriptor_name":"Blood Flow Velocity","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006935","descriptor_name":"Hypercapnia","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018810","descriptor_name":"Magnetic Resonance Angiography","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057054","descriptor_name":"Molecular Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057054","descriptor_name":"Molecular Imaging","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010092","descriptor_name":"Oximetry","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":"","qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2016.06.010","pdf_url":null,"source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":true,"is_in_doaj":true,"is_indexed_in_scopus":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false},{"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27291492","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_indexed_in_scopus":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":["National Institutes of Health"],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.69}],"grants":[],"datasets":[],"versions":[],"referenced_works_count":66,"referenced_works":["https://openalex.org/W1490034507","https://openalex.org/W1817846039","https://openalex.org/W187453383","https://openalex.org/W1901020111","https://openalex.org/W1926550607","https://openalex.org/W1966506253","https://openalex.org/W1967578708","https://openalex.org/W1971456886","https://openalex.org/W1994156254","https://openalex.org/W1994606962","https://openalex.org/W2000563517","https://openalex.org/W2002896876","https://openalex.org/W2005251537","https://openalex.org/W2007044580","https://openalex.org/W2038243884","https://openalex.org/W2039895323","https://openalex.org/W2044047480","https://openalex.org/W2044874692","https://openalex.org/W2051426766","https://openalex.org/W2052644075","https://openalex.org/W2054988239","https://openalex.org/W2057280125","https://openalex.org/W2057695752","https://openalex.org/W2058253334","https://openalex.org/W2058709849","https://openalex.org/W2060003084","https://openalex.org/W2060467175","https://openalex.org/W2061601951","https://openalex.org/W2067417098","https://openalex.org/W2071714163","https://openalex.org/W2073748140","https://openalex.org/W2075961514","https://openalex.org/W2078231944","https://openalex.org/W2082724398","https://openalex.org/W2087653213","https://openalex.org/W2088768348","https://openalex.org/W2090608123","https://openalex.org/W2091910719","https://openalex.org/W2093011968","https://openalex.org/W2093518292","https://openalex.org/W2093971930","https://openalex.org/W2095517065","https://openalex.org/W2102474541","https://openalex.org/W2102673550","https://openalex.org/W2112023375","https://openalex.org/W2114144533","https://openalex.org/W2116641010","https://openalex.org/W2119994688","https://openalex.org/W2129289310","https://openalex.org/W2129932089","https://openalex.org/W2130256616","https://openalex.org/W2133670545","https://openalex.org/W2143395710","https://openalex.org/W2150322963","https://openalex.org/W2150543553","https://openalex.org/W2150992284","https://openalex.org/W2152346792","https://openalex.org/W2153228639","https://openalex.org/W2153425956","https://openalex.org/W2159172202","https://openalex.org/W2170426231","https://openalex.org/W2237099831","https://openalex.org/W2279348102","https://openalex.org/W2470594653","https://openalex.org/W4235770099","https://openalex.org/W636946897"],"related_works":["https://openalex.org/W4253937632","https://openalex.org/W4205866527","https://openalex.org/W2997548647","https://openalex.org/W2460293179","https://openalex.org/W2071001789","https://openalex.org/W2049932968","https://openalex.org/W2028814883","https://openalex.org/W2017977110","https://openalex.org/W1977549674","https://openalex.org/W1595276058"],"abstract_inverted_index":null,"cited_by_api_url":"https://api.openalex.org/works?filter=cites:W2409206425","counts_by_year":[{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4}],"updated_date":"2025-01-21T17:54:53.117344","created_date":"2016-06-24"}